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Search Results: 1 - 10 of 445 matches for " Zare;Zolfagharian "
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Clinical and biochemical manifestation produced by scorpion (Hemiscorpius lepturus) venom in experimental animals
Mirakabbadi A., Zare;Zolfagharian, H.;Hedayat, A.;Jalali, A.;
Journal of Venomous Animals and Toxins including Tropical Diseases , 2007, DOI: 10.1590/S1678-91992007000400007
Abstract: several studies have been published about the clinical and biochemical manifestations produced by the venom of scorpions of the buthidae family, but very few reports have indicated the manifestations induced by the venom of the scorpionidae family. hemiscorpius lepturus is an important scorpion species present in the south and southwestern part of iran, causing morbidity and mortality in children and adults. for the present study, h. lepturus venom was extracted by electric shock and subcutaneously injected (6.3mg/kg) into a group of six rabbits. blood collection was carried out before and three hours after venom injection for determination of osmotic fragility and levels of blood sugar, alanine aminotransferase (alt), aspartate aminotransferase (ast), lactate dehydrogenase (ldh), creatine phosphokinase (cpk) and alkaline phosphatase (alp). in vitro studies were also carried out to verify the osmotic fragility of red blood cells (rbcs) exposed to venom concentrations ranging from 0-90μg/2ml blood. results showed the extreme effect of this venom on the lysis of rbcs both in vitro and in vivo. venom injection caused significant (p>0.001) increase in alt, ast, ldh and blood sugar levels. there was also an increase in cpk, and alp levels after venom injection; however, it was not statistically significant. all animals died four hours after having received the venom. the current study revealed that the neurological effect of h. lepturus venom is similar to that of scorpions of the buthidae family. however, they differ in rbcs lysis, which was highly significant when induced by h. lepturus venom, probably due to the presence of a type of phospholipase in this venom. further studies are needed to provide a clearer view of the mechanism of action of h. lepturus venom.
In vivo evaluation of homeostatic effects of Echis carinatus snake venom in Iran
Salmanizadeh Hossein,Babaie Mahdi,Zolfagharian Hossein
Journal of Venomous Animals and Toxins including Tropical Diseases , 2013, DOI: 10.1186/1678-9199-19-3
Abstract: Background The venom of the family Viperidae, including the saw-scaled viper, is rich in serine proteinases and metalloproteinases, which affect the nervous system, complementary system, blood coagulation, platelet aggregation and blood pressure. One of the most prominent effects of the snake venom of Echis carinatus (Ec) is its coagulation activity, used for killing prey. Materials and methods Subfractions F1A and F1B were isolated from Ec crude venom by a combination of gel chromatography (Sephadex G-75) and ion exchange chromatography on a DEAE-Sepharose (DE-52). These subfractions were then intravenously (IV) injected into NIH male mice. Blood samples were taken before and after the administration of these subfractions. Times for prothrombin, partial thromboplastin and fibrinogen were recorded. Results and conclusions Comparison of the prothrombin time before and after F1A and F1B administrations showed that time for blood coagulation after injection is shorter than that of normal blood coagulation and also reduced coagulation time after Ec crude venom injection. This difference in coagulation time shows the intense coagulation activity of these subfractions that significantly increase the coagulation cascade rate and Causes to quick blood coagulation. The LD50 of the Ec crude venom was also determined to be 11.1 μg/mouse. Different crude venom doses were prepared with physiological serum and injected into four mice. Comparison of the prothrombin times after injection of subfractions F1A and F1B showed that the rate of mouse blood coagulation increases considerably. Comparing the partial thromboplastin times after injecting these subfractions with this normal test time showed that the activity rate of intrinsic blood coagulation system rose sharply in mice. Finally, by comparing the fibrinogen time after subfraction injections and normal test time, we can infer intense activation of coagulation cascade and fibrin production.
