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Search Results: 1 - 10 of 120037 matches for " Zhehai Wang "
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Efficacy and Toxicity of Pemetrexed or Gemcitabine Combined with Cisplatin in the Treatment of Patients with Advanced Non-small Cell Lung Cancer
Xingsheng HU,Shunchang JIAO,Shucai ZHANG,Zhehai WANG
Chinese Journal of Lung Cancer , 2012, DOI: 10.3779/j.issn.1009-3419.2012.10.02
Abstract: Background and objective Due to the various inter-individual differences in the biological characteristics of tumor cells, as well as issues on the efficacy, adverse reactions, and defects of existing drugs, we compared the clinical efficacy and toxicity of pemetrexed and gemcitabine combined with cisplatin for the treatment of previously untreated advanced non-small cell lung cancer (NSCLC). Methods 251 patients were randomly divided into pemetrexed combined with cisplatin group (PP group) with 127 cases and gemcitabine combined with cisplatin group (GP group) with 124 cases. PP group received pemetrexed 500 mg/m2 iv infusion d1 and cisplatin 75 mg/m2 iv infusion d1, whereas GP group received gemcitabine 1,000 mg/m2 iv infusion d1,8 and cisplatin 75 mg/m2 iv infusion d1. The treatment cycle was once every three weeks. In addition, folic acid, vitamin B12, and dexamethasone were administered in both groups. Results The total clinical effective rates in PP group and GP group were 25.20% and 17.74%, respectively. The total efficiencies of non-squamous cell carcinoma were 27.62% and 16.00%. The tumor progression duration in these two groups was 6.5 and 5.6 months, respectively. The median survival time in the two groups was 16.9 and 17.0 months, respectively, with 59.62% and 65.87% survival rates of 1 year and 27.28% and 27.93% survival rates of 2 years, respectively. The total efficacy of non-squamous cell carcinoma in the PP group was significantly higher than that in GP group. The results were statistically significant. However, there were no significant differences in total response rates, tumor progression duration, and median survival rates of 1 and 2 years. The rate of adverse reactions, including white blood cell reduction, lower platelet count, lower hemoglobin, and hair loss in the PP group was significantly lower than that in the GP group. The results were statistically significant. Conclusion The clinical efficacy of pemetrexed and gemcitabine combined with cisplatin for the treatment of previously untreated advanced NSCLC was roughly the same, but the adverse reactions decreased significantly in the PP group compared with those in the GP group. Therefore, pemetrexed combined with cisplatin can be used as a safe and effective drug for clinical first-line treatment for previously untreated NSCLC.
Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese
Jie Liu, Bao Song, Xueli Bai, Wenjian Liu, Zengjun Li, Jialin Wang, Yan Zheng, Zhehai Wang
BMC Cancer , 2010, DOI: 10.1186/1471-2407-10-456
Abstract: We genotyped three SNPs of the IL-10 promoter (-1082A/G, -819T/C and -592A/C) using polymerase chain reaction-restriction fragment length polymorphism analysis in 262 subjects with PCa and 270 age-matched healthy controls. Odds ratio and 95% confidence interval were determined by logistic regression for the associations between IL-10 genotypes and haplotypes with the risk of PCa and advanced PCa grade.No significant differences in allele frequency or genotype distribution were observed for any of the IL-10 SNPs between PCa patients and control subjects. Significantly higher frequencies of -1082G, -819C and -592C allele and GCC haplotype were observed, however, in early stage patients in comparison to advanced PCa patients (for -1082 G, 13.9% vs 6.1%, OR = 2.48, P = 0.005; for -819 C 40.3% vs 30.8%, OR = 1.51, P = 0.043; for -512C, 40.3% vs 30.8%, OR = 1.51, P = 0.043; and for haplotype GCC 11.1%vs 5.1%, OR = 2.66, P = 0.008, respectively).Our results identify that IL-10 promoter polymorphisms might not be a risk factor for PCa in Chinese cohorts, but rather incidence of polymorphisms associates with PCa grade, suggesting that IL-10 expression may impact PCa progression.Prostate cancer (PCa) is among the most common malignant tumors in Western males, ranking second only to lung cancer in cancer mortality [1]. PCa incidence in Asian men is significantly lower, however, the incidence of PCa in China has increased significantly in recent years [2]. While age, ethnicity, diet, and geographic factors are believed to contribute to the etiology of this disorder [3-5], genetic variations may play a role in susceptibility to PCa [6]. Recent studies suggest that genetic polymorphisms of genes involved in innate immunity and chronic inflammation, including the anti-inflammatory cytokine Interleukin-10 (IL-10), may impact susceptibility to PCa [6].IL-10 is produced primarily by macrophages and T lymphocytes. It has important anti-inflammatory and immunosuppressive activities, in
