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Search Results: 1 - 10 of 268069 matches for " Zhao Z-L "
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Preparation and in vitro and in vivo characterization of cyclosporin A-loaded, PEGylated chitosan-modified, lipid-based nanoparticles
Zhang L, Zhao Z-L, Wei X-H, Liu J-H
International Journal of Nanomedicine , 2013, DOI: http://dx.doi.org/10.2147/IJN.S39685
Abstract: eparation and in vitro and in vivo characterization of cyclosporin A-loaded, PEGylated chitosan-modified, lipid-based nanoparticles Original Research (764) Total Article Views Authors: Zhang L, Zhao Z-L, Wei X-H, Liu J-H Published Date February 2013 Volume 2013:8 Pages 601 - 610 DOI: http://dx.doi.org/10.2147/IJN.S39685 Received: 29 October 2012 Accepted: 16 December 2012 Published: 05 February 2013 Ling Zhang,1,2,# Zhi-Liang Zhao,3,# Xiao-Hong Wei,1 Jin-Hua Liu2 1School of Medicine, 2College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, 3Tongde Hospital of Zhejiang Province, Hangzhou, People’s Republic of China #These authors contributed equally to this paper Background and methods: A new cyclosporin A-loaded, PEGylated chitosan-modified lipid-based nanoparticle was developed to improve upon the formulation of cyclosporin A. PEGylated chitosan, synthesized in three steps using mild reaction conditions, was used to modify the nanoparticles. Cyclosporin A-loaded, PEGylated chitosan-modified nanoparticles were prepared using an emulsification/solvent evaporation method. The drug content and encapsulation efficiency of the cyclosporin A-loaded, PEGylated chitosan-modified nanoparticles were measured by high-performance liquid chromatography. The average size of the nanoparticles was determined by transmission electron microscopy and dynamic light scattering. The pharmacokinetic behavior of the nanoparticles was investigated in rabbits after intravenous injection. Cyclosporin A concentrations in a whole blood sample were analyzed by high-performance liquid chromatography using tamoxifen as the internal standard. The pharmacokinetic parameters were calculated using the 3p87 software program. Results: Fourier transform infrared spectroscopy and nuclear magnetic resonance confirmed the structure of PEGylated chitosan. The drug content and encapsulation efficiency of the cyclosporin A-loaded, PEGylated chitosan-modified nanoparticles were 37.04% and 69.22%, respectively. The average size of the nanoparticles was 89.4 nm. The nanoparticles released 30% cyclosporin A-loaded in 48 hours in vitro, with no initial burst release. The mode of release in vitro was prone to bulk erosion. The in vivo results showed the biological half-life of the elimination phase (t1/2β) of the nanoparticles was 21 times longer than that of the cyclosporin A solution, and the area under the curve for the nanoparticles was 25.8 times greater than that of the cyclosporin A solution. Conclusion: Modification of PEGylated chitosan prolonged the retention time of the nanoparticles in the circulatory system and improved the bioavailability of cyclosporin A.
Preparation and in vitro and in vivo characterization of cyclosporin A-loaded, PEGylated chitosan-modified, lipid-based nanoparticles
Zhang L,Zhao Z-L,Wei X-H,Liu J-H
International Journal of Nanomedicine , 2013,
Abstract: Ling Zhang,1,2,# Zhi-Liang Zhao,3,# Xiao-Hong Wei,1 Jin-Hua Liu21School of Medicine, 2College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, 3Tongde Hospital of Zhejiang Province, Hangzhou, People’s Republic of China #These authors contributed equally to this paperBackground and methods: A new cyclosporin A-loaded, PEGylated chitosan-modified lipid-based nanoparticle was developed to improve upon the formulation of cyclosporin A. PEGylated chitosan, synthesized in three steps using mild reaction conditions, was used to modify the nanoparticles. Cyclosporin A-loaded, PEGylated chitosan-modified nanoparticles were prepared using an emulsification/solvent evaporation method. The drug content and encapsulation efficiency of the cyclosporin A-loaded, PEGylated chitosan-modified nanoparticles were measured by high-performance liquid chromatography. The average size of the nanoparticles was determined by transmission electron microscopy and dynamic light scattering. The pharmacokinetic behavior of the nanoparticles was investigated in rabbits