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Two healthy dogs weighing 18 kg and 13
kg each received an intravenous injection of 7 μg/kg 25-hydroxyvitamin D3 (25OHD3). Subsequently,
they were blood-sampled
in order to determine the plasma levels of 25(OH)D3 over 4-hourly
time intervals and for a time period of 24 hours. After a period of 18 days
since the last blood sampling, the animals were brought to a hyperthyroid state
and the intravenous injection of 7 μg/kg 25OHD3 was repeated. Blood sampling was performed every 4
hours and over a time period of 24 hours in order to determine the levels of
25OHD3. The graphic plotting of plasma levels of 25OHD3 in the euthyroid state did not differ from that in the hyperthyroid state. This
finding in dog animal experimentation is indicative that the increased levels
of thyroid hormones did not affect the activity of CYP27B1 and CYP24A1 enzymes
that are related to the catabolism of 25OHD3 over a minimum of 24
The knowledge of the epidemiology of parasitic infections in stray and domestic animals, especially of its incidence and prevalence, is fundamental to adopting effective prophylactic measures. Stray dogs play an important role in environmental contamination favoring the transmission cycle of zoonotic agents. Among the parasitic infections that affect humans, Giardia duodenalis is the most common intestinal protozoa and was designated as a re-emerging infectious disease. This study aimed to determine the prevalence of G. duodenalis in dogs siezed by the Center for Control of Zoonoses (CCZ) of the city of Lages, Santa Catarina, Brazil using two diagnostic techniques. In 357 stool samples analysed, the prevalence of G. duodenalis cysts was 5.3% (19/357) and 4.8% (17/357) detected by floatation and sedimentation techniques, respecttively. No correspondence between gender and age was found among the methods used for analyzing the infected dogs in this study. Our data suggested that two diagnostic techniques should be used in a complementary way to ensure that false negatives are not neglected.
Many studies have been done and many results have been established for studying cancers in human and the ways of treating it. However, one thing that remains relevant is the study model that is used to diagnose, cure or conclude treatment methods for human cancers. The scientists have tried some ways to link the data and tried to analyze the malicious disease in various animal models in order to solve the problem for humans. Out of all the models, scientists have preferred dogs as the most suitable model and conducted studies on them. Our article will review the reason for preferences given to dog as a study model and what the previous studies have tried to conclude by considering the dreaded disease in dogs. Our article has focused on most of the recent observations and tried to elucidate the reasons/preferences for studying cancer disease in dogs (scientific name; Canis Lupus familiaris). We will also talk about the idea of comparative oncology programs that many centers adapt in order to study the disease called cancer.