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Search Results: 1 - 10 of 24130 matches for " Zhiyong Zheng "
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Simulation and Improvement of the Processing Subsystem of the Manchester Dataflow Computer
Lai Zhiyong,
Lai Zhiyong
,Zheng Shouqi

计算机科学技术学报 , 1995,
Abstract: The Manchester dataflow computer is a famous dynamic dataflow computer.It is centralized in architecture and simple in organization. Its overhead for communication and scheduling is very small. Its efficiency comes down, when processing elements in the processing subsystem increaJse. Several articles eval uated its performance and presented improved methods. The authors studied its processing subsystem and carried out the simulation. The simulation rer sults show that the efficiency of the processing subsystem drops dramatically when average instruction execution microcycles become less and the maximum instruction execution rate is nearly attained. Two improved methods are pre-sented to overcome the disadvantage. The improved processing subsystem with a cheap distributor made up of a bus and a twthlevel fixed priority circuit pos-sesses almost full efficiency no matter whether the average instruction execution microcycles number is large or small and even if the mtalmum instruction execution rate is approached.
β-Tubulin-III Is an Immunohistochemical Marker for the Early Invasive Foci of Nonmucinous Lung Adenocarcinoma  [PDF]
Qinghai Yang, Huiling Chen, Dehua Zeng, Xuzhou Wang, Zhiyong Zheng
Open Journal of Pathology (OJPathology) , 2016, DOI: 10.4236/ojpathology.2016.63019
Abstract: Objective: The present study is to investigate the expression of CD34, β-Tubulin-III and Collagen IV-Laminin in adenocarcinoma in situ (AIS), the AIS component of minimally invasive adenocarcinoma (MIA), and early invasive foci, in order to find a valuable immunohistochemical marker for discriminating AIS and its early invasive foci. Methods: A total of 51 AIS patients and 88 MIA patients were included in the present study. In addition, 40 atypical adenomatous hyperplasia (AAH) patients and 54 invasive adenocarcinoma (IA) patients were included as control. Immunohisto-chemical staining of β-Tubulin-III, CD34, CD31, F8 and Collagen IV-Laminin was performed by serial sectioning. β-Tubulin-III was used to show invasive adenocarcinoma foci, CD34 was used to indicate interstitial cells in AIS, CD31 and F8 were used to identify capillary endothelial cells in tumor tissues, and Collagen IV-Laminin was used to visualize the basement membrane component of AIS. Results: The basement membranes and interstitial cells of AAH, AIS and the AIS component of MIA had positive expression of CD34, while mucinous AIS and various invasive adenocarcinomas had no CD34-positive basement membranes or interstitial cells. Invasive cancers such as alveolar adenocarcinoma, papillary adenocarcinoma, micropapillary adenocarcinoma and solid adenocarcinoma had strong positive expression of β-Tubulin-III, while AAH, AIS and the AIS component of MIA, and invasive mucinous adenocarcinoma had negative expression of β-Tubulin-III. AAH, AIS and the AIS component of MIA were surrounded by basement membranes with positive expression of Collagen IV-Laminin, AIS and the AIS component of MIA had significantly thickened basement membranes, and none of invasive adenocarcinomas was surrounded by basement membranes. Conclusions: The present study demonstrates that immunohistochemical staining of CD34, β-Tubulin-III, and Collagen IV-Laminin discriminates AIS component of lung adenocarcinoma from early invasive foci, with the efficacy of β-Tubulin-III being the best. Staining of β-Tubulin-III precisely identifies the early invasive foci of MIA, and can be used as a marker for the identification of the early invasive foci of nonmucinous lung adenocarcinoma.
On the distribution of Jacobi sums
Qing Lu,Weizhe Zheng,Zhiyong Zheng
Mathematics , 2013,
Abstract: Let $\mathbf{F}_q$ be a finite field of $q$ elements. For multiplicative characters $\chi_1,\dots, \chi_m$ of $\mathbf{F}_q^\times$, we let $J(\chi_1,\dots, \chi_m)$ denote the Jacobi sum. Nicholas Katz and Zhiyong Zheng showed that for $m=2$, the normalized Jacobi sum $q^{-1/2}J(\chi_1,\chi_2)$ ($\chi_1\chi_2$ nontrivial) is asymptotically equidistributed on the unit circle as $q\to \infty$, when $\chi_1$ and $\chi_2$ run through all nontrivial multiplicative characters of $\mathbf{F}_q^\times$. In this paper, we show a similar property for $m\ge 2$. More generally, we show that the normalized Jacobi sum $q^{-(m-1)/2}J(\chi_1,\dots,\chi_m)$ ($\chi_1\dotsm \chi_m$ nontrivial) is asymptotically equidistributed on the unit circle, when $\chi_1,\dots, \chi_m$ run through arbitrary sets of nontrivial multiplicative characters of $\mathbf{F}_q^\times$ with two of the sets being sufficiently large. The case $m=2$ answers a question of Shparlinski.
Protein Globule Formation in the Liver Graft during Cold Preservation for Liver Transplantation: Its Clinical and Pathological Significance  [PDF]
Changyin Feng, Tongmei He, Haijian Huang, Lijuan Qu, Yi Jiang, Wenhua Zhang, Zhiyong Zheng
Open Journal of Pathology (OJPathology) , 2013, DOI: 10.4236/ojpathology.2013.33022
Abstract:

