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Pronóstico de las bacteriemias adquiridas en la comunidad ingresadas en un Servicio de Medicina Interna
Lizarralde Palacios,E.; Gutiérrez Macías,A.; Martínez Odriozola,P.; Ibarmia Lahuerta,J.; la Villa,F. M. de;
Anales de Medicina Interna , 2005, DOI: 10.4321/S0212-71992005000300002
Abstract: objective: to analyze mortality and associated factors in community-acquired bacteremia admitted to an internal medicine department. patient and methods: prospective study of bacteremia admitted in 1 year (may 1999-april 2000). we have collected demographic data, previous comorbid conditions, functional status, source of infection, complications, vital signs, laboratory values, apache ii and sofa scores, blood cultures, therapy and 28-day mortality. in bivariate analysis, we have used chi-square, student-t test and mann-whitney u as needed. significant variables have been introduced in a stepwise backward logistic regression model with mortality as the dependent variable. results: we have observed 115 episodes of bacteremia in 114 patients. the source of bacteremia was urinary tract in 57.4% episodes and the most common isolate was escherichia coli (54.4%). 28-day mortality was 15.3%. factors independently associated with mortality were septic shock (or 10.4), non-urinary source of bacteremia (or 9.3), apache ii score higher than 20 (or 5,5), and previous dependent functional status (or 4.8). conclusions: mortality risk factors were septic shock, non-urinary source of bacteremia, apache ii score and dependent functional status.
The Study of Blood Culture for Prevalent Bacteria and Antibiotic Resistance on Hospitalized Patients
H Alaodolei,F Sedighian,Z Shahandeh
Iranian Journal of Public Health , 2007,
Abstract: Background: Bacteremia means invasion of bacteria to coronary- arthery system. One third of these cases lead to septicemia and in 40-50% cases, it causes patient’s death. Therefore information about resistance and prevalent of bacteria isolated from blood culture is important for deciding about suitable therapeutic management. Methods: This retrospective study was done on all positive blood cultures for typing and detecting of antibiotic resistance during 2001- 2005. Data was analyzed by statistical procedure. Results: In 252 (4.35%) of studied blood cultures, the most prevalent bacteries were Staph. epidermidis (35.2%) and E. Coli (18.5%). The greatest and the least resistance antibiotics were βLactam (75.2%) and glycopeptide (7.8%) groups, respectively. Conclusion: With regard to antibiotic resistance increased during these years, awaring of the last changes about it in every therapeutic center is necessary.
Bacteremia with Cutaneous Nodules, Due to Pseudomonas Aeruginosa  [PDF]
Ali Akbar Heydari, Maryam Mojtabavi
Advances in Infectious Diseases (AID) , 2011, DOI: 10.4236/aid.2011.12004
Abstract: Pseudomonas aeruginosa bacteremia rarely occurs in non-immunocompromised adults and can be difficult to be treated. We report a case of 35-year-old woman who presented with respiratory distress, fever and skin lesions. There was pleural effusion in chest radiograph, and CT scan of thorax showed necrotizing pneumonia and loculated empyema. Among the cultures of blood, empyema, sputum and the skin nodules aspirates, all were positive for Pseudomonas aeruginosa. The patient was treated with ciprofloxacin, amikacin and then pleural decortications. Laboratory tests failed to reveal any immunological deficits. After a period of 21 days of antibiotic therapy, the patient was discharged from hospital with a good condition.
