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Search Results: 1 - 10 of 104248 matches for " Zhang GN "
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Changes in urinary nanocrystallites in calcium oxalate stone formers before and after potassium citrate intake
Duan CY,Xia ZY,Zhang GN,Gui BS
International Journal of Nanomedicine , 2013,
Abstract: Chao-Yang Duan,1 Zhi-Yue Xia,2 Guang-Na Zhang,2 Bao-Song Gui,1 Jun-Fa Xue,2 Jian-Ming Ouyang21Department of Nephrology, the Second Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China; 2Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou, People's Republic of ChinaAbstract: The property changes of urinary nanocrystallites in 13 patients with calcium oxalate (CaOx) stones were studied before and after ingestion of potassium citrate (K3cit), a therapeutic drug for stones. The analytical techniques included nanoparticle size analysis, transmission electron microscopy, X-ray diffraction, and Fourier-transform infrared spectroscopy. The studied properties included the components, morphologies, zeta potentials, particle size distributions, light intensity autocorrelation curves, and polydispersity indices (PDIs) of the nanocrystallites. The main components of the urinary nanocrystallites before K3cit intake included uric acid, β-calcium phosphate, and calcium oxalate monohydrate. After K3cit intake, the quantities, species, and percentages of aggregated crystals decreased, whereas the percentages of monosodium urate and calcium oxalate dehydrate increased, and some crystallites became blunt. Moreover, the urinary pH increased from 5.96 ± 0.43 to 6.46 ± 0.50, the crystallite size decreased from 524 ± 320 nm to 354 ± 173 nm, and the zeta potential decreased from 4.85 ± 2.87 mV to 8.77 ± 3.03 mV. The autocorrelation curves became smooth, the decay time decreased from 11.4 ± 3.2 ms to 4.3 ± 1.7 ms, and the PDI decreased from 0.67 ± 0.14 to 0.53 ± 0.19. These changes helped inhibit CaOx calculus formation.Keywords: nanotechnology, zeta potential, aggregation
Assessing prognosis for early breast cancer: clinical versus genetic profiles
GN Hortobagyi
Breast Cancer Research , 2007, DOI: 10.1186/bcr1684
Abstract:
Present and future role of bisphosphonates in treatment
GN Hortobagyi
Breast Cancer Research , 2007, DOI: 10.1186/bcr1698
Abstract: There is much interest and ongoing trials to define the role of bisphosphonates in the preventive treatment of primary breast cancer. Whether bisphosphonates can prevent osseous metastases or not, emerging information about their use in treatment-induced bone loss might lead to the incorporation of these agents into the combined modality management of primary breast cancer anyway. This makes the determination of therapeutic benefit, optimal dose and schedule of administration very important.
Preoperative systemic treatment for operable disease: biological correlates of response to neoadjuvant treatment
GN Hortobagyi
Breast Cancer Research , 2007, DOI: 10.1186/bcr1701
Abstract:
Present situation and future of genetic profiling for prognosis and treatment
GN Hortobagyi
Breast Cancer Research , 2005, DOI: 10.1186/bcr1209
Abstract: The Human Genome Project was a major milestone in the history of medicine. Both the genetic information obtained and the technological advances that took place during this large multicenter effort have had enormous influence over all fields of medicine. For the field of prognostication and prediction in breast cancer, the major consequence was the development of technology that led to the simultaneous evaluation of gene expression for hundreds and, more recently, thousands of genes. In fact, recently launched gene arrays include the entire human genome. Thus, we have the opportunity to assess, in a small tumor sample, the expression profile of all known human genes. There are multiple technological platforms under evaluation for this purpose, and the results obtained with one cannot automatically be substituted for results obtained with another platform. Nevertheless, on the basis of several reports, it can be stated that gene expression profiling of human breast cancer provides valuable information in the following areas:1. Molecular classification of primary breast cancer2. Identification of multiple distinct prognostic subgroups3. Determination of expression level of several genes of interest (ER, PR, HER2, etc.)4. Identification of genetic networks5. Prediction of response to chemotherapyThe initial reports were based on small patient numbers that presented substantial statistical challenges for adequate estimation of end-points and to prevent frequent false-positive or false-negative results. More recent analyses have included several dozen and up to a few hundred patients. These reports provide greater statistical power and greater reliability. However, these reports still represent retrospective analyses of subsets of patients, and prospective validation is still sorely needed. Reports are beginning to appear comparing the performance of different platforms on the same tumor samples and considering the same end-points. The source of tumor material, the manner
Neoadjuvant treatment: the MD Anderson experience
GN Hortobagyi
Breast Cancer Research , 2005, DOI: 10.1186/bcr1222
