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Search Results: 1 - 10 of 144783 matches for " Yvo B Roos "
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Ethnicity and thrombolysis in ischemic stroke: a hospital based study in Amsterdam
Jonathan M Coutinho, Eva C Klaver, Yvo B Roos, Jan Stam, Paul J Nederkoorn
BMC Neurology , 2011, DOI: 10.1186/1471-2377-11-81
Abstract: Retrospective single-centre study. Patients admitted with an ischemic stroke between 2003 and 2008 were included. Ethnicity was determined by self-identification and stratified into white and non-white (all other ethnicities). The main outcome measure was the difference in thrombolysis rate between white and non-white patients. Logistic regression analysis was used to identify potential confounders of the relation between ethnicity and thrombolysis.510 patients were included, 392 (77%) white and 118 (23%) non-white. Non-white patients were younger (median 69 vs. 60 years, p < 0.001), had a higher blood pressure at admission (median systolic 150 vs. 160 mmHg, p = 0.02) and a lower stroke severity (median NIHSS 5 vs. 4, p = 0.04). Non-white patients were significantly less often treated with thrombolysis compared to white patients (odds ratio 0.34, 95% CI 0.17-0.71), which was partly explained by a later arrival at the hospital. After adjustment for potential confounders (late arrival, age, blood pressure above upper limit for thrombolysis, and oral anticoagulation use), a trend towards a lower thrombolysis rate in non-whites remained (adjusted odds ratio 0.38, 95% CI 0.13 to 1.16).Non-white stroke patients less often received thrombolysis than white patients, partly as a result of a delay in presentation. In this single centre study, potential bias due to hospital differences or insurance status could be ruled out as a cause. The magnitude of the difference is worrisome and requires further investigation. Modifiable causes, such as patient delay, awareness of stroke symptoms, language barriers and treatment of cardiovascular risk factors, should be addressed specifically in these ethnic groups in future stroke campaigns.Despite its proven efficacy, only a minority of patients with an acute ischemic stroke are treated with intravenous thrombolysis [1-3]. A delay in hospital presentation is the most important reason why this treatment is withheld from stroke patients [
Patch: platelet transfusion in cerebral haemorrhage: study protocol for a multicentre, randomised, controlled trial
Koen de Gans, Rob J de Haan, Charles B Majoie, Maria M Koopman, Anneke Brand, Marcel G Dijkgraaf, Marinus Vermeulen, Yvo B Roos, the PATCH Investigators
BMC Neurology , 2010, DOI: 10.1186/1471-2377-10-19
Abstract: The primary objective is to investigate whether platelet transfusion improves outcome in intracerebral haemorrhage patients who are on antiplatelet treatment. The PATCH study is a prospective, randomised, multi-centre study with open treatment and blind endpoint evaluation. Patients will be randomised to receive platelet transfusion within six hours or standard care. The primary endpoint is functional health after three months. The main secondary endpoints are safety of platelet transfusion and the occurrence of haematoma growth. To detect an absolute poor outcome reduction of 20%, a total of 190 patients will be included.To our knowledge this is the first randomised controlled trial of platelet transfusion for an acute haemorrhagic disease.The Netherlands National Trial Register (NTR1303)In studies on outcome prediction after intracerebral haemorrhage (ICH), increasing haematoma volume is a consistent, independent predictor of poor outcome [1,2]. A study with follow-up head CT-scans in the acute phase showed a ≥ 33% increase of haematoma volume during the first 24 hours in at least 38% of patients [3]. This haematoma growth mostly occurs in the first six hours after onset [4,5]. Unsurprisingly, patients suffering from haematoma growth have worse outcome than those without haematoma growth [6]. At our institution we investigated the in hospital mortality after spontaneous ICH. We retrospectively reviewed the charts of all ICH patients who were admitted over a three year period and divided them in three groups. Patients using antiplatelet therapy (APT) had a 40% in hospital mortality (15/38 patients). In patients using oral anticoagulants the mortality rate was 28% during stay in the hospital (11/39) and patients without any antithrombotic medication had a 23% mortality (27/118). This poor outcome for APT patients was unexpected. We first considered this high mortality rate to be an epiphenomenon since the APT patients were older and had more previous cardiovascular
Astrophysical and Cosmological Probes of Dark Matter  [PDF]
Matts Roos
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.329150
Abstract: Dark matter has been introduced to explain substantial mass deficits noted at different astronomical scales, in galaxies, groups of galaxies, clusters, superclusters and even across the full horizon. Dark matter does not interact with baryonic matter except gravitationally, and therefore its effects are sensed only on the largest scales. Although it is still unknown whether dark matter consists of particles or of a field or has some other nature, it has a rich phenomenology. This review summarizes all the astrophysical and cosmological probes that have been used to produce evidence for its existence. The breadth of the subject does not permit details on the observational methods (the reference list then helps), thus the review is intended to be useful mainly to cosmologists searching to model dark matter.
