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Search Results: 1 - 10 of 9087 matches for " Zehui Meng "
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Effects of Nourishing “Yin”-Removing “Fire” Chinese Herb Mixture on the Expression of GABAB Receptors in Hypothalamus of Precocious Puberty Female Rats  [PDF]
Zhejun Chen, Zehui Meng, Shiran Wang, Liting Zhu, Zhanzhuang Tian
Chinese Medicine (CM) , 2016, DOI: 10.4236/cm.2016.72008
Abstract: Objectives: To investigate the potential role of GABAB Receptors (GABABRs) involved in the effect of Nourishing “Yin”-Removing “Fire” Chinese herb mixture (TCM) treatment on precocious puberty. Methods: Female Sprague-Dawley rats were randomly divided into four groups: normal (N), central precocious puberty (CPP) model (M), CPP fed with normal saline (S) and CPP fed with Nourishing “Yin”-Removing “Fire” Chinese herb mixture (TCM). Rats of postnatal day 5 were given a single subcutaneous injection of 240 μg danazol to establish CPP model rats. Rats of S and TCM groups were continuously administered with saline or nourishing “Yin”-removing “Fire” Chinese herb mixture since postnatal day 15. The expression of GABABRs was detected by means of real-time PCR and immunohistochemistry. Results: The expression of hypothalamic GnRH mRNA in M was significantly increased on the day of pre-puberty when compared with that of N (P < 0.01). On the day of onset-puberty, LH levels were higher in M than those in N (P < 0.01), while the serum E2 and LH levels of TCM decreased when compared with those of M (P < 0.05). On the day of pre-puberty, the number of GABAB1 receptor (GABABR1) immunoreactive cells in the arcuate nucleus (ARN) was decreased in M when compared with that of N (P < 0.05) and increased in TCM compared with that of M (P < 0.05); simultaneously, the expression of GABABR1 mRNA in hypothalamus was significantly decreased in M when compared with that of N (P < 0.01) and increased in TCM compared with that of M (P < 0.01). On the day of onset-puberty, the number of GABABR1 immunoreactive cells in medial septum (MS) was decreased in M compared with that in N (P < 0.05) and increased in TCM comparing with that of M (P < 0.05); meanwhile, the mRNA expression of GABABR1 in hypothalamus was decreased in M compared with that in N (P < 0.05), while the numbers of GABAB2 receptor (GABABR2) immunoreactive cells in the ARN, MS and diagnonal band of broca (DBB) were decreased in M when compared with those of N (P < 0.05) and increased in TCM compared with those of M (P < 0.05) on the day of onset-puberty. At the same time, the mRNA expression of GABABR2 was significantly decreased in M compared with that of N (P < 0.01). Conclusions: These results indicated that the GABABRs might
Electroacupuncture (EA) Speeds Up the Regulation of Hypothalamic Pituitary Adrenal Axis Dysfunction in Acute Surgical Trauma Rats: Mediated by Hypothalamic Gamma-Aminobutyric Acid (GABA)A Receptors  [PDF]
Liting Zhu, Jing Zhu, Zhejun Chen, Zehui Meng, Mingda Ju, Mizhen Zhang, Gencheng Wu, Zhanzhuang Tian
Journal of Behavioral and Brain Science (JBBS) , 2018, DOI: 10.4236/jbbs.2018.812042
Abstract: Hypothalamic Corticotropin-releasing factor (CRF) directly activates the hypothalamic pituitary adrenal axis (HPA axis) during the surgical trauma induced stress response. Electroacupuncture (EA) has been demonstrated to have stress relieving effects in breast surgery, colorectal surgery, prostatectomy and craniotomy. This study was aimed to investigate the hypothesis that EA could regulate hypothalamic CRF in surgical trauma rats. In experiment one, Sprague-Dawley (SD) male rats were divided into intact, model (10% partial hepatectomy), sham EA and EA group. Rats from the Sham EA and EA group were stimulated at ST36-Zusanli and SP6-Sanyiniiao acupoints twice, 24 hours before the surgery and immediately after the surgery. Expressions of hypothalamic CRF and CRFR, GABA receptors, glutamate decarboxylase (GAD), serum adrenocorticotropic hormone (ACTH) and Corticosterone (CORT) were observed at 2, 4, 8 and 24 h after the surgery by radioimmunoassay (RIA), western blot, real-time PCR and immunohistochemistry. In the experiment two, SD male rats were divided into the intact, model, model + vehicle, model + L-838,417 EA and EA + L838,417 group. It was found that hypothalamus CRF, serum ACTH and CORT levels were increased in model group compared with the intact group, and those in the EA group decreased in comparison with the model group. Compared with the model group, hypothalamus-aminobutyric acid (GABA) receptor Aα3 mRNA and protein expressions of the EA group raised strikingly. In conclusion, EA alleviated surgical stress response by improving the GABA synthesis in hypothalamus, thus enhancing GABA receptors’ inhibitory regulation of the HPA axis dysfunction in rats with acute surgical trauma.
