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Search Results: 1 - 8 of 8 matches for " Zijad Durakovic "
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Common SNPs in FTO Gene Are Associated with Obesity Related Anthropometric Traits in an Island Population from the Eastern Adriatic Coast of Croatia
Ge Zhang,Rebekah Karns,Nina Smolej Narancic,Guangyun Sun,Hong Cheng,Sasa Missoni,Zijad Durakovic,Pavao Rudan,Ranajit Chakraborty,Ranjan Deka
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010375
Abstract: Multiple studies have provided compelling evidence that the FTO gene variants are associated with obesity measures. The objective of the study was to investigate whether FTO variants are associated with a broad range of obesity related anthropometric traits in an island population.
Finding Missing Heritability in Less Significant Loci and Allelic Heterogeneity: Genetic Variation in Human Height
Ge Zhang, Rebekah Karns, Guangyun Sun, Subba Rao Indugula, Hong Cheng, Dubravka Havas-Augustin, Natalija Novokmet, Zijad Durakovic, Sasa Missoni, Ranajit Chakraborty, Pavao Rudan, Ranjan Deka
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0051211
Abstract: Genome-wide association studies (GWAS) have identified many common variants associated with complex traits in human populations. Thus far, most reported variants have relatively small effects and explain only a small proportion of phenotypic variance, leading to the issues of ‘missing’ heritability and its explanation. Using height as an example, we examined two possible sources of missing heritability: first, variants with smaller effects whose associations with height failed to reach genome-wide significance and second, allelic heterogeneity due to the effects of multiple variants at a single locus. Using a novel analytical approach we examined allelic heterogeneity of height-associated loci selected from SNPs of different significance levels based on the summary data of the GIANT (stage 1) studies. In a sample of 1,304 individuals collected from an island population of the Adriatic coast of Croatia, we assessed the extent of height variance explained by incorporating the effects of less significant height loci and multiple effective SNPs at the same loci. Our results indicate that approximately half of the 118 loci that achieved stringent genome-wide significance (p-value<5×10?8) showed evidence of allelic heterogeneity. Additionally, including less significant loci (i.e., p-value<5×10?4) and accounting for effects of allelic heterogeneity substantially improved the variance explained in height.
Extent of Height Variability Explained by Known Height-Associated Genetic Variants in an Isolated Population of the Adriatic Coast of Croatia
Ge Zhang, Rebekah Karns, Guangyun Sun, Subba Rao Indugula, Hong Cheng, Dubravka Havas-Augustin, Natalija Novokmet, Dusko Rudan, Zijad Durakovic, Sasa Missoni, Ranajit Chakraborty, Pavao Rudan, Ranjan Deka
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0029475
Abstract: Background Human height is a classical example of a polygenic quantitative trait. Recent large-scale genome-wide association studies (GWAS) have identified more than 200 height-associated loci, though these variants explain only 2~10% of overall variability of normal height. The objective of this study was to investigate the variance explained by these loci in a relatively isolated population of European descent with limited admixture and homogeneous genetic background from the Adriatic coast of Croatia. Methodology/Principal Findings In a sample of 1304 individuals from the island population of Hvar, Croatia, we performed genome-wide SNP typing and assessed the variance explained by genetic scores constructed from different panels of height-associated SNPs extracted from five published studies. The combined information of the 180 SNPs reported by Lango Allen el al. explained 7.94% of phenotypic variation in our sample. Genetic scores based on 20~50 SNPs reported by the remaining individual GWA studies explained 3~5% of height variance. These percentages of variance explained were within ranges comparable to the original studies and heterogeneity tests did not detect significant differences in effect size estimates between our study and the original reports, if the estimates were obtained from populations of European descent. Conclusions/Significance We have evaluated the portability of height-associated loci and the overall fitting of estimated effect sizes reported in large cohorts to an isolated population. We found proportions of explained height variability were comparable to multiple reference GWAS in cohorts of European descent. These results indicate similar genetic architecture and comparable effect sizes of height loci among populations of European descent.
Progressive Muscular Dystrophies in Children
Osman Sinanovic,Suada Kapidzic-Durakovic
Acta Medica Saliniana , 2010, DOI: 10.5457/199
Abstract: is not provided
On Complex Langevin Dynamics and the Evaluation of Observables
Amel Durakovic,Emil Cortes Andre,Anders Tranberg
Physics , 2014,
Abstract: In stochastic quantisation, quantum mechanical expectation values are computed as averages over the time history of a stochastic process described by a Langevin equation. Complex stochastic quantisation, though theoretically not rigorously established, extends this idea to cases where the action is complex-valued by complexifying the basic degrees of freedom, all observables and allowing the stochastic process to probe the complexified configuration space. We review the method for a previously studied one-dimensional toy model, the U(1) one link model. We confirm that complex Langevin dynamics only works for a certain range of parameters, misestimating observables otherwise. A curious effect is observed where all moments of the basic stochastic variable are misestimated, although these misestimated moments may be used to construct, by a Taylor series, other observables that are reproduced correctly. This suggests a subtle but not completely resolved relationship between the original complex integration measure and the higher-dimensional probability distribution in the complexified configuration space, generated by the complex Langevin process.