Incidence of Bacteremia and Septicemia in patients attending in tertiary care center, Nepal
R Chaudhary,S Karmacharya,S Shrestha,RK Dahal,SK Mishra,NR Banjade,HP Kattel,BP Rijal,JB Sherchand,BM Pokhrel
Journal of Institute of Medicine , 2012, DOI: 10.3126/joim.v34i3.8915
Abstract: Introduction: Bacteremia and septicemia is life threatening condition resulting in major cause of mortality and morbidity.The aim of study was to determine the etiology of bacteremia and septicemia with antibiotic sensitivity profile of those organisms. Methods: A prospective study was carried out among the suspected cases from both inpatient and outpatient of TUTH from October 2009 .March 2010. Blood samples were collected and processed according to standard methodology. Results: Out of 2259 samples only 237 (10.49 %) showed bacterial growth. The most common isolates among Salmonella group was Salmonella enterica serotype typhi 71(29.95%) followed by Salmonella enterica serotype Paratyphi A 45(18.98%). Among non Salmonella group Pseudomonas aeruginosa 34(14.34%), Klebsiella pneumoniae 22(9.28%), Acinetobacter spp 15 (6.32%), Citrobacter spp 5(2.10%), Escherichia coli 3(1.26%) while Staphylococcus aureus 34 (14.3%) was most common followed by Enterococcus spp 3(1.26%), Streptococcus spp 2(0.84%), Coagulase Negative Staphylococcus 2(0.84%) and Listeria spp 1(0.42%) among Gram Positive organisms. Antibiogram revealed Cefotaxime, Ceftazidime, Azithromycin and Chloramphenicol for Salmonella group while for non Salmonella Imipenem, Meropenem and Amikacin as most effective antibiotics while Clindamycin, Cipro!oxacin and O!oxacin for gram positive. Conclusion: Gram negative bacteria was the predominant organism causing bacteremia and septicemia. Among them salmonella typhi and salmonella paratyphi were the leading aetiology. DOI: http://dx.doi.org/10.3126/joim.v34i3.8915 ? Journal of Institute of Medicine, December, 2012; 34:32-38
Hematogenous Osteomyelitis by Acinetobacter Baumannii: Case Report and Literature Review  [PDF]
Rajendrakumar Chimanlal Patel, Sumir Prakash Sahgal, Shervin Mortazavi, Yagnang Kaushikkumar Vyas, Richard Joseph Adam, Vera Salim Antonios
World Journal of AIDS (WJA) , 2011, DOI: 10.4236/wja.2011.12004
Abstract: Skeletal infection with Acinetobacter baumanii is a rare condition and found mainly among soldiers injured in war. Multidrug resistant (MDR) Acinetobacter baumanii (A. baumanii) osteomyelitis is difficult to treat and requires long course of intravenous antibiotics. Most of reported cases in the literature are the consequences of direct inoculation of the pathogen. Here in, we report the first case of A. Baumannii osteomyelitis disseminated through hematogenous route and the therapeutic approach for this rare infection. Clinical Presentation: A 46 year old African-American male patient with human immunodeficiency virus (HIV) and end- stage renal disease on hemodialysis, who developed persistent MDR A. baumanii bacteremia in the hospital, thought to be secondary to the hemodialysis catheter, necessitating replacement of the catheter. Three months after his discharge to a skilled nursing facility (SNF), he developed left leg swelling without noticeable pain or fever. MRI revealed findings consistent with chronic osteomyelitis of left tibia and intra operative bone culture grew MDR A. baumannii. The patient had good outcome after three surgical debridements and prolonged period (7 Months) of dual antimicrobial therapy. Discussion: While in most documented cases of A. baumannii osteomyelitis, entry appears to require direct inoculation; our case suggests that this pathogen can seed into bone hematogenously in the setting of immunosuppression, persistent bacteremia and possibly in the presence of underlying bone infarcts. Clinicians need to be aware of this rare possible consequence of A. baumannii bacteremia. In conclusion, combination of multiple surgical debridements and dual antimicrobial therapy for a long period may result in a good outcome.
Statins and Sepsis Literature Review  [PDF]
Alicia Hernández Torres, Ana Belén Hernández Cascales, Pedro Pujante Alarcón, Alfonso López Ruiz, María Dolores Hellín Gil, María ángeles Ibá?ez Gil
Pharmacology & Pharmacy (PP) , 2013, DOI: 10.4236/pp.2013.48082
Abstract: Recent data suggest that, in addition to improving dyslipidemia, statin may reduce the risk of infections and infection-related complications. The aim of this study is to make a review of the literature about the effects of statins on clinically relevant outcomes of patients admitted to the hospital and having an infection and/or sepsis, principally in terms of intensive care unit admissions and related death.
A Retrospective Quality Study of Hemodialysis Catheter-Related Bacteremia in a Danish Hospital  [PDF]
Sophie Kaarup, Bente Olesen, Mahshid Pourarsalan, Lene Boesby, Lisbet Brandi
Open Journal of Nephrology (OJNeph) , 2016, DOI: 10.4236/ojneph.2016.64014
Background: Hemodialysis catheter-related bacteremia (HD CRB) is a major complication of long-term hemodialysis (HD) therapy and bacteremia is secondary only to cardiovascular disease as the leading cause of death in patients receiving renal replacement therapy. A large part may be preventable and surveillance is a critical aspect of infection control and prevention. Aim: To analyze incidence, causative species, and treatment of HD CRB in adult chronic HD patients at Nordsjaellands Hospital (NOH), Denmark. Methods: All episodes of bacteremia in the Department of Cardiology, Nephrology and Endocrinology (KNEA), NOH from 2010 to 2013 were analyzed. Inclusion criteria: Adult chronic HD patients with a tunneled dialysis catheter diagnosed with HD CRB. Causative microorganism and antimicrobial treatment were recorded for each episode. Findings: Ninetynine episodes of HD CRB in 72 patients were found with a mean incidence rate of 0.9/1000 catheter-days. Gram-positive bacteria were isolated in 71% of the episodes, gram-negative bacteria in 25%, both in 3%, and yeast in 1%. The most frequently isolated microorganisms were Staphylococcus aureus (33%), Coagulase-negative staphylococci (29%), enterobacteriaceae (20%) and enterococci (8%). The most commonly used empiric antimicrobials were cefuroxime and vancomycin and the overall efficacy was 77%. Conclusion: The well-functioning infection prevention strategy seems to be successful resulting in a relatively low incidence rate of HD CRB compared with that shown in international studies. The high proportion of gram-negative bacteria raises the question as to whether future antimicrobial guidelines should cover both gram-positive and gram-negative bacteria.