A Relationship between Epithelial Maturation, Bronchopulmonary Dysplasia, and Chronic Obstructive Pulmonary Disease
Abraham B. Roos,Tove Berg,Magnus Nord
Pulmonary Medicine , 2012, DOI: 10.1155/2012/196194
Abstract:
A Relationship between Epithelial Maturation, Bronchopulmonary Dysplasia, and Chronic Obstructive Pulmonary Disease
Abraham B. Roos,Tove Berg,Magnus Nord
Pulmonary Medicine , 2012, DOI: 10.1155/2012/196194
Abstract: Premature infants frequently develop bronchopulmonary dysplasia (BPD). Lung immaturity and impaired epithelial differentiation contribute together with invasive oxygen treatment to BPD onset and disease progression. Substantial evidence suggests that prematurity is associated with long term pulmonary consequences. Moreover, there is increasing concern that lung immaturity at birth may increase the risk of developing chronic obstructive pulmonary disease (COPD). The mechanisms contributing to this phenomenon remains unknown, largely as a consequence of inadequate experimental models and clinical follow-up studies. Recent evidence suggests that defective transcriptional regulation of epithelial differentiation and maturation may contribute to BPD pathogenesis as well as early onset of COPD. The transcriptional regulators CCAAT/enhancer-binding protein (C/EBP)α and C/EBPβ, SMAD family member (Smad)3, GATA binding protein (GATA)6, and NK2 homeobox (NKX)2-1 are reported to be involved in processes contributing to pathogenesis of both BPD and COPD. Increased knowledge of the mechanisms contributing to early onset COPD among BPD survivors could translate into improved treatment strategies and reduced frequency of respiratory disorders among adult survivors of BPD. In this paper, we introduce critical transcriptional regulators in epithelial differentiation and summarize the current knowledge on the contribution of impaired epithelial maturation to the pathogenesis of inflammatory lung disorders. 1. Introduction Premature infants with immature lungs frequently develop respiratory distress syndrome (RDS). Bronchopulmonary dysplasia (BPD) is the most common chronic respiratory disorder observed among premature infants with severely immature lungs [1, 2]. It is well established that BPD develops as a consequence of lung immaturity together with invasive critical care treatment regiments. The precise role of lung immaturity in this process is still relatively unknown, although several studies have tried to address this. Substantial evidence that airway dysfunction and long term morbidity can be observed among children and young adults surviving BPD has emerged [3–6]. In addition, there are increasing concerns that prematurely delivered individuals are more susceptible to chronic obstructive pulmonary disease (COPD) [4, 5, 7–10]. Experimental data support that defective transcriptional regulation of epithelial differentiation and maturation contributes to inflammatory processes involved in long term respiratory outcomes in immature lungs [11]. There is in light of
No effect of epoprostenol on right ventricular diameter in patients with acute pulmonary embolism: a randomized controlled trial
Albertus J Kooter, Richard G IJzerman, Otto Kamp, Anco B Boonstra, Yvo M Smulders
BMC Pulmonary Medicine , 2010, DOI: 10.1186/1471-2466-10-18
Abstract: In a randomized, single-blind study, 14 patients with acute pulmonary embolism received epoprostenol or placebo infusion for 24 hours on top of conventional treatment. Effects on right ventricular end-diastolic diameter, systolic pulmonary artery pressure, right ventricle fractional area changeand tricuspid annular plane systolic excursion were assessed by serial echocardiography. Furthermore Troponin T and NT-proBNP were measured serially.Compared to placebo, epoprostenol was associated with a relative change from baseline in right ventricular end-diastolic diameter of +2% after 2.5 hours and -8% after 24 hours. Epoprostenol did not have a significant effect on systolic pulmonary artery pressure, right ventricular fractional area change and tricuspid annular plane systolic excursion, nor on biochemical parameters.In patients with acute pulmonary embolism and right ventricular overload, treatment with epoprostenol did not improve right ventricular dilatation or any other measured variables of right ventricular overload.Registration: URL: NCT01014156Medical ethical committee: Medisch-ethische toetsingscommissie (METc) from the VUmc (free university medical centre)Pulmonary embolism is a frequent and potentially fatal disorder. Despite immediate treatment with anticoagulants, morbidity and mortality are still high when hemodynamically stable patients with pulmonary embolism have echocardiographic signs of acute right ventricular overload [1-3].An acute increase in right ventricular afterload is the hallmark of severe pulmonary embolism, and is responsible for many of its clinical manifestations and complications. The traditional view is that mechanical obstruction by thrombus mass causes pulmonary hypertension. Therefore, treatment focusses on relieving mechanical obstruction, either by anticoagulation if patients are stable, or by thrombolytic therapy in case of hemodynamic instability [4]. The optimal treatment for haemodynamically stable patients with signs of righ
