oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 18 )

2018 ( 185 )

2017 ( 193 )

2016 ( 204 )

Custom range...

Search Results: 1 - 10 of 16810 matches for " Zhangfeng Zhong "
All listed articles are free for downloading (OA Articles)
Page 1 /16810
Display every page Item
Nanotechnologies for Curcumin: An Ancient Puzzler Meets Modern Solutions
Shengpeng Wang,Miao Tan,Zhangfeng Zhong,Meiwan Chen,Yitao Wang
Journal of Nanomaterials , 2011, DOI: 10.1155/2011/723178
Abstract: Curcumin, a low-molecular-weight natural polyphenol mainly found in the plant Curcuma longa (turmeric), is widely used as a food colorant and as a potential protective agent against several chronic diseases including cancer, HIV-infection, neurological, cardiovascular, and skin diseases. Moreover, evidences from long-term use process and preclinical trials have demonstrated low toxicity of curcumin, even at relatively high doses. However, it has been well known that the application of curcumin was limited owing to its water insolubility, instability, and poor bioavailability. For decades, many attempts have been made to compensate for these disadvantages, with the development of improved delivery platforms as the feasible approaches. The past ten years witnessed the encouraging progress in the use of nanoscale drug delivery systems on curcumin such as loading curcumin into liposomes or nanoparticles, forming self-microemulsifying drug delivery systems (SMEDDS), cyclodextrin inclusions, and solid dispersions, as well as the latest reported technologies such as nadodisks and nanotubes. This paper summarizes the recent works on the design and development of nanoscale delivery systems of curcumin, with the goal of harnessing the true difficulties of this multifunctional agent in the clinical arena. 1. Introduction Curcumin (Figure 1), an active constituent mainly derived from Curcuma longa (turmeric), is a natural yellow-orange polyphenol which has been used for its medicinal benefits for centuries [1, 2]. Curcumin was firstly extracted in impure form in 1815, then in 1870 the pure crystalline state was prepared. Almost three decades later, its composition was finally elucidated as 1, 6-heptadiene-3, 5-dione-1, 7-bis-(4-hydroxy-3-methoxyphenyl)-(1E, 6E) [3–6]. In China, curcumin has been used as a part of herbal medicine for centuries to alleviate throbbing pain in the chest and hypochondriac region, mass in abdomen, and pain of the shoulder due to win-cold or traumatic injuries. The accumulating of experimental and clinical evidences indicates that curcumin has a variety of pharmacological activities, such as antitumor, antiinflammatory, antivirus, antioxidation, anti-HIV, and low toxicity [7–11]. Figure 1: Chemical structure of curcumin. However, good things never come easy. Applicational advancement of curcumin has been hindered by its water insolubility, degradation at alkaline pH, and photodegradation and thus extremely low bioavailability in both vascular and oral administration [12, 13]. Therefore, many approaches have been investigated, including
Recent advances in nanoparticle formulation of oleanolic acid
Meiwan Chen, Zhangfeng Zhong, Wen Tan, Shengpeng Wang, Yitao Wang
Chinese Medicine , 2011, DOI: 10.1186/1749-8546-6-20
Abstract: Oleanolic acid (OA), a naturally occurring pentacyclic triterpenoid extracted from the leaves and roots of Olea europaea, Viscum album L., Aralia chinensis L. and over 120 other plant species [1], is chemically known as 3β-hydroxy-olea-12-en-28-oic acid [2] (Figure 1). OA exhibits many biological activities such as anti-inflammatory, antitumor, antiviral, hepatoprotective and anti-hyperlipidemic effects. OA has been used in Chinese medicine to treat liver disorders for over 20 years [2]. Conventional formulations of OA are tablets and capsules [3]; however, OA's poor aqueous solubility and low bioavailability in vivo make it necessary to develop new formulations for clinical applications.Derived from nanotechnology, nanoparticulate delivery system provides an innovative approach to drug delivery [4-7]; nanoparticulate technique reduces particles to nanometer ranges, thus reducing the dose and reactive nature of the molecule [8]. Various nanoparticulate drug delivery systems have been explored, such as nanoparticles, nanospheres, nanocapsules, solid lipid nanoparticles (SLN), self-emulsifying drug delivery systems (SEDDS) and submicron/nanoemulsions [9][10]. Compared to conventional dosage forms, nanoparticulate drug delivery system has many advantages, namely enhancement of solubility and stability, protection from toxicity, enrichment of pharmacological activities, improvement of tissue macrophage distribution, bioavailability and sustained delivery, protection from physical and chemical degradation [7,11].This article reviews recent advances in nanoparticulate formulation of OA.Solid lipid nanoparticles (SLN), which remain solid at room temperature, have emerged as a new pharmaceutical delivery system or formulation to modify the release profile for many drugs [12]. SLN has characteristics of drug carriers such as lipophilicity, hydrophilicity as well as low bio-toxicity. Main advantages of SLN include: controlling drug release, targeting with reduced toxicity, in
Influence of reducing anneal on the ferromagnetism in single crystalline Co-doped ZnO thin films

