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Search Results: 1 - 10 of 42120 matches for " Yun Jung Lee "
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Perspective Projection Algorithm Enabling Mobile Device’s Indoor Positioning  [PDF]
Seo Woo Han, Yun Jung Lee, Ji Hyeok Yun, Chang Yong Han, Dae Ho Lee, Doug Young Suh
Journal of Computer and Communications (JCC) , 2018, DOI: 10.4236/jcc.2018.61017
Abstract:
In order to improve the user’s satisfaction with the augmented reality (AR) technology and the accuracy of the service, it is important to obtain the exact position of the user. Frequently used techniques for finding outdoors locations is the global positioning system (GPS), which is less accurate indoors. Therefore, an indoor position is measured by comparing the reception level about access point (AP) signal of wireless fidelity (Wi-Fi) or using bluetooth low energy (BLE) tags. However, Wi-Fi and Bluetooth require additional hardware installation. In this paper, the proposed method of estimating the user’s position uses an indoor image and indoor coordinate map without additional hardware installation. The indoor image has several feature points extracted from fixed objects. By matching the feature points with the feature points of the user image, we can obtain the position of the user on the Indoor map by obtaining six or more pixel coordinates from the user image and solving the solution using the perspective projection formula. The experimental results show that the user position can be obtained more accurately in the indoor environment by using only the software without additional hardware installation.
The Outcome of the Chemotherapy and Oncothermia for Far Advanced Adenocarcinoma of the Lung: Case Reports of Four Patients  [PDF]
Doo Yun Lee, Joon Seok Park, Hae Chul Jung, Eun Seol Byun, Seok Jin Haam, Sung Soo Lee
Advances in Lung Cancer (ALC) , 2015, DOI: 10.4236/alc.2015.41001
Abstract:

Lung cancer is one of the most aggressive and lethal form of cancers. Patients with far advanced lung cancer are treated by chemotherapy with or without radiotherapy. However, median survival of these patients is less than 6 months. To increase survival and quality of life for these patients, various forms of complementary treatments have been tried in clinical practices, and oncothermia is supposed to be one of the promising candidates. From May 2008 to November 2013, 4 patients with far advanced lung adenocarcinoma (stages IIIB and IV) were treated with oncothermia in addition to conventional chemotherapy at Gangnam Severance Hospital and Bundang CHA Hospital. All these patients have survived for more than 2 years.

Enhancement in Light Extraction Efficiency of GaN-Based Light-Emitting Diodes Using Double Dielectric Surface Passivation  [PDF]
Chung-Mo Yang, Dong-Seok Kim, Yun Soo Park, Jae-Hoon Lee, Yong Soo Lee, Jung-Hee Lee
Optics and Photonics Journal (OPJ) , 2012, DOI: 10.4236/opj.2012.23028
Abstract: SiO2Al2O3 double dielectric stack layer was deposited on the surface of the GaN-based light-emitting diode (LED). The double dielectric stack layer enhances both the electrical characteristics and the optical output power of the LED because the first Al2O3 layer plays a role of effectively passivating the p-GaN surface and the second lower index SiO2 layer increases the critical angle of the light emitted from the LED surface. In addition, the effect of the Fresnel reflection is also responsible for the enhancement in output power of the double dielectric passivated LED. The leakage current of the LED passivated with Al2O3 layer was -3.46 × 10-11 A at -5 V, at least two and three orders lower in magnitude compared to that passivated with SiO2 layer (-7.14 × 10-9 A) and that of non-passivated LED (-1.9 × 10-8 A), respectively, which indicates that the Al2O3 layer is very effective in passivating the exposed GaN surface after dry etch and hence reduces nonradiative recombination as well as reabsorption of the emitted light near the etched surface.
Macrophage PD-L1 strikes back: PD-1/PD-L1 interaction drives macrophages toward regulatory subsets  [PDF]
Yun-Jung Lee, Young-Hye Moon, Kyeong Eun Hyung, Jong-Sun Yoo, Mi Ji Lee, Ik Hee Lee, Byung Sung Go, Kwang Woo Hwang
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.48A3003
Abstract:

Activated macrophages have been simply de?ned as cells that secrete in?ammatory mediators and kill intracellular pathogens until few years ago. Recent studies have proposed a new classification system to separate activated macrophages based on their functional phenotypes: host defense, wound healing, and immune regulation. Regulatory macrophages can arise following innate or adaptive immune responses and hinder macrophage-mediated host defense and inflammatory functions by inhibiting the production of pro-inflammatory mediators. In this study, we investigated whether PD-1 and PD-L1 interaction between macrophages and T cells alters macrophage activities. Our data provide evidence for PD-1/PD-L1 engagement inducing a regulatory profile in macrophages. Regulatory macrophages derived from PD-L1 signaling lost their host defense activity, which consists of the production of pro-inflammatory cytokine IL-6 and the exhibition of increased IL-10, SPHK1 and LIGHT gene levels in early phases of LPS stimulation. This differentiation seems to occur through excessive activation of TLR4 downstream MAPK signaling pathways. Regulatory macrophages induced from PD-1/PD-L1 interaction decrease inflammatory mediators and produce anti-inflammatory cytokines, so this macrophage subset has been under considerable attention as a possible immune regulation mechanism. Understanding and modulating regulatory macrophages may lead to new approches to treat or prevent auto-immune diseases such as type I diabetes, rheumatic syndrome and hypersensitivity-related diseases, which are concerned with the overproduction of inflammatory cytokines in macroages.

