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Search Results: 1 - 10 of 22926 matches for " chagas disease "
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The undetermined form of Chagas' heart disease: concept and forensic implications
Barretto, Antonio Carlos Pereira;Ianni, Barbara Maria;
Sao Paulo Medical Journal , 1995, DOI: 10.1590/S1516-31801995000200010
Abstract: the undetermined form of chagas' disease is diagnosed in asymptomatic subjects with a positive blood test for chagas' disease, normal resting electrocardiogram, chest x-ray, barium esophageal and large bowel radiological studies. other investigation methods are not recommended for identification of other organs damage lesions in this phase of the disease. when other methods of investigation were employed, cardiac and digestive abnormalities of small magnitude were detected without prognostic implications. these findings do not warrant frequent examinations of patients with undetermined form of the disease except for the electrocardiogram or if the patients report other clinical manifestations. the benign course of the disease does not preclude ability to work and the subjects should be considered apt for work in any profession.
Synthesis and Trypanocidal Evaluation of Some Novel 2-(Substituted Benzylidene)-5, 7-Dibromo-6-Hydroxy-1-Benzofuran-3(2H)-Ones  [PDF]
K. L. Ameta, Nitu S. Rathore, Biresh Kumar, Edith S. Malaga M, Manuela Verastegui P, Robert H. Gilman, B. L. Verma
International Journal of Organic Chemistry (IJOC) , 2012, DOI: 10.4236/ijoc.2012.223040
Abstract: Substituted 2-benzylidene-1-benzofuran-3-ones are commonly known as aurones. This class of bioactive heterocycles belongs to flavonoid family. The article intends to put forth the rational design and synthesis of a new series of aurones using 3’,5’-dibromo-2’,4’-dihydroxychalcones and copper bromide in presence of DMF-water mixture (8:2, v/v) for the first time. Preliminary bioassay shows that most of compounds have good trypanocidal activity against Trypanosoma cruzi at 10 μg/mL. Few compounds are equally potent to the standard drugs Benznidazole and Nifurtimox. The structures of the newly synthesized products 2a-n were established by elemental analysis, FTIR, 1H NMR, 13C NMR and mass spectroscopic studies.
Impact of Chagas Disease on Human Evolution: The Challenges Continue  [PDF]
Elaine Cristina Navarro, Paulo Camara Marques Pereira
Advances in Anthropology (AA) , 2013, DOI: 10.4236/aa.2013.34A001
Abstract:

Chagas disease affects 8 to 10 million people worldwide and, although most of them live in Latin America, there has been an increase in cases occurring in countries of Europe and North America although most of them live in Latin America. This study aims to describe the epidemiological situation in the present as well as government and research centers actions, particularly the study group of Chagas disease of the School of Medicine of Botucatu (FMB/UNESP)/Brazil.

Estado actual en el tratamiento de la enfermedad de Chagas
APT B,WERNER; ZULANTAY A,INéS;
Revista médica de Chile , 2011, DOI: 10.4067/S0034-98872011000200016
Abstract: efficient drugs against chagas' disease must have an effect on the amastigote forms or intracellular reproduction elements of trypanosoma cruzi (t. cruzi). trypomastigote and epimastigote forms derive from the former and their response to medications is less marked. the only drugs used in humans are nifurtimox (nf) and benznidazole (bnz). other useful medications are allopurinol and itraconazole. nf acts producing free radicals and bnz inhibits the synthesis of macromolecules. there is consensus that chagas' disease must be treated in all its periods, since t.cruzi dna is detected by polymerase chain reaction in chronic cases, even when microscopy is negative. the pharmacological treatment modifies the natural evolution of the disease. it also helps to solve a public health problem, considering that there is a high number of subjects with chagas' disease. subjects with chronic chagasic cardiomyopathy with terminal heart failure are the only cases without indication for treatment. due to the digestive and skin secondary effects of the drugs, treated patients must be controlled clinically and with complete blood counts and hepatic proiles before, during and after the therapy. approximately 30% of patients will experience secondary effects. children have a better tolerance to the drugs. congenital or acquired acute, intermediate and chronic cases should be treated.
Estado actual en el tratamiento de la enfermedad de Chagas Update on the treatment of Chagas' disease
WERNER APT B,INéS ZULANTAY A
Revista médica de Chile , 2011,
Abstract: Efficient drugs against Chagas' disease must have an effect on the amastigote forms or intracellular reproduction elements of Trypanosoma cruzi (T. cruzi). Trypomastigote and epimastigote forms derive from the former and their response to medications is less marked. The only drugs used in humans are nifurtimox (NF) and benznidazole (BNZ). Other useful medications are allopurinol and itraconazole. NF acts producing free radicals and BNZ inhibits the synthesis of macromolecules. There is consensus that Chagas' disease must be treated in all its periods, since T.cruzi DNA is detected by polymerase chain reaction in chronic cases, even when microscopy is negative. The pharmacological treatment modifies the natural evolution of the disease. It also helps to solve a public health problem, considering that there is a high number of subjects with Chagas' disease. Subjects with chronic chagasic cardiomyopathy with terminal heart failure are the only cases without indication for treatment. Due to the digestive and skin secondary effects of the drugs, treated patients must be controlled clinically and with complete blood counts and hepatic proiles before, during and after the therapy. Approximately 30% of patients will experience secondary effects. Children have a better tolerance to the drugs. Congenital or acquired acute, intermediate and chronic cases should be treated.
