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Search Results: 1 - 10 of 58862 matches for " Zhiqian Yang "
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Strategies of polyhydroxyalkanoates modification for the medical application in neural regeneration/nerve tissue engineering  [PDF]
Xiaoyun Lu, Leilei Wang, Zhiqian Yang, Haixia Lu
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.46097

Neural regeneration was once considered to be impossible, especially in the central nervous system where neural regeneration comprise the generation of new neurons, glia, axons, myelin, and synapses. Until recently, neural stem cells/neural progenitor cells (NSCs/NPCs) were identified from various areas of brain and brought hopes to the neural repair and regeneration. Tissue engineering has revolutionized the current neural regeneration technology and it has become a pioneering interdisciplinary field in the areas of biomedical research. Polyhydoxyalkanoate (PHA) as one of biodegradable material has been successfully used as tissue engineering materials. It has also been applied in nerve tissue engineering due to the high biocompatibility and low cytotoxicity. Over the past 10 years, different kinds of modification strategies have been undertaken to improve the properties of PHA to fit the requirements from various fields. Several members of PHA family have been attempted for neural regeneration. This article reviewed the recent modification strategies for improving the properties of PHA and highlighted the pioneer applications in neural regeneration.

Felicitous Labellings of Some Network Models  [PDF]
Jiajuan Zhang, Bing Yao, Zhiqian Wang, Hongyu Wang, Chao Yang, Sihua Yang
Journal of Software Engineering and Applications (JSEA) , 2013, DOI: 10.4236/jsea.2013.63B007
Abstract: Building up graph models to simulate scale-free networks is an important method since graphs have been used in researching scale-free networks. One use labelled graphs for distinguishing objects of communication and information networks. In this paper some methods are given for constructing larger felicitous graphs from smaller graphs having special felicitous labellings, and some network models are shown to be felicitous.
Impact of Educational Expenditure on the Development of Regional Marine Economy: Evidence from Chinese Coastal Provinces  [PDF]
Zhiqian Li
Journal of Human Resource and Sustainability Studies (JHRSS) , 2018, DOI: 10.4236/jhrss.2018.61030
Abstract: Marine economy is an important growth stage of Chinese economic development in the 21st century. The Chinese marine economy has become a technology and capital-intensive economy from extensive past development of economy. The human capital factor has become an indispensable and important driving force for the domestic marine economy. Different with the existing literature on human capital elements, which is focused on the study of the average level of education represented by the stock of human capital, this article uses the per capita education expenditure within the region to measure human capital increment, explain the coastal marine economic development momentum. At the same time, the author analyzes the correctness of this interpretation and analysis from the data of 11 coastal provinces and autonomous regions in China from 2006 to 2014. Based on this, some feasible policy suggestions would be put forward.
Alteration of cadherin isoform expression and inhibition of gap junctions in stomach carcinoma cells
Li Jinping,Zhang Zhiqian,Ning Tao,Ke Yang,Lin Zhongxiang
Chinese Science Bulletin , 2001, DOI: 10.1007/BF02901134
Abstract: To explore cell malignant phenotype correlated changes of cell surface adhesion molecules and cell-cell communication in carcinogenesis, human stomach transformed and cancer cell lines were investigated. Expressions of E-cadherin, N-cadherin, α-catenin, β-catenin as well as gap junction (GJ) protein Cx32 were studied by utilization of immunoblotting, immunocytochemical and fluorescent dye transfer methods. Mammalian normal stomach mucosal cells expressed E-cadherin but not N-cadherin. E-cadherin immunofluorescence was detected at cell membranous adherens junctions (AJ) where colocalization with immunofluorescent staining of inner surface adhesion plaque proteins αand β-catenins was observed. The existence of E-cadherin/ catenin (α-, β-) protein complexes as AJ was suggested. In transformed and stomach cancer cells E-cadherin was inhibited, instead, N-cadherin was expressed and localized at membranous AJ where co-staining with α-and β-catenin fluorescence was observed. Formation of N-cadherin/catenin (α-, β-) protein complex at AJs of transformed and cancer cells was suggested. The above observations were further supported by immunoblotting results. Normal stomach muscosal and transformed cells expressed Cx32 at membranous GJ and were competent of gap junction communication (GJIC). In stomach cancer cells, Cx32 was inhibited and GJIC was defective. The results suggested that changes of signal pathways mediated by both cell adhesion and cell communication systems are associated intracellular events of stomach carcinogenesis. The alteration of cadherin isoform from E-to N-cadherin in transformed and stomach cancer cells is the first report.
Identification of MicroRNAs in Helicoverpa armigera and Spodoptera litura Based on Deep Sequencing and Homology Analysis
Xie Ge, Yong Zhang, Jianhao Jiang, Yi Zhong, Xiaonan Yang, Zhiqian Li, Yongping Huang, Anjiang Tan
International Journal of Biological Sciences , 2013,
Abstract: The current identification of microRNAs (miRNAs) in insects is largely dependent on genome sequences. However, the lack of available genome sequences inhibits the identification of miRNAs in various insect species. In this study, we used a miRNA database of the silkworm Bombyx mori as a reference to identify miRNAs in Helicoverpa armigera and Spodoptera litura using deep sequencing and homology analysis. Because all three species belong to the Lepidoptera, the experiment produced reliable results. Our study identified 97 and 91 conserved miRNAs in H. armigera and S. litura, respectively. Using the genome of B. mori and BAC sequences of H. armigera as references, 1 novel miRNA and 8 novel miRNA candidates were identified in H. armigera, and 4 novel miRNA candidates were identified in S. litura. An evolutionary analysis revealed that most of the identified miRNAs were insect-specific, and more than 20 miRNAs were Lepidoptera-specific. The investigation of the expression patterns of miR-2a, miR-34, miR-2796-3p and miR-11 revealed their potential roles in insect development. miRNA target prediction revealed that conserved miRNA target sites exist in various genes in the 3 species. Conserved miRNA target sites for the Hsp90 gene among the 3 species were validated in the mammalian 293T cell line using a dual-luciferase reporter assay. Our study provides a new approach with which to identify miRNAs in insects lacking genome information and contributes to the functional analysis of insect miRNAs.
Algorithm for Cost Non-preemptive Scheduling of Partial k-Trees  [PDF]
Yiming Li, Zhiqian Ye, Xiao Zhou
Open Journal of Applied Sciences (OJAppS) , 2012, DOI: 10.4236/ojapps.2012.24B053
Abstract: Let G be a graph, in which each vertex (job) v has a positive integer weight (processing time) p(v) and eachedge (u,v) represented that the pair of jobs u and v cannot be processed in the same slot. In this paper we assume that every job is non-preemptive. Let C={1,2,...} be a color set. A multicoloring (scheduling) F of G is to assign each job v a set of p(v) consecutive positive integers (processing consecutive time slots) in C so that any pair of adjacent vertices receive disjoint sets. Such a multicoloring is called a non-preemptive scheduling. The cost non-preemptive scheduling problem is to find an optimal multicoloring of G.
The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance
Fei Xie, Lin Ye, Jinfeng Chen, Nan Wu, Zhiqian Zhang, Yue Yang, Lijian Zhang, Wen G Jiang
Journal of Translational Medicine , 2011, DOI: 10.1186/1479-5876-9-95
Abstract: In this study, we assessed the expression levels of MTSS1 in tumours and its matched adjacent non-tumour tissues obtained from 105 ESCC patients. We also used ESCC cells with differing MTSS1 expression and assessed the influence of MTSS1 on ESCC cells.Down-regulation of MTSS1 expression was observed both in oesophageal tumour tissues and ESCC cancer cell lines. We also reported that MTSS1 expression was associated with tumour grade (p = 0.024), lymph node metastasis (p = 0.010) and overall survival (p = 0.035). Patients with high levels of MTSS1 transcripts had a favorable prognosis in comparison with those who had reduced or absent expression levels. Using over-expression and knockdown approach, we created sublines from ESCC cells and further demonstrated that MTSS1 expression in ESCC cells significantly influenced the aggressiveness of the oesophageal cancer cells, by reducing their cellular migration and in vitro invasiveness.MTSS1 serves as a potential prognostic indicator in human ESCC and may be an important target for cancer therapy.Tumour metastasis is the most significant contributor to the mortality of patients with cancers. Metastasis of cancer cells proceeds via a long series of sequential, interrelated steps modulated largely by activators and suppressors of metastasis. Metastasis suppressor genes are defined by their ability to inhibit metastasis at any step of the metastatic cascade. To date, only a limited number of metastasis suppressor genes, including NM23, KAI1, KiSS1, MKK4, BRMS1, RHOGDI2, CRSP3 and VDUP1, have been identified [1]. These metastasis suppressor genes inhibit metastasis of a cancer cell line in vivo without blocking its tumourigenicity.MTSS1 (metastasis suppressor-1), also known as MIM (Missing-In-Metastasis), MIM-B, BEG4 (Basal cell carcinoma-enriched gene 4) or KIAA0429, was first identified as a potential metastasis suppressor gene missing in metastatic bladder carcinoma cell lines [2] and subsequently investigated in some types
Cost Edge-Coloring of a Cactus  [PDF]
Zhiqian Ye, Yiming Li, Huiqiang Lu, Xiao Zhou
World Journal of Engineering and Technology (WJET) , 2015, DOI: 10.4236/wjet.2015.33C018

