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Search Results: 1 - 10 of 495 matches for " Zhisheng Her "
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Myeloid Cell Arg1 Inhibits Control of Arthritogenic Alphavirus Infection by Suppressing Antiviral T Cells
Kristina S. Burrack?,Jeslin J. L. Tan?,Mary K. McCarthy?,Zhisheng Her,Jennifer N. Berger?,Lisa F. P. Ng?,Thomas E. Morrison
PLOS Pathogens , 2015, DOI: 10.1371/journal.ppat.1005191
Abstract: Arthritogenic alphaviruses, including Ross River virus (RRV) and chikungunya virus (CHIKV), are responsible for explosive epidemics involving millions of cases. These mosquito-transmitted viruses cause inflammation and injury in skeletal muscle and joint tissues that results in debilitating pain. We previously showed that arginase 1 (Arg1) was highly expressed in myeloid cells in the infected and inflamed musculoskeletal tissues of RRV- and CHIKV-infected mice, and specific deletion of Arg1 from myeloid cells resulted in enhanced viral control. Here, we show that Arg1, along with other genes associated with suppressive myeloid cells, is induced in PBMCs isolated from CHIKV-infected patients during the acute phase as well as the chronic phase, and that high Arg1 expression levels were associated with high viral loads and disease severity. Depletion of both CD4 and CD8 T cells from RRV-infected Arg1-deficient mice restored viral loads to levels detected in T cell-depleted wild-type mice. Moreover, Arg1-expressing myeloid cells inhibited virus-specific T cells in the inflamed and infected musculoskeletal tissues, but not lymphoid tissues, following RRV infection in mice, including suppression of interferon-γ and CD69 expression. Collectively, these data enhance our understanding of the immune response following arthritogenic alphavirus infection and suggest that immunosuppressive myeloid cells may contribute to the duration or severity of these debilitating infections.
IL-1β, IL-6, and RANTES as Biomarkers of Chikungunya Severity
Lisa F. P. Ng, Angela Chow, Yong-Jiang Sun, Dyan J. C. Kwek, Poh-Lian Lim, Frederico Dimatatac, Lee-Ching Ng, Eng-Eong Ooi, Khar-Heng Choo, Zhisheng Her, Philippe Kourilsky, Yee-Sin Leo
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0004261
Abstract: Background Little is known about the immunopathogenesis of Chikungunya virus. Circulating levels of immune mediators and growth factors were analyzed from patients infected during the first Singaporean Chikungunya fever outbreak in early 2008 to establish biomarkers associated with infection and/or disease severity. Methods and Findings Adult patients with laboratory-confirmed Chikungunya fever infection, who were referred to the Communicable Disease Centre/Tan Tock Seng Hospital during the period from January to February 2008, were included in this retrospective study. Plasma fractions were analyzed using a multiplex-microbead immunoassay. Among the patients, the most common clinical features were fever (100%), arthralgia (90%), rash (50%) and conjunctivitis (40%). Profiles of 30 cytokines, chemokines, and growth factors were able to discriminate the clinical forms of Chikungunya from healthy controls, with patients classified as non-severe and severe disease. Levels of 8 plasma cytokines and 4 growth factors were significantly elevated. Statistical analysis showed that an increase in IL-1β, IL-6 and a decrease in RANTES were associated with disease severity. Conclusions This is the first comprehensive report on the production of cytokines, chemokines, and growth factors during acute Chikungunya virus infection. Using these biomarkers, we were able to distinguish between mild disease and more severe forms of Chikungunya fever, thus enabling the identification of patients with poor prognosis and monitoring of the disease.
Pretreated methods on loess-palaeosol samples granulometry
Huayu Lu,Zhisheng An
Chinese Science Bulletin , 1998, DOI: 10.1007/BF02898920
Abstract: Twenty representative samples were collected from the Chinese loess plateau and each sample was prepared in 6 different ways respectively in order to test the influences of pretreated methods on grain size measurement. The results show that (i) different pretreated methods can make a big difference for the samples granulometry; (ii) soaking in distilled water for one day, and then treating with an ultrasonic machine for 10 min can make the sample dispersed.
Pretreated methods on loess-palaeosol samples granulometry

Huayu Lu,Zhisheng An,

科学通报(英文版) , 1998,
Abstract: Twenty representative samples were collected from the Chinese loess plateau and each sample was prepared in 6 different ways respectively in order to test the influences of pretreated methods on grain size measurement. The results show that (i) different pretreated methods can make a big difference for the samples granulometry; (ii) soaking in distilled water for one day, and then treating with an ultrasonic machine for 10 min can make the sample dispersed.
State-of-the-art IV-VI Semiconductor Light-Emitting Devices in Mid-Infrared Opto-Electronic Applications
Mukherjee Shaibal,Shi Zhisheng
IETE Technical Review , 2009,
Abstract: This paper presents recent developments in the field of lead-salt light-emitting devices, having enormous applications in mid-infrared (MIR) opto-electronics. For the first time, achievement of an electrically excited edge-emitting QW laser on PbSnSe substrate is described. Novel fabrications of freestanding microstructures in the form of rod, tube and pillar, having vast applications in MEMS and NEMS, are reported.
