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Search Results: 1 - 10 of 9698 matches for " Zhirong Zeng "
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A New Immunofluorescence Assay for Fecal Calprotectin Distinguishes Inflammatory Bowel Disease from Functional Bowel Disease  [PDF]
Lixia Xu, Peisi Rao, Xin Liu, Zhirong Zeng
Open Journal of Gastroenterology (OJGas) , 2018, DOI: 10.4236/ojgas.2018.811042
Abstract: Aims: To investigate the diagnostic value of fecal calprotectin (FC) determined by a new immunofluorescence assay-fluorescence enzyme immunoassay (FEIA) in patient with inflammatory bowel disease (IBD) or functional bowel disease, compared with the typical ELISA kit. Methods: FC was determined simultaneously by FEIA and an ELISA kit in 26 patients with functional bowel disease and 77 patients with IBD. We compared the difference of FC levels between patients with IBD and patients with functional bowel disease. Receiver operating characteristics curve (ROC) was constructed to obtain the optimal cut-off value of FC for distinguishing IBD from functional bowel disease and the corresponding sensitivity and specificity. Results: The median FC levels of patients with IBD in clinical active stage or clinical remission stage was significantly higher than that of patients with functional bowel disease. The median FC levels of patients with IBD in clinical active stage, IBD in clinical remission stage and functional bowel disease were as follow: 699.91 (346.14 ~ 1647.54) μg/g; 407.36 (121.81 ~ 878.48) μg/g; 39.04 (12.09 ~ 81.04) μg/g when FC was measured by FEIA. The median FC levels were 716.99 (240.42 ~ 1232.53) μg/g; 338.46 (53.08 ~ 692.82) μg/g; 41.44 (11.77 ~ 73.19) μg/g among such above three groups of patients respectively, when FC was measured by ELISA kit. The diagnostic value of IBD with FC determined by FEIA (optimal cut-off = 131.79 μg/g) and ELISA kit (optimal cut-off = 121.85 μg/g) presented an area under the curve of 0.881 and 0.873, respectively. Conclusions: FC determined by FEIA was an accurate surrogate marker to distinguish IBD from functional bowel disease.
Abbreviations in Maritime English
Zhirong Yang
English Language Teaching , 2011, DOI: 10.5539/elt.v4n1p209
Abstract: Aiming at the phenomena that more and more abbreviations occur in maritime English correspondences, the composing laws of the abbreviations in maritime English correspondence are analyzed, and the correct methods to answer the abbreviations are pointed out, and the translation method of abbreviations are summarized in this article, and the research results are practically significant for the reading, teaching, and scientific research of maritime English.
Aspirin Promotes Oligodendrocyte Precursor Cell Proliferation and Differentiation after White Matter Lesion
Zhirong Liu
Frontiers in Aging Neuroscience , 2014, DOI: 10.3389/fnagi.2014.00007
Abstract: Cerebral white matter lesion (WML) is one of the main causes for cognitive impairment and is often caused by chronic cerebral hypoperfusion. A line of evidence has shown that aspirin has neuroprotective effects and produces some benefits in long-term outcome and survival for ischemic stroke patients. However, whether aspirin exerts a protective effect against WML is still largely unknown. Here, we showed that aspirin could promote oligodendrocyte precursor cell (OPC) proliferation and differentiation into oligodendrocytes after WML. Male Sprague-Dawley rats were subjected to permanent bilateral common carotid artery occlusion, a well-established model for WML. Four weeks later, Morris water maze test showed an impairment of learning and memory ability of rat while aspirin treatment improved behavioral performance. Low dose of aspirin (25 mg/kg) was found to elevate the number of OPCs while relatively high doses (100–200 mg/kg) increased that of oligodendrocytes, and ameliorated WML-induced the thinning of myelin, as revealed by the electron microscope. Similarly, our in vitro study also showed that relatively low and high doses of aspirin enhanced OPC proliferation and differentiation into oligodendrocytes, respectively. Furthermore, we revealed that aspirin enhanced extracellular signal-related kinase (ERK) but inhibited RhoA activities. In summary, we provided the first evidence that aspirin can promote oligodendrogenesis and oligodendrocyte myelination after WML, which may involve ERK and RhoA pathways.