Abstract: Published studies of anthracycline-based preoperative chemotherapy demonstrate pCR rates of up to 17%. Several recently reported studies including the sequential use of anthracycline-based regimens and taxanes have achieved significantly higher pathologic responses, ranging from 25% to 34%. Our studies focused on the sequential use of anthracyclines and taxanes, showing excellent tolerance and efficacy of this strategy. In addition, we demonstrated the therapeutic superiority of weekly paclitaxel in this setting. These findings were subsequently confirmed by much larger, randomized trials conducted by another cooperative group. We used the neoadjuvant strategy for the initial evaluation of trastuzumab in patients with primary breast cancer. That small randomized trial indicated an almost threefold increase in pCR with the addition of trastuzumab to chemotherapy.Currently, we conduct studies with gene profiling in the neoadjuvant setting to determine predictors of pCR, and therefore long-term prognosis, and to develop individualized medicine for patients with primary breast cancer.There are multiple remaining questions related to the use of this strategy, however. Some pertain to optimal local-regional therapies: when should axillary assessment be performed in relation to NACT, what should be the criteria for administration of postmastectomy radiation therapy following NACT, and how to optimally perform breast-conserving surgery following NACT. The role and relative timing of neoadjuvant hormone therapy (NAHT) is also under intensive evaluation at this time. This is solely relevant to the group of patients with hormone receptor-positive tumors, but has potential impact on the type and sequence of local, regional and systemic therapies.
Influence of parenting styles on adolescent delinquency in delta central senatorial district
GN Okorodudu
Edo Journal of Counselling , 2010,
Abstract: The study investigated the influence of parenting styles on adolescents’ delinquency. 404 sample sizes were used for the study. 6 research questions and 6 research hypotheses were designed and formulated for the purpose of the study. Regression statistic was used for the analyses of the study. Irrespective of gender, location and age, the results of the analyses show that lassair-faire parenting style effectively predicts adolescents’ delinquency while authoritarian and authoritative did not. Parents who are positively oriented in their styles (demandingess and responsiveness) will make their adolescents socially competent and goal – directed. Parents who exerted control and monitored adolescent activities and promoted self-autonomy were found to have the most positive effects on adolescents’ behaviour. Uninvolving parents and also non responsive to adolescents needs had negative impacts on their behaviour. Key Words: Parenting Styles, Adolescents, Delinquency
ATM Technology and Banking System in West African Sub-Region: Prospects and Challenges
GN Odachi
African Research Review , 2011,
Abstract: Automated Teller Machine (ATM) technology has had its significant impact in banking system in Nigeria and some other West African Countries. The most significant impact of ATM technology is the customer’s ability to withdraw money outside banking hours. But this feat achieved by ATM technology is not without challenges. ATM technology is prone to fraud, and this has made many people shun its use. In view of the above, this paper explores the prospects and challenges of ATM application in banking in West African sub region and how the challenges posed by its use can be removed or minimized.
The Mediating Impact of Personality and Socio-Economic Status in the Treatment of Stress in Adolescents
GN Okorodudu
Edo Journal of Counselling , 2011,
Abstract: This was a quasi-experimental study designed to examine the impact of personality and socio-economic status as moderator variables in stress reduction among 90 diploma students of the Institute of Education, Delta State University, Abraka. The paper employed 3x2x2 pretest posttest control group design. Two therapeutic methods Rational Emotive Behaviour Therapy (REBT) and Recreational Exercises Therapy (RET) were used to bring about stress reduction among adolescents. The Analysis of Co-variance (ANCOVA) Statistic was used for data analysis. The results showed that personality had a great impact on stress reduction of adolescents. There was no difference in the impact of personality types A and B. Likewise, the result of socio-economic status revealed a lot of impact on stress reduction among adolescents. Participants from high SES had more impact than those from low SES. These findings have implications for adolescent Counselling in the University system.
A Legal Approach to Combating Terrorism: Modern Dimension
GN Okeke
Nnamdi Azikiwe University Journal of International Law and Jurisprudence , 2011,
Abstract: Terrorism is a behavioural flu plaguing the entire world at an alarming rate. Legal prescriptions based on legal prognosis have been in the form of application of sanctions directed against terrorists. Additionally, a hostile attitude to terrorists as reflected in the legal instruments rolled out to contain the dreaded affliction is grossly insufficient to tackle it effectively. The Security Council Resolution 1373 in addition to the existing treaties on terrorism have been battling to contain acts of terrorism with measurable success. However, the introduction of psycho-social techniques in curbing the scourge is strongly recommended. Those techniques comprise the trouble shooting technique; pre-emptive appeal technique; “firing the devil” technique and programme technique.
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