Neutron activation analysis of multimetallic accumulation in dolomites
Zovko Emira,Puji? Zdravko,?ehi? Zijad,Bandi? Jasmina
Hemijska Industrija , 2008, DOI: 10.2298/hemind0801001z
Abstract: The reason for exploring polymetallic ores, which are found in dolomite structures of the Veova a and Borovica zone near Vare , lies in the fact that there is very little information about its chemical structure. The isolated concentrates that we analyzed from surface mines, have shown significant difference in quantity of trace elements. Deep probing of the whole area was not performed, but there are presumptions that there are roots of ore-rich dolomites in the areas of 30 - 40 km. The future concept of exploitation of these mines in the Vare zone would probably require deeper probing. There are prospects for finding higher quality deposits with significant quantities of polymetallic components. By the method of neutron activation analysis the existence of mercury in amounts of about 0.4 % was confirmed. Because of the presence of mercury, these concentrates are not appropriate for pyrometallurgy, since it may result in environment contamination.
Effect of Temperature Storage on Hematological Parameters of Avian Turkey Blood
Nejra Hadzimusic,Muhamed Katica,Zijad Muharemovic,Jasmin Mu?anovic
International Journal of Collaborative Research on Internal Medicine & Public Health , 2010,
Abstract: Background: Hematology results are often influenced by the time between blood sampling and measurement, as well as storage conditions (e.g., temperature and time) during sample delivery between laboratories may further affect the resulting data. Hematological changes may occur in the measured parameters as a consequence of delayed analysis and may complicate interpretation of the data. Delayed analysis of blood samples may be caused by restricted access to laboratories. Blood samples collected from turkeys in remote locations (farms) often wait for laboratory processing. Objectives: The aim of this study was to investigate changes that occur in the packed cell volume (PCV), hemoglobin concentration, red blood cell (RBC) counts and mean corpuscular values (MCV) of turkey blood samples due to storage, including: blood samples stored at refrigerator (4°C), laboratory (24°C) and water bath (33°C) temperatures across a storage period of 72 h. Methods: Blood samples were collected from 25 adult turkeys (British United Turkey 600 hybrids – BUT 600). Hematological determinations were carried out on the blood samples immediately upon collection to obtain the baseline value (BV) and thereafter at specific time intervals across the 72-h duration of storage (DOS). Results: Results showed that for the samples stored at 4°C, there were no significant changes at p<0.05 level from the BV in the PCV, hemoglobin concentration and RBC counts, all through the 72-h DOS, but significantly increased values (p<0.05) were obtained when samples stored at 24°C and 33°C. Conclusion: Based on our research results we concluded following: blood samples obtained from turkey stored up to 72 hours at 4°C provides legitimate results for PCV, Hgb concentration and RBC count. MCV value is reliable if blood sample was stored up to 30 hours.
Functional Recovery of Patients After Stroke
Amela Cickusic,Osman Sinanovic,Maida Zonic-Imamovic,Suada Kapidzic-Durakovic
Acta Medica Saliniana , 2012, DOI: 10.5457/ams.156.10
Abstract: Introduction: Rehabilitation of patients after the stroke is very demanding and complex process, because in addition to damage of motor functions, the patients suffer from the range of other dysfunctions and complications. Timely and early initiation of rehabilitation treatment can reduce the degree of disability; it can result in increased mobility, independent functioning and shorter period of hospitalization. Aim: of this study was to determine the outcome of early rehabilitation treatment of patients suffering from ischemic and hemorrhagic stroke, in relation to their age, sex, degree of disability, and activities of daily living. Subjects and methods: This was a prospective study, which included 50 patients suffering from ischemic stroke and 50 patients suffering from hemorrhagic stroke. All patients were tested on admission and discharge from the hospital. Age and sex of the patients was analyzed, in addition to Rankin scale, used for evaluation of functional disability, and Barthel index used for evaluation of activities of daily living. Results and discussion: The outcome of early rehabilitation treatment was negatively influenced by the older age of patients (p=0.03). Males showed significantly better functional recovery from females (p=0.03). The values of Rankin scale and Barthel index showed significant recovery in all patients on discharge ((p< 0.001), however, these values were statistically more significant in patients with hemorrhagic stroke (Rankin scale p=0.03; Barthel index p=0.04). Conclusion: Older age of patients negatively affects the outcome of early rehabilitation treatment. Male stroke patients showed better results of early rehabilitation treatment. The degree of disability is significantly reduced, while the degree of activity of daily living is significantly improved with the early rehabilitation treatment. However, this was more prominent in patients suffering from hemorrhagic stroke.
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