IκBα polymorphism at promoter region (rs2233408) influences the susceptibility of gastric cancer in Chinese
Shiyan Wang, Linwei Tian, Zhirong Zeng, Mingdong Zhang, Kaichun Wu, Minhu Chen, Daiming Fan, Pinjin Hu, Joseph JY Sung, Jun Yu
BMC Gastroenterology , 2010, DOI: 10.1186/1471-230x-10-15
Abstract: A population-based case-control study was conducted between 1999 and 2006 in Guangdong Province, China. A total of 564 gastric cancer patients and 566 healthy controls were enrolled in this study. rs2233408 genotypes in IκBα were analyzed by TaqMan SNP genotyping assay.Both rs2233408 T homozygote (TT) and T heterozygotes (TC and TT) had significantly reduced gastric cancer risk (TT: OR = 0.250, 95% CI = 0.069-0.909, P = 0.035; TC and TT: OR = 0.721, 95% CI = 0.530-0.981, P = 0.037), compared with rs2233408 C homozygote (CC). rs2233408 T heterozygotes were significantly associated with reduced risk of intestinal-type gastric cancer with ORs of 0.648 (95% CI = 0.459-0.916, P = 0.014), but not with the diffuse or mix type of gastric cancer. The association between rs2233408 T heterozygotes and gastric cancer appeared more apparent in the older patients (age>40) (OR = 0.674, 95% CI = 0.484-0.939, P = 0.02). rs2233408 T heterozygotes was associated with non-cardiac gastric cancer (OR = 0.594, 95% CI = 0.411-0.859, P = 0.006), but not with cardiac gastric cancer. However, rs2233408 polymorphism was not associated with the prognosis of gastric cancer patients.IκBα rs2233408 T heterozygotes were associated with reduced risk of gastric cancer, especially for the development of certain subtypes of gastric cancer in Chinese population.Nuclear factor-κB (NF-κB) regulates many cellular functions including cell proliferation, apoptosis, angiogenesis, immune response, cell adhesion and differentiation [1]. NF-κB pathway plays important roles in linking inflammation to tumour development and progression in humans and mice [1]. Under unstimulated condition, NF-κB is inhibited by inhibitor nuclear factor-kappa B (IκB). Many oncogenes and carcinogens cause phosphorylation of IκB through the NF-κB inhibitor kinase (IKK) complex and proteasome-mediated degradation of IκB, leading to release of activated NF-κB [2]. The activated NF-κB system provides the cells with the production of grow
Simultaneous desulfurization and denitrification by a biological method

Xie Zhirong,Wei Zaishan,Zeng Guihu,Kuang Wanwen,Kuang Ting,

环境工程学报 , 2009,
Abstract: The trickling biofilter filled with ceramsite was set up to study simultaneous removal of sulfur dioxide(SO2) and nitrogen oxides(NOx) from flue gas.The effects of inlet concentration,spring density,pH and empty bed retention time((EBRT) on simultaneous desulfurization and denitrification,and biodegradation kinetics were evaluated.The experimental results showed that the trickling biofilter could remove SO2 and NOx effectively,simultaneous desulfurization and denitrification efficiency achieved 99.9% and 88...
Nonnative Interactions in Coupled Folding and Binding Processes of Intrinsically Disordered Proteins
Yongqi Huang,Zhirong Liu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0015375
Abstract: Proteins function by interacting with other molecules, where both native and nonnative interactions play important roles. Native interactions contribute to the stability and specificity of a complex, whereas nonnative interactions mainly perturb the binding kinetics. For intrinsically disordered proteins (IDPs), which do not adopt rigid structures when being free in solution, the role of nonnative interactions may be more prominent in binding processes due to their high flexibilities. In this work, we investigated the effect of nonnative hydrophobic interactions on the coupled folding and binding processes of IDPs and its interplay with chain flexibility by conducting molecular dynamics simulations. Our results showed that the free-energy profiles became rugged, and intermediate states occurred when nonnative hydrophobic interactions were introduced. The binding rate was initially accelerated and subsequently dramatically decreased as the strength of the nonnative hydrophobic interactions increased. Both thermodynamic and kinetic analysis showed that disordered systems were more readily affected by nonnative interactions than ordered systems. Furthermore, it was demonstrated that the kinetic advantage of IDPs (“fly-casting” mechanism) was enhanced by nonnative hydrophobic interactions. The relationship between chain flexibility and protein aggregation is also discussed.
