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Search Results: 1 - 10 of 104659 matches for " ZHANG Lihua "
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Combined 18F-FDG PET/CT with Enhanced CT Perform One-Stop Shop Imaging for Assessing Pancreatic Carcinoma  [PDF]
Miao Zhang, Min Zhang, Lihua Wang, Jiajia Hu, Biao Li
Journal of Cancer Therapy (JCT) , 2012, DOI: 10.4236/jct.2012.35070
Abstract: Objective: To evaluate the role of PET/CT with contrast enhanced CT in diagnosing and staging for pancreatic diseases and optimize the use of enhanced PET/CT as one-stop imaging modality. Methods: Fifty-six patients who presented with suspected pancreatic carcinoma underwent whole-body 18F-FDG PET/CT and enhanced CT imaging. Images were interpreted and compared with the histopathology findings. The sensitivity, specificity and accuracy of enhanced CT, PET/CT and combined PET/CT with contrast enhanced CT diagnosis were analyzed. The vascular invasion and distant metastases of pancreatic lesions on different imaging modality were analyzed and compared. Results: Among the fifty-six patients evaluated for primary tumor, thirty-nine patients had malignant diseases and seventeen had benign lesions. Sensitivity, specificity and accuracy of enhanced CT were 87.5%, 75% and 83.9%, those of non-enhanced PET/CT were 89.7%, 88.2% and 89.2%, of PET/CT with enhanced CT were 100%, 94.1% and 98.2%. Combined PET/CT with enhanced CT had highest sensitivity, specificity and accuracy in diagnosing pancreatic carcinoma. Average SUVmax of malignant lesions was 6.72 ± 3.84, compared with 2.56 ± 1.22 for patients with benign disease (P < 0.01). Combined PET/CT with enhanced CT can help to make accurate staging especially in assessing metastases and vascular invasion. Seven patients deemed surgical candidates were changed to non-surgical treatment. SUVmax didn’t correlate with distant metastases and survival time (Pearson = –0.243, P = 0.136). Distant metastases correlate with survival time (Pearson = –0.447, P = 0.004). Conclusion: PET/CT with contrast enhanced CT is of greater value in the diagnosis of pancreatic lesions as well as preoperative staging especially in assessing vascular invasion and distant metastasis. It is feasible to perform one-stop shop imaging by combining PET/CT with enhanced CT, supplying more accurate assessment before operation and help to select optimal therapeutic plan.
Histopathologic features of esophageal glands in the region of the gastroesophageal junction in Chinese patients with gastric cardiac cancer involving the esophagus
Qin Huang, Lihua Zhang
Pathology and Laboratory Medicine International , 2010, DOI: http://dx.doi.org/10.2147/PLMI.S10172
Abstract: topathologic features of esophageal glands in the region of the gastroesophageal junction in Chinese patients with gastric cardiac cancer involving the esophagus Original Research (4240) Total Article Views Authors: Qin Huang, Lihua Zhang Published Date May 2010 Volume 2010:2 Pages 33 - 40 DOI: http://dx.doi.org/10.2147/PLMI.S10172 Qin Huang1,2,3, Lihua Zhang1 1Department of Pathology of the Nanjing Drum Tower Hospital, Nanjing, China; 2Department of Pathology and Laboratory Medicine, Veterans Affairs, Boston Healthcare System, West Roxbury, MA, USA; 3Harvard Medical School, Boston, MA, USA Abstract: Esophageal glands (EGs) were implicated previously as a potential origin of carcinomas of the gastroesophageal junction (GEJ). The studies of histopathology on diseases in EGs, however, are scarce. In the present study, we systematically investigated EGs in 36 resection cases of gastric cardiac carcinomas involving the esophagus (GCE) in Chinese patients. All cases showed chronic inflammation in EGs and 14 (39%) with Helicobacter pylori infection. Hyperplasia, atrophy, and dysplasia were common in EGs and observed in 21 (58%), 14 (39%), and 28 (78%) cases, respectively. These changes were associated with various types of metaplasia, including intestinal (6, 17%), oncocytic (26, 72%), pancreatic acinar (11, 30%), and squamoid metaplasia (8, 22%). Oncocytic metaplasia was patchy, frequently replaced the entire lobule with dysplastic features. Pancreatic acinar metaplasia was present in superficial EGs as small acinar patches. Squamoid metaplasia was limited to the EG drainage ductile epithelium without keratin pearls or intercellular bridges; however, cytoplasmic vesicles and secretory vacuoles were common, suggesting dual differentiation. Dysplastic EGs featured architectural disarray with fused acini, cribriforming, abortive growth, and nuclear hyperchromasia, enlargement, and overlapping. The results demonstrate a spectrum of histopathologic changes in EGs and ductile epithelium, which is similar to those observed in GCE in Chinese patients.
