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Search Results: 1 - 10 of 10801 matches for " ZhiYong Qian "
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Uptake and Cytotoxicity of Ce(IV) Doped TiO2 Nanoparticles in Human Hepatocyte Cell Line L02
Jian Mao,Long Wang,Zhiyong Qian,Mingjing Tu
Journal of Nanomaterials , 2010, DOI: 10.1155/2010/910434
Abstract: Ce(IV) doped anatase TiO2 nanoparticles (CDTs) were prepared and the underlying mechanism by which CDT nanoparticle enters into cell and its cytotoxicity were investigated in a human hepatocellular line L02 cell. The results showed that CDTs can enter into cytoplasm of L02 cell via endocytosis and nonendocytic ways. Large aggregation of CDTs went into cell by endocytosis and finally formed an endocytic vesicle with membrane boundary. Tiny aggregation of CDTs entered into cell cytoplasm via channels similar to that for lung-blood substance exchange in the alveolar-airway barrier. In addition, tiny aggregation of CDTs was observed in nucleus, and maybe CDTs could pass through the nucleus envelope via the channels provided by nuclear pore complexes (NPCs). Results from MTT assay, fluorescence microscope, and TEM observations showed that the cell viability, cell morphology, cell growth, and cell division periods could not be obviously impaired when cells were exposed to CDTs of different concentration from 30 to 150 g mL?1 without UV irradiation. However, large vacuoles containing CDTs were found in cytoplasm, some structure changes were observed in mitochondria, and smooth envelope around the nucleus was shrank and deformed.
Reconfiguration decision making in cognitive wireless network
Ping Zhang,Qian He,ZhiYong Feng,QiXun Zhang
Chinese Science Bulletin , 2012, DOI: 10.1007/s11434-012-5255-3
Abstract: Facing the challenges of dynamic adaptation capabilities in the time-varying environment of cognitive wireless networks (CWNs), we introduce reconfiguration capabilities that flexibly and dynamically adapt to changing wireless environments and service requirements. As an essential characteristic of CWNs, the cognitive reconfiguration can meet user requirements, realize interoperability between heterogeneous networks, make full use of radio resources and adapt to time-varying environments to achieve end-to-end requirements. However, the reconfiguration implementation is still challenging due to the need for complex environment cognition, multi-objective optimization, autonomic decision-making and end-to-end requirement extraction. As an intelligent technology for solving complex issues, we apply adaptive neuro-fuzzy inference system (ANFIS) techniques in this paper to address these challenges in cognitive reconfiguration for self-learning and optimal decision making based on multi-domain cognition results. Moreover, this paper designs a generic ANFIS cognitive reconfiguration system including three functional entities, which are the context management module, multi-domain database and ANFIS optimization module. Finally, numerous results prove the effective performance improvements of the ANFIS based reconfiguration solution in CWN for global end-to-end goals.
Decay Rate for a Viscoelastic Equation with Strong Damping and Acoustic Boundary Conditions  [PDF]
Zhiyong Ma
Journal of Applied Mathematics and Physics (JAMP) , 2017, DOI: 10.4236/jamp.2017.54081
Abstract: This paper is concerned with a nonlinear viscoelastic equation with strong damping: \"\". The objective of the present paper is to provide some results on the long-time behavior to this equation with acoustic boundary conditions. By using the assumptions on the relaxation function due to Tatar [1], we show an arbitrary rate of decay with not necessary of an exponential or polynomial one and without the assumption \"\" condition. The result extends and improves some results given in Cavalcanti [2].
Uniform Attractors for a Non-Autonomous Thermoviscoelastic Equation with Strong Damping  [PDF]
Zhiyong Ma
Journal of Applied Mathematics and Physics (JAMP) , 2018, DOI: 10.4236/jamp.2018.612209
Abstract: This paper considers the existence of uniform attractors for a non-autonomous thermoviscoelastic equation with strong damping in a bounded domain ΩRn(n≥1) by establishing the uniformly asymptotic compactness of the semi-process generated by the global solutions.
Prevention of post-surgical abdominal adhesions by a novel biodegradable thermosensitive PECE hydrogel.
