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Histone H1/MBP hydrolysing antibodies - novel potential marker in diagnosis of disease severity in systematic lupus erythematosus patients  [PDF]
Valentyna Chopyak, Yaroslav Tolstiak, Iryna Magoryvska, Rostyslav Bilyy, Rostyslav Bilyy, Natalya Korniy, Yuriy Kit, Rostyslav Stoika
Health (Health) , 2010, DOI: 10.4236/health.2010.210177
Abstract: Recently we have shown the presence of catalytically active IgGs, capable to cleave histone H1 and bovine myelin basic protein (MBP), in blood serum of SLE patients. Here we present data that demonstrate the correlation between a) proteolytic activity towards histone H1 and MBP of IgG-antibodies from blood serum of SLE patients and b) disease severity level in these patients. IgGs were isolated from blood serum by chromatography on protein G-sepharose. Commercial preparations of bovine myelin basic proteins (MBP) and calf thymus histone H1 were used as substrates. Analysis of the proteolytic activity showed that 16 of 38 lgG-preparations (42,1%) obtained from blood serum of SLE patients were capable of cleaving both histone H1 and MBP with different efficiency. It was revealed that the presence in blood serum of lgGs possessing proteolytic activity towards both histone H1 and bMBP closely correlates with manifestation of the disease severity in SLE patients.
Influence of the temperature at the Black Sea ctenophores-aliens bioluminescence characteristics  [PDF]
Mashukova Olga, Tokarev Yuriy
Advances in Bioscience and Biotechnology (ABB) , 2012, DOI: 10.4236/abb.2012.33037
Abstract: Successful invasion of Mnemiopsis leidyi A. Agassiz, 1865 and Beroe ovata Mayer, 1912 into the Black Sea and their important role in this region pelagic ecosystem is stipulated mainly by the considerable eurythermy of these species. Many ecological-physiological characteristics of ctenophores—aliens are studied quite well. However, bioluminescence, one of the most important elements of the ctenophores ecology and the bioluminescence reaction temperature optimum for these individuals under different environment temperatures were not studied sufficiently. Therefore our researches in this scientific field are significant and conceptually novel for ctenophores ecology study. Experimental investigations were carried out in the period of 2008-2009 in the IBSS. Uni-sized (40 mm) ctenophores were collected in the Sevastopol coastal zone and divided in several groups, contained under different temperatures: from 10°C ± 1°C to 30°C ± 1°C. Ctenophore bioluminescence was investigated under chemical and mechanical stimulation. M. leidyi light emission maximal amplitude (1432.94 ± 71.64 × 108 quantum·s–1·cm–2) with duration of 3.54 ± 0.15 s is fixed under the temperature of 26°C ± 1°C. Temperature increase up to 30°C ± 1°C led to the 4 times decrease of the bioluminescence intensity. Under temperature decrease up to 10°C ± 1°C this parameter decreased 20 times (p < 0.05). Bioluminescence emission intensity characteristics of B. ovata achieved maximal values under the temperature of 22°C ± 1°C (1150.12 ± 57.51 × 108 quantum·s–1·cm–2) with duration of 3.03 ± 0.15 s. The luminescence intensity decreased under the temperature increase to 30°C ± 1°C more than 20 times. Temperature decrease to the values of 10°C ± 1°C impacted decreasing the amplitude of bioluminescence up to the minimal –4.92 ± 0.22 × 108 quantum·s–1·cm–2. The data obtained testify that characteristics of the ctenophores bioluminescence can be conditioned not only by the modification the environment temperature but by the variability of their physiological condition.
The Anisotropy of Cosmic Rays and the Global Anisotropy of Physical Space  [PDF]
Yuriy Alexeevich Baurov
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.311216
Abstract: The influence of a new anisotropic factor onto the mechanism of accelerating cosmic rays up to ultrahigh energies (CR UHE) due to a new global natural force with the anisotropic behavior is considered. The directions in the physical space along which CR UHE can arrive, are predicted. A brief comparative analysis of these directions together with the obtained experimental results is given. Their qualitative coincidences are shown.
Variability of the bioluminescence characteristics of the Black Sea ctenophores-aliens in connection with different conditions of nutrition  [PDF]
Mashukova Olga, Tokarev Yuriy
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.411128

Many ecological-physiological characteristics of ctenophores-aliensMnemiopsis leidyi A. Agassiz, 1865 and Beroe ovata Mayer, 1912 are studied quite well because they play a very important ecological role in the Black Sea ecosystem. However, bioluminescence, one of the most important elements of the ctenophores ecology and its connection with feeding regime were not studied sufficiently. Experiments have shown that characteristics of the ctenophores bioluminescence differed considerably in dependence of food supplies. Thus, amplitude and light-emitting energy of the fed ctenophores B. ovata are maximal, 3 times more than analogical indices of the just-caught individuals and 4 times more than ones of starving individuals. More prolonged flash signal (to 3.5 s), which exceeds light-emitting duration of the starving individuals twice, can be registered from the fed ctenophores. Investigation of the M. leidyi bioluminescence has shown that amplitude and light-emitting energy of the just-caught ctenophores were two times more than those of the starving individuals. At the same time, light-emitting amplitude of the fed individuals is 6.5 times and light-emitting energy is 3 - 4 times higher than that of the just-caught ctenophores. The light-emitting duration of the starving and justcaught organisms is practically the same. The most prolonged signal is registered from the fed ctenophores—up to 2.8 s. The data obtained testify that characteristics of the ctenophores bioluminescence can be conditioned not only by nutritional value but by the composition of the food as well.