Lu Zhong-Lin,Zou Wen-Qin,Xu Ming-Xiang,ZhangFeng-Ming,

中国物理 B , 2010,
Abstract: This paper reports that the high-quality Co-doped ZnO single crystalline films have been grown on $a$-plane sapphire substrates by using molecular-beam epitaxy. The as-grown films show high resistivity and non-ferromagnetism at room temperature, while they become good conductive and ferromagnetic after annealing in the reducing atmosphere either in the presence or absence of Zn vapour. The x-ray absorption studies indicate that all Co ions in these samples actually substituted into the ZnO lattice without formatting any detectable secondary phase. Compared with weak ferromagnetism (0.16~$\mu _{\rm B}$/Co$^{2 + })$ in the Zn$_{0.95}$Co$_{0.05}$O single crystalline film with reducing annealing in the absence of Zn vapour, the films annealed in the reducing atmosphere with Zn vapour are found to have much stronger ferromagnetism (0.65~$\mu _{\rm B}$/Co$^{2 + })$ at room temperature. This experimental studies clearly indicate that Zn interstitials are more effective than oxygen vacancies to activate the high-temperature ferromagnetism in Co-doped ZnO films, and the corresponding ferromagnetic mechanism is discussed.
Evodiamine Synergizes with Doxorubicin in the Treatment of Chemoresistant Human Breast Cancer without Inhibiting P-Glycoprotein
Shengpeng Wang, Lu Wang, Zhi Shi, Zhangfeng Zhong, Meiwan Chen, Yitao Wang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0097512
Abstract: Drug resistance is one of the main hurdles for the successful treatment of breast cancer. The synchronous targeting of apoptosis resistance and survival signal transduction pathways may be a promising approach to overcome drug resistance. In this study, we determined that evodiamine (EVO), a major constituent of the Chinese herbal medicine Evodiae Fructus, could induce apoptosis of doxorubicin (DOX)-sensitive MCF-7 and DOX-resistant MCF-7/ADR cells in a caspase-dependent manner, as confirmed by significant increases of cleaved poly(ADP-ribose) polymerase (PARP), caspase-7/9, and caspase activities. Notably, the reversed phenomenon of apoptosis resistance by EVO might be attributed to its ability to inhibit the Ras/MEK/ERK pathway and the expression of inhibitors of apoptosis (IAPs). Furthermore, our results indicated that EVO enhanced the apoptotic action of DOX by inhibiting the Ras/MEK/ERK cascade and the expression of IAPs without inhibiting the expression and activity of P-glycoprotein (P-gp). Taken together, our data indicate that EVO, a natural product, may be useful applied alone or in combination with DOX for the treatment of resistant breast cancer.
Anti-cancer natural products isolated from chinese medicinal herbs
Wen Tan, Jinjian Lu, Mingqing Huang, Yingbo Li, Meiwan Chen, Guosheng Wu, Jian Gong, Zhangfeng Zhong, Zengtao Xu, Yuanye Dang, Jiajie Guo, Xiuping Chen, Yitao Wang
Chinese Medicine , 2011, DOI: 10.1186/1749-8546-6-27
Abstract: Surgery, chemotherapy and radiotherapy are the main conventional cancer treatment often supplemented by other complementary and alternative therapies in China [1]. While chemotherapy is one of the most extensively studied methods in anti-cancer therapies, its efficacy and safety remain a primary concern as toxicity and other side effects of chemotherapy are severe. Moreover, multi-drug resistant cancer is even a bigger challenge. Medicinal herbs are main sources of new drugs. Newman et al. reported that more than half of the new chemicals approved between 1982 and 2002 were derived directly or indirectly from natural products [2]. Some active compounds have been isolated from Chinese medicinal herbs and tested for anti-cancer effects. For example, β-elemene, a compound isolated from Curcuma wenyujin Y. H. Chen et C. Ling (Wenyujin), is used as an anti-cancer drug in China. For this study, we searched three databases, namely PubMed, Scopus and Web of Science, using keywords "cancer", "tumor", "neoplastic" and "Chinese herbs" or "Chinese medicine". Publications including research and review papers covered in this review were dated between 1987 and 2011, the majority of which were published between 2007 and 2011. Chinese herb-derived ingredients, including flavonoids, alkaloids, terpenes, quinones and saponins, were found.GA (Figure 1A) is the principal active ingredient of gamboges which is the resin from various Garcinia species including Garcinia hanburyi Hook.f. (Tenghuang) [3]. GA has various biological effects, such as anti-inflammatory, analgesic and anti-pyretic [3] as well as anti-cancer activities [4,5]. In vitro and in vivo studies have demonstrated its potential as an excellent cytotoxicity against a variety of malignant tumors, including glioblastoma, as well as cancers of the breast, lung and liver. GA is currently investigated in clinical trials in China [6-8].GA induces apoptosis in various cancer cell types and the action mechanisms of GA remain unclea
Material Basis-based Pharmacokinetic Investigation of Chinese Medicine
基于药效物质基础的中药药物代谢动力学

