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Search Results: 1 - 10 of 42809 matches for " Zhimin Xu "
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Chronic Toxicity Study in Rats Orally Exposed to Mulberry Sea-Buckthorn Beverage Concentrate  [PDF]
Qingping Sun, Zhimin Xu
Pharmacology & Pharmacy (PP) , 2014, DOI: 10.4236/pp.2014.59102
Abstract:

Objective: This study is designed to observe the chronic toxicity after the administration of mulberry sea-buckthorn beverage concentrate for 3 months on rats and to predict the possible adverse effect and the potential toxicity target organs. Method: The rats (SPF level) were randomly divided into high-dose (20 mL/kg BW), middle-dose (10 mL/kg BW), low-dose (5 mL/kg BW) groups and negative control group (20 mL/kg BW of purified water) with 30 rats in each group. Each group was orally given mulberry sea-buckthorn beverage concentrate for 3 months and recovered by stop feeding samples for 2 weeks for a recovery observation. The rats’ general condition, the organ coefficient, the indexes of hematology and blood biochemistry and the histological changes of the main organs were determined. Result: The appearance and behavior of activity in rats showed no anomalies in all these groups and all the rats put on weight during this period. Comparing to the negative control group, no obvious differences were observed in the weekly weight and organ coefficient of each dose group. After 3 months of administration, HGB in both mulberry sea-buckthorn beverage concentrate low-dose group and high-dose group were increased. No significant differences were observed in the indexes of hematology after 2 weeks of recovery. CREA in low-dose, middle-dose and high-dose groups were significantly increased after 3 months of administration and it remained in the high level in middle-dose and high-dose group even after 2 weeks of recovery. No drug-related lesions were observed in the histological changes of major organs. Conclusion: The results show that long term use of mulberry concentrated sea-buckthorn beverage can lead to increased CREA, which suggested kidney toxicity. Although no obvious pathological change was found in kidney, we should pay attention to chronic kidney damage in the further research.

Some New Delay Integral Inequalities Based on Modified Riemann-Liouville Fractional Derivative and Their Applications  [PDF]
Zhimin Zhao, Run Xu
Journal of Applied Mathematics and Physics (JAMP) , 2015, DOI: 10.4236/jamp.2015.35059
Abstract: By using the properties of modified Riemann-Liouville fractional derivative, some new delay integral inequalities have been studied. First, we offered explicit bounds for the unknown functions, then we applied the results to the research concerning the boundness, uniqueness and continuous dependence on the initial for solutions to certain fractional differential equations.
Topography of acoustic response characteristics in the midbrain inferior colliculus of Kunming mouse
Junxian Shen,Zhimin Xu,Lijian Shen
Chinese Science Bulletin , 2003, DOI: 10.1360/03tb9033
Abstract: Topography of acoustic response characteristics of the midbrain inferior colliculus (IC) of the Kunming mouse was studied by using extracellular recording techniques. The characteristic frequency (CF) range represented in the different divisions of the IC differed markedly: 4–15 kHz in the dorsal cortex (DC), 10–70 kHz in the central nucleus (CN), and 4–35 kHz in the external cortex (EC). The CF in the CN increased from dorsal and lateral to ventral and medial, higher CFs represented at its ventromedial part and lower CFs at its dorsal part. The isofrequency contours of CFs were incurvate. Minimum thresholds (MT) of the auditory neurons in DC and the central part of CN were lower (about 10 dB SPL), but considerably higher in the dorsal and ventral region of EC. Results suggest that each of the divisions in the mouse IC may have different auditory functions.
Topography of acoustic response characteristics in the auditory cortex of the Kunming mouse
Junxian Shen,Zhimin Xu,Yudong Yao
Chinese Science Bulletin , 2000, DOI: 10.1007/BF02884948
Abstract: Topography of acoustic response characteristics in the auditory cortex (AC) of the Kunming (KM) mouse has been examined by using microelectrode recording techniques. Based on best-frequency (BF) maps, both the primary auditory field (AI) and the anterior auditory field (AAF) are tonotopically organized with a counter running frequency gradient. Within an isofrequency stripe, the width of the frequency-threshold curves of single neurons increases, and minimum threshold (MT) decreases towards more ventral locations. BFs in AI and AAF range from 4 to 38 kHz. Auditory neurons with BFs above 40 kHz are located at the rostrodorsal part of the AC. The findings suggest that the KM mouse is a good model suitable for auditory research.
Topography of acoustic response characteristics in the auditory cortex of the Kunming mouse
SHEN Junxian,XU Zhimin,YAO Yudong,

