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Search Results: 1 - 10 of 233263 matches for " and George C. Wagner "
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Voluntary exercise inhibits intestinal tumorigenesis in ApcMin/+ mice and azoxymethane/dextran sulfate sodium-treated mice
Jihyeung Ju, Bonnie Nolan, Michelle Cheh, Mousumi Bose, Yong Lin, George C Wagner, Chung S Yang
BMC Cancer , 2008, DOI: 10.1186/1471-2407-8-316
Abstract: In Experiments 1 and 2, five-week old female ApcMin/+ mice were either housed in regular cages or cages equipped with a running wheel for 6 weeks (for mice maintained on the AIN93G diet; Experiment 1) or 9 weeks (for mice on a high-fat diet; Experiment 2). In Experiment 3, male CF-1 mice at 6 weeks of age were given a dose of AOM (10 mg/kg body weight, i.p.) and, 12 days later, 1.5% DSS in drinking fluid for 1 week. The mice were then maintained on a high-fat diet and housed in regular cages or cages equipped with a running wheel for 16 weeks.In the ApcMin/+ mice maintained on either the AIN93G or the high-fat diet, voluntary exercise decreased the number of small intestinal tumors. In the AOM/DSS-treated mice maintained on a high-fat diet, voluntary exercise also decreased the number of colon tumors. In ApcMin/+ mice, voluntary exercise decreased the ratio of serum insulin like growth factor (IGF)-1 to IGF binding protein (BP)-3 levels. It also decreased prostaglandin E2 and nuclear β-catenin levels, but increased E-cadherin levels in the tumors.These results indicate hat voluntary exercise inhibited intestinal tumorigenesis in ApcMin/+ mice and AOM/DSS-treated mice, and the inhibitory effect is associated with decreased IGF-1/IGFBP-3 ratio, aberrant β-catenin signaling, and arachidonic acid metabolism.Colorectal cancer is the second most common form of cancer in incidence and mortality in developed countries [1]. While its etiology remains unknown, it is thought that both genetic and environmental factors play critical roles in causing colorectal cancer. Epidemiological studies consistently show that physical activity is associated with a reduced risk of colon cancer [2-5]. However, the protective effect of exercise against colon carcinogenesis has not been consistently demonstrated in animal models [6-9]. The inconsistent results observed in animal studies is likely due to the nature of the animal model as well as the type of exercise employed. For example, volun
Sleep Insufficiency, Sleep Health Problems and Performance in High School Students
Xue Ming, Rebecca Koransky, Victor Kang, Sarah Buchman, Christina E. Sarris, and George C. Wagner
Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine , 2012, DOI: 10.4137/CCRPM.S7955
Abstract: A survey on sleep schedule, sleep health, school performance and school start times was conducted in 1,941 adolescents. A high level of early and circadian-disadvantaged sleep/wake schedules during weekdays was observed. Shorter sleep duration on weekdays was reported, especially in upper classmen. Complaints of inadequate sleep and sleepiness during weekdays, alarm clock use, and napping were prevalent. Night awakening and prolonged sleep onset were common and associated with poor school performance. Students with a sleep length of less than 7 hours on both weekdays and weekends exhibited poorer performance, while those who made up this sleep loss on weekends did not. The total number of poor sleep factors in an individual also correlated with poor school performance. Earlier school start times were associated with a perception of poor sleep quality, shorter sleep duration and more sleep health problems. We conclude that sleep inadequacies and sleep health problems were prevalent in this population, especially in those who started school earlier in the morning, and that these poor sleep factors were associated with school performance.
Sleep Deficiency and Sleep Health Problems in Chinese Adolescents
Victor Kang, Jesus Shao, Kai Zhang, Martha Mulvey, Xue Ming and George C. Wagner
Clinical Medicine Insights: Pediatrics , 2012, DOI: 10.4137/CMPed.S8407
Abstract: A survey of sleep schedules, sleep health, and the impact on school performance was conducted in 585 adolescents in a high school in China. A high level of early and circadian-disadvantaged sleep/wake schedules during weekdays was observed. Significantly shorter sleep duration on weekdays was reported (P < 0.0001). Older teenagers slept significantly less than the younger teenagers (P < 0.0001). Complaints of inadequate sleep and sleepiness during weekdays were prevalent. Night awakenings were reported in 32.2% of students. Students with a sleep length of less than 7 hours, complaint of inadequate sleep, or excessive daytime sleepiness during weekdays were more likely to report an adverse effect of poor sleep on performance. The present observations are qualitatively similar to those reported in our study in American adolescents, particularly with respect to Chinese adolescents exhibiting a similar sleep deficiency on weekdays. We concluded that sleep deficiency and sleep health problems were prevalent in the participating adolescents in China, and were perceived to adversely affect school performance.