Activation of AMP-Activated Protein Kinase and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells
Sung-Yun Cho,Hyo-Jeong Lee,Hyo-Jung Lee,Deok-Beom Jung
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/974313
Abstract:
Portulaca oleracea Ameliorates Diabetic Vascular Inflammation and Endothelial Dysfunction in db/db Mice
An Sook Lee,Yun Jung Lee,So Min Lee,Jung Joo Yoon,Jin Sook Kim,Dae Gill Kang,Ho Sub Lee
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/741824
Abstract: Type 2 diabetes is associated with significantly accelerated rates of micro- and macrovascular complications such as diabetic vascular inflammation and endothelial dysfunction. In the present study, we investigated the protective effect of the aqueous extract of Portulaca oleracea L. (AP), an edible plant used as a folk medicine, on diabetic vascular complications. The db/db mice were treated with AP (300 mg/kg/day, p.o.) for 10 weeks, and AP treatment markedly lowered blood glucose, plasma triglyceride, plasma level of LDL-cholesterol, and systolic blood pressure in diabetic db/db mice. Furthermore, AP significantly increased plasma level of HDL-cholesterol and insulin level. The impairment of ACh- and SNP-induced vascular relaxation of aortic rings were ameliorated by AP treatment in diabetic db/db mice. This study also showed that overexpression of VCAM-1, ICAM-1, E-selectin, MMP-2, and ET-1 were observed in aortic tissues of untreated db/db mice, which were significantly suppressed by treatment with AP. We also found that the insulin immunoreactivity of the pancreatic islets remarkably increased in AP treated db/db mice compared with untreated db/db mice. Taken together, AP suppresses hyperglycemia and diabetic vascular inflammation, and prevents the development of diabetic endothelial dysfunction for the development of diabetes and its vascular complications.
On the Stability of Generalized Additive Functional Inequalities in Banach Spaces
Jung Rye Lee,Choonkil Park,Dong Yun Shin
Journal of Inequalities and Applications , 2008, DOI: 10.1155/2008/210626
Abstract: We study the following generalized additive functional inequality ¢ € –af(x)+bf(y)+cf(z) ¢ € – ¢ ‰ ¤ ¢ € –f( ±x+ 2y+ 3z) ¢ € –, associated with linear mappings in Banach spaces. Moreover, we prove the Hyers-Ulam-Rassias stability of the above generalized additive functional inequality, associated with linear mappings in Banach spaces.
Laser Ultrasonic System for Surface Crack Visualization in Dissimilar Welds of Control Rod Drive Mechanism Assembly of Nuclear Power Plant
Yun-Shil Choi,Hyomi Jeong,Jung-Ryul Lee
Shock and Vibration , 2014, DOI: 10.1155/2014/296426
Abstract: In this paper, we propose a J-groove dissimilar weld crack visualization system based on ultrasonic propagation imaging (UPI) technology. A full-scale control rod drive mechanism (CRDM) assembly specimen was fabricated to verify the proposed system. An ultrasonic sensor was contacted at one point of the inner surface of the reactor vessel head part of the CRDM assembly. Q-switched laser beams were scanned to generate ultrasonic waves around the weld bead. The localization and sizing of the crack were possible by ultrasonic wave propagation imaging. Furthermore, ultrasonic spectral imaging unveiled frequency components of damage-induced waves, while wavelet-transformed ultrasonic propagation imaging enhanced damage visibility by generating a wave propagation video focused on the frequency component of the damage-induced waves. Dual-directional anomalous wave propagation imaging with adjacent wave subtraction was also developed to enhance the crack visibility regardless of crack orientation and wave propagation direction. In conclusion, the full-scale specimen test demonstrated that the multiple damage visualization tools are very effective in the visualization of J-groove dissimilar weld cracks. 