Let C be a set of colors, and let \"\" ?be an integer cost assigned to a color c in C. An edge-coloring of a graph \"\" ?is assigning a color in C to each edge \"\" ?so that any two edges having end-vertex in common

A Dynamic Programming Algorithm for the Ridersharing Problem Restricted with Unique Destination and Zero Detour on Trees  [PDF]
Yiming Li, Huiqiang Lu, Zhiqian Ye, Xiao Zhou
Journal of Applied Mathematics and Physics (JAMP) , 2017, DOI: 10.4236/jamp.2017.59140
We deal with the problem of sharing vehicles by individuals with similar itineraries which is to find the minimum number of drivers, each of which has a vehicle capacity and a detour to realize all trips. Recently, Gu et al. showed that the problem is NP-hard even for star graphs restricted with unique destination, and gave a polynomial-time algorithm to solve the problem for paths restricted with unique destination and zero detour. In this paper we will give a dynamic programming algorithm to solve the problem in polynomial time for trees restricted with unique destination and zero detour. In our best knowledge it is a first polynomial-time algorithm for trees.
A preliminary Study on Vegetable Growing Techniques is Desert Hinterland Under Saline Irrigation Condition

Chen Guoxong,Zhang Zhiqian,Wu Zurong,Yang Haijun,Peng Xiaoyu,

中国生态农业学报 , 1995,
Abstract: To grow vegetables in the hinterland of desert by saline irrigation,firstly a sand shifting control system was constructed.Based on this adaptive faculty of 20varieties of vegetables to this region were studied for selecting the suitable breed. From the results,9 varieties from the 20 such as custard squash,water melon,eggplant and etc. have the highest adaptibility to this region and suggestions were given for their extension.The studies also presented the key technicals forgrowing vegetables by saline irrigation in this region:growing seed for transplantation,intensive management during darlier stages,large quantity well-rotted farmyard manure as base fertilizer,regular top dressing but smaller amount every time,combination sprinkling irrigation with surface flooding for salt leaching,carefully adjust the vegetables to coordinate the nutritive and productive growth.
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