Semi-Markovian Model of Two-Line Queuing System with Losses  [PDF]
Yuriy E. Obzherin
Intelligent Information Management (IIM) , 2016, DOI: 10.4236/iim.2016.82003
Abstract: In the present paper, to build model of two-line queuing system with losses GI/G/2/0, the approach introduced by V.S. Korolyuk and A.F. Turbin, is used. It is based on application of the theory of semi-Markov processes with arbitrary phase space of states. This approach allows us to omit some restrictions. The stationary characteristics of the system have been defined, assuming that the incoming flow of requests and their service times have distributions of general form. The particular cases of the system were considered. The used approach can be useful for modeling systems of various purposes.
Estimating the number of data clusters via the contrast statistic  [PDF]
Yuriy Lyakh, Vitaliy Gurianov, Oleg Gorshkov, Yuriy Vihovanets
Journal of Biomedical Science and Engineering (JBiSE) , 2012, DOI: 10.4236/jbise.2012.52012
Abstract: A new method (the Contrast statistic) for estimating the number of clusters in a set of data is proposed. The technique uses the output of self-organising map clustering algorithm, comparing the change in dependency of “Contrast” value upon clusters number to that expected under a uniform distribution. A simulation study shows that the Contrast statistic can be used successfully either, when variables describing the object in a multi-dimensional space are independent (ideal objects) or dependent (real biological objects).
Myorelaxation in the training process of skilled athletes  [PDF]
Yuriy P. Denisenko, Yuriy V. Vysochin, Leonid G. Yatsenko
Open Journal of Molecular and Integrative Physiology (OJMIP) , 2013, DOI: 10.4236/ojmip.2013.32013

At the present time, a number of various ways of sportspersons’ special physical capability (SPC) based mainly on training and competitive loadings ramp up. They are effective enough to reach the main goal, but none of them provides sportspersons’ health safety. Moreover, with the increase in volume and intensity of the loadings, which in sport have almost reached their limits, the sport traumatism and morbidity rate grow progressively. Proceeding from this, there was an evident necessity for the search of conceptually new ways for a simultaneous solution of these two the most complex and, in the opinion of many research workers, almost incompatible problems—the problem of achieving the highest levels of special physical working capacity, and the problem of sportspersons’ health maintenance and improving-associated by us into one general problem of human motor activity efficiency enhancement. Therefore it is necessary to physiologically substantiated the basic methods and principles of special relaxation training, directed on increase of efficiency of process of training of sportsmen at all stages of the development of athletic skills. Under the efficiency of the motor activity, we understand achieve the highest levels of the special physical performance while maintaining sports longevity and health of athletes.

On Optical Detection of Densely Labeled Synapses in Neuropil and Mapping Connectivity with Combinatorially Multiplexed Fluorescent Synaptic Markers
Yuriy Mishchenko
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0008853
Abstract: We propose a new method for mapping neural connectivity optically, by utilizing Cre/Lox system Brainbow to tag synapses of different neurons with random mixtures of different fluorophores, such as GFP, YFP, etc., and then detecting patterns of fluorophores at different synapses using light microscopy (LM). Such patterns will immediately report the pre- and post-synaptic cells at each synaptic connection, without tracing neural projections from individual synapses to corresponding cell bodies. We simulate fluorescence from a population of densely labeled synapses in a block of hippocampal neuropil, completely reconstructed from electron microscopy data, and show that high-end LM is able to detect such patterns with over 95% accuracy. We conclude, therefore, that with the described approach neural connectivity in macroscopically large neural circuits can be mapped with great accuracy, in scalable manner, using fast optical tools, and straightforward image processing. Relying on an electron microscopy dataset, we also derive and explicitly enumerate the conditions that should be met to allow synaptic connectivity studies with high-resolution optical tools.
Regular and chaotic motion of a bush-shaft system with tribological processes
Yuriy Pyryev
Mathematical Problems in Engineering , 2006,
Abstract: The methods of both analysis and modeling of contact bush-shaft systems exhibiting heat generation and wear due to friction are presented 3,4,5. From the mathematical point of view, the considered problem is reduced to the analysis of ordinary differential equations governing the change of velocities of the contacting bodies, and to the integral Volterra-type equation governing contact pressure behavior. In the case where tribological processes are neglected, thresholds of chaos are detected using bifurcation diagrams and Lyapunov exponents identification tools. In addition, analytical Mel'nikov's method is applied to predict chaos. It is shown, among the others, that tribological processes play a stabilizing role. The following theoretical background has been used in the analysis: perturbation methods, Mel'nikov's techniques 7,8, Laplace transformations, the theory of integral equations, and various variants of numerical analysis.
Yuriy Chynchenko
Proceedings of National Aviation University , 2011,
Abstract: . The article deals with the analysis of the researches conducted in field of the SESAR concept.Benefits of the concept, work packages and stakeholders of SESAR joint undertake have been reviewed.Principles of implementation and impact on air traffic services system have been analysed and generalsolutions appropriable for Ukraine have been proposed.
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