1. Introduction Control rod drive mechanism (CRDM) assembly includes a reactor vessel head (RVH) and many penetration nozzles made of carbon steel and alloy 690, respectively, as shown in Figure 1(a). The two dissimilar metal parts, namely, the RVH and penetration nozzle, are coupled with welding as shown in the unit structure of the CRDM assembly in Figure 1(b). The inner surface of the RVH, which is in direct contact with the primary coolant, is covered with cladding to prevent any reaction between the carbon steel ingredient in the RVH and the boric ingredient in the coolant. During a nuclear power plant (NPP) operation period, thermal and pressure loadings are concentrated on the penetration nozzles and dissimilar metal welding, which are comparatively fragile spots. As the operation period of nuclear plants has increased, there has been an increase in the growth of primary water stress corrosion (PWSCC) on the welds of dissimilar metals or penetration nozzles by cyclic stress. As shown in Figure 2(a), these PWSCCs ultimately grow into surface cracks and become the path of primary water leakage. While the boric acid ingredient in the coolant not only accumulates on the outer surface of the reactor vessel as boric acid deposits, but it also creates a cavity by reacting with the carbon steel ingredient of the RVH, as shown in Figure 2(b) [1]. Practically,
Noninvasive Prenatal Testing for Fetal Chromosomal Abnormalities Using Massively Parallel Sequencing: Clinical Experience from 7910 Korean Pregnancies  [PDF]
Seon Young Yun, Hyuk Jung Kwon, Amit Goyal, Katiyar P. Shashank, Heesu Im, Joungsu Joo, Jin-Sik Bae, Min Seob Lee, Sunghoon Lee
Open Journal of Genetics (OJGen) , 2018, DOI: 10.4236/ojgen.2018.83005
Abstract: Objective: The purpose of this study is to review the clinical experience and performance of noninvasive prenatal testing (NIPT) method, using cell-free DNAto detect chromosomes 21, 18, 13, X, and Y abnormalities in over 7910 clinical samples from South Korean population. Method: Pregnant women between 1st of November 2015 to 18th of February 2018, with obstetric clinical findings participated in the study. NIPT was performed based on masivelly parallel sequencing with 0.3× low coverage paired-end sequencing using cell-free DNA in maternal plasma. Further invasive prenatal testing was recommended for pregnant women with positive NIPT results. Results: Of the total 7910 participants, 7890 (99.75%) were tested for NIPT and the remaining 20 (0.25%) were below the Quality Control (QC) standards. T13, T18, XXX, XXY and XYY had 100% of sensitivity, specificity, positive predictive values (PPV) and accuracy. The overall sensitivity was 100% and specificity, PPV and accuracy of all chromosomal abnormalities with further validation were 99.92%, 94.25%, and, 99.92% respectively. Conclusion: Our NIPT results showed high positive predictive value for the detection of autosomal trisomies and sex chromosome aneuploidies in
Anti-TNF-α Activity of Portulaca oleracea in Vascular Endothelial Cells
An Sook Lee,Jin Sook Kim,Yun Jung Lee,Dae Gill Kang,Ho Sub Lee
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13055628
Abstract: Vascular inflammation plays a key role in the pathogenesis and progression of atherosclerosis, a main complication of diabetes. The present study investigated whether an aqueous extract of Portulaca oleracea (AP) prevents the TNF-α-induced vascular inflammatory process in the human umbilical vein endothelial cell (HUVEC). The stimulation of TNF-α induced overexpression of adhesion molecules affects vascular cell adhesion molecule (VCAM)-1, intercellular adhesion molecule (ICAM)-1 and E-selectin for example. However, AP significantly suppressed TNF-α-induced over-expression of these adhesion molecules in a dose-dependent manner. In addition, pretreatment with AP dose-dependently reduced an increase of the adhesion of HL-60 cells to TNF-α-induced HUVEC. Furthermore, we observed that stimulation of TNF-α significantly increased intracellular reactive oxygen species (ROS) production. However, pretreatment with AP markedly blocked TNF-α-induced ROS production in a dose-dependent manner. The western blot and immunofluorescence analysis showed that AP inhibited the translocation of p65 NF-κB to the nucleus. In addition, AP suppressed the TNF-α-induced degradation of IκB-α and attenuated the TNF-α-induced NF-κB binding. AP also effectively reduced TNF-α-induced mRNA expressions of monocyte chemoattractant protein (MCP)-1 and interleukin (IL)-8 in a dose-dependent manner. Taken together, AP prevents the vascular inflammatory process through the inhibition of intracellular ROS production and NF-κB activation as well as the reduction of adhesion molecule expression in TNF-α-induced HUVEC. These results suggested that AP might have a potential therapeutic effect by inhibiting the vascular inflammation process in vascular diseases such as atherosclerosis.
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