Chryseobacterium indologenes Bacteremia: Clinical and Microbiological Characteristics of an Emerging Infection  [PDF]
Danny Alon, Eli Karniel, Iris Zohar, Gideon Y. Stein
International Journal of Clinical Medicine (IJCM) , 2018, DOI: 10.4236/ijcm.2018.96045
Abstract: Purpose: Since Chryseobacterium indologenes (C. indologenes) is a rare human pathogen, its clinical significance has not yet been fully established. C. indologenes contamination of medical devices involving fluids and of surgical implants has led to an increasing number of serious infectious reported in recent years, mainly in patients in extremes ages and an immunocompromised state. In this study, we describe the clinical and microbiological characteristics of seven adult patients with C. indologenes bacteremia treated in a tertiary medical center in Israel over a six-year period. Methods: Adult patients hospitalized in Rabin Medical Center, Israel, with a blood culture positive for C. indologenes during the period 2009-2014 were identified retrospectively and their medical records were reviewed. Results: Seven episodes of C. indologenes bacteremia in seven patients were identified during the study period. Five patients were females; the mean age was 76.8 years (41 - 92). Serious underlying conditions were present in all patients. All patients but one, presented after a recent invasive healthcare related intervention. Two patients required mechanical ventilation. Two patients died. All but one isolates were susceptible to ciprofloxacin. Conclusions: Despite our limited number of cases, to the best of our knowledge, our study serves as the largest cohort of adult patients with C. indologenes bacteremia reported in recent years.
Bacteriemia relacionada a catéter por Ralstonia mannitolilytica
Soloaga,Rolando; Carrión,Natalia; Vazquez,Miriam; Pidone,Juan Carlos; Suar,María Beatriz; Salinas,Andrea; Guelfand,Liliana; Alvarez,Verónica; Margari,Alejandra; Altieri,Rosana;
Acta bioqu?-mica cl?-nica latinoamericana , 2011,
Abstract: ralstonia mannitolilytica is a glucose non-fermentative, aerobic gram-negative bacillus formerly known as ralstonia picketti biovar3/"thomasii" of relatively low virulence. it has been isolated from a wide kind of infections like bacteremia, meningitis, endocarditis, osteomielitis and from the respiratory tract of patients with cystic fibrosis. the case presented is related to a 26-year-old male patient with diabetes insipidus, hypothyroidism and histiocytosis x with a two-day-febrile syndrome and chills associated with the presence of a porthacat catheter used for administrating medication. an episode of catheter-related bloodstream infection was documented by using bact-alert blood culture system and differential-time-to-positivity method for central venous catheter versus peripheral blood cultures (>120min). once removed, it was confirmed through maki semiquantitative technique (>15 ufc). the microorganism was identified by api 20 ne, vitek 2c and vitek 1 as. ralstonia mannitolilytica.
Bacteriemia por Leuconostoc spp. en paciente sin factores de riesgo
Cinza Sanjurjo,S.; Cabarcos Ortiz de Barrón,A.; Castilla Galicia,G.; Lorenzo Zú?iga,V.;
Anales de Medicina Interna , 2006, DOI: 10.4321/S0212-71992006000200006
Abstract: leuconostoc spp are gram-positive coccobacilli, catalasa and oxidase negative, vancomycin resistant. causes of infection have been reported previously but it has not been described confirmed bacteremia due to leuconostoc spp in patient without other immunological disorders. we describe a case of bacteremia in a 64-years-old man with a prosthetic valve 7 months before to begin fever of unknown origin. we confirmed bacteremia due leuconostoc spp and the treatment with respectives antibiotics permits the cure. leuconostoc spp should be considered as a potencial cause of bacteriemia, but we would be observant to the bacteremias due vancomicin resitant germs, because in most cases the laboratory do not find the sensitivity to this antibiotic.
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