In liver transplantation, liver graft ischemia-reperfusion injury occurs mainly due to cold preservation and warm reperfusion. In this research, we study the affection of plasma protein of the donor on liver graft during cold preservation and warm reperfusion. In this study, 34 liver transplantations were performed from 2007 to 2010, and the clinical data were collected retrospectively from the Dongfang Hospital database. 34 specimens were harvested from 34 liver grafts when graft trimming as Group A and 34 specimens harvested from the same 34 liver grafts during liver transplantation surgery but before abdominal closure as B group. All liver tissue specimens were fixed with 40 g/L neutral formalin, embedded in paraffin. Light microscopy, transmission electron microscopy, Periodic Acid-Schiff (PAS) stain and immunohistochemical stain of IgG, IgM, IgA, C3d, C4d, Fib, C1q, and CD61 were used. In this study, we found that eosinophilic bodies emerged in liver lobes during liver transplantation which had not been reported previously in the literature. 1) Protein globules were found exclusively in liver graft specimens. The globules were round or oval with sharp edges, measured approximately 1.59 to 9.41 μm in diameter, and were scattered in the liver sinusoids or space of Disse or hepatocyte cytoplasm, were stained with IgG, IgM, IgA, Fib, C3d by immunohistochemical staining; 2) There was no statistical significant difference of protein globules number between A group and B group (P > 0.05); 3) IRI score of B group was not correlated with protein globules number (P > 0.05). Protein globules contain plasma composition, and may form during cold preservation.

Decay Rate for a Viscoelastic Equation with Strong Damping and Acoustic Boundary Conditions  [PDF]
Zhiyong Ma
Journal of Applied Mathematics and Physics (JAMP) , 2017, DOI: 10.4236/jamp.2017.54081
Abstract: This paper is concerned with a nonlinear viscoelastic equation with strong damping: \"\". The objective of the present paper is to provide some results on the long-time behavior to this equation with acoustic boundary conditions. By using the assumptions on the relaxation function due to Tatar [1], we show an arbitrary rate of decay with not necessary of an exponential or polynomial one and without the assumption \"\" condition. The result extends and improves some results given in Cavalcanti [2].
Uniform Attractors for a Non-Autonomous Thermoviscoelastic Equation with Strong Damping  [PDF]
Zhiyong Ma
Journal of Applied Mathematics and Physics (JAMP) , 2018, DOI: 10.4236/jamp.2018.612209
Abstract: This paper considers the existence of uniform attractors for a non-autonomous thermoviscoelastic equation with strong damping in a bounded domain ΩRn(n≥1) by establishing the uniformly asymptotic compactness of the semi-process generated by the global solutions.
126Gln is the residue of human IL-2 binding to IL-2R γ subunit
Zhiyong Wang,Zhongcheng Zheng,Lanying Sun,Xinyuan Liu
Science China Life Sciences , 1997, DOI: 10.1007/BF02882044
Abstract: The 126Gln of human interleukin-2 (IL-2) is a conserved amino acid residue. After substitution of 126Gln with Asp, the binding abilities of this mutant to different composites of IL-2 receptor (R) subunits have been determined. Results show that 126AspIL-2 has higher affinity to IL-2R α β γ complex and normal affinity to IL-2R α β complex, but loses its binding ability to IL-2R β γ complex, demonstrating that the 126Gln is the residue of human IL-2 which binds to IL-2R γ subunit.
126Gln is the residue of human IL-2 binding to IL-2R γ subunit