Anchoring Intrinsically Disordered Proteins to Multiple Targets: Lessons from N-Terminus of the p53 Protein
Yongqi Huang,Zhirong Liu
International Journal of Molecular Sciences , 2011, DOI: 10.3390/ijms12021410
Abstract: Anchor residues, which are deeply buried upon binding, play an important role in protein–protein interactions by providing recognition specificity and facilitating the binding kinetics. Up to now, studies on anchor residues have been focused mainly on ordered proteins. In this study, we investigated anchor residues in intrinsically disordered proteins (IDPs) which are flexible in the free state. We identified the anchor residues of the N-terminus of the p53 protein (Glu17–Asn29, abbreviated as p53N) which are involved in binding with two different targets (MDM2 and Taz2), and analyzed their side chain conformations in the unbound states. The anchor residues in the unbound p53N were found to frequently sample conformations similar to those observed in the bound complexes ( i.e.,?Phe19, Trp23, and Leu26 in the p53N-MDM2 complex, and Leu22 in the p53N-Taz2 complex). We argue that the bound-like conformations of the anchor residues in the unbound state are important for controlling the specific interactions between IDPs and their targets. Further, we propose a mechanism to account for the binding promiscuity of IDPs in terms of anchor residues and molecular recognition features (MoRFs).
The evolution simulation of zinc finger domain sequence
Zhirong Sun,Hao Han
Chinese Science Bulletin , 1997, DOI: 10.1007/BF02882793
Amygdalin Attenuates Atherosclerosis Progress Through Inhibiting of Toll-Like Receptors Expression and Activity
Fei Zhao,Zhirong Yang
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2012.1613.1621
Abstract: Toll-Like Receptors (TLRs) and TLR signaling cascade play a pivotal role in the innate immune responses, especially in initiation and progression of atherosclerosis. Thus in the present study, researchers examined the anti-atherosclerosis effects of amygdalin and explored whether the anti-atherosclerosis function was achieved via inhibiting TLRs expression and TLR signaling. ApoE knockout mice were fed on high fat diet and received daily injection of amygdalin. By comparing lipid profiles, atherosclerotic lesions and serum proinflammatory cytokine concentrations, mice untreated with amygdalin experienced more severe atherosclerosis compared with mice received amygdalin treatment. TLR2 and TLR4 mRNA and protein levels were found to be reduced after amygdalin treatment. Expression of key MyD88-dependent signaling components was inhibited by amygdalin. Amygdalin may play a protective role in the development of atherosclerosis via the inhibition of TLR2 and TLR4 expression.
Statistical Analysis of Crossed Undulator for Polarization Control in a SASE FEL
Yuantao Ding,Zhirong Huang
Physics , 2008, DOI: 10.1103/PhysRevSTAB.11.030702
Abstract: There is a growing interest in producing intense, coherent x-ray radiation with an adjustable and arbitrary polarization state. In this paper, we study the crossed undulator scheme (K.-J. Kim, Nucl. Instrum. Methods A {\bf 445}, 329 (2000)) for rapid polarization control in a self-amplified spontaneous emission (SASE) free electron laser (FEL). Because a SASE source is a temporally chaotic light, we perform a statistical analysis on the state of polarization using FEL theory and simulations. We show that by adding a small phase shifter and a short (about 1.3 times the FEL power gain length), $90^\circ$ rotated planar undulator after the main SASE planar undulator, one can obtain circularly polarized light -- with over 80% polarization -- near the FEL saturation.
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