Functional Deficits in Pak5, Pak6 and Pak5/Pak6 Knockout Mice
Melody A. Furnari, Michelle L. Jobes, Tanya Nekrasova, Audrey Minden, George C. Wagner
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061321
Abstract: The p21-activated kinases are effector proteins for Rho-family GTPases. PAK4, PAK5, and PAK6 are the group II PAKs associated with neurite outgrowth, filopodia formation, and cell survival. Pak4 knockout mice are embryonic lethal, while Pak5, Pak6, and Pak5/Pak6 double knockout mice are viable and fertile. Our previous work found that the double knockout mice exhibit locomotor changes and learning and memory deficits. We also found some differences with Pak5 and Pak6 single knockout mice and the present work further explores the potential differences of the Pak5 knockout and Pak6 knockout mice in comparison with wild type mice. The Pak6 knockout mice were found to weigh significantly more than the other genotypes. The double knockout mice were found to be less active than the other genotypes. The Pak5 knockout mice and the double knockout mice performed worse on the rotorod test. All the knockout genotypes were found to be less aggressive in the resident intruder paradigm. The double knockout mice were, once again, found to perform worse in the active avoidance assay. These results indicate, that although some behavioral differences are seen in the Pak5 and Pak6 single knockout mice, the double knockout mice exhibit the greatest changes in locomotion and learning and memory.
Lyapunov Instability for a hard-disk fluid in equilibrium and nonequilibrium thermostated by deterministic scattering
C. Wagner
Physics , 2000,
Abstract: We compute the full Lyapunov spectra for a hard-disk fluid under temperature gradient and shear. The system is thermalized by deterministic and time-reversible scattering at the boundary. This thermostating mechanism allows for energy fluctuations around a mean value which is reflected by only two vanishing Lyapunov exponents in equilibrium and nonequilibrium. The Lyapunov exponents are calculated with a recently developed formalism for systems with elastic hard collisions. In a nonequilibrium steady state the average phase space volume is contracted onto a fractal attractor leading to a negative sum of Lyapunov exponents. Since the system is driven inhomogeneously we do not expect the conjugate pairing rule to hold which is confirmed numerically.
Aktuelles: Ungewollte Schwangerschaften: Zahlen und Fakten aus sterreich
Linemayr-Wagner C
Speculum - Zeitschrift für Gyn?kologie und Geburtshilfe , 2013,
Client-centered Direction: Or How to Get There When You’re Not Sure Where You’re Going
Christopher C. Wagner
Motivational Interviewing : Training, Research, Implementation, Practice , 2012, DOI: 10.5195/mitrip.2012.22
Abstract: Change is broader than behavior, and often starts before a goal or plan is conceived, with clients first opening up to the vague possibility of betterness. Collaboration is a hallmark of MI spirit, and therapeutic direction can be developed collaboratively in MI through the process of evoking client values, desires, needs, hopes, and goals. Counselors may initially aspire to help clients find better lives, and narrow the focus to discrete change goals when specific client behaviors are collaboratively identified as obstacles to achieving a better life, or when absence of behaviors is identified as inhibiting progress toward it
Unification of Couplings and the Dynamical Breakdown of the Electroweak Symmetry
C. E. M. Wagner
Physics , 1993,
Abstract: I discuss the properties of the minimal supersymmetric extension of the standard model, in the case in which there is a dynamical breakdown of the electroweak symmetry induced by the formation of condensates of the third generation of quarks and their supersymmetric partners. The top quark and Higgs mass predictions derived within this scheme are essentially equivalent to those ones obtained from the requirement of bottom-tau Yukawa coupling unification in a supersymmetric grand unified scenario, if the compositeness scale is identified with the grand unification scale. I give an explanation of this interesting result, for which the relevance of the infrared quasi fixed point on the top quark Yukawa coupling is emphasized.
Physics at LEP and Yukawa Coupling Unification
C. E. M. Wagner
Physics , 1995,
Abstract: We discuss the impact of the recent precision measurements at LEP on the minimal supersymmetric standard model. We show that the values of $\tan\beta$ necessary to induce large positive corrections to $R_b$ are the same as the ones preferred by the unification of the bottom and $\tau$ Yukawa couplings in the MSSM for the current measured value of $M_t$. We discuss the relevance of the preferred parameter space for the Higgs and sparticle searches at LEP2. Remarkably, it follows that the LEP measurements can provide information about the structure of soft supersymmetry breaking parameters at $M_{GUT}$. Finally, we briefly discuss the properties of a supersymmetric model with four generations, for which the fit to $R_b$ naturally improves with respect to the one in the Standard Model.
Visualization of the flow profile inside a thinning filament during capillary breakup of a polymer solution via particle image velocimetry (PIV) and particle tracking velocimetry (PTV)
S. Gier,C. Wagner
Physics , 2012,
Abstract: We investigated the flow profile of a polymer solution in a thinning capillary bridge. Fluorescent tracer particles with a diameter of 3$\mu$m were used to visualize the flow. The cylindrical shape of the filament introduced strong optical abberations that could be corrected for, and we were able to characterize the flow in filaments with a thickness ranging from 150 to 30 $\mu$m. In the first regime when the filament was still sufficiently large, we used a PIV algorithm to deduce the flow field. At later stages when the number of particles in the observation plane decreased a PTV algorithm was used. The main two results of our measurements are as follows. First, the flow profile at the formation of the cylindrical filament is highly inhomogeneous and there is only flow in the outer parts of the filament. Second, we find that in most parts of the regime, where the temporal radius of the thinning filament can be fitted with an exponential law the flow indeed is purely extensional.
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