Chen Xiuping,Zhong Zhangfeng,Xu Zengtao,Yan Ru,Li Pengtao,Wang Yitao,
陈修平
,钟章锋,徐曾涛,燕茹,李澎涛,王一涛

世界科学技术-中医药现代化 , 2011,
Abstract: The pharmacokinetic study of Chinese medicine (CM) is a new research direction in recent years. The pharmacokinetics of some CM and its formula have been investigated and a number of related theories and hypotheses have been proposed, which provide some insights into this area. However, the overall studies in this aspect were still at the early exploratory stage and further studies are needed. This paper summarizes the recent advances, interprets the definition, characteristics and difficulties of CM pharmacokinetic study. The authors proposed the material basis-based evaluation model for CM pharmacokinetic study.
Systematic Study of Chinese Medicine Herb Pairs(Ⅱ)—— Pharmacodynamics and Pharmacokinetics Study
中药药对的系统研究(Ⅱ)——药效与药动学研究

Wang Shengpeng,Hu Yangyang,Chen Ruie,Zhong Zhangfeng,Chen Meiwan,Wang Yitao,
王胜鹏
,胡杨洋,陈锐娥,钟章锋,陈美婉,王一涛

世界科学技术-中医药现代化 , 2012,
Abstract: 药对,作为单味药应用的拓展和方剂形成的雏形,在中药发展史上具有重要地位,是中药复方研究绕不开的环节,更是探求复方机理的突破口。运用体内外模型和分子生物学的方法,对中药药对进行药效药代学的研究并深入探究其机制,不仅能更好地掌握药对临床应用的准确性,有助于深入了解中药复方的特点和内涵,而且能够为推进系统生物学的研究思路和推动中药复方国际化提供依据。本文对近年来药对的现代药理和药物代谢研究所取得的成果加以整理,分析药对配伍的机制,并探讨了未来中药药对药效研究的方向,以期为复方研究和中药现代化提供新的思路。
IDENTIFICATION OF KURARINONE BY LC/MS AND INVESTIGATION OF ITS THERMAL STABILITY
PENGFEI LIU,TIANSHENG DENG,CUIPING YE,ZHANGFENG QIN
Journal of the Chilean Chemical Society , 2009,
Abstract: A herbal ingredient kurannone (7, 2', 4,-trihydroxy-8-lavandulyl-5-methoxy flavanone) was isolated from the roots of sophoraflavescens Ait by ultrasonic extraction, which is one of tradicional Chinese medicine (TCM) materials. A reliable high performance liquid chromatography with mass spectrometry (HPLC-MS) method was used for determination of kurarinone. C18 column (150x4.6 mm, 5 μm) and methanol-water mobile phase (70:30, by volume) were used in the chromatographic separation of active components from the herb. HPLC-ESI-MS (UV, 288 nm; m/z, 437.5 [M-H]-) was adopted for kurarinone identification. Kurarinone with purity of 95.5% was obtained by silica gel column foUowed by reverse-phase column chromatography. The thermal stability of kurarinone was investigated, which illustrates that kurarinone was stable below 25 °C in 48 h, but a degradation of 25.54% was observed at 80 °C for 2 h.