Histopathologic features of esophageal glands in the region of the gastroesophageal junction in Chinese patients with gastric cardiac cancer involving the esophagus
Qin Huang,Lihua Zhang
Pathology and Laboratory Medicine International , 2010,
Abstract: Qin Huang1,2,3, Lihua Zhang11Department of Pathology of the Nanjing Drum Tower Hospital, Nanjing, China; 2Department of Pathology and Laboratory Medicine, Veterans Affairs, Boston Healthcare System, West Roxbury, MA, USA; 3Harvard Medical School, Boston, MA, USAAbstract: Esophageal glands (EGs) were implicated previously as a potential origin of carcinomas of the gastroesophageal junction (GEJ). The studies of histopathology on diseases in EGs, however, are scarce. In the present study, we systematically investigated EGs in 36 resection cases of gastric cardiac carcinomas involving the esophagus (GCE) in Chinese patients. All cases showed chronic inflammation in EGs and 14 (39%) with Helicobacter pylori infection. Hyperplasia, atrophy, and dysplasia were common in EGs and observed in 21 (58%), 14 (39%), and 28 (78%) cases, respectively. These changes were associated with various types of metaplasia, including intestinal (6, 17%), oncocytic (26, 72%), pancreatic acinar (11, 30%), and squamoid metaplasia (8, 22%). Oncocytic metaplasia was patchy, frequently replaced the entire lobule with dysplastic features. Pancreatic acinar metaplasia was present in superficial EGs as small acinar patches. Squamoid metaplasia was limited to the EG drainage ductile epithelium without keratin pearls or intercellular bridges; however, cytoplasmic vesicles and secretory vacuoles were common, suggesting dual differentiation. Dysplastic EGs featured architectural disarray with fused acini, cribriforming, abortive growth, and nuclear hyperchromasia, enlargement, and overlapping. The results demonstrate a spectrum of histopathologic changes in EGs and ductile epithelium, which is similar to those observed in GCE in Chinese patients.Keywords: esophageal glands, esophagus, stomach, cancer, Chinese
Association between Vitamin D Receptor Gene Polymorphisms and Breast Cancer Risk: A Meta-Analysis of 39 Studies
Kai Zhang, Lihua Song
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0096125
Abstract: Background The associations between vitamin D receptor (VDR) gene polymorphisms and breast cancer risk were comprehensively investigated to clarify issues that remain controversial. Methodology/Principal Findings An electronic search was conducted of several databases, including PubMed, the Cochrane library, Web of Science, EMBASE, CBM and CNKI, for papers that describe the association between Fok1, poly-A repeat, Bsm1, Taq1 or Apa1 polymorphisms of the VDR gene and breast cancer risk. Summary odds ratios and 95% confidence intervals (CI) were estimated based on a fixed-effect model (FEM) or random-effect model (REM), depending on the absence or presence of significant heterogeneity. A total of 39 studies met the inclusion criteria. A meta-analysis of high-quality studies showed that the Fok1 polymorphism of the VDR gene was associated with an increased risk of breast cancer (ff vs. Ff+FF, OR: 1.09, 95%CI: 1.02 to 1.16, p = 0.007). No significant associations were observed between the other polymorphisms and breast cancer risk. No positive results were detected by pooling the results of all relevant studies. Conclusion A meta-analysis of high-quality studies demonstrated that the Fok1 polymorphism of the VDR gene was closely associated with breast cancer risk.
