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Search Results: 1 - 10 of 15954 matches for " chronic diseases "
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Intra-renal and urinary RNA expression of podcyte-associated molecules in patients with IgA nephropathy  [PDF]
Gang Wang, Bonnie Ching Kwan, Fernand Mac-Moune Lai, Paul Cheung-Lung Choi, Kai-Ming Chow, Philip Kam-Tao Li, Cheuk-Chun Szeto
Advances in Bioscience and Biotechnology (ABB) , 2010, DOI: 10.4236/abb.2010.13032
Abstract: Background Podocyte injury probably plays important roles in the pathogenesis of IgA nephropathy (IgAN). We studied intra-renal and urinary messenger RNA (mRNA) expression of podocyte-associated molecules in patients with IgAN. Methods We studied 43 consecutive patients with biopsy-proven IgAN. Intra-renal and urinary expression of mRNAs was determined and compared to that of 20 patients with nephrectomy for kidney cancer and 12 normal subjects. Results Intra-renal mRNA expression levels of nephrin, podocin and synaptopodin were significantly lower in patients with IgAN than that of controls. In contrast, their urinary mRNA expression levels were similar. Intra-renal gene expression of nephrin inversely correlated with proteinuria (r = –0.620, P < 0.001), GFR (r = 0.538, P < 0.001), and the degree of tubulointerstitial scarring (r = –0.423, P = 0.013). After followed for an average of 33.4 ? 12.6 months, intra-renal nephrin expression significantly correlated with the rate of GFR decline (r = 0.324, P = 0.041). Conclusions Intra-renal mRNA expression of podocyte associated molecules was down-regulated in patients with IgAN, and the degree of down- regulation of nephrin correlated with disease severity and the rate of progression. Our result supports the hypothesis that podocyte injury is an important component in the pathophysiology of IgAN.
The law of unintended consequences and antibiotics  [PDF]
James D. Thacker, Carol M. Artlett
Open Journal of Immunology (OJI) , 2012, DOI: 10.4236/oji.2012.22007
Abstract: Antibiotic therapy has been of unquestionable value in terms of saving lives and reducing suffering caused by infectious diseases. However, the widespread and indiscriminant use of antibiotics has not been without significant consequences. Some of these consequences include increased antibiotic resistance in pathogenic strains of bacteria. In addition, the indiscriminate use of antibiotics has recently been shown to alter the host microbiota and this has been associated with chronic disease. However, abandoning the use of antibiotics would be unthinkable. We have been exploring a strategy of modulating the host tolerance/resistance mechanisms as a means to ablate infection. We postulate that the obvious advantage of this therapeutic strategy is that, by targeting host tolerance/resistance mechanisms, the selective pressure for the expression of pathogen resistance is greatly reduced or altogether absent.
Study on Chronic Diseases Comprehensive Intervention in Baoji of Shaanxi Province in China  [PDF]
Honglin Wang, Feng Deng, Meng Qu, Peirong Yang, Biao Yang
Open Journal of Epidemiology (OJEpi) , 2014, DOI: 10.4236/ojepi.2014.44024
Abstract: Background: There is very limited data available about the epidemiology trial on chronic diseases comprehensive intervention. The aim of this study was to assess the effect of comprehensive intervention on chronic diseases in Baoji and provide basis for the improvement of chronic diseases intervention measures. Methods: Using four stages stratified random sampling method, comprehensive intervention measures were implemented on intervention group (575 individuals) respectively aimed at three crowds of whole population, high risk population and chronic diseases patients. The control group (782 individuals) did not receive special treatment. Two groups were evaluated effect after one year observation. Results: The chronic diseases prevalence rate of whole population in intervention group was lower than that in control group (P < 0.05), the blood pressure level and smoking proportion of high risk population in intervention group were lower than in control group (P < 0.05), and the blood pressure, blood glucose control rate of chronic diseases patients in intervention group were higher than in control group (P < 0.05). Conclusion: Comprehensive intervention could prevent the rise of chronic diseases prevalence. The intervention is effective in reducing or halting risk factors of high risk population, particularly in controlling blood pressure, blood glucose of patients. We should establish government leading, department cooperation, social participation, longtime and classified comprehensive intervention mechanism of chronic diseases. We believe that whole population should control the risk factors, high risk population should early diagnosis and treatment, chronic diseases patients should normalized management, and it could be applied in other counties.