after intravenous injection. Cyclosporin A concentrations in a whole blood sample were analyzed by high-performance liquid chromatography using tamoxifen as the internal standard. The pharmacokinetic parameters were calculated using the 3p87 software program.Results: Fourier transform infrared spectroscopy and nuclear magnetic resonance confirmed the structure of PEGylated chitosan. The drug content and encapsulation efficiency of the cyclosporin A-loaded, PEGylated chitosan-modified nanoparticles were 37.04% and 69.22%, respectively. The average size of the nanoparticles was 89.4 nm. The nanoparticles released 30% cyclosporin A-loaded in 48 hours in vitro, with no initial burst release. The mode of release in vitro was prone to bulk erosion. The in vivo results showed the biological half-life of the elimination phase (t1/2β) of the nanoparticles was 21 times longer than that of the cyclosporin A solution, and the area under the curve for the nanoparticles was 25.8 times greater than that of the cyclosporin A solution.Conclusion: Modification of PEGylated chitosan prolonged the retention time of the nanoparticles in the circulatory system and improved the bioavailability of cyclosporin A.Keywords: nanoparticle, PEGylation, chitosan, pharmacokinetics, cyclosporin A, long circulation, bioavailability
Polimorfismo genético de la β-lactoglobulina en la leche de vacas Holstein y criollo lechero tropical
Meza-Nieto, Martín A.;González-Córdova, Aarón F.;Becerril-Pérez, Carlos M.;Ruíz-López, Felipe J.;Díaz-Rivera, Pablo;Vallejo-Cordoba, Belinda;
Agrociencia , 2010,
Abstract: the genetic variants (a and b) of the β-lactoglobulin in cow's milk has been associated with important technological properties in dairy processing. the objectives of this study were to determine the genetic variants and to estimate the phenotypic frequencies of β-lactoglobulin (β-lg) in cow's milk of holstein and tropical milking criollo (tmc), as well as to evaluate the effect of the phenotypes on the total concentration of β-lg. the phenotype was determined in 382 milk samples of holstein and 64 of tmc. the genetic variants identified by capillary electrophoresis in free zone were a and b, with genotypes aa, ab and bb. the genotypic frequencies (0.14, 0.33 and 0.53 in tmc; 0.19, 0.57 and 0.24 in holstein) were compared using the chi-squared test (χ2) and were different (p<0.01) in the two breeds. the total concentration of β-lg in milk was higher (p<0.05) when the allele a was present. the total concentration of β-lg according to the phenotype followed the order ab > aa > bb for both breeds; these differences were significant in tmc cows. the analysis of the results suggests that the physical-chemical and technological characteristics of tmc cow's milk could be different from those of the holstein cows.
Urinary Excretion of Phenolic Acids by Infants and Children: A Randomised Double-Blind Clinical Assay
J. Uberos, V. Fernández-Puentes, M. Molina-Oya, R. Rodríguez-Belmonte, A. Ruíz-López, P. Tortosa-Pinto, A. Molina-Carballo and A. Mu oz-Hoyos
Clinical Medicine Insights: Pediatrics , 2012, DOI: 10.4137/CMPed.S9349
Abstract: Objectives: The present study, which is part of the ISRCTN16968287 clinical assay, is aimed at determining the effects of cranberry syrup or trimethoprim treatment for UTI. Methods: This Phase III randomised clinical trial was conducted at the San Cecilio Clinical Hospital (Granada, Spain) with a study population of 192 patients, aged between 1 month and 13 years. Criteria for inclusion were a background of recurrent UTI, associated or otherwise with vesico-ureteral reflux of any degree, or renal pelvic dilatation associated with urinary infection. Each child was randomly given 0.2 mL/Kg/day of either cranberry syrup or trimethoprim (8 mg/mL). The primary and secondary objectives, respectively, were to determine the risk of UTI and the levels of phenolic acids in urine associated with each intervention. Results: With respect to UTI, the cranberry treatment was non-inferior to trimethoprim. Increased urinary excretion of ferulic acid was associated with a greater risk of UTI developing in infants aged under 1 year (RR 1.06; CI 95% 1.024–1.1; P = 0.001). Conclusions: The results obtained show the excretion of ferulic acid is higher in infants aged under 1 year, giving rise to an increased risk of UTI, for both treatment options.