Inferring the Fact that Static Magnetic Field Exists Along with Electrostatic Field and Conducting Experimental Verification in Accordance with the Theory of Relativity
Kexin Yao,Zhisheng Wang
Applied Physics Research , 2012, DOI: 10.5539/apr.v4n1p222
Abstract: It is considered in the superposition principle of electrostatic field and the special relativity that the electric field around the moving electrons in permanent magnet still exists and presents length contraction in the direction of movement. Through experimental analysis, it is also considered that the motion states of two electric fields having same direction and opposite direction of motion cancel out each other. Based on the two above-mentioned basic concepts, it can be inferred that negative electrostatic field exists in the vicinity of cubic permanent magnet N and S pole surface edge while positive electrostatic field exists in the vicinity of side edge. In addition, the results of experimental verification are also introduced.
Improved SOM-Based High-Dimensional Data Visualization Algorithm
Wang Zhisheng,Xu Xiaobing
Computer and Information Science , 2012, DOI: 10.5539/cis.v5n4p110
Abstract: In this paper, a new high-dimensional data visualization algorithm based on the Self-Organizing Map (SOM) is proposed. It is named TDSOM (three-dimensional self-organizing map) to describe its special characteristics. TDSOM trains the high-dimensional data with SOM network and projects it into particular point sets in the three-dimensional coordinate system. In the three-dimensional coordinate system, the x axis represents attributes of the original data set; the y axis represents the weight of each attribute; the z axis represents different categories of the mapping result. The most important is that researchers can watch the three-dimensional model from different viewpoints by rotating it and gain some interesting patterns. Through the experiment, TDSOM is proved to be much more accurate and more analytical than the traditional methods in displaying the high-dimensional data. The main innovation of the new TDSOM algorithm is the presentation of large data in three-dimensional coordinate system which provides a much wider view than the two-dimensional one. What’s more, users are able to discover some interesting patterns according to their own research areas through the model. The algorithm can be widely applied in areas such as data mining, pattern recognition and so on.
Distributed Adaptive Attitude Synchronization of Multiple Spacecraft
Zhongkui Li,Zhisheng Duan
Mathematics , 2011, DOI: 10.1007/s11431-011-4475-0
Abstract: This paper addresses the distributed attitude synchronization problem of multiple spacecraft with unknown inertia matrices. Two distributed adaptive controllers are proposed for the cases with and without a virtual leader to which a time-varying reference attitude is assigned. The first controller achieves attitude synchronization for a group of spacecraft with a leaderless communication topology having a directed spanning tree. The second controller guarantees that all spacecraft track the reference attitude if the virtual leader has a directed path to all other spacecraft. Simulation examples are presented to illustrate the effectiveness of the results.
Distributed Adaptive Consensus Protocols for Linear Multi-agent Systems with Directed Graphs and External Disturbances
Zhongkui Li,Zhisheng Duan
Computer Science , 2014,
Abstract: This paper addresses the distributed consensus design problem for linear multi-agent systems with directed communication graphs and external disturbances. Both the cases with strongly connected communication graphs and leader-follower graphs containing a directed spanning tree with the leader as the root are discussed. Distributed adaptive consensus protocols based on the relative states of neighboring agents are designed, which can ensure the ultimate boundedness of the consensus error and adaptive gains in the presence of external disturbances. The upper bounds of the consensus error are further explicitly given. Compared to the existing consensus protocols, the merit of the adaptive protocols proposed in this paper is that they can be computed and implemented in a fully distributed fashion and meanwhile are robust with respect to external disturbances.
Phase transitions of dielectric elastomers in a circular frame
Zhang Hui, , Zhang Zhisheng
- , 2017, DOI: 10.3969/j.issn.1003-7985.2017.04.001
Abstract: In order to imitate biological adhesion performance and skin properties, phase transitions on dielectric elastomers(DE)with high voltages are studied. The states of flat, wrinkled and bulging on the circular active area which is coated with electrodes verify the theoretical prediction of phase transitions and failure phenomena. When the DE membrane is subjected to a radial force and increasing voltage, four experimental phenomena are discovered before electric breakdown: The active region expands, and the thin membrane is still flat till breakdown; bulging forms instead of a flat area on the membrane; wrinkles and bulging coexist; and the active area is completely wrinkled. In the fourth state, there are two types of phase transitions between the flat and wrinkled regions in a membrane: Wrinkles form in small regions, and then propagate at the expense of the flat area until the entire active part becomes wrinkled; both the wrinkled and flat regions move interchangeably on a membrane with ramping voltage till breakdown. It is found that when there is no prestretch of a DE membrane, bulging will occur with the increasing voltage. Wrinkles commonly appear at large prestretch and, therefore, the prestretched ratio significantly affects electromechanical phase transitions.
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