Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99


Any time

2019 ( 29 )

2018 ( 212 )

2017 ( 219 )

2016 ( 200 )

Custom range...

Search Results: 1 - 10 of 12685 matches for " Zijun Luo "
All listed articles are free for downloading (OA Articles)
Page 1 /12685
Display every page Item
Impact of miRNA Sequence on miRNA Expression and Correlation between miRNA Expression and Cell Cycle Regulation in Breast Cancer Cells
Zijun Luo, Yi Zhao, Robert Azencott
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095205
Abstract: The miRNAs regulate cell functions by inhibiting expression of proteins. Research on miRNAs had usually focused on identifying targets by base pairing between miRNAs and their targets. Instead of identifying targets, this paper proposed an innovative approach, namely impact significance analysis, to study the correlation between mature sequence, expression across patient samples or time and global function on cell cycle signaling of miRNAs. With three distinct types of data: The Cancer Genome Atlas miRNA expression data for 354 human breast cancer specimens, microarray of 266 miRNAs in mouse Embryonic Stem cells (ESCs), and Reverse Phase Protein Array (RPPA) transfected by 776 miRNAs in MDA-MB-231 cell line, we linked the expression and function of miRNAs by their mature sequence and discovered systematically that the similarity of miRNA expression enhances the similarity of miRNA function, which indicates the miRNA expression can be used as a supplementary factor to predict miRNA function. The results also show that both seed region and 3' portion are associated with miRNA expression levels across human breast cancer specimens and in ESCs; miRNAs with similar seed tend to have similar 3' portion. And we discussed that the impact of 3' portion, including nucleotides , is not significant for miRNA function. These results provide novel insights to understand the correlation between miRNA sequence, expression and function. They can be applied to improve the prediction algorithm and the impact significance analysis can also be implemented to similar analysis for other small RNAs such as siRNAs.
The Complete Mitochondrial Genome of Bean Goose (Anser fabalis) and Implications for Anseriformes Taxonomy
Gang Liu, Lizhi Zhou, Lili Zhang, Zijun Luo, Wenbin Xu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0063334
Abstract: Mitochondrial DNA plays an important role in living organisms, and has been used as a powerful molecular marker in a variety of evolutionary studies. In this study, we determined the complete mtDNA of Bean goose (Anser fabalis), which is 16,688 bp long and contains 13 protein-coding genes, 2 rRNAs, 22 tRNAs and a control region. The arrangement is similar to that of typical Anseriform species. All protein-coding genes, except for Cyt b, ND5, COI, and COII, start with an ATG codon. The ATG start codon is also generally observed in the 12 other Anseriform species, including 2 Anser species, with sequenced mitochondrial genomes. TAA is the most frequent stop codon, one of three–TAA, TAG, and T- –commonly observed in Anseriformes. All tRNAs could be folded into canonical cloverleaf secondary structures except for tRNASer(AGY) and tRNALeu(CUN), which are missing the dihydrouridine (DHU) arm. The control region of Bean goose mtDNA, with some conserved sequence boxes, such as F, E, D, and C, identified in its central domain. Phylogenetic analysis of complete mtDNA data for 13 Anseriform species supports the classification of them into four major branches: Anatinae, Anserinae, Dendrocygninae and Anseranatidae. Phylogenetic analyses were also conducted on 36 Anseriform birds using combined Cyt b, ND2, and COI sequences. The results clearly support the genus Somateria as an independent lineage classified in its own tribe, the Somaterini. Recovered topologies from both complete mtDNA and combined DNA sequences strongly indicate that Dendrocygninae is an independent subfamily within the family Anatidae and Anseranatidae represents an independent family. Based on the results of this study, we conclude that combining ND2, Cyt b, and COI sequence data is a workable solution at present for resolving phylogenetic relationships among Anseriform species in the absence of sufficient complete mtDNA data.
A Neuron Model with Dendritic Nonlinearity for Predicting the Influence of Overreaction in Shanghai Stock Market  [PDF]
Sha Zijun, Hu Lin
Chinese Studies (ChnStd) , 2015, DOI: 10.4236/chnstd.2015.41001
Abstract: On the basis of previous research, this study assembled trading data from January 2004 to October 2014 to verify the overreaction in Shanghai stock market. The influence of overreaction decreases with time from 2007 onwards and turns to disappear from 2011. The neuron model with dendritic nonlinearity (NMDN) proposed in this paper fits and predicts the variability of abnormal returns of ill-preforming and well-preforming stocks in the test period. This experiment demonstrates that NMDN possesses high computational ability and succeeds to predict trends in the influence of overreaction.
miRNA Regulatory Circuits in ES Cells Differentiation: A Chemical Kinetics Modeling Approach
Zijun Luo, Xuping Xu, Peili Gu, David Lonard, Preethi H. Gunaratne, Austin J. Cooney, Robert Azencott
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0023263
Abstract: MicroRNAs (miRNAs) play an important role in gene regulation for Embryonic Stem cells (ES cells), where they either down-regulate target mRNA genes by degradation or repress protein expression of these mRNA genes by inhibiting translation. Well known tables TargetScan and miRanda may predict quite long lists of potential miRNAs inhibitors for each mRNA gene, and one of our goals was to strongly narrow down the list of mRNA targets potentially repressed by a known large list of 400 miRNAs. Our paper focuses on algorithmic analysis of ES cells microarray data to reliably detect repressive interactions between miRNAs and mRNAs. We model, by chemical kinetics equations, the interaction architectures implementing the two basic silencing processes of miRNAs, namely “direct degradation” or “translation inhibition” of targeted mRNAs. For each pair (M,G) of potentially interacting miRMA gene M and mRNA gene G, we parameterize our associated kinetic equations by optimizing their fit with microarray data. When this fit is high enough, we validate the pair (M,G) as a highly probable repressive interaction. This approach leads to the computation of a highly selective and drastically reduced list of repressive pairs (M,G) involved in ES cells differentiation.
Donaldson-Thomas theory of $[\mathbb{C}^2/\mathbb{Z}_{n+1}]\times \mathbb{P}^1$
Zijun Zhou
Mathematics , 2015,
Abstract: We study the relative orbifold Donaldson-Thomas theory of $[\mathbb{C}^2/\mathbb{Z}_{n+1}]\times \mathbb{P}^1$. We establish a correspondence between the DT theory relative to 3 fibers to quantum multiplication by divisors in the Hilbert scheme of points on $[\mathbb{C}^2/\mathbb{Z}_{n+1}]$. This determines the whole theory if a further nondegeneracy condition is assumed. The result can also be viewed as a crepant resolution correspondence to the DT theory of $\mathcal{A}_n\times \mathbb{P}^1$.
Relative Orbifold Donaldson-Thomas Theory and the Degeneration Formula
Zijun Zhou
Mathematics , 2015,
Abstract: We generalize the notion of expanded degenerations and pairs for a simple degeneration or smooth pair to the case of smooth Deligne-Mumford stacks. We then define stable quotients on the classifying stacks of expanded degenerations and pairs and prove the properness of their moduli's. On 3-dimensional smooth projective DM stacks this leads to a definition of relative Donaldson-Thomas invariants and the associated degeneration formula.
A Game Theoretic Approach for Analyzing the System of Incentives and Restraints Present in Chinese Financial Systems  [PDF]
Lin Hu, Fan Yang, Zijun Sha
Theoretical Economics Letters (TEL) , 2014, DOI: 10.4236/tel.2014.47066