Who Benefits from Altruism in Supply Chain Management?  [PDF]
Zehui Ge, Qiying Hu
American Journal of Operations Research (AJOR) , 2012, DOI: 10.4236/ajor.2012.21007
Abstract: The significant effect of social preference on strategic behavior has been convinced by recent research. Along this stream of research, we study firms’ altruistic incentives in supply chains since the selfish rationality can’t deal with economic behaviors. We show that the performance of the supply chain in consideration of altruism is between those of scenarios under decentralization and under integration. We further shows that a manufacturer, as a leader, should find an egoistic retailer, while a retailer, as a follower, should find a manufacturer with altruistic liability, to form a good chain.
General Cell-Binding Activity of Intramolecular G-Quadruplexes with Parallel Structure
Tianjun Chang, Cui Qi, Jie Meng, Nan Zhang, Tao Bing, Xianda Yang, Zehui Cao, Dihua Shangguan
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0062348
Abstract: G-quadruplexes (G4s) are four-stranded nucleic acid structures adopted by some repetitive guanine-rich sequences. Putative G-quadruplex-forming sequences (PQSs) are highly prevalent in human genome. Recently some G4s have been reported to have cancer-selective antiproliferative activity. A G4 DNA, AS1411, is currently in phase II clinical trials as an anticancer agent, which is reported to bind tumor cells by targeting surface nucleolin. AS1411 also has been extensively investigated as a target-recognition element for cancer cell specific drug delivery or cancer cell imaging. Here we show that, in addition to AS1411, intramolecular G4s with parallel structure (including PQSs in genes) have general binding activity to many cell lines with different affinity. The binding of these G4s compete with each other, and their targets are certain cellular surface proteins. The tested G4s exhibit enhanced cellular uptake than non-G4 sequences. This uptake may be through the endosome/lysosome pathway, but it is independent of cellular binding of the G4s. The tested G4s also show selective antiproliferative activity that is independent of their cellular binding. Our findings provide new insight into the molecular recognition of G4s by cells; offer new clues for understanding the functions of G4s in vivo, and may extend the potential applications of G4s.
Mechanics Analysis of Overhead Transmission Lines Based On-line Monitoring  [PDF]
Lili Dai, Yongli Zhu, Zehui Liang
Open Journal of Applied Sciences (OJAppS) , 2013, DOI: 10.4236/ojapps.2013.32B001
Abstract: At present, the on-line monitoring is widely applied to the power line monitoring. In this paper, a new mechanical calculation model is established according to the on-line monitoring. And this model is based on the parameters that tension sensors and angle sensors on suspended points detect, and combines with the parameters of the wire itself, and also considers the deflection angel of wires due to wind. In this model, mechanics parameters of wires are turned into the new coordinate plane after deflection angel of wires due to wind, or windage yaw plane. A statics tension balance equation is built in the vertical direction of the new windage yaw plane. According to the theoretical analysis and algorithm, we verify the accuracy of this newly developed mechanical calculation model.
Comparison of Three Modes of AT-fed Traction Power Networks  [PDF]
Qingan Ma, Qunzhan Li, Zehui Mi
Energy and Power Engineering (EPE) , 2013, DOI: 10.4236/epe.2013.54B196
Abstract:

The features of three modes of AT-fed traction power networks (TPNs) have been briefly described in the existing literature, which is not adequate yet. In this paper, these three modes of TPNs are compared mainly on TPN capacity, transformer capacity, rail potential and voltage level, etc., and conclusions are drawn.