Bing Yang, ChangYang Gong, ZhiYong Qian, Xia Zhao, ZhengYu Li, XiaoRong Qi, ShengTao Zhou, Qian Zhong, Feng Luo, YuQuan Wei
BMC Biotechnology , 2010, DOI: 10.1186/1472-6750-10-65
Abstract: The PECE hydrogel in sol state could be transformed into gel in less than 20 s at 37°C. In addition, the PECE hydrogel could be easily adhered to the damaged peritoneal surfaces, and be gradually degraded and absorbed by the body within 14 days along with the healing of peritoneal wounds. A notable efficacy of the PECE hydrogel in preventing peritoneal adhesions was demonstrated in the animal models. In contrast, all untreated animals developed adhesions requiring sharp dissection. Furthermore, no significant histopathological changes were observed in main organs of the hydrogel-treated animals.Our results suggested that the thermosensitive PECE hydrogel was an effective, safe, and convenient agent on preventing post-surgical intro-abdominal adhesions.Post-operative peritoneal adhesions are common and serious complications for patients. The incidence of intra-abdominal adhesions ranges from 67 to 93% after general surgical abdominal procedures and is even up to 97% after gynecologic pelvic opening-operations [1-3]. They can induce a broad range of diseases such as infertility, pain, bowel obstruction, and difficulties experienced during re-operative interventions [4-8].Peritoneal adhesions generally form in the early post-operative period. For decades, unremitting efforts on the issue are focused on developing products used during laparotomy. Numerous drugs against postoperative adhesion have been tested, and have shown promise in animal models, but few have penetrated into clinical practice [9-11]. An approach to prevent abdominal adhesions is to apply barrier in the form of a polymer solution or synthetic solid membrane, separating the injured regions during peritoneal healing. For polymer solutions such as sodium hyaluronate (HA) and carboxymethylcellulose (CMC), the residence time at the site of administration is relatively brief [9]. For synthetic solid membranes such as oxidized-regenerated cellulose (Interceed) [12], PTFE [13], and HA-CMC (Seprafilm) [14], co
Preparation of alginate coated chitosan microparticles for vaccine delivery
XingYi Li, XiangYe Kong, Shuai Shi, XiuLing Zheng, Gang Guo, YuQuan Wei, ZhiYong Qian
BMC Biotechnology , 2008, DOI: 10.1186/1472-6750-8-89
Abstract: The prepared alginate coated BSA loaded chitosan microparticles had loading efficiency (LE) of 60% and loading capacity (LC) of 6% with mean diameter of about 1 μm. When the weight ratio of alginate/chitosan microparticles was greater than 2, the stable system could be obtained. The rapid charge inversion of BSA loaded chitosan microparticles (from +27 mv to -27.8 mv) was observed during the coating procedure which indicated the presence of alginate layer on the chitosan microparticles surfaces. According to the results obtained by scanning electron microscopy (SEM), the core-shell structure of BSA loaded chitosan microparticles was observed. Meanwhile, in vitro release study indicated that the initial burst release of BSA from alginate coated chitosan microparticles was lower than that observed from uncoated chitosan microparticles (40% in 8 h vs. about 84% in 0.5 h). SDS-polyacrylamide gel electrophoresis (SDS-PAGE) assay showed that alginate coating onto chitosan microparticles could effectively protect the BSA from degradation or hydrolysis in acidic condition for at least 2 h. The structural integrity of alginate modified chitosan microparticles incubated in PBS for 24 h was investigated by FTIR.The prepared alginate coated chitosan microparticles, with mean diameter of about 1 μm, was suitable for oral mucosal vaccine. Moreover, alginate coating onto the surface of chitosan microparticles could modulate the release behavior of BSA from alginate coated chitosan microparticles and could effectively protect model protein (BSA) from degradation in acidic medium in vitro for at least 2 h. In all, the prepared alginate coated chitosan microparticles might be an effective vehicle for oral administration of antigens.Development of an oral antigens (protein, and etc) delivery system for mucosal vaccine is a meaningful challenge for pharmaceutical scientists. The instability and poor absorption of antigens in gastrointestinal tract is major obstacles in the development
5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice
Yongsheng Wang, Changyang Gong, Li Yang, Qinjie Wu, Shuai Shi, Huashan Shi, Zhiyong Qian, Yuquan Wei
