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Search Results: 1 - 10 of 462060 matches for " Zachou A "
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Primary biliary cirrhosis-specific autoantibodies in first degree relatives of Greek primary biliary cirrhosis patients
Theodoros A Zografos,Nikolaos Gatselis,Kalliopi Zachou,Christos Liaskos
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i34.4721
Abstract: AIM: To determine the prevalence and significance of primary biliary cirrhosis (PBC)-specific autoantibodies in first-degree relatives (FDRs) of Greek PBC patients. METHODS: The presence of antimitochondrial antibodies (AMA) and PBC-specific antinuclear antibodies (ANA) were determined using indirect immunofluorescence assays, dot-blot assays, and molecularly based enzyme-linked immunosorbent assays in 101 asymptomatic for liver-related symptoms FDRs of 44 PBC patients. In order to specify our results, the same investigation was performed in 40 healthy controls and in a disease control group consisting of 40 asymptomatic for liver-related symptoms FDRs of patients with other autoimmune liver diseases namely, autoimmune hepatitis-1 or primary sclerosing cholangitis (AIH-1/PSC). RESULTS: AMA positivity was observed in 19 (only 4 with abnormal liver function tests) FDRs of PBC patients and none of the healthy controls. The prevalence of AMA was significantly higher in FDRs of PBC patients than in AIH-1/PSC FDRs and healthy controls [18.8%, 95% confidence interval (CI): 12%-28.1% vs 2.5%, 95% CI: 0.1%-14.7%, P = 0.01; 18.8%, 95% CI: 12%-28.1% vs 0%, 95% CI: 0%-10.9%, P = 0.003, respectively]. PBC-specific ANA positivity was observed in only one FDR from a PSC patient. Multivariate analysis showed that having a proband with PBC independently associated with AMA positivity (odds ratio: 11.24, 95% CI: 1.27-25.34, P = 0.03) whereas among the investigated comorbidities and risk factors, a positive past history for urinary tract infections (UTI) was also independently associated with AMA detection in FDRs of PBC patients (odds ratio: 3.92, 95% CI: 1.25-12.35, P = 0.02). CONCLUSION: In FDRs of Greek PBC patients, AMA prevalence is significantly increased and independently associated with past UTI. PBC-specific ANA were not detected in anyone of PBC FDRs.
New developments in the use of prostatic stents
Papatsoris AG,Junaid I,Zachou A,Kachrilas S
Open Access Journal of Urology , 2011,
Abstract: Athanasios G Papatsoris, Islam Junaid, Alexandra Zachou, Stefanos Kachrilas, Faruquz Zaman, Junaid Masood, Noor BuchholzDepartment of Endourology, Barts and the London NHS Trust, London, UKAbstract: Bladder outflow obstruction is a very common age-related clinical entity due to a variety of benign and malignant diseases of the prostate. Surgical treatment under general or regional anesthesia is not suitable for high-risk elderly patients who seek minimally invasive management. Unfortunately, for patients who are not fit for transurethral and/or laser prostatectomy, few treatment options remain, other than long-term catheterization and insertion (under local anesthesia) of a prostatic stent. In this review, we present developments in the use of prostatic stents.Keywords: prostatic stent, stent migration, urethal lumen, bladder outlet obstruction
Multiple Autoimmune Propensity and B-Non-Hodgkin Lymphoma: Cause or Effect?
