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Search Results: 1 - 10 of 452 matches for " Yukiko Shimoda "
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Usefulness of Fractional Exhaled Nitric Oxide-Guided Treatment in Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap  [PDF]
Taisuke Akamatsu, Toshihiro Shirai, Yuko Tanaka, Hirofumi Watanabe, Yoshinari Endo, Yukiko Shimoda, Takahito Suzuki, Rie Noguchi, Mika Saigusa, Akito Yamamoto, Yuichiro Shishido, Takefumi Akita, Satoru Morita, Kazuhiro Asada
Open Journal of Respiratory Diseases (OJRD) , 2018, DOI: 10.4236/ojrd.2018.81001
Abstract:
Background: Some patients present clinical features of both asthma and chronic obstructive pulmonary disease (COPD), which has led to the recent proposal of asthma-COPD overlap (ACO) as a diagnosis. Fractional exhaled nitric oxide (FeNO) is a candidate biomarker to diagnose ACO. We assessed the effect of an add-on treatment with budesonide/formoterol (BUD/FM) combination in patients with ACO, which was diagnosed by FeNO. Methods: This was a prospective, single-arm, open-label, before and after comparison study. Subjects included 83 patients with COPD who attended outpatient clinics for routine checkups at Shizuoka General Hospital between June and November 2016. All patients fulfilled the GOLD definition of COPD and were receiving long-acting muscarinic antagonist (LAMA) or LAMA/long-acting β2 agonist (LABA) combinations. After an 8-week run-in period, BUD/FM was added to the patients with FeNO levels of ≥35 ppb, defined as having ACO. For patients receiving LAMA/LABA, BUD/FM was added after the discontinuation of LABA. The modified British Medical Research Council (mMRC) score, COPD assessment test (CAT) score, spirometric indices, forced oscillation parameters, and FeNO were assessed before and after 8 weeks of BUD/ FM add-on treatment. Results: Twenty-four patients (28.9%) had FeNO levels ≥ 35 ppb, and 17 patients completed the study (mean age: 73 years and GOLD I/II/III/IV, 5/10/1/1). The mean CAT scores significantly improved (9.2 to 5.4, p = 0.015) and 10 patients (58.8%) showed ≥2 points improvement, a minimal clinically important difference. The mean FeNO levels significantly decreased from 63.0 to 34.3 ppb (p < 0.006). However, there were no changes in mMRC scores, spirometric indices, or forced oscillation parameters. Conclusions: FeNO-guided treatment with BUD/FM improves symptoms in patients with ACO.
Consideration of the Construction Period of the Khmer Temples along the East Royal Road to Preah Khan of Kompong Svay and the Provenance of Sandstone Blocks Based on Their Magnetic Susceptibility  [PDF]
Etsuo Uchida, Ichita Shimoda, Mariko Shimoda
Archaeological Discovery (AD) , 2013, DOI: 10.4236/ad.2013.12004
Abstract: To the east of the Angkor monuments, there is a royal road that connects the Angkor area to provincial Khmer cities that include Beng Mealea and Preah Khan of Kompong Svay. Khmer buildings known as Temples d’étape and Fire Shrines are placed approximately every 15 km along this east royal road. In this paper, we investigate the magnetic susceptibility and other characteristics of the sandstone blocks used to construct these buildings in conjunction with their architectural characteristics. As a result, we reconfirmed that the Temples d’étape and Fire Shrines have been constructed during the early Angkor Wat pe- riod and the late Bayon period, respectively. In addition, it was revealed that most of the sandstone blocks used in these buildings along the east royal road were likely supplied from quarries at the southeastern foot of Mt. Kulen. However, we consider that the sandstone blocks used in the buildings of Preah Khan of Kompong Svay, except its central part, the Temple d’étape at Prasat Trapeang Chambok and the Fire Shrine at Prasat Supheap Tbong, were supplied from quarries surrounding Preah Khan of Kompong Svay.
The Advanced Hydraulic City Structure of the Royal City of Angkor Thom and Vicinity Revealed through a High-Resolution Red Relief Image Map  [PDF]
Shimoda Ichita, Haraguchi Tsuyoshi, Chiba Tatsuro, Shimoda Mariko
Archaeological Discovery (AD) , 2016, DOI: 10.4236/ad.2016.41003
Abstract: Numerical topographic data acquired through airborne laser scanning (LiDAR) performed at the Angkor Archaeological Park in Cambodia in April 2012 has revealed a large number of heretofore obscured water channels and ponds (Evans et al., 2013). Using this data, a high-resolution red relief image map (RRIM) was created of areas inside and outside the moated royal capital of Angkor Thom built during the latter half of the 12th century. The land around Angkor Thom is extensively covered by tropical jungle which has relatively well preserved the original urban structures and middle/post-Angkorian period modifications and renovations by escaping human-induced surface alteration except for the tourism-related infrastructure and renovations from the 20th century onward. The RRIM provided a new visualization method of localizing, minute topographical changes in regions with large undulations over a wide area. It has proved to be effective in mapping, on a single wide-area map, the numerous buried remains that exist as comparable height differences or minute undulations measuring less than 1 meter in height, and provides a unique aerial view of their widespread distribution. Based on the RRIM map, past archaeological studies were referenced to reconstruct the layout of the water channel network system. Past studies revealed that a large number of ponds had been dug inside Angkor Thom. The RRIM expanded the investigation and revealed the existence of many ponds outside the royal capital indicating that a residential community had flourished outside the moat-surrounded capital city. This paper was discussed the functional aspects of the water channel network and ponds that utilized the gentle gradient of the natural land to overcome the climatic induced environmental changes that were characterized by an extreme divide between the rainy and dry seasons.