Edge-Colored Graphs with Applications To Homogeneous Faults
Yongge Wang,Yvo Desmedt
Mathematics , 2012,
Abstract: In this paper, we use the concept of colored edge graphs to model homogeneous faults in networks. We then use this model to study the minimum connectivity (and design) requirements of networks for being robust against homogeneous faults within certain thresholds. In particular, necessary and sufficient conditions for most interesting cases are obtained. For example, we will study the following cases: (1) the number of colors (or the number of non-homogeneous network device types) is one more than the homogeneous fault threshold; (2) there is only one homogeneous fault (i.e., only one color could fail); and (3) the number of non-homogeneous network device types is less than five.
Equilibria of Plurality Voting with Abstentions
Yvo Desmedt,Edith Elkind
Computer Science , 2010,
Abstract: In the traditional voting manipulation literature, it is assumed that a group of manipulators jointly misrepresent their preferences to get a certain candidate elected, while the remaining voters are truthful. In this paper, we depart from this assumption, and consider the setting where all voters are strategic. In this case, the election can be viewed as a game, and the election outcomes correspond to Nash equilibria of this game. We use this framework to analyze two variants of Plurality voting, namely, simultaneous voting, where all voters submit their ballots at the same time, and sequential voting, where the voters express their preferences one by one. For simultaneous voting, we characterize the preference profiles that admit a pure Nash equilibrium, but show that it is computationally hard to check if a given profile fits our criterion. For sequential voting, we provide a complete analysis of the setting with two candidates, and show that for three or more candidates the equilibria of sequential voting may behave in a counterintuitive manner.
Preliminary Analysis of Google+'s Privacy
Shah Mahmood,Yvo Desmedt
Computer Science , 2011,
Abstract: In this paper we provide a preliminary analysis of Google+ privacy. We identified that Google+ shares photo metadata with users who can access the photograph and discuss its potential impact on privacy. We also identified that Google+ encourages the provision of other names including maiden name, which may help criminals performing identity theft. We show that Facebook lists are a superset of Google+ circles, both functionally and logically, even though Google+ provides a better user interface. Finally we compare the use of encryption and depth of privacy control in Google+ versus in Facebook.
Your Facebook Deactivated Friend or a Cloaked Spy (Extended Abstract)
Shah Mahmood,Yvo Desmedt
Computer Science , 2012,
Abstract: With over 750 million active users, Facebook is the most famous social networking website. One particular aspect of Facebook widely discussed in the news and heavily researched in academic circles is the privacy of its users. In this paper we introduce a zero day privacy loophole in Facebook. We call this the deactivated friend attack. The concept of the attack is very similar to cloaking in Star Trek while its seriousness could be estimated from the fact that once the attacker is a friend of the victim, it is highly probable the attacker has indefinite access to the victims private information in a cloaked way. We demonstrate the impact of the attack by showing the ease of gaining trust of Facebook users and being befriended online. With targeted friend requests we were able to add over 4300 users and maintain access to their Facebook profile information for at least 261 days. No user was able to unfriend us during this time due to cloaking and short de-cloaking sessions. The short de-cloaking sessions were enough to get updates about the victims. We also provide several solutions for the loophole, which range from mitigation to a permanent solution
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