Currently, the most important issue with respect to financial institutions is how to motivate staff without providing perverse incentives. For instance, with the implementation of a proper incentive system, staff will be motivated via their self-interest to create financial innovations to better price and hedge risk. However, this system must also be designed with checks and balances in mind because it is also very easy to institute a system in which perverse incentives drive individual behavior. In an effort to modernize the Chinese financial system, it is important to understand both the underlying mechanism by which people respond to incentives to better design compensation schemes that maximize innovation. Utilizing game theory, it is possible to analyze the interplay between these two drivers of human action. From this analysis it becomes possible to design better ways of compensating staff to curb undesirable behavior by those in the financial industry while still promoting innovation within the field.

An Unusual Life-Threatening Hemobilia Caused by Hepatic Pseudoaneurysm Following Choledochostomy: A Case Report  [PDF]
Zijun Liu, Shiyong Yang, Pengcheng Xi
Case Reports in Clinical Medicine (CRCM) , 2016, DOI: 10.4236/crcm.2016.52007
Abstract: The present report describes a case of hemobilia caused by hepatic pseudoaneurysm. A 63-year-old woman was admitted with abdominal pain and mild jaundice. She was diagnosed as choledocholithiasis and hypersplenism and underwent choledocolithotomy and splenectomy. 9th day post operation, massive fresh blood suddenly flew out from T tube and she underwent emergency abdominal exploration but there were no obvious bleeding sites in the abdominal cavity and no bleeding sites in the biliary tree by choledochoscope. 7th day after the second operation, fresh blood suddenly flew out from T tube again and angiography showed two small peudoaneurysms at the second branch of right hepatic artery which might result in hemobilia. The hemobilia was treated successfully with coil embolisation of peudoaneurysms and she recovers fully.
Asset Pricing with Relative Performance and Heterogeneous Agents  [PDF]
Ting Levy, Xiangbo Liu, Zijun Liu, Zhigang Qiu
Theoretical Economics Letters (TEL) , 2012, DOI: 10.4236/tel.2012.25096
Abstract: This paper studies the impact of relative performance on portfolio choices and asset prices when fund managers differ in size and exogenous financial shocks. We find that with these heterogeneities, fund managers change their trading behaviors significantly.
IR and Raman Spectra Properties of Bi2O3-ZnO-B2O3-BaO Quaternary Glass System  [PDF]
Feng He, Zijun He, Junlin Xie, Yuhui Li
American Journal of Analytical Chemistry (AJAC) , 2014, DOI: 10.4236/ajac.2014.516121
Abstract: Among new low-melting-point glasses, bismuth ate glass is deemed to have the most potential as an environmentally friendly replacement for polluting Pb-containing glasses. Current studies of boro-bismuthate glasses focus on the structural influence of the additional oxide in the context of low-melting-point electronic sealing applications. In this study, the structure of quaternary Bi2O3- ZnO-B2O3-BaO glasses was investigated spectroscopic ally, with Fourier-transform-infrared (FT-IR) and Raman spectra recorded for glasses with different main oxide contents. Signals in the FT-IR are mainly observed around 500 cm﹣1, 720 cm﹣1, 840 cm﹣1, 980 - 1080 cm﹣1, and 1200 - 1500 cm﹣1, while the Raman scattering peaks are located at 130 cm﹣1, 390 cm﹣1, 575 cm﹣1, 920 cm﹣1, and 1250 cm﹣1. The glasses are mainly structured around [BO3] units and the numbers of [BiO6] and [BiO3] units increase with the Bi2O3 content increasing. Concurrently, the FT-IR absorption peaks associated with [BO4] units shift to lower wave numbers, indicating a loosening of the glass structure. However, as the B2O3 content is increased, the numbers of [BO3] and [BO4] units increase, while those of [BiO3] and [BiO6] units decrease, highlighting a densification of the glass structure. ZnO acts as a network modifier in these glasses.
Page 1 /12685
Display every page Item

Copyright © 2008-2017 Open Access Library. All rights reserved.