BMC Cancer , 2010, DOI: 10.1186/1471-2407-10-402
Abstract: A biodegradable PEG-PCL-PEG (PECE) triblock copolymer was successfully synthesized. The biodegradable and temperature sensitive hydrogel was developed to load 5-FU. Methylene blue-loaded hydrogel were also developed for visible observation of the drug release. The effects and toxicity of the 5-FU-hydrogel system were evaluated in a murine CRPC model.The hydrogel system is an injectable flowing solution at ambient temperature and forms a non-flowing gel depot at physiological temperature. 5-FU-hydrogel was subsequently injected into abdominal cavity in mice with CT26 cancer cells peritoneal dissemination. The results showed that the hydrogel delivery system prolonged the release of methylene blue; the 5-FU-hydrogel significantly inhibited the peritoneal dissemination and growth of CT26 cells. Furthermore, intraperitoneal administration of the 5-FU-hydrogel was well tolerated and showed less hematologic toxicity.Our data indicate that the 5-FU-hydrogel system can be considered as a new strategy for peritoneal carcinomatosis, and the hydrogel may provide a potential delivery system to load different chemotherapeutic drugs for peritoneal carcinomatosis of cancers.Peritoneal carcinomatosis (PC) is one of the most common causes of incurability of intra-abdominal cancers, among which colorectal peritoneal carcinomatosis (CRPC) is a result of transcoelomic invasion by the primary cancer or intraperitoneal seeding during surgical manipulation. Approximately 8% of patients have isolated peritoneal seeding at the time of primary surgery, and 25% of patients with recurrence have disease confined to the peritoneal cavity [1,2]. Neither systemic chemotherapy nor intraperitoneal chemotherapy alone had any significant impact on survival [3]. The current goal of treatment for most abdominal/peritoneal metastases is palliative, rather than curative. It is imminent to sought new strategies to improve the therapeutic effects of intraperitoneal chemotherapy. Intraperitoneal infusion of
Intelligent and efficient development of wireless networks: A review of cognitive radio networks
Ping Zhang,Yang Liu,ZhiYong Feng,QiXun Zhang,Qian Li,Ding Xu
Chinese Science Bulletin , 2012, DOI: 10.1007/s11434-012-5334-5
Abstract: Facing the challenges on how to improve spectrum efficiency and how to realize heterogeneous network convergence in future wireless networks, a cognitive radio network (CRN) is proposed as one of the solutions. This has become a major research topic in recent years and it is timely to give an overview of the development of CRN and to summarize key issues and technologies. The fundamental concepts of CRN, including the cognitive cycle model, the network architecture, and the cognitive ability and intelligent decision functions, are introduced in detail based on recent advances. Key issues for each topic, followed with recent research on theory and method, are then classified and the industrialization developments of CRN testbeds based on TD-LTE cellular system and standards are briefly presented. Finally, conclusions are reached on the perspectives and directions of future development.
Blind MPSK signal detection based on complex-valued multistate continuous Hopfield neural networks

QIAN Jianping,ZHANG Zhiyong,RUAN Xiukai,

重庆邮电大学学报(自然科学版) , 2012,
Abstract: An optimization performance function is constructed to detect M-ary phase shift keying (MPSK) signals blindly and directly. To use complex-valued Hopfield neural network(CVHNN) for solving above optimization performance function, a novel complex-valued multistate continuous activation function is given to improve network performance, and a new energy function is proposed to prove the stability of CVHNN with the given activation function.Computer simulation results show that the proposed method has faster convergence for the blind detection of MPSK signals than classical algorithms such as subspace algorithm and so on.
Two Implicit Runge-Kutta Methods for Stochastic Differential Equation  [PDF]
Fuwen Lu, Zhiyong Wang
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.310162
Abstract: In this paper, the Ito-Taylor expansion of stochastic differential equation is briefly introduced. The colored rooted tree theory is applied to derive strong order 1.0 implicit stochastic Runge-Kutta method(SRK). Two fully implicit schemes are presented and their stability qualities are discussed. And the numerical report illustrates the better numerical behavior.
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