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Search Results: 1 - 10 of 119818 matches for " Yuzhou Wang "
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Research Advance on the Role of IGF Network in Non-small Cell Lung Cancer
Yuzhou WANG,Xiaohong NING,Jianfeng ZHOU
Chinese Journal of Lung Cancer , 2009,
Abstract:
Theoretical Study on the Optical and Electrical Properties of AlxGa1-xN Crystals  [PDF]
Xuewen Wang, Yuzhou Jing, Xinkang Zhu, Chan Liu, Jiangni Yun, Zhiyong Zhang
Journal of Modern Physics (JMP) , 2013, DOI: 10.4236/jmp.2013.43A063
Abstract:
By making use of the density functional theory (DFT) of the first principles and generalized gradient approximation method, the electronic structures and properties of ideal GaN and AlxGa1-xN crystals (x = 0.25, 0.5, 0.75) have been calculated and analyzed, and the influence of the doping quantity of x on the characteristics of AlxGa1-xN has been studied. The calculation results show that optical band gap of AlxGa1-xN crystal is widened that the
Analysis of Treatment Response and Chest CT Characteristics for Patients Treated by EGFR-TKI in Relapse Advanced Lung Adenocarcinoma
Yuzhou WANG,Xiaohong NING,Jianfeng ZHOU,Shuchang CHEN
Chinese Journal of Lung Cancer , 2008,
Abstract: Background and objective For previously treated recurrent non-small cell lung cancer, many studies have proven that inhibitors of the tyrosine kinase of epidermal growth factor receptor (EGFR-TKI), such as gefitinib and erlotinib can increase survival, especially in non-smoker adenocarcinoma. The objective of this study is to investigate the relationship between the characteristics of chest Computed tomography (CT) and objective response of gefitinib and erlotinib for recurrent lung adenocarcinoma. Methods Thirty-seven patients with recurrent advanced lung adenocarcinoma were treated from Jan 1, 2004 to Mar 31, 2007 in our department. The patients consisted of 17 males and 20 females previously treated with 1-6 cycle of platinum-based chemotherapy. The age changed from 54 to 85 yrs (media 67.5 yrs). The gefitinib and erlotinib was given 250 mg and 150 mg respectively per day until disease progression. The characteristics of chest CT were evaluated before therapy and reviewed every 2 month as follow up. The objective response was analyzed according to RECIST system. Results In 37 patients, 21 patients benefited (including 7 partial response and 14 stable disease) from the treatment. Chest CT characteristic analysis showed that, the benefit rate was 79.9% (15/19) in patients with greater than 3 metastasis of lung or diffused disease, vs. 33.3% (6/18) in others,P<0.05; the benefit rate was 73.1% (19/26) and 67.4% (31/46) respectively in patients with pleural effusion and moderate contrast disease focus in enhancement CT scanning, vs. 22.2% (2/9) and 37.5% (9/24) in patients without pleural effusion and non-enhancement respectively, P<0.05. But Cox regression analyses show no relationship between CT presentation and progress free survival (PFS) or overall survival (OS), HR, 0.766, P>0.05. Conclution For advanced lung adenocarcinoma, CT presentation of multiple metastasis of lung or diffused disease, pleural effusion and enhancing contrast disease focus may be a predictor for response when treated by EGFR-TKI. But those CT character does not represent as independent factor for prognosis.
Changes of Exercise and the Clinical Effects among Eldly Non-small Cell Lung Cancer Survivors
Hongyan YING,Yuzhou WANG,Xiaohong NING,Jianfeng ZHOU
Chinese Journal of Lung Cancer , 2010,
Abstract: Background and objective Exercise can improve circulation, muscular strength and happiness of cancer survivors. But more data were needed to demonstrate both the exercise ability of cancer suivivors after pulmonary lobectomy and the influences of exercise on their survivals. The aim of this study was to examine changes of exercise and its clinical effects among eldly non-small cell lung cancer survivors. Methods Elderly non-small cell lung cancer survivors who had progression-free disease after surgery, chemotherapy, radiation therapy or tyrosine kinase inhibitors were included. Their exercises and participation rates per week before cancer diagnosis, after 3 months anticancer therapy and 1 year after diagnosis as well as their exercise motivations and prevalences were investigated retrospectively. Results Forty-eight elderly non-small cell lung cancer survivors were selected. Moderate-vigorous intensity exercise had by the elderly progressin-free non-small cell lung cancer survivors after diagnosis decreased, but the participation rate of light intensity exercise was higher in 1 year after diagnosis than before diagnosis. 75.9% (14/58) patients had exercise up to the standard and the cancer recurrence rate was 20.0% (7/35). The recurrence rate of the other group was 35.7% (5/14), and the risk ratio of recurrence was 2.14 (95%CI: 0.81-5.68, P=0.26). The most common motivations of exercise were improving health, increasing physical activity, maintaining healthy life style and improving immunity. And the main disturbances were fatigue, discomfort and lack of motivation. Conclusion The exercise participation rate during anticancer treatment among the elderly non-small cell lung cancer survivors decreased and did not return to prediagnosis levels after treatments were completed. The relationship between exercise and recurrence of cancer was not clear and needed further work.