A Novel and Simple Route to Synthesis Nanocrystalline Titanium Carbide Via the Reaction of Titanium Dioxide and Different Carbon Source  [PDF]
Youjian Chen, Yongyong Deng, Hong Zhang, Lihua Wang, Jianhua Ma
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.211215
Abstract: A novel and simple route for synthesizing nanocrystalline ceramic powders in molten salt was introduced in the paper. Titanium carbide (TiC) was prepared via the reaction of metallic magnesium powders with titanium dioxide (TiO2), carbon source and molten salt in an autoclave at 650°C. Carbon source (oxalic acid and citric acid) in this paper was stable, low toxic and cheap. X-ray powder diffraction (XRD) patterns indicated that the products were cubic TiC. Scanning electron microscopy (SEM) images showed that the samples consisted of particles with an average size of 200 nm and 100 nm in diameter, respectively. Energy Dispersive Spectrometer (EDS) analysis of the samples suggested the products contained carbon and titanium elements. The product was also studied by the thermogravimetric analysis (TGA). It had good thermal stability and oxidation resistance below 350°C in air.
Effect of Temperature and Metal Ions on Degradation of Oxytetracycline in Different Matrices  [PDF]
Yingying Zhang, Heqing Tang, Qian Zhou, Lihua Zhu
Journal of Environmental Protection (JEP) , 2014, DOI: 10.4236/jep.2014.58068
Abstract:

Composting is widely applied in animal manure treatment and reclamation. The degradation of organic pollutants during the composting treatment is attributed to two parallel processes: one is the bioprocess induced by the used microorganisms, and the other is the chemical process. In order to clarify the relative contribution of the chemical process to the compositing, in this paper, oxytetracycline (OTC) was chosen to study the degradation of tetracyclines (TCs) in water and chicken manure. It was observed that the degradation of OTC in water was much faster than that in chicken mature. At 40°C, 95% of OTC in water could be removed in two days, while it took about one month in mature. By increasing the temperature to 50°C, 60°C and 70°C, the required degradation time (with the degradation efficiency more than 95%) was shortened to 22, 13 and 9 days, respectively. This difference was caused by desorption hysteresis and irreversible fixation due to the formation of complexes of OTC with co-existed metal ions in the matrix. It was found that the coexisted Ca2+, Zn2+ and Ni2+ ions decreased the degradation of OTC, whereas Cu2+ ions promoted the degradation of OTC.

Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout mice
Lihua Li, Hua Zhang, AS Verkman
BMC Neuroscience , 2009, DOI: 10.1186/1471-2202-10-94
Abstract: We investigated the involvement of AQP4 in disease severity in an established mouse model of experimental autoimmune encephalomyelitis (EAE) produced by immunization with myelin oligodendrocyte glycoprotein (MOG35–55) peptide. EAE was remarkably attenuated in AQP4 null mice compared to identically treated wildtype mice. Whereas most wildtype mice developed progressive tail and hindlimb paralysis, clinical signs were virtually absent in AQP4 null mice. Brain and spinal cords from AQP1 null mice showed greatly reduced mononuclear cell infiltration compared to wildtype mice, with relatively little myelin loss and axonal degeneration.The reduced severity of autoimmune encephalomyelitis in AQP4 deficiency suggests AQP4 as a novel determinant in autoimmune inflammatory diseases of the central nervous system and hence a potential drug target.Aquaporin-4 (AQP4) is a water-selective channel expressed in plasma membranes of astrocytes throughout the central nervous system (CNS), particularly at astrocyte foot processes at the blood-brain barrier and brain-cerebrospinal fluid interfaces [1,2]. AQP4 facilitates water movement in the brain and spinal cord, astrocyte migration, and neuroexcitatory phenomena (reviewed in ref. [3]). Mice lacking AQP4 manifest remarkable phenotype differences from wildtype mice in models of cytotoxic [4] and vasogenic [5] cerebral edema, brain injury associated with glial scarring [6], epilepsy [7] and cortical spreading depression [8]. Structural data on AQP4 from electron crystallography suggested a possible new role of AQP4 in cell-cell adhesion [9,10], though subsequent experimental studies did not confirm this role [11].Another potential new role for AQP4 that is unrelated to its cell membrane water transport function was suggested by the discovery of circulating autoantibodies against AQP4 in most patients with the inflammatory demyelinating disease neuromyelitis optica (NMO) [12]. Indirect evidence, including correlations of NMO-IgG titer wit