Seqüência de transmiss?es n?o habituais da infec??o chagásica em uma mesma família: transfusional para a m?e e congênita para o filho, de cepa de Trypanosoma cruzi resistente ao tratamento
Fragata Filho, Abilio Augusto;Correia, Edileide de Barros;Borges Filho, Renato;Vasconcelos, Marcos de Oliveira;Janczuk, Daniel;Martins, Cícero Soares de Souza;
Revista da Sociedade Brasileira de Medicina Tropical , 2008, DOI: 10.1590/S0037-86822008000100014
Abstract: the authors present two cases of unusual transmission of chagas infection in the same family: the mother by blood transfusion and her second child across the placenta. the child was diagnosed by chance and etiological treatment for both the mother and the child was ineffective in eradicating the parasitemia. at present, they continue to present the indeterminate form of the disease.
Chagasic megaesophagus and megacolon diagnosed in childhood and probably caused by vertical transmission
DA-COSTA-PINTO, Elizete Aparecida Lomazi;ALMEIDA, Eros A.;FIGUEIREDO, Deolinda;BUCARETCHI, Fábio;HESSEL, Gabriel;
Revista do Instituto de Medicina Tropical de S?o Paulo , 2001, DOI: 10.1590/S0036-46652001000400010
Abstract: reports on children presenting symptoms compatible with the chronic phase of chagas disease are sporadic. we report a case of a 7-year-old boy who had megaesophagus and megacolon, both of them a consequence of the trypanosomiasis. the etiology was established by means of laboratory and histological features. based on epidemiological data, the authors concluded that vertical transmission was the most probable route of acquisition. this diagnosis should be considered in children presenting similar complaints, even those living away from endemic areas.
Chagasic megaesophagus and megacolon diagnosed in childhood and probably caused by vertical transmission
DA-COSTA-PINTO Elizete Aparecida Lomazi,ALMEIDA Eros A.,FIGUEIREDO Deolinda,BUCARETCHI Fábio
Revista do Instituto de Medicina Tropical de S?o Paulo , 2001,
Abstract: Reports on children presenting symptoms compatible with the chronic phase of Chagas disease are sporadic. We report a case of a 7-year-old boy who had megaesophagus and megacolon, both of them a consequence of the trypanosomiasis. The etiology was established by means of laboratory and histological features. Based on epidemiological data, the authors concluded that vertical transmission was the most probable route of acquisition. This diagnosis should be considered in children presenting similar complaints, even those living away from endemic areas.
Therapeutic Targets in Chagas’ Disease: a Focus on Trypanothione Reductase [Alvos Terapêuticos na Doen a de Chagas: a Tripanotiona Redutase como Foco]
Samuel S. da R. Pita,Pedro G. Pascutti
Revista Virtual de Química , 2011,
Abstract: The work of Carlos Chagas culminated with the description of the disease that bears his name. His discovery reaches over a century. Since the first reports of this disease, many therapeutic approaches have been developed intending treatment of the disease. However, to date, none therapy has proven to be enough to cure the acute and chronic disease’s manifestations without severe adverse effects.Several approaches relying on modern techniques including rational drug design from a potent prototype compound, have achieved relative success. Different routes are used which the main objective is the development of an effective therapy suitable for populations economically disadvantaged. This mini-review highlights some classes of these therapies, mostly in the experimental stage, and discusses many approaches to enzyme inhibition of the protozoan that have proved promising in the fight against Chagas’ disease. The specific focus is the enzyme trypanothione reductase.
Ocorrência de Panstrongylus guentheri Berg (Hemiptera: Reduviidae) no Mato Grosso do Sul
Almeida, Paulo S. de;Santos, Honório R. dos;Barata, José M.S.;Obara, Marcos T.;Ceretti Jr., Walter;
Neotropical Entomology , 2008, DOI: 10.1590/S1519-566X2008000100019
Abstract: the first occurrence of panstrongylus guentheri berg in brazil is presented. this species had been reported only in the territories of argentina, paraguay, bolivia and uruguay. we have extended the geographic distribution of this triatominae, with two specimens captured in bodoquena and itapor? cities, both in mato grosso do sul state, brazil. these specimens were found in the intradomestic environment.
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