E. Koumati,M. Palassopoulou,P. Matsouka,A. Polyzos,G. N. Dalekos,K. Zachou
Autoimmune Diseases , 2011, DOI: 10.4061/2011/841325
Abstract: We report a case of multiple autoimmunity consisting of the presence of autoimmune haemolytic anaemia (AIHA), antimitochondrial antibodies (AMAs), and antiphospholipid antibodies (APLAbs) as the presenting manifestations of an extrahepatic B-non-Hodgkin lymphoma (B-NHL) in a 63-year-old woman. The patient presented with fatigue attributed to severe AIHA. Due to increased serum IgM and -GT levels, an investigation for AMA was performed, which proved positive with anti-M2 specificity. A prolongation of activated partial thromboplastin time (aPTT) led to the determination of APLAbs (lupus anticoagulant and other APLAbs) which were also positive. Bone marrow biopsy in combination with immmunohistochemical studies established the diagnosis of lymphoplasmacytic B-NHL. Ten months later, B-NHL was in remission while AMA and APLAbs were still positive. In conclusion, we documented the coexistence of multiple autoimmune reactions together with B-NHL highlighting the possible common pathogenetic pathways of the two entities. 1. Introduction Lymphoproliferative disorders include several well-recognized disease entities, defined by different cell origin, pathology, and prognosis. Immune dysregulation is thought to play a major role in lymphomagenesis as attested by the increased risk of certain lymphomas following organ transplantation, infections, immunodeficiency states, and autoimmune diseases or syndromes [1–3]. On the other hand, autoimmune diseases comprise a broad variety of conditions characterized by dysregulation of the immune response leading to the loss of tolerance to self-antigens. Diverse associations between malignancy and autoimmunity have been shown in multiple levels [2, 4]. In particular, the association between lymphomas and autoimmunity is well known several years ago, starting by observations that autoimmunity is often present in patients with non-Hodgkin lymphoma (NHL), mouse strains showing association between autoimmune disease and lymphoma, and epidemiologic evidence that autoimmune disorders carry a significantly increased risk of NHL development compared to healthy population [1, 5, 6]. Exploring the pathogenetic mechanisms of this association, recent data show that they might be bi-directional [7–9]. However, autoimmune rheumatic features and/or autoimmune phenomena occur frequently in the course of lymphoproliferative malignancies, and they may sometimes be the first sign of the malignancy [7]. However, to the best of our knowledge, multiple autoimmunity consisting of the presence of autoimmune haemolytic anaemia (AIHA),
New developments in the use of prostatic stents
Papatsoris AG, Junaid I, Zachou A, Kachrilas S, Zaman F, Masood J, Buchholz N
Research and Reports in Urology , 2011, DOI: http://dx.doi.org/10.2147/RRU.S11752
Abstract: evelopments in the use of prostatic stents Review (3450) Total Article Views Authors: Papatsoris AG, Junaid I, Zachou A, Kachrilas S, Zaman F, Masood J, Buchholz N Published Date April 2011 Volume 2011:3 Pages 63 - 68 DOI: http://dx.doi.org/10.2147/RRU.S11752 Athanasios G Papatsoris, Islam Junaid, Alexandra Zachou, Stefanos Kachrilas, Faruquz Zaman, Junaid Masood, Noor Buchholz Department of Endourology, Barts and the London NHS Trust, London, UK Abstract: Bladder outflow obstruction is a very common age-related clinical entity due to a variety of benign and malignant diseases of the prostate. Surgical treatment under general or regional anesthesia is not suitable for high-risk elderly patients who seek minimally invasive management. Unfortunately, for patients who are not fit for transurethral and/or laser prostatectomy, few treatment options remain, other than long-term catheterization and insertion (under local anesthesia) of a prostatic stent. In this review, we present developments in the use of prostatic stents.
Comprehension of past tense marking in Greek developmental dyslexia: language impairment or processing deficit?
Zachou Angeliki,Clahsen Harald,Stavrakaki Stavroula
Annals of General Psychiatry , 2006, DOI: 10.1186/1744-859x-5-s1-s246
Abstract:
Early Primary Biliary Cirrhosis: A New Association with Erythema Nodosum of Unknown Origin
Nikolaos K. Gatselis,Kalliopi Zachou,George N. Dalekos
Gastroenterology Research and Practice , 2010, DOI: 10.1155/2010/121620
Abstract: Primary biliary cirrhosis (PBC) is associated with immune-mediated dermatologic disorders. The association of PBC with erythema nodosum (EN) seems rare. We report two females (42 and 44 years old) with low-grade fever, arthralgias, and elevated cholestatic enzymes in the first and fatigue in the second. Patients were also suffering from typical EN lesions characterized by multiple erythematous, painful nodules over the anterior portions of their lower extremities. Clinical and extensive laboratory work up excluded all known EN causes. PBC diagnosis was established according to the cholestatic biochemical profile, anti-mitochondrial antibodies (AMA) positivity and liver histology (first), and AMA and antinuclear (ANA) PBC-specific antibodies (second). Our report may suggest that PBC could be kept in mind in EN patients of unknown aetiology and particularly, when middle-aged female patients are affected. In such cases a thorough evaluation for AMA and/or ANA PBC-specific antibodies could be helpful to achieve a correct and timely diagnosis. 