Development of contingent valuation method in evaluating non-market values of resources and environment in China

XiuJuan Zhang,LiHua Zhou,

寒旱区科学 , 2012,
Abstract: The contingent valuation method (CVM) is one of the main methods for evaluating non-market values of resources. It originated in the United States and was introduced into China during the 1980s and 1990s. However, application of CVM in China is highly controversial based on three primary aspects: (1) the appropriate guidelines for CVM; (2) the elicitation techniques for willingness to pay (WTP); and (3) reliability and validity testing of CVM. The major objectives of this paper are to review the recent developments pertaining to guidelines, elicitation techniques, and reliability and validity testing for application of CVM, and to summarize the limitations of and measures for improving application of CVM in China. The applicability of CVM in China is discussed to enhance the future development of CVM in China.
MICROSTRUCTURE IN FUSION-CAST MAGNESITE- CHROME BRICKS FOR USE IN COPPER FLASH-SMELTER

Zhong Xiangchong,Zhang Lihua,

金属学报 , 1981,
Abstract: The principal mineralogical constituents of fusion-cast magnesite chrome refractories were identified as periclase solid solution, intergranular spinel and forsterite solid solution. Their amount and composition, their crystal size and some of the optical properties are determined and their empirical formulae have been predicated. The characteristics of each type of microstructure observed as well as the conditions of its formation are discussed. Such brick after service in copper flash smelters may be distinguished into slag zone, reaction zone and unaltered zone. It is due to the thin reaction zone and absence of a transition zone that no penetration of low melting phase has substantially occurred. From the results of chemical analysis and petrological observation of various zones, it may be concluded that the main attack comes from the ferrous silicates and iron oxide in the slag which corrode the periclase and spinel in the brick, and that the periclase is more easily eroded than intergranular spinel. The basic requirements for the microstructure of the brick for service in copper flash smelter are discussed and measures for control of the microstructure have been suggested.
Comparative Proteomic Analysis of Helicobacter pylori Strains Isolated from Chinese Patients  [PDF]
Boqing Li, Wanju Sun, Lihua He, Hong Jiang, Zhen Zhang, Donglong Du, Jianzhong Zhang
Pharmacology & Pharmacy (PP) , 2013, DOI: 10.4236/pp.2013.45A002
Abstract: Helicobacter pylori, the major cause of gastritis, peptic ulcer and gastric cancer, infects half of the world population, but only a few infections lead to serious disease. In order to investigate specific proteins related to the pathogenic difference of this bacterium, comparative proteome analyses of Helicobacter pylori C1 (isolated from patients with gastric cancer) and G1 (isolated from patients with gastritis) were performed using two-dimensional gel electrophoresis (2-DE) and matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS). Four proteins (inorganic pyrophosphatase, 3-oxoadipate CoA-transferase subunit B, translation elongation factor, and aldo-keto reductase) were found only in Helicobacter pylori C1, and one protein (alkyl hydroperoxide reductase) was found in G1. Additionally, different isoelectric points (pI) of Hsp60 were observed from the two strains. Then we cloned and sequenced Hsp60 genes from forty-nine Helicobacter pylori isolated from gastric cancer and gastritis. Gene sequencing showed that one C→G single nucleotide polymorphism occurred in the 1399th nucleotide of Hsp60. These results indicate that pathogenic differences exist in various Helicobacter pylori isolated from Chinese patients.
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