Software Industry Cluster be Disagreement on Theory and Practice  [PDF]
Yang Wang, Luqian Wang
Intelligent Information Management (IIM) , 2010, DOI: 10.4236/iim.2010.210069
Abstract: In the view of traditional industry cluster theory, it is easy to copy the software industry cluster pattern, or it is easy to copy another Silicon Valley, due to low reliability of the resources and the guidance factors of locations in software industry. But it is much more difficult to copy a Silicon Valley mode practically than imaginatively and the difficulties of bringing up and supporting high-tech initiatives is more than theoretic anticipation. In China, the software companies have just gathered together geographically and therefore no initiative center can be formed. All these above signify that software industry cluster is distinct from the traditional industry clusters, but the cognition of the reasons of software industry cluster is not clear yet. Furthermore, reasonable explanations of the bewilderment in the economical practice of software industry cluster are urgently needed.
The Economic Growth Effect of Logistics Industry FDI Analysis  [PDF]
Yang Wang, Luqian Wang
iBusiness (IB) , 2010, DOI: 10.4236/ib.2010.24049
Abstract: Based on the direction of the international FDI changed, from manufacturing to service industries, we should concern about the influence of the introduction of China’s logistics industry FDI to the national economy. The paper sets up regression model to examine logistics FDI and GDP in two aspects of time series and growth rate, we find that the logistics FDI reaches a high correlation with GDP, and logistics FDI is one of the major driving forces of economic development. Therefore, China should expand the introduction of logistics FDI, improve the quality of foreign investment, develop the positive economic growth effect of logistics FDI and promote the change of China’s economic growth pattern to ensure the development of China’s economy.
The Predictive Effects of Online Communication on Well-Being among Chinese Adolescents  [PDF]
Jinliang Wang, Haizhen Wang
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.24056
Abstract: Based on theories and previous studies on online communication, we proposed two hypotheses to better under- stand the effects of online communication on subjective well-being with a sample of Chinese adolescents (n = 190). The results of liner regression analysis found that online communication was positively related to adoles- cents’ subjective well-being. For boys, the coefficient of determination of online communication on subjective well-being was .143, and for girls the coefficient of determination was .040, indicating that boys benefit more from online communication than do girls.
The Impact of Radical Prostatectomy on the Survival of Patients with Carcinosarcoma of the Prostate  [PDF]
Jue Wang, Fenwei Wang
Journal of Cancer Therapy (JCT) , 2011, DOI: 10.4236/jct.2011.24064
Abstract: Background: The objective of this study was to evaluate the impact of radical prostatectomy on carcinosarcoma of the prostate. Methods: Patients diagnosed with carcinosarcoma of the prostate from 1977 through 2007 were identified in the Surveillance, Epidemiology, and End Results (SEER) database. Outcomes were examined with Kaplan-Meier survival analysis and Cox models. The association between clinical and demographic characteristics and survival of carcinosarcoma of the prostate was examined. Results: A total of fifty-four cases of histology confirmed carcinosarcoma of the prostate were identified. Median age of the patients was 74 years (range 28 - 94). Of the patients with a known tumor stage, all but one patient had a locally advanced or distant stage; all of the patients with known histology grade had poorly or undifferentiated histology. Twenty (37%) patients underwent transurethral resection only and Fourteen (25.9%) patients underwent radical prostatectomy. Eight (14%) patients received radiation therapy in combination with surgery. The median cancer specific survival was 16 months (95% CI 0 - 32 months). 1-, 3-, and 5- year cancer specific survival rate were 55.1%, 32.3% and 21.1%. In a multivariate analysis, radical prostatectomy was found to be a significant prognostic factor for cancer-specific survival. Conclusions: Carcinosarcoma of the prostate commonly occurs in older patients and associated with aggressive disease and poor prognosis. Radical prostatectomy is the only treatment modality that significantly improves survival. Emphasis on early diagnosis and detection and multimodality therapy of this disease is needed to improve the outcome for patients with this malignancy.