1. Introduction Erythema nodosum (EN) is the most common form of paniculitis. It is a cutaneous reaction pattern characterized clinically by the presence of erythematous tender nodules and raised plaques. They tend to be symmetrical in distribution and are usually located bilaterally on the lower extremities, particularly on the anterior tibial surface, although they may also involve the ankles, the lower parts of the thighs, and the forearms [1–4]. Although EN usually has no specific documented cause, it is imperative to investigate possible triggers. Among them, streptococcal infections, tuberculosis, inflammatory bowel disease (IBD), drug reactions, infective endocarditis, and sarcoidosis are the most common causes in children and adults [1–4]. Primary biliary cirrhosis (PBC) is an autoimmune cholestatic liver disease, which affects mainly middle-aged women and is characterized by a progressive immune mediated inflammatory destruction of the small intrahepatic bile ducts with portal inflammation leading to cirrhosis and subsequent liver failure [5, 6]. The diagnostic hallmark of the disease is the detection of antibodies reactive to mitochondria antigens (AMA) [7–9], though several other autoantibodies have been detected either disease-specific or not [7, 10–13]. The disease is frequently associated with a variety of extrahepatic autoimmune or immune-mediated conditions, including Sjogren’s syndrome, Hashimoto’s thyroiditis, scleroderma, Henoch-Schonlein purpura, and antiphospholipid syndrome [6, 14–16]. However, so
The Spread of Infectious Disease on Network Using Neutrosophic Algebraic Structure  [PDF]
A. Zubairu, A. A. Ibrahim
Open Journal of Discrete Mathematics (OJDM) , 2017, DOI: 10.4236/ojdm.2017.72009
Abstract: Network theory and its associated techniques has tremendous impact in various discipline and research, from computer, engineering, architecture, humanities, social science to system biology. However in recent years epidemiology can be said to utilizes these potentials of network theory more than any other discipline. Graph which has been considered as the processor in network theory has a close relationship with epidemiology that dated as far back as early 1900 [1]. This is because the earliest models of infectious disease transfer were in a form of compartment which defines a graph even though adequate knowledge of mathematical computation and mechanistic behavior is scarce. This paper introduces a new type of disease propagation on network utilizing the potentials of neutrosophic algebraic group structures and graph theory.
A Comparative Investigation of Lead Sulfate and Lead Oxide Sulfate Study of Morphology and Thermal Decomposition  [PDF]
S. A. A. Sajadi
American Journal of Analytical Chemistry (AJAC) , 2011, DOI: 10.4236/ajac.2011.22024
Abstract: The compound lead oxide sulfate PbSO4.PbO was prepared in our laboratory. The Thermal behavior of PbSO4 was studied using techniques of Thermogravimetry under air atmosphere from 25 to 1200°C. The identity of both compounds was confirmed by XRD technique. Results obtained using both techniques support same decomposition stages for this compound. The electron microscopic investigations are made by SEM and TEM. The compound is characterized by XRD and the purity was determined by analytical Methods. Also a series of thermogravimetric analysis is made and the ideal condition is determined to convert this compound to pure lead oxide.
Metal ion-binding properties of L-glutamic acid and L-aspartic acid, a comparative investigation  [PDF]
S. A. A. Sajadi
Natural Science (NS) , 2010, DOI: 10.4236/ns.2010.22013
Abstract: A comparative research has been developed for acidity and stability constants of M(Glu)1, M(Asp)2 and M(Ttr)3 complexes, which have been determined by potentiometric pH titration. Depending on metal ion-binding properties, vital differences in building complex were observed. The present study indicates that in M(Ttr) com-plexes, metal ions are arranged to the carboxyl groups, but in M(Glu) and M(Asp), some metal ions are able to build chelate over amine groups. The results mentioned-above demonstrate that for some M(Glu) and M(Asp) complexes, the stability constants are also largely determined by the affinity of metal ions for amine group. This leads to a kind of selectivity of metal ions, and transfers them through building complexes accompanied with glutamate and aspartate. For heavy metal ions, this building complex helps the absorption and filtration of the blood plasma, and consequently, the excursion of heavy metal ions takes place. This is an important method in micro-dialysis. In this study the different as-pects of stabilization of metal ion complexes regarding to Irving-Williams sequence have been investigated.
Determining the Basaltic Sequence Using Seismic Reflection and Resistivity Methods  [PDF]
A. Alanezi, A. Qadrouh
Open Journal of Geology (OJG) , 2013, DOI: 10.4236/ojg.2013.32B004
Abstract:

This study was carried out in Harat Rahat (south of Almadinah Almonwarah) using seismic reflection and resistivity methods. The main objectives of this study are to determine the extent of the basaltic layer and to define the subsurface faults and fractures that could affect and control the groundwater movement in the study area. A 2D seismic profile was acquired and the result shows that the subsurface in the study area has a major fault. We obtained a well match when the seismic result was compared with drilled wells. As a complementary tool, the resistivity method was applied in order to detect the groundwater level. The results of the resistivity method showed that six distinct layers have been identified. The interpretation of these six layers show that the first three layers, the fourth layer, the fifth layer and the bottom of the section indicated various subsurface structures and lithologies; various basaltic layers, fractured basalt, weathered basement and fresh basaltic layers, respectively. It is obvious that the eventual success of geophysical surveys depend on the combination with other subsurface data sources in order to produce accurate maps.

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