AndroidCare: A Simple and Low Cost Assisted Living Solution  [PDF]
Abraham Otero, Alejandro Escario, David G. Márquez, Gabriel Caffarena, Rodrigo García-Carmona, Ana Iriarte, Rafael Raya
Journal of Biomedical Science and Engineering (JBiSE) , 2016, DOI: 10.4236/jbise.2016.910B003
Population aging places a growing stress on society’s resources. There is a need for Assisted Living (AL) technologies that allow the elderly to live independently as long as possible. The AndroidCare open source project aims to explore what functionality can be provided in a low cost AL solution where no professional health organization is involved in the deployment or maintenance of the solution, nor in supervising the pa-tient; all these tasks are carried out by a relative of the elder. Therefore, in the system’s design simplicity of use has prevailed over having a lot of features. It is based on stan-dard off-the-shell commodity hardware (a smartphone) and it provides 1) assistance to the elder in complying with the treatment of chronic diseases; 2) monitors and alerts of the occurrence of risk situations such as falls; and 3) simplifies the supervision of the elder’s therapy and behavior by the caregiver.
O método da pesquisa convergente assistencial em um estudo com pessoas com doen?a arterial coronariana
Bonetti, Albertina;Silva, Denise Guerreiro V. da;Trentini, Mercedes;
Escola Anna Nery , 2013, DOI: 10.1590/S1414-81452013000100025
Abstract: the objective of this report is to highlight the relevance of the method of converging assistance research (pca). it takes as reference a study that aimed to introduce innovations in the context of the practice through the construction, implementation and analysis of a body ludic experience program with persons diagnosed with coronary arteriosclerosis disease. the pca approach is characterized by its property of interacting with the health assistance. accordingly, health actions are gradually incorporated in the research process and vice versa. the findings showed that the pca consisted of a proper method for introducing innovation in the health practice for self care and for the prevention of the coronary arteriosclerosis disease complications. the study also has contributed for the knowledge development related to self-care and to prevention of coronary atherosclerosis complications.
Chronic inflamatory bowel diseases
Turk Pediatri Ar?ivi , 2011,
Abstract: There are two main types of chronic inflamatory bowel diseases: crohn’s disease affecting the whole gastrointestinal system from oral cavity to rectum and ulcerative colitis affecting only the colon. A third group of such diseases consist of indeterminated colitis. Chronic inflomatory bowel disesases emerge by means of triggering factors on a genetic basis. These disease with similarities and differences concerning clinical prognosis and laboratory findings have started to be seen in younger popilations. In this rewiew prognosis, diagnosis and treatment of inflamotory bowel diseases have been discussed. (Turk Arch Ped 2011; 46 Suppl: 70-8)
Important Points in Taking Care of Elderly Patients with Chronic Diseases
Hale Karapolat
Türkiye Fiziksel Tip ve Rehabilitasyon Dergisi , 2009,
Abstract: In the last century, the ratio of elderly population has risen together with the increment in life expectancy and an associated increase is observed in chronic diseases. Deterioration of health status due to chronic diseases and the associated decrease in functional ability increases the individual’s dependency to others. In this respect, the elderly are in more need of health care as well as social and economic care. The necessity of institutions for elderly care is gradually increasing across the globe. The required attention should be paid to this issue and necessary steps should be taken in order to ensure healthy, peaceful and content societies in the future. Turk J Phys Med Rehab 2009; 55 Suppl 2: 88-9.