Large Area C60 Film Obtained by Microwave Oven Irradiation from an Organic Resin
J. Martínez-Reyes,L. G. Díaz Barriga-Arceo,L. Rendón-Vazquez,R. Martínez-Guerrero,N. Romero-Parada,E. Palacios-González,V. Garibay-Febles,J. Ortíz-López
ISRN Nanomaterials , 2013, DOI: 10.1155/2013/524548
Abstract: In the present work the synthesis of fullerene thin film produced in a conventional microwave oven from the decomposition of terpenoid is reported. The polycrystalline structure of the sample was determined by X-ray diffraction (XRD); the sample showed several phases, and the main phase corresponds to fullerene ordered in a face-centered cubic structure (FCC), with a lattice parameter ??, with two more structures: one is orthorhombic system with lattice parameters ??, ??, and ??, and the other is the monoclinic system with lattice parameters ??, ??, ??, and ° coexisting also with graphite 2H phase with lattice parameters ??, ??. It was observed in a scanning electron microscopy (SEM) that the sample formed thin films of stacked carbon. The film thickness was measured by a SEM, and it was 140.8 to 523?nm and the macroscopic area of 12?cm2, whereas a high-resolution transmission electron microscopy (HRTEM) revealed that the main phase of the material is C60 ordered in a face-centered cubic structure (FCC). In the sample surface by atomic force microscopy (AFM), islands deposited crystals were observed having symmetry m crystal habit associated with the tetrahedron. 1. Introduction Carbon thin films are important for the development of applications in semiconductors, nano electronics, and aerospace industry due to the physical properties of their crystal structure. These properties are high electric conductivity or semiconductivity, photo conductivity, and optical nonlinearity [1]. Several methods are currently used for the preparation of carbon films [2–5]. In these methods the films are obtained in temperature conditions at ranges of 950–1250°C [6] with different energies from 100 to 1000?eV [7] at pressure from 1 to Torr [8–10] using inert atmospheres or carbon gases as control atmospheres with flowing in a continuous way to obtain small area films with thicknesses from 500?nm to 10?000?nm with a crystalline or amorphous structure [11], making this synthesis expensive. Comparing the carbon film precursors at present, the use of organic resins such as terpenoids has proven to be efficient in obtaining carbon films by using techniques such as CVD [12–17]. Comparing the chemical precursors used in the synthesis of carbon films, it was observed that organic resins present more advantages than the inorganic precursors because some of these resins are environment friendly [18]. It is important to mention that camphor resin has been successfully used in carbon nanomaterials synthesis and also in carbon films, graphene, carbon nanotubes, and other carbon
Mapping the b-values along the Longmenshan fault zone before and after the 12 May 2008, Wenchuan, China, MS 8.0 earthquake
Y. Z. Zhao,Z. L. Wu
Natural Hazards and Earth System Sciences (NHESS) & Discussions (NHESSD) , 2008,
Abstract: The b-value in the Gutenberg-Richter frequency-magnitude distribution, which is assumed to be related to stress heterogeneity or asperities, was mapped along the Longmenshan fault zone which accommodated the 12 May 2008, Wenchuan, MS 8.0 earthquake. Spatial distributions of b-value before and after the Wenchuan earthquake, respectively, were compared with the slip distribution of the mainshock. It is shown that the mainshock rupture nucleated near to, but not within, the high-stress (low b-value) asperity in the south part of the Longmenshan fault, propagating north-eastward to the relatively low stress (high b-value) region. Due to the significant difference between the rupture process results from different sources, the comparison between slip distribution and pre-seismic b-value distribution leads to only conclusion of the rule-of-thumb. The temporal change of b-value before the mainshock shows a weak trend of decreasing, being hard to be used as an indicator of the approaching of the mainshock. Distribution of b-values for the aftershocks relates the termination of the mainshock rupture to the harder patch along the Longmenshan fault to the north.
Detection and location of nonlinearities in MDOF structural systems
Z. Q. Lang,L. Zhao
Acta Montanistica Slovaca , 2010,
Abstract: The study is concerned with the development of a new technique for the detection and location of nonlinearities in MDOFstructural systems where multiple nonlinear components may exist due to different faulty conditions. The basis is a concept knownas Nonlinear Output Frequency Response Functions and associated properties. The technique determines the location of nonlinearcomponents in MDOF structural systems directly from the system input and output signals, which can be the measurements of sensorsfitted into the system for structural health monitoring purpose. Simulation studies demonstrate the effectiveness of the proposedtechnique.
Thermoelectric Performance of Micro/Nano-Structured Bismuth-Antimony-Telluride Bulk from Low Cost Mechanical Alloying  [PDF]
Z. Li, G. L. Zhao, P. Zhang, S. Guo, J. Tang
Materials Sciences and Applications (MSA) , 2012, DOI: 10.4236/msa.2012.312121
Abstract: In this work, micro/nano-structured Bi0.5Sb1.5Te3bulk thermoelectric materials were synthesized by mechanical alloying from elemental shots of Bi, Sb, and Te. Cold pressing and subsequent heat treatments with hydrogen reduction were used to form bulk solid samples with good thermoelectric properties in the temperature range around 75℃to 100℃. In comparison to crystal growth methods and chemical solution synthesis, the reported technique can be readily implemented for mass production with relatively low cost.
Impact of Data Quality on Predictive Accuracy of ANFIS based Soft Sensor Models
S. Jassar,Z. Liao,L. Zhao
Lecture Notes in Engineering and Computer Science , 2009,
Abstract:
Data Quality in Hybrid Neuro-Fuzzy based Soft-Sensor Models: An Experimental Study
S. Jassar,Z. Liao,L. Zhao
IAENG International Journal of Computer Science , 2010,
Abstract:
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