A Research on the Relationship between FDI and Jiangsu’s Regional Economy Disparity  [PDF]
Baoqian Wang, Cheng Wang
Technology and Investment (TI) , 2012, DOI: 10.4236/ti.2012.33018
Abstract: Through reading and summarizing relevant articles, the authors analyze two different kinds of effects that FDI influence the regional economy. Location and digesting ability reflects such non-equilibrium. By using regression analysis, the authors discover, in south Jiangsu, which the unit FDI increase contributes most to the GDP development, with middle and north Jiangsu lagging behind. The regression coefficient is 1.198, 0.429 and 0.572 respectively. Considering the index of digestion ability, unit FDI increase and unit GDP contribution rate still share strong relevant relationship. However, the coefficients change. The effects that FDI stimulate GDP growth are weakened, been made up by the endogenous ability. The granger test shows that in south Jiangsu, there exists a cycle of accumulative effect, namely both the FDI increase and the GDP growth do well with each other. However, in the rest of Jiangsu province, such effect is not obvious. Considering the elements of location and digesting ability, this paper offers tactics for Jiangsu for a better coordinate of future development.
Causes of and Remedies for Chinglish in Chinese College Students’ Writings  [PDF]
Ping Wang, Weiping Wang
Open Journal of Modern Linguistics (OJML) , 2012, DOI: 10.4236/ojml.2012.22009
Abstract: Based on Interlanguage Theory and other theories, this study examines data from samples of Chinese college students’ writings and interviews with the students to explore the causes of and remedies for Chinglish (a term used to refer English with Chinese characteristics). It claims that Chinglish is mainly caused by syntactic transfer from Chinese, the influence of Chinese thought patterns, inadequate exposure to authentic English and insufficient practice in English writing. The interviews with the students showed that the proportion of L1 thinking decreased with the writer’s L2 development. The recommended remedies for Chinglish include raising students’ awareness of distinctions between English and Chinese, increasing their exposure to authentic English and practice in English writing, and adjusting their thought patterns.
An Entanglement Criterion for States in Infinite Dimensional Bipartite Quantum Systems  [PDF]
Yinzhu Wang, Danxia Wang
Journal of Quantum Information Science (JQIS) , 2012, DOI: 10.4236/jqis.2012.23013
Abstract: In this paper, an entanglement criterion for states in infinite dimensional bipartite quantum systems is presented. We generalize some of separability criterion that was recently introduced by Wu and Anandan in (Phys. Lett. A, 2002, 297, 4-8) to infinite dimensional bipartite quantum systems. In addition, we give an example aimed to illustrate the application of the theorem.
Common Fixed Point Theorems for Totally Quasi-G-Asymptotically Nonexpansive Semigroups with the Generalized f-Projection  [PDF]
Chunjie Wang, Yuanheng Wang
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.51004
Abstract:

In this paper, we introduce some new classes of the totally quasi-G-asymptotically nonexpansive mappings and the totally quasi-G-asymptotically nonexpansive semigroups. Then, with the generalized f-projection operator, we prove some strong convergence theorems of a new modified Halpern type hybrid iterative algorithm for the totally quasi-G-asymptotically nonexpansive semigroups in Banach space. The results presented in this paper extend and improve some corresponding ones by many others.

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