科学通报(英文版) , 2000,
Abstract: Topography of acoustic response characteristics in the auditory cortex (AC) of the Kunming (KM) mouse has been examined by using microelectrode recording techniques. Based on best-frequency (BF) maps, both the primary auditory field (AI) and the anterior auditory field (AAF) are tonotopically organized with a counter running frequency gradient. Within an isofrequency stripe, the width of the frequency-threshold curves of single neurons increases, and minimum threshold (MT) decreases towards more ventral locations. BFs in AI and AAF range from 4 to 38 kHz. Auditory neurons with BFs above 40 kHz are located at the rostrodorsal part of the AC. The findings suggest that the KM mouse is a good model suitable for auditory research.
Superconvergence of Immersed Finite Element Methods for Interface Problems
Waixiang Cao,Xu Zhang,Zhimin Zhang
Mathematics , 2015,
Abstract: In this article, we study superconvergence properties of immersed finite element methods for the one dimensional elliptic interface problem. Due to low global regularity of the solution, classical superconvergence phenomenon for finite element methods disappears unless the discontinuity of the coefficient is resolved by partition. We show that immersed finite element solutions inherit all desired superconvergence properties from standard finite element methods without requiring the mesh to be aligned with the interface. In particular, on interface elements, superconvergence occurs at roots of generalized orthogonal polynomials that satisfy both orthogonality and interface jump conditions.
Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans
Zhimin Yan,Hong Hua,Yanying Xu,Lakshman P. Samaranayake
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/106583
Abstract: This study was designed to evaluate the in vitro antifungal activities of four traditional Chinese medicine (TCM) extracts. The inhibitory effects of pseudolaric acid B, gentiopicrin, rhein, and alion were assessed using standard disk diffusion and broth microdilution assays. They were tested against six oral Candida species, Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, Candida dubliniensis, and Candida guilliermondii, including clinical isolates from HIV-negative, HIV-positive, and Sjögren's syndrome patients. It was found that pseudolaric acid B had the most potent antifungal effect and showed similar antifungal activity to all six Candida spp, and to isolates from HIV-negative, HIV-positive, and Sjögren's syndrome patients. The MIC values ranged from 16 to 128 g/mL. More interestingly, a synergistic effect of pseudolaric acid B in combination with fluconazole was observed. We suggest that pseudolaric acid B might be a potential therapeutic fungicidal agent in treating oral candidiasis.
Fractionation of the rice bran layer and quantification of vitamin E, oryzanol, protein, and rice bran saccharide
Rebecca Schramm, Alicia Abadie, Na Hua, Zhimin Xu, Marybeth Lima
Journal of Biological Engineering , 2007, DOI: 10.1186/1754-1611-1-9
Abstract: The importance of rice to the world population's dietary requirement is evident from its presence in the diet of a quarter of the world's people [1]. Rice processing or milling produces several streams of material, including husks, milled rice, and bran. In the United States, rice bran material is considered a by-product of the milling process and is most commonly used in animal feed or as a food ingredient due to its high nutritional content [2].As interest in value-added processing research grows, attempts are being made to increase the value of agricultural crop by-products, including rice bran, by increasing their pharmaceutical or nutraceutical potential. While rice bran has traditionally been utilized for pet food products [3], there is growing interest in the wide array of potentially human-health enhancing compounds found in rice bran. Rice bran is a good source of antioxidants including vitamin E and oryzanol, high quality oil and protein, and cholesterol-lowering waxes and anti-tumor compounds like rice bran saccharide [4-6]. Value-added processing to obtain these phytochemicals has the potential to be an important way of improving human health while increasing economic rates of return.In the unsaponifiable portion of rice bran oil, two groups of antioxidant compounds were identified as tocotrienols and gamma (γ)-oryzanol [7]. Tocotrienols, which are members of the vitamin E family, and γ-oryzanol, have been studied for potential health benefits [7]. Epidemiological studies have shown that antioxidants reduce oxidative damage to bimolecular structures that play a role in the prevention of chronic diseases. Antioxidants may help slow the onset of diabetes and Alzheimer's disease, and appear to play a role in the prevention of heart disease and cancer [8]. Tocotrienols have been shown to address free radicals in cell membranes and help in the prevention of coronary artery disease; γ-oryzanol (oryzanol) has been shown to lower blood cholesterol and to reduce
Nanometer properties of oceanic polymetallic nodules and cobalt-rich crusts
Zhimin Bai,Caiqiao Yin,Xunxiong Jiang,Xu Liu,Shengdong Wang
Chinese Science Bulletin , 2002, DOI: 10.1360/02tb9290
Abstract: An ammonia leaching process was utilized to extract Co, Ni and Cu from oceanic polymetallic nodules, whereas an acid leaching process was utilized to extract Co, Ni, Cu, Zn and Mn from cobalt-rich crusts. Both processes produced nanometer materials—ammonia leaching residue and acid leaching residue. A systematic study was conducted on the phase, composition and physicochemistry properties of these residues. The result shows that both residues contain a large amount of nanometer minerals. Ammonia l eaching residue mainly consists of rhodochrosite, with the average grain diameter of 17.9 nm; whereas the acid leaching residue mainly consists of well-developed bassanite, with the average grain deameter of 9.5 nm. The bassanite also has a microporous structure, the volume of the pore space is 1.23 × 10 2 mL/g. Both the ammonia and acid leaching residues have a large specific surface area, and they display a strong adsorption capacity to saturate sodium chloride vapour, N2 and SO2. Both residues have high contents of rare earth elements, and most of these elements exist in the state of ionic adsorption. The content of σ FeO is high. The P2O5 enrichment is observable in acid leaching residues. The unique composition and nanometer solid properties of the leaching residues displayed their potential value and promised a bright future for their application in the field of environmental protection and materials.
THE TRANSVERSE DEFLECTION ANALYSIS OF UNSYMMETRICAL COMPOSITE LAMINATED PLATES
复合材料非对称层板的横向变形特性分析

Xu Ke,Zhang Zhimin,
许可
,张志民

力学学报 , 1997,
Abstract: The nonlinear governing equations of composite laminated plates with elastical restraint are established by use of energy variational principle and nonlinear geometric equations in this paper. The governing equations are solved by means of generalized Fourier series method,subsequently the corresponding load deflection curves are obtained. The analysis in this paper is focused on the transverse deflection of unsymmetrical laminates.
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