WANG Zhiyong,ZHENG Zhongcheng,SUN Lanying,LIU Xinyuan,

中国科学C辑(英文版) , 1997,
Abstract: The 126Gln of human interleukin-2 (IL-2) is a conserved amino acid residue. After substitution of 126Gln with Asp, the binding abilities of this mutant to different composites of IL-2 receptor (R) subunits have been determined. Results show that 126AspIL-2 has higher affinity to IL-2R α β γ complex and normal affinity to IL-2R α β complex, but loses its binding ability to IL-2R β γ complex, demonstrating that the 126Gln is the residue of human IL-2 which binds to IL-2R γ subunit. Project supported by the “863” Project of China.
Epidermal growth factor (EGF) and interleukin (IL)-1β synergistically promote ERK1/2-mediated invasive breast ductal cancer cell migration and invasion
Ma Liqiang,Lan Fenghua,Zheng Zhiyong,Xie Feilai
Molecular Cancer , 2012, DOI: 10.1186/1476-4598-11-79
Abstract: Background Patients with invasive breast ductal carcinoma (IBDC) with metastasis have a very poor prognosis. Little is known about the synergistic action of growth and inflammatory factors in IBDC metastases. Methods The expression of activated extracellular signal-regulated kinase1/2 (phosphorylated or p-ERK1/2) was analyzed by immunohistochemistry in IBDC tissue samples from 80 cases. BT474 IBDC cell migration and invasion were quantified using the Transwell assay. Matrix metalloproteinase (MMP)-9 expression and activity were analyzed by RT-PCR, Western blotting and zymography. Activator protein (AP)-1 activity was measured with a luciferase reporter gene assay. The Wilcoxon signed-rank test, Chi-square test, the partition of Chi-square test, independent t-test, and Spearman’s method were used for the statistical analysis. Results Phosphorylated ERK1/2 was detected in 58/80 (72.5%) IBDC tissues, and was associated with higher TNM stage and lymph node metastasis, but not patient age or tumor size. Individually, epidermal growth factor (EGF), and interleukin (IL)-1β activated ERK1/2, increased cell migration and invasion, MMP-9 expression and activity, AP-1 activation in vitro and the expression of p-ERK1/2 was positively correlated with EGF expression levels, as well as IL-1β, MMP-9 and c-fos in IBDC tissue samples. Co-stimulation with EGF and IL-1β synergistically increased ERK1/2 and AP-1 activation, cell migration and invasion, and MMP-9 expression and activity. Inhibition of ERK1/2 using U0126 or siRNA abolished EGF and/or IL-1β-induced cell migration and invasion in a dose-dependent manner. Conclusion Activated ERK1/2 was associated with higher TNM stage and lymph node metastasis in IBDC. Both in vitro and in vivo studies indicated that ERK-1/2 activation may increase the metastatic ability of IBDC cells. Growth and inflammatory factors synergistically induced IBDC cell migration and invasion via ERK1/2 signaling, AP-1 activation and MMP-9 upregulation.
The Retrospective Analysis of Different Therapies on 150 Elderly Patients with Advanced Non-Small Cell Lung Cancer
Jihua ZHENG,Weimin ZHANG,Hai CHEN,Zhiyong XU
Chinese Journal of Lung Cancer , 2009,
Abstract: Background and objective There is still no standard regiment for the treatment of advanced elderly patients with non-small cell lung cancer (NSCLC). The aim of this study is to explore the best method for the advanced elderly NSCLC patients by analyzing the efficacy and toxicity of cisplatin combined chemotherapy, docetaxel chemotherapy and the best support care (BSC). Methods One hundred and fifty elderly NSCLC patients (≥65 years) with different treatments from March 2003 to March 2007 in our hospital were retrospectively analyzed. Results The objective response rate (ORR) was 41.2% in cisplatin combined chemotherapy, which was significantly higher than 20.0% in docetaxel chemotherapy (P <0.05). Median survival time (MST) was 10.7 months, 9.2 months and 6.3 months, and one year survival rate was 39.7%, 36.7% and 17.3%, respectively in cisplatin combined chemotherapy, docetaxel chemotherapy and the best support care. MST was significantly longer (P <0.05) and one year survival rate was significantly higher (P <0.05) in the patients with chemotherapy than that with best support care. There was no significant difference of MST and one year survival between cisplatin combined chemotherapy and docetaxel chemotherapy (P >0.05). Grade 3-4 toxicity was more serious in cisplatin combined group than that in docetaxel group (P <0.05). Conclusion Chemotherapy can prolong the survival time in elderly NSCLC patients. Even though the ORR is higher in cisplatin combined chemotherapy than that in docetaxel chemotherapy, there was no significant difference of MST and one year survival between cisplatin combined chemotherapy and docetaxel chemotherapy (P >0.05), which may due to the more serious toxicity. Docetaxel chemotherapy should be one of the standard regiment for the elderly NSCLC patients.
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