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Search Results: 1 - 10 of 127159 matches for " Yuxia Li "
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Two New Integrable Hierarchies and Their Nonlinear Integrable Couplings  [PDF]
Hui Chang, Yuxia Li
Journal of Applied Mathematics and Physics (JAMP) , 2018, DOI: 10.4236/jamp.2018.66113
Abstract: By introducing an invertible linear transform, a new Lie algebra G is obtained from the Lie algebra H. Making use of the compatibility conditions of the respective isospectral problems, a generalized NLS-MKdV hierarchy and a new integrable soliton hierarchy are achieved by using the trace identity or the variational identity. Then, two special non-semisimple Lie algebras \"\"?and \"\"?are explicitly conducted. As an application, the nonlinear continuous integrable couplings of the obtained integrable systems as well as their bi-Hamiltonian structures are established, respectively.
Nuclear Receptor Small Heterodimer Partner in Apoptosis Signaling and Liver Cancer
Yuxia Zhang,Li Wang
Cancers , 2011, DOI: 10.3390/cancers3010198
Abstract: Small heterodimer partner ( SHP, NR0B2) is a unique orphan nuclear receptor that contains the dimerization and a putative ligand-binding domain, but lacks the conserved DNA binding domain. SHP exerts its physiological function as an inhibitor of gene transcription through physical interaction with multiple nuclear receptors and transcriptional factors. SHP is a critical transcriptional regulator affecting diverse biological functions, including bile acid, cholesterol and lipid metabolism, glucose and energy homeostasis, and reproductive biology. Recently, we and others have demonstrated that SHP is an epigenetically regulated transcriptional repressor that suppresses the development of liver cancer. In this review, we summarize recent major findings regarding the role of SHP in cell proliferation, apoptosis, and DNA methylation, and discuss recent progress in understanding the function of SHP as a tumor suppressor in the development of liver cancer. Future study will be focused on identifying SHP associated novel pro-oncogenes and anti-oncogenes in liver cancer progression and applying the knowledge gained on SHP in liver cancer prevention, diagnosis and treatment.
Characterization of the Mitochondrial Localization of the Nuclear Receptor SHP and Regulation of Its Subcellular Distribution by Interaction with Bcl2 and HNF4α
Yuxia Zhang, Li Wang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0068491
Abstract: The nuclear receptor small heterodimer partner SHP was shown recently to translocate to the mitochondria, interact with Bcl2, and induce apoptosis in liver cancer cells. However, the exact mitochondrial localization of SHP remains to be determined. In addition, the detailed interaction domains between SHP and Bcl2 have not been characterized. Using biochemistry and molecular biology approaches, we demonstrate that SHP is localized to the mitochondrial outer membrane. Interestingly, compared with the full-length SHP, the N-terminal deleted protein exhibits increased expression in the mitochondria and decreased expression in the nucleus. GST pull-down assays demonstrate that the interaction domain of SHP shows the strongest interaction with Bcl2. Furthermore, the interaction of Bcl2 with SHP is completely abolished by deletion of the Bcl2 transmembrane domain (TM), whereas deletion of the Bcl2 BH1 domain enhances the interaction. As expected, AHPN, a synthetic SHP ligand, markedly augments the direct protein-protein interaction between Bcl2 and SHP. Ectopic expression of hepatocyte nuclear factor 4 alpha (HNF4α) results in exclusive nuclear translocation of SHP proteins that contain either the full-length or the N-terminal domain, but has a minimal effect on the subcellular distribution of SHP protein containing only the interaction domain or repression domain. These results indicate that the N-terminal domain of SHP is important for itsnuclear translocation via HNF4α. Overall, this study provides novel insights into the domains of SHP that are critical for its shutting between different subcellular compartments.
A Routing Protocol for Wireless Sensor Networks with Congestion Control  [PDF]
Qi Li, Zongwu Ke, Duanfeng Xia, Yuxia Sun
Communications and Network (CN) , 2013, DOI: 10.4236/cn.2013.53B2030
Abstract: This paper proposed a novel RED protocol which takes the node’s energy into account depending on the length of the data packet. It also proposed a routing protocol for wireless sensor networks with congestion control which imitates the ant colony foraging behavior. Sensor nodes choose routings according to the pheromone density. The experiment result shows that the algorithm balances the energy consumption of each node. It mitigated congestion effectively with the proposed routing protocol.
Arλ3(λ1,λ2,Ω)-Weighted Inequalities with Lipschitz and BMO Norms
Yuxia Tong,Juan Li,Jiantao Gu
Journal of Inequalities and Applications , 2010, DOI: 10.1155/2010/589040
Abstract: We first define a new kind of Arλ3(λ1,λ2,Ω) two-weight, then obtain some two-weight integral inequalities with Lipschitz norm and BMO norm for Green's operator applied to differential forms.
-Weighted Inequalities with Lipschitz and BMO Norms
Tong Yuxia,Li Juan,Gu Jiantao
Journal of Inequalities and Applications , 2010,
Abstract: We first define a new kind of two-weight, then obtain some two-weight integral inequalities with Lipschitz norm and BMO norm for Green's operator applied to differential forms.