The Expression Levels of Plasma micoRNAs in Atrial Fibrillation Patients
Zheng Liu, Cheng Zhou, Yuzhou Liu, Sihua Wang, Ping Ye, Xiaoping Miao, Jiahong Xia
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044906
Abstract: Background MicroRNA (miRNA) has been found in human blood. It has been increasingly suggested that miRNAs may serve as biomarkers for diseases. We examined the potential of circulating miRNA to serve as predictors of atrial fibrillation (AF). Methodology/Principal Findings During the discovery stage of this project, we used massively parallel signature sequencing (MPSS) to carry out an in-depth analysis of the miRNA expression profile (miRNome) in 5 healthy controls, 5 patients with paroxysmal atrial fibrillation (PAF) alone, and 5 patients with persistent atrial fibrillation (PersAF) alone. Twenty-two specific miRNAs were found to be dysregulated in each PAF group, PersAF group, or control group. Four candidate microRNAs (miRNA-146a, miRNA-150, miRNA-19a, and miRNA-375) met our selection criteria and were evaluated in an independent cohort of 90 plasma samples using TaqMan miRNA quantitative reverse transcriptase–polymerase chain reaction (qRT-PCR). We found miRNA-150 levels to be reduced by a factor of approximately 17 in PAF relative to controls and a factor of approximately 20 in PersAF relative to controls (P<.0001). Logistic regression analyses were carried out to evaluate the reduced miRNA-150 expression levels (odds ratio [OR] 1.96, 95% confidence interval [CI] 1.5 to 3.57, P<0.001), age (OR 1.1, 95% CI 1.36 to 2.73, P<0.001), and Left atrial diameter (LAD) (OR 1.5, 95% CI 1.36 to 1.8, P<0.001). Each was independently associated with AF. Much of the identified target genes related to AF were part of the inflammatory response system. We found that plasma levels of CRP were negatively correlated with the plasma levels of miRNA-150. Conclusions/Significance In summary, we firstly found that plasma miRNA-150 levels in from AF patients were substantially lower than that from healthy people. Circulating reduced miRNA-150 was significantly associated with AF.
Equilibrium dialysis study on the interaction between Cu(II) and HSA or BSA
Hong Liang,Bengang Xin,Xiujian Wang,Yuzhou Yuan,Yongqia Zhou,Panwen Shen
Chinese Science Bulletin , 1998, DOI: 10.1007/BF02883720
Abstract: The interaction of Cu(II) and human serum albumin (HSA) or bovine serum albumin (BSA) at physiological pH is studied by equilibrium dialysis. The successive stability constants are obtained by non-linear least square methods fitting Bjerrum formula. For both the Cu(II)-HSA and Cu(II)-BSA systems, the order of magnitude of K1 and K2 was found to be ≈104 mol 1· dm3. There are about twenty stoichiometry binding sites found in one HSA or BSA molecule. They can be divided into two or three sets. Results of equilibrium dialysis experiments suggest that there exists one strong metal binding site in both Cu(II)-HSA and Cu (II)-BSA. It is the imidazol group nitrogen atoms of His3 that are primarily concerned with copper binding site. After reaching dialysis equilibrium, there is the interaction among the different binding sites, the values ofK all deviate from the simple statistical effect except forK 1 and K2 in both Cu(II)-HSA and Cu(II)-BSA systems, and the positive cooperative effect is found.
STUDY OF PEAK-PEAK PRECISION INVERSION FOR REFLECTED WAVE TESTING CURVES OF SINGLE DEFECT PILES
单缺陷桩反射波法动测曲线峰-峰点反演的精度研究

Liu Dongjia,Liu Yuzhou,Wang Jieying,
刘东甲
,刘煜洲,王杰英

岩石力学与工程学报 , 2003,
Abstract: Based on theoretical calculation,physical interpretation and practical testing data,the precision of inversion of shaft defect locations by peak-peak reflected wave testing curves for single piles is studied. The results indicate that the precision mainly depends on the ratio of the defect length to the critical defect length defined in this paper when the wave velocity in the piles is accurate. If the ratio is more than or equal to 1,the inversion defect locations are close to the true ones. If the ratio is less than 1,the inversion depth of the upper defect surface is shallower,while that of the lower defect surface is deeper. The inversion defect length for piles with short defect becomes larger than real one because of the superimposition of upward tensile wave reflected by the upper surface and upward compressive wave reflected by the lower surface,and this is verified by practical testing data.