Phonological Analysis in Al-sahifa Al-Sajjādiyya ( Fī Al-isteāde Supplication)  [PDF]
Afarin Zare, Leila Dianat
Open Journal of Modern Linguistics (OJML) , 2012, DOI: 10.4236/ojml.2012.24024
Abstract: Implication, taken from the root “implicate”, means directing; like the implication of smoke for fire. The denotative meaning of implication is: forming a meaning in mind by imagining the word. Word visualizetion in the human’s mind is done through different means such as: structure of the word, role of the word in the clause, use of the dictionary, style and manner of pronouncing a word, and phonemes in a word. The present study tries to analyze” Fī Al-isteāde Supplication “from Al-sahifa Al-Sajjādiyya based on the trends of phonology. Also, it tries to show the role of phonemes, having been used in Al-sahifa Al-Sajjādiyya, in communicating the message to the reader. In this article, the fact that the interrelatedness of form and content is obviously seen in all the supplications of Al-sahifa Al-Sajjādiyya is unraveled. The most important finding of this research is that all the phonemes employed in Al-sahifa are used as they are appropriate to the context. When Imām Sajjād is talking about God’s mercy, he uses soft and delicate sounds but when he is talking about heavenly retribution, he uses harsh and bitter sounds in a manner that one cannot replace one with another. The sounds have such an effect on the text that we can appreciate their meanings by merely listening to them.
Diagnosis and Resolution of Infeasibility in the Constraint Method for Solving Multi Objective Linear Programming Problems  [PDF]
Mohammadreza Safi, Hossein Zare Marzooni
American Journal of Operations Research (AJOR) , 2012, DOI: 10.4236/ajor.2012.23034
Abstract: In this paper we discuss about infeasibility diagnosis and infeasibility resolution, when the constraint method is used for solving multi objective linear programming problems. We propose an algorithm for resolution of infeasibility, which is a combination of interactive, weighting and constraint methods.Numerical examples are provided to illustrate the techniques developed.
Preparing and Characterizing Chitosan Nanoparticles Containing Hemiscorpius lepturus Scorpion Venom as an Antigen Delivery System
Mohammadpour Dounighi, N.,Damavandi, M.,Zolfagharian, H.,Moradi, S.
Archives of Razi Institute , 2012,
Abstract: In recent years, chitosan nanoparticles have been studied widely for protein delivery. In this study, Hemiscorpius lepturus (HL) venom was encapsulated in chitosan nanoparticles. The aim of the present work was to carry out a systematic study for preparing biocompatible and biodegradable nanoparticles for loading HL scorpion venom and to evaluate their potential as an antigen delivery system. In this study, HL venom loaded chitosan nanoparticles fabricated by ionic gelation of chitosan and tripolyphosphate and the factors which may be influenced in the preparation of nanoparticles were analyzed. Also, their physicochemical properties and in vitro release behavior were studied. The optimum encapsulation efficiency and capacity were observed when the chitosan concentration and HL venom were 2mg/ml and 500μg/ml, respectively. The HL venom loaded nanoparticles were in the size range of 130-160nm (polydispersity index values of 0.423) and exhibited the positive zeta potential. Transmission electron microscope imaging showed spherical and smooth surface of nanoparticles. The profiles of the release exhibited a burst releases about 50% in the first 4 hr and then slowed down at a constant rate. The obtained results suggested that the chitosan nanoparticles prepared in this work had the potential for antigen delivery.
Melamine Trisulfonic Acid as a Highly Efficient and Reusable Catalyst for the Synthesis of β-Acetamido Ketones
Abdolkarim Zare
Journal of Chemistry , 2012, DOI: 10.1155/2012/173197
Abstract: A highly efficient protocol for the one-pot multi-component condensation of acetophenones with aromatic aldehydes, acetonitrile and acetyl chloride in the presence of melamine trisulfonic acid (MTSA) as a highly efficient and recyclable sulfonic acid-containing catalyst at room temperature is described. In this method, β-acetamido ketone derivatives are obtained in high to excellent yields and in relatively short reaction times.