Nonlinear Dynamics and Chaos in Fractional-Order Hopfield Neural Networks with Delay
Xia Huang,Zhen Wang,Yuxia Li
Advances in Mathematical Physics , 2013, DOI: 10.1155/2013/657245
Abstract: A fractional-order two-neuron Hopfield neural network with delay is proposed based on the classic well-known Hopfield neural networks, and further, the complex dynamical behaviors of such a network are investigated. A great variety of interesting dynamical phenomena, including single-periodic, multiple-periodic, and chaotic motions, are found to exist. The existence of chaotic attractors is verified by the bifurcation diagram and phase portraits as well. 1. Introduction Fractional calculus, which mainly deals with derivatives and integrals of arbitrary order, was firstly introduced 300 years ago. However, it is only in recent decades that fractional calculus is applied to physics and engineering [1–3]. The main advantage of fractional-order models in comparison with its integer-order counterparts is that fractional derivatives provide an excellent tool in the description of memory and hereditary properties of various processes. In fractional calculus, a generalized capacitor, called “fractance,” is often considered to be the main operator. It is actually an electrical circuit in which its voltage and current are related by the fractional-order differential equation [4]. Chaos theory has been extensively investigated in various fields of research after the first observation of chaotic attractors in Lorenz system. Recently, study on the complex dynamical behaviors of fractional-order systems has become a hot research topic due to the fact that fractional-order systems show higher nonlinearity and more degrees of freedom in the models, and therefore fractional-order chaotic systems are considered to have the potential ability of improving the security of chaotic communication systems [5]. It has been known that chaos in many well-known integer-order chaotic systems will remain when the orders become fractional, and a great number of fractional-order chaotic systems have been proposed as a consequence [6–14]. Moreover, chaotic behaviors have also been found to exist in some discontinuous systems with fractional derivatives [15]. However, it is worthwhile to note that none of the aforementioned fractional-order chaotic systems are time-delayed systems. On the other hand, the dynamics of delayed neural networks (DNNs) with traditional integer-order derivatives have been extensively studied both in theory and applications. [16–25]. It has been reported that DNNs can really display quite rich dynamical behaviors. For instance, Lu studied the complex dynamics of a DNN of Hopfield-type with two neurons and concluded that for a certain set of system parameters
Optimal Reciprocal Reinsurance under GlueVaR Distortion Risk Measures  [PDF]
Yuxia Huang, Chuancun Yin
Journal of Mathematical Finance (JMF) , 2019, DOI: 10.4236/jmf.2019.91002
Abstract: This article investigates the optimal reciprocal reinsurance strategies when the risk is measured by a general risk measure, namely the GlueVaR distortion risk measures, which can be expressed as a linear combination of two tail value at risk (TVaR) and one value at risk (VaR) risk measures. When we consider the reciprocal reinsurance, the linear combination of three risk measures can be difficult to deal with. In order to overcome difficulties, we give a new form of the GlueVaR distortion risk measures. This paper not only derives the necessary and sufficient condition that guarantees the optimality of marginal indemnification functions (MIF), but also obtains explicit solutions of the optimal reinsurance design. This method is easy to understand and can be simplified calculation. To further illustrate the applicability of our results, we give a numerical example.
Cross-Regulation of Protein Stability by p53 and Nuclear Receptor SHP
Zhihong Yang, Yuxia Zhang, Jongsook Kim Kemper, Li Wang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0039789
Abstract: We report here a novel interplay between tumor suppressor p53 and nuclear receptor SHP that controls p53 and SHP stability. Overexpression of p53 causes rapid SHP protein degradation, which does not require the presence of Mdm2 and is mediated by the proteosome pathway. Overexpressing SHP alone does not affect p53 stability. However, SHP destabilizes p53 by augmentation of Mdm2 ubiquitin ligase activity toward p53. The single amino acid substitution in the SHP protein SHPK170R increases SHP binding to p53 relative to SHP wild-type, whereas SHPG171A variant shows a diminished p53 binding. As a result of the cross-regulation, the tumor suppressor function of p53 and SHP in inhibition of colon cancer growth is compromised. Our findings reveal a unique scenario for a cross-inhibition between two tumor suppressors to keep their expression and function in check.
Zhili Li,Yuxia Pang,Hongming Lou,Xueqing Qiu
BioResources , 2009,
Abstract: Different molecular weight fractions of lignosulfonates (LS), LS having different cations, and modified LS with different degree of sulfonation and intrinsic viscosity were prepared and used as dispersants for Dimethomorph water-dispersible granules (DWG). The suspending ratio of DWG was tested to evaluate the effectiveness of LS as a dispersant. Moreover, the stability of DWG suspensions was measured by a new instrument (Turbiscan LabExpert). The suspending ratios of DWG having different molecular weight fraction of LS increased with increasing molecular weight in a suitable range. The kind of cation associated with the LS didn’t have an obvious influence the effectiveness of LS as a dispersant. Furthermore, the higher degree of sulfonation of LS, of which the intrinsic viscosity was similar, the better was its effectiveness as a dispersant. When the intrinsic viscosity increased within a suitable range, the effectiveness of LS as a dispersant increased. Similar findings were achieved by evaluating the stability of DWG suspensions with all the LS as dispersants, and larger molecular weight could decrease the growth of particle size.
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