A Meta-Analysis Approach for Characterizing Pan-Cancer Mechanisms of Drug Sensitivity in Cell Lines
Kendric Wang, Raunak Shrestha, Alexander W. Wyatt, Anupama Reddy, Joseph Lehár, Yuzhou Wang, Anna Lapuk, Colin C. Collins
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0103050
Abstract: Understanding the heterogeneous drug response of cancer patients is essential to precision oncology. Pioneering genomic analyses of individual cancer subtypes have begun to identify key determinants of resistance, including up-regulation of multi-drug resistance (MDR) genes and mutational alterations of drug targets. However, these alterations are sufficient to explain only a minority of the population, and additional mechanisms of drug resistance or sensitivity are required to explain the remaining spectrum of patient responses to ultimately achieve the goal of precision oncology. We hypothesized that a pan-cancer analysis of in vitro drug sensitivities across numerous cancer lineages will improve the detection of statistical associations and yield more robust and, importantly, recurrent determinants of response. In this study, we developed a statistical framework based on the meta-analysis of expression profiles to identify pan-cancer markers and mechanisms of drug response. Using the Cancer Cell Line Encyclopaedia (CCLE), a large panel of several hundred cancer cell lines from numerous distinct lineages, we characterized both known and novel mechanisms of response to cytotoxic drugs including inhibitors of Topoisomerase 1 (TOP1; Topotecan, Irinotecan) and targeted therapies including inhibitors of histone deacetylases (HDAC; Panobinostat) and MAP/ERK kinases (MEK; PD-0325901, AZD6244). Notably, our analysis implicated reduced replication and transcriptional rates, as well as deficiency in DNA damage repair genes in resistance to TOP1 inhibitors. The constitutive activation of several signaling pathways including the interferon/STAT-1 pathway was implicated in resistance to the pan-HDAC inhibitor. Finally, a number of dysregulations upstream of MEK were identified as compensatory mechanisms of resistance to the MEK inhibitors. In comparison to alternative pan-cancer analysis strategies, our approach can better elucidate relevant drug response mechanisms. Moreover, the compendium of putative markers and mechanisms identified through our analysis can serve as a foundation for future studies into these drugs.
Environmental Modeling and Exposure Assessment of Sediment-Associated Pyrethroids in an Agricultural Watershed
Yuzhou Luo,Minghua Zhang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0015794
Abstract: Synthetic pyrethroid insecticides have generated public concerns due to their increasing use and potential effects on aquatic ecosystems. A modeling system was developed in this study for simulating the transport processes and associated sediment toxicity of pyrethroids at coupled field/watershed scales. The model was tested in the Orestimba Creek watershed, an agriculturally intensive area in California' Central Valley. Model predictions were satisfactory when compared with measured suspended solid concentration (R2 = 0.536), pyrethroid toxic unit (0.576), and cumulative mortality of Hyalella azteca (0.570). The results indicated that sediment toxicity in the study area was strongly related to the concentration of pyrethroids in bed sediment. Bifenthrin was identified as the dominant contributor to the sediment toxicity in recent years, accounting for 50–85% of predicted toxicity units. In addition, more than 90% of the variation on the annual maximum toxic unit of pyrethroids was attributed to precipitation and prior application of bifenthrin in the late irrigation season. As one of the first studies simulating the dynamics and spatial variability of pyrethroids in fields and instreams, the modeling results provided useful information on new policies to be considered with respect to pyrethroid regulation. This study suggested two potential measures to efficiently reduce sediment toxicity by pyrethroids in the study area: [1] limiting bifenthrin use immediately before rainfall season; and [2] implementing conservation practices to retain soil on cropland.
Two new species of genus Rhopalopsole (Insecta, Plecoptera, Leuctridae) from China
Qian Yuhan,Du Yuzhou
ZooKeys , 2011, DOI: 10.3897/zookeys.154.2234
Abstract: Two new species of Rhopalopsole Klapálek from China are described: R. exiguspina Du & Qian, sp. n. and R. ampulla Du & Qian, sp. n., which were collected in Guizhou province, China.
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