The child with chronic cough: when does double-channel pH monitoring rule out gastroesophageal reflux  [PDF]
Richard Kitz, Peter Ahrens, Olaf Eickmeier, Hansjosef Boehles, Markus A. Rose
Open Journal of Pediatrics (OJPed) , 2011, DOI: 10.4236/ojped.2011.13006
Abstract: Background: gastroesophageal reflux (GER) plays a major role in the pathogenesis of pediatric chronic airway disease. Esophageal pH-monitoring (epHM) is the diagnostic gold standard for acid GER. To date, there are no cut-off values for chronically coughing children ruling out relevant GER. Methods: 24-hour, double-channel epHM was performed in 549 children (3 months to 16 years old) with chronic pulmonary disease. We stratified according to age as follows: ≤ 1.5 years, > 1.5 - 4 years, > 4 - 8 years, > 8 < 12 years and > 12 - 16 years. Following parameters were calculated for both channels: total number of reflux episodes, number of reflux episodes > 5 minutes, duration of the longest reflux episode, and reflux index. Results: according to the above given age classification, the median number of reflux episodes in the lower esophagus was 31, 27, 32, 34, and 42 and for the upper esophagus 20, 13, 15, 14, and 11 respectively. The median reflux index at the distal esophagus was 2.55, 2.1, 2.3, 2.15, and 1.9; at the upper esophagus it was 1.4, 1.0, 1.1, 0.9, and 0.6 respectively. Conclusions: our data contribute useful support to the evaluation of pediatric airway disease. We provide reference values for decisions in the exploration of children with airway disorders and suspected GER.
Adolescents’ Knowledge of Diet-Related Chronic Diseases and Dietary Practices in Ghana  [PDF]
Christina A. Nti, Augustina Brown, Angelina Danquah
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.311199
Abstract: Diet-related chronic diseases constitute public health and developmental challenges in Ghana. The Ghana Health Service in 2007 reported a national prevalence of diabetes of 11.6%, 27.8% for hypertension and 25% of women were reported to be overweight. Adolescents usually adopt lifestyles that negatively affect their nutritional and health status and increase their risk for development of diet-related chronic diseases later in life. The study was therefore carried out to investigate adolescents’ knowledge of diet-related chronic diseases and its influence on their dietary practices. The study design was a cross-sectional survey involving 313 adolescents aged 14 18 years from public and private senior high schools. Structured interviews and diet assessment methods were used to collect information on respondents’ knowledge of diet-related chronic diseases and dietary practices. The data collected were analyzed using the SPSS program version 16. The Chi-square test and ANOVA were used to determine the relationships between respondents’ knowledge of diet-related chronic diseases and dietary practices. The results revealed that knowledge of diabetes, hypertension and obesity were low among the respondents with most of them (89.2%) having fair to poor knowledge of the diseases. Eighty-eight percent of the adolescents ate three or more times in a day. Meals mostly skipped were breakfast and lunch. Dietary diversity of the respondents was generally poor. There was a significant relationship between knowledge of diet-related chronic diseases and the dietary practices of the adolescents. As knowledge of the diseases increased, dietary diversity also improved.
Chronic pain profile: An interaction between biological and psychosocial factors*  [PDF]
Marcus A. Alcantara, Rosana F. Sampaio, Mariana A. P. Souza, Fabiana C. M. Silva, Renata N. Kirkwood
Pain Studies and Treatment (PST) , 2013, DOI: 10.4236/pst.2013.12003
Abstract: OBJECTIVE: To Identify subgroups of workers with chronic pain based on the interaction of different pain dimensions (sensory, affective, evaluative and mixed), depression, beliefs regarding pain, physical incapacity and socio-demographic-clinical data. METHODS:An observational cross-sectional study was carried out with a convenience sample made up of 115 patients with work-related musculoskeletal disorders (WRMD). The participants answered the McGill Pain Questionnaire, Beck Depression Inventory, Survey of Pain Attitudes, Roland-Morris Disability Questionnaire and a form for socio-demographic and clinical data. RESULTS: Four distinct subgroups were identified, two of which reported pain of a sensory-affective nature and two reported predominantly sensory pain. The individuals in subgroups I and III reported higher levels for all variables analyzed, while the first cluster had the highest mean scores. The subgroup II exhibited moderate degrees of physical disability and a high sick leave index, although the members of this group were less depressed and less dependent upon analgesics. Lower levels of pain, physical disability and depression were associated to subgroup IV, which also had the greatest proportion of males. Beliefs were similar among the subgroups. CONCLUSIONS: Patients with moderate to strong chronic pain associated to sensory and affective components exhibited a higher degree of disability and depression. The results suggest that the chronification process of pain and its functional consequences vary between individuals and are influenced by emotional factors.
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