Effects of STATCOM Control Mode on Voltage Stability
Ali Zare
Majlesi Journal of Electrical Engineering , 2008, DOI: 10.1234/mjee.v2i4.133
Abstract: STATCOM is one of the most popular devices that been used for voltage stability. There has been no report on the effect of SATCOM control mode on voltage stability. It is very important to understand which parameters and what value of these parameters affect the voltage stability. The results of previous studies have shown that the STATCOM have considerable effects on the improvement of voltage stability, but there have not been any investigations on the effects of the control mode of STATCOM on the voltage stability. This paper deals with the effect of the STATCOM control mode on voltage stability. Simulation results on the IEEE 30-bus test system show the high effect of the STATCOM control mode on voltage stability.
N-body problem in $R^n$: Necessary conditions for a constant configuration measure
Kal Zare
Electronic Journal of Differential Equations , 2008,
Abstract: A formulation of the N-body problem is presented in which $m_{i}$ and $r_{i}in mathbb{R}^d$ are the mass and the position vector of the i-th body, $ x=(sqrt{m_{1}}r_{1},dots ,sqrt{m_{N}}r_{N})in mathbb{R}^n$ and $ n=dN$ ($d=1,2,3$). The configuration measure $ Z =|x|F $, where $F$ is the Poincare's force function, which plays an important role in this formulation. The orbit plane is a two dimensional linear subspace of $ mathbb{R}^n $ spanned by the position vector $x$ and the velocity vector $dot{x}$. The N-body motion in $mathbb{R}^n$ has been decomposed into an orbit in the orbit plane and the instantaneous orientation of the orbit plane. For a solution to stay on a level manifold of $Z$, it is necessary that the orbit in the orbit plane be elliptic ($h<0$), parabolic( $h=0$)or hyperbolic ($h>0$) where h is the total energy. The instantaneous orientation of the orbit plane can be obtained by integration of certain differential equations. These possible solutions include the central configuration solutions in which the orbit plane is fixed in $mathbb{R}^n$.
Can Sonography Predict the Presence of Retained Products of Conception Following First-trimester Spontaneous Abortion?
Zahra Zare
Iranian Journal of Radiology , 2009,
Abstract: "nIntroduction: The aim of this study was to identify ultrasound criteria that are the best predictors of the presence of retained product of conception (RPOC) within the uterine cavity in women with the clinical diagnosis of incomplete first trimester abortion. "nMaterials and Methods: This is a prospective study on 100 patients with a diagnosis of incomplete abortion and RPOC based on clinical and sonographic findings. The gold standard test was pathologic reports of samples obtained during dilatation and curettage. Endometrial thickness and homogeneity of the endometer were determined by sonography. The sensitivity and specificity of the measurements for detecting RPOC were assessed. "nResults: Histopathological reports confirmed the diagnosis of RPOC in 71 patients (71%). The mean endometrial thickness with RPOC was 16.3 mm versus 12.1 mm without RPOC. Heterogenic endometrium was seen in 56 0f 71 patients (78 %). The sensitivity and specificity of an endometrial thickness greater than 11.25mm for detecting RPOC were 81% and 45%, respectively. Regarding the endometrial thickness and heterogenic endometer, 13.5 mm had the best performance criteria with a sensitivity and specificity of 60% and 63%, respectively. "nConclusion: An endometrial thickness of 11.25mm or more detected by sonography has the best diagnostic efficacy, considering the heterogeneity with a 13.5mm thickness of endometer, has the best performance criteria for detection of RPOC following first trimester spontaneous abortion.
Melamine Trisulfonic Acid as a Highly Efficient and Reusable Catalyst for the Synthesis of β-Acetamido Ketones
Abdolkarim Zare
Journal of Chemistry , 2012, DOI: 10.1155/2012/173197
Abstract: A highly efficient protocol for the one-pot multi-component condensation of acetophenones with aromatic aldehydes, acetonitrile and acetyl chloride in the presence of melamine trisulfonic acid (MTSA) as a highly efficient and recyclable sulfonic acid-containing catalyst at room temperature is described. In this method, β-acetamido ketone derivatives are obtained in high to excellent yields and in relatively short reaction times.
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