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Search Results: 1 - 10 of 3307 matches for " Yves Barral "
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Budding Yeast Dma Proteins Control Septin Dynamics and the Spindle Position Checkpoint by Promoting the Recruitment of the Elm1 Kinase to the Bud Neck
Laura Merlini,Roberta Fraschini,Barbara Boettcher,Yves Barral,Giovanna Lucchini,Simonetta Piatti
PLOS Genetics , 2012, DOI: 10.1371/journal.pgen.1002670
Abstract: The first step towards cytokinesis in budding yeast is the assembly of a septin ring at the future site of bud emergence. Integrity of this ring is crucial for cytokinesis, proper spindle positioning, and the spindle position checkpoint (SPOC). This checkpoint delays mitotic exit and cytokinesis as long as the anaphase spindle does not properly align with the division axis. SPOC signalling requires the Kin4 protein kinase and the Kin4-regulating Elm1 kinase, which also controls septin dynamics. Here, we show that the two redundant ubiquitin-ligases Dma1 and Dma2 control septin dynamics and the SPOC by promoting the efficient recruitment of Elm1 to the bud neck. Indeed, dma1 dma2 mutant cells show reduced levels of Elm1 at the bud neck and Elm1-dependent activation of Kin4. Artificial recruitment of Elm1 to the bud neck of the same cells is sufficient to re-establish a normal septin ring, proper spindle positioning, and a proficient SPOC response in dma1 dma2 cells. Altogether, our data indicate that septin dynamics and SPOC function are intimately linked and support the idea that integrity of the bud neck is crucial for SPOC signalling.
Anti-conservateur, anti-radical, pro-militant : Richard Rorty, ou la séparation de la philosophie et de l’Etat
David Barral
Transatlantica : Revue d'études Américaines , 2008,
Abstract: Liste des abréviations pour les ouvrages de Richard Rorty :PSH : Philosophy and Social Hope (1999)AOC : Achieving Our Country (1999)ORT : Objectivity, Relativism, and Truth (1991)Parmi les accueils les moins favorables réservés en France au pragmatisme du philosophe américain Richard Rorty, il en est un qui souligne parfaitement le problème qui va nous occuper ici, celui de la relation (ou de la non-relation) entre philosophie et politique. Dans Recommencer la Philosophie : La philosophie amé...
Elegia por uma democracia Desencantada - Crise e Consolida o Democrática na América Latina
Welber Barral
Sequência : Estudos Juridicos e Politicos , 1992,
O protocolo de Olivos e o Mercosul
Welber Barral
Sequência : Estudos Juridicos e Politicos , 2002,
Sistema monetário Europeu
Welber Barral
Sequência : Estudos Juridicos e Politicos , 1997,
Produ o Discente: Tecnodemocracia: Limites e perspectivas
Welber Barral
Sequência : Estudos Juridicos e Politicos , 1992,
Desenvolvimento e sistema jurídico: li es de experiências passadas
Welber Barral
Sequência : Estudos Juridicos e Politicos , 2005,
Abstract: Desde o final da Segunda GuerraMundial, houve tentativas importantes deavan ar na compreens o da rela o entresistema jurídico e promo o do desenvolvimento.Este artigo se dedica a revisar as diversasteorias que, ao longo da história,buscaram compreender as rela es entreordem jurídica e processo de desenvolvimento.Estas teorias, entretanto, esgotaramsediante da falta de uma teoria de base, quepudesse explicitar de forma coerente as diversasmatizes desta complexa rela o.Since the end of the Second WorldWar, there were several important attemptsin order to succeed on understanding therelation between legal system and ondevelopment promotion. This paper focuson reviewing several theories that, throughthe history, looked for understanding therelations between jurisprudence anddevelopment process. These theories,however, went down due to the lack of a basictheory, that could make clear and coherentlydiverse shades of this complex relation.
Inverse problems in multifractal analysis
Julien Barral
Mathematics , 2013,
Abstract: Multifractal formalism is designed to describe the distribution at small scales of the elements of $\mathcal M^+_c(\R^d)$, the set of positive, finite and compactly supported Borel measures on $\R^d$. It is valid for such a measure $\mu$ when its Hausdorff spectrum is the upper semi-continuous function given by the concave Legendre-Fenchel transform of the free energy function $\tau_\mu$ associated with $\mu$; this is the case for fundamental classes of exact dimensional measures. For any function $\tau$ candidate to be the free energy function of some $\mu\in \mathcal M^+_c(\R^d)$, we build such a measure, exact dimensional, and obeying the multifractal formalism. This result is extended to a refined formalism considering jointly Hausdorff and packing spectra. Also, for any upper semi-continuous function candidate to be the lower Hausdorff spectrum of some exact dimensional $\mu\in\mathcal M^+_c(\R^d)$, we build such a measure. Our results transfer to the analoguous inverse problems in multifractal analysis of H\"older continuous functions.
Imuniza??o específica nas leishmanioses tegumentares: revis?o
Barral Netto, M.;Barral, A.;
Memórias do Instituto Oswaldo Cruz , 1987, DOI: 10.1590/S0074-02761987000200019
Abstract: we have reviewed the literature on specific immunoprotection against tegumentary leshmainias. papers dealing with human beings as well as with experimental animals have been included. the review is divided into there main topics: 1) studies attempting protection by using virulent parasites of the same strain; 2) the use of parasites, virulent or not, for preventing other strains of leishmania; and 3) the use of "attenuated" parasites, or parasite products, for inducing protection against the infection.
Annotating novel genes by integrating synthetic lethals and genomic information
Daniel Sch?ner, Markus Kalisch, Christian Leisner, Lukas Meier, Marc Sohrmann, Mahamadou Faty, Yves Barral, Matthias Peter, Wilhelm Gruissem, Peter Bühlmann
BMC Systems Biology , 2008, DOI: 10.1186/1752-0509-2-3
Abstract: We analyze synthetic lethality data for arp1 and jnm1, two spindle migration genes, in order to identify novel members in this process. To this end, we use an unsupervised statistical method that integrates additional information from biological data sources, such as gene expression, phenotypic profiling, RNA degradation and sequence similarity. Different from existing methods that require large amounts of synthetic lethal data, our method merely relies on synthetic lethality information from two single screens. Using a Multivariate Gaussian Mixture Model, we determine the best subset of features that assign the target genes to two groups. The approach identifies a small group of genes as candidates involved in spindle migration. Experimental testing confirms the majority of our candidates and we present she1 (YBL031W) as a novel gene involved in spindle migration. We applied the statistical methodology also to TOR2 signaling as another example.We demonstrate the general use of Multivariate Gaussian Mixture Modeling for selecting candidate genes for experimental characterization from synthetic lethality data sets. For the given example, integration of different data sources contributes to the identification of genetic interaction partners of arp1 and jnm1 that play a role in the same biological process.One of the major challenges in computational biology is the extraction of relevant information from the increasing amounts of data resulting from large scale experimentation. While the reliability of the results of single high-throughput assays has often been challenged, there is great promise that the confidence and precision of the outcomes can be increased through integration and combination of multiple data sources. We applied statistical modeling, based on data integration, for finding yeast genes involved in spindle migration from two synthetic lethality screens performed with arp1 and jnm1.Synthetic lethality describes the phenomenon of observing a lethal pheno
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