Effective of Microwave-KOH Pretreatment on Enzymatic Hydrolysis of Bamboo  [PDF]
Zhiqiang Li, Zehui Jiang, Benhua Fei, Yan Yu, Zhiyong Cai
Journal of Sustainable Bioenergy Systems (JSBS) , 2012, DOI: 10.4236/jsbs.2012.24015
Abstract: Bamboo, with its advantages of fast growth, short renovation, easy propagation and rich in cellulose and hemicellulose, is a potential feedstock for bioethanol or other biofuels production. The objective of this study was to examine the feasibility of microwave assistant KOH pretreatments to enhance enzymatic hydrolysis of bamboo. Pretreatment was carried out by immersing the bamboo in KOH (12% and 8% w/w bamboo) solutions and exposing the slurry to microwave radiation power of 400 W for 30min. Chemical composition of the pretreated substrates and spent liquor was analyzed. Pretreated substrates were enzymatic hydrolyzed, and glucose and xylose in the hydrolysate were analyzed. The results showed that the pretreated substrate with microwave assisted KOH had significantly higher sugar yield than the untreated samples. The fermentation inhibitors formic acid, furfural, HMF and levulinic acid were much lower than acid pretreatment reported.
Heat Transfer Modelling of Plate Heat Exchanger in Solar Heating System  [PDF]
Yan Jia, Can Wang, Zehui Chang, Wenxiong Li, Chi Zhang
Open Journal of Fluid Dynamics (OJFD) , 2017, DOI: 10.4236/ojfd.2017.73029
Abstract:
Plate heat exchanger can obtain higher thermal performance because of its advantages in high heat transfer coefficient, small scale, and can realize pure counter current flow. It has been widely applied in HVAC industry. In this paper, the numerical research of plate heat exchanger in solar heating system has been proposed. Aimed at the type of herringbone corrugated plate which has better thermal performance and been widely used, the three dimensional model is established by Gambit software. Using FLUENT software for numerical calculation, by studying the effect of corrugated inclination angle, corrugated depth, corrugated spacing and inlet velocity of heat exchanger on internal temperature, pressure, velocity distributions of domains, the relationship between the above parameters and the Nusselt Number and the pressure drop was obtained by simulation data. Heat transfer coefficient and pressure drop correlations used to measure the overall performance of the heat exchanger. The result shows that the optimal structure parameters is corrugated angle 60°, corrugated depth 4 mm and corrugated spacing 16 mm.
A RESEARCH ON REALIZING THE INTEGRATED EVALUATION INDEX SYSTEM OF TERRITORIAL RESOURCES ON A COMPUTER
在计算机上实现国土资源综合评价指标体系的研究

Li Zehui,
李泽辉

自然资源学报 , 1993,
Abstract: In this paper, the author first probes the integrated evaluation system of territorial resources and proposes the corresponding evaluation index. Then the author introduces how to establish a system on the computer in which the evaluation index of resources can produce automatically and the method of how to use this system to produce the needed index. Also, the problems which need to be studies further are pointed out. What the author has done is to provide some experiences for the automation of evaluating the study of the exploitation of regional resources.
Learner Requirement Analysis based on the Classification Framework of Online Learning Activities: A Mixed Method Research
Zehui Zhan,Fuyin Xu,Hu Mei
Journal of Computers , 2011, DOI: 10.4304/jcp.6.12.2623-2630
Abstract: The purpose of this paper is to set up a classification framework of online learning activities and analyze online learners’ requirements based on it. Fifty-nine online learning activity cases were collected from seven disciplines. Open coding, axial coding, and selective coding were conducted according to Grounded Theory. After step-by-step validation, the classification framework consists of six core categories (Argumentation, Resource Sharing, Collaboration, Inquiry, Evaluation, and Social Network) has been set up. Based on this, the online learners’ perceived demands have been extracted and the index weight has been investigated. Further study is needed to get more insight into each category and establish effective activity-based instruction models.
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