IDENTIFICATION OF KURARINONE BY LC/MS AND INVESTIGATION OF ITS THERMAL STABILITY
LIU,PENGFEI; DENG,TIANSHENG; YE,CUIPING; QIN,ZHANGFENG; HOU,XIANGLIN; WANG,JIANGUO;
Journal of the Chilean Chemical Society , 2009, DOI: 10.4067/S0717-97072009000100019
Abstract: a herbal ingredient kurannone (7, 2', 4,-trihydroxy-8-lavandulyl-5-methoxy flavanone) was isolated from the roots of sophoraflavescens ait by ultrasonic extraction, which is one of tradicional chinese medicine (tcm) materials. a reliable high performance liquid chromatography with mass spectrometry (hplc-ms) method was used for determination of kurarinone. c18 column (150x4.6 mm, 5 μm) and methanol-water mobile phase (70:30, by volume) were used in the chromatographic separation of active components from the herb. hplc-esi-ms (uv, 288 nm; m/z, 437.5 [m-h]-) was adopted for kurarinone identification. kurarinone with purity of 95.5% was obtained by silica gel column fouowed by reverse-phase column chromatography. the thermal stability of kurarinone was investigated, which illustrates that kurarinone was stable below 25 °c in 48 h, but a degradation of 25.54% was observed at 80 °c for 2 h.
Study of Micro-stress Technics of XM-23 Sealant for Space Optical Remote Sensor
航天光学遥感器用XM-23密封剂的微应力使用工艺研究

liuqiang,zhangfeng,hexin,lichang,
(刘强
,张峰,何欣,李畅

红外 , 2012,
Abstract: The XM-23 sealant for space application was studied carefully. The application of it in the mirror subassembly of a space optical remote sensor as a damping agent was mainly considered. Its composition and function were analyzed. The mass ratio of each component was selected reasonably and the adding sequence of each composition in the sealant mixing process was optimized. Finally, an ideal curing process route for sealing the mirror subassembly of a space optical remote sensor in micro-stress was obtained. The testing result showed that the process route had the features of less time, less internal stress and reasonable composition ratio. It met the micro-stress requirements of the sealant used for space application. Therefore, it could be widely used in the structures for space application.
Page 1 /16810
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.