Representations of Parenting and Gender Roles in the Shōshika Era: Comparisons of Japanese and English-Language Parenting Magazines
SHIMODA, Tomoko
Electronic Journal of Contemporary Japanese Studies , 2008,
Abstract: This article examines how Japanese parenting magazines portray parenting and gender roles in the shōshika era, an era of sustained decline in the Japanese birth-rate. Recent surveys indicate that Japanese society remains ambivalent about the need for fathers to be involved in child rearing. This article examines why these attitudes and ideas persist and how the Japanese media, specifically Japanese parenting magazines, may contribute to perpetuating traditional attitudes towards parenting roles. The article explores how parenting is represented in text and visual elements of contemporary popular parenting magazines, with comparisons made between the distinct approaches of selected Japanese and English-language parenting magazines. The findings indicate that narrow and stereotypical representations of mothers and fathers remain common in the Japanese parenting magazines. The findings also highlight the lack of visibility of the social context within which parenting occurs, with parenting represented as a largely individual-level experience. In contrast, the English-language parenting magazines depict a more diverse range of social issues of relevance to parenting, a more diverse range of family structures, and greater involvement of fathers in parenting compared to Japanese parenting magazines.
Assessment of Long-Term Compost Application on Physical, Chemical, and Biological Properties, as Well as Fertility, of Soil in a Field Subjected to Double Cropping  [PDF]
Yukiko Yanagi, Haruo Shindo
Agricultural Sciences (AS) , 2016, DOI: 10.4236/as.2016.71004
Abstract: The aim of this article was to assess the influence of long-term application of compost on the physical, chemical, and biological properties, as well as the fertility, of soil in a field subjected to double cropping (paddy rice and barley), mainly by integrating previous studies of the effects of compost and manure on soil qualities. Continuous compost application, especially at a high level (30 Mg·ha-1·y-1), into the double cropping soils increased the activities of organic C-, N-, and P-decomposing enzymes and the contents of organic C, total N, and microbial biomass N, as well as the cation exchange capacity, thereby contributing to the enhancement of soil fertility. Also, the compost application increased the degree of water-stable soil macroaggregation (>0.25 mm), which was correlated significantly (r > 0.950, p < 0.05) with the contents of hydrolyzable carbohydrates (with negative charge) and active Al (with positive charge), and resulted in the modification of soil physical properties. Furthermore, the application increased the amount of soil organic matter, including humic acid with a low degree of darkening and fulvic acid, and contributed to C sequestration and storage. Physical fractionation of soil indicated that about 60% of soil organic C was distributed in the silt-sized (2 - 20 μm) aggregate and clay-sized (<2 μm) aggregate fractions, while about 30% existed in the decayed plant fractions (53 - 2000 μm). The results obtained unambiguously indicate that long-term application of compost can improve soil qualities in the field subjected to double cropping, depending on the amount applied.
Successful endoscopic procedures for intraductal papillary neoplasm of the bile duct: A case report
Kohei Tsuchida, Michiko Yamagata, Yasuyuki Saifuku, Dan Ichikawa, Kazunari Kanke, Toshimitsu Murohisa, Masaya Tamano, Makoto Iijima, Yukiko Nemoto, Wataru Shimoda, Toshiaki Komori, Hirokazu Fukui, Kazuhito Ichikawa, Hitoshi Sugaya, Kazuhito Miyachi, Taka
World Journal of Gastroenterology , 2010,
Abstract: Attention has recently been focused on biliary papillary tumors as the novel disease entity intraductal papillary neoplasm of the bile duct (IPNB), which consists of papillary proliferation of dysplastic biliary epithelium. As even benign papillary tumors are considered as premalignant, some investigators recommend aggressive surgical therapy for IPNB, although no guidelines are available to manage this disease. Few reports have described long-term follow-up of patients with benign IPNB without radical resection. If patients with IPNB who are treated only with endoscopic procedures are noted, clinical profiles and alternative therapies other than resection may be recommended. We report the case of a patient who experienced repetitive cholangitis for 10 years and was finally diagnosed with IPNB. Radical resection could not be recommended because of the age of the patient, therefore, endoscopic sphincterotomy was performed. Although an endoscopic retrograde biliary drainage catheter was placed several times for repetitive cholangitis, the patient has done well during follow-up. Our case may offer insights into the natural course and management decisions for the novel disease entity of IPNB.
Bioremediation of Bisphenol A by Glycosylation with Immobilized Marine Microalga Amphidinium crassum
——Bioremediation of Bisphenol a by Immobilized Cells
 [PDF]

Kei Shimoda, Ryohei Yamamoto, Hiroki Hamada
Advances in Chemical Engineering and Science (ACES) , 2011, DOI: 10.4236/aces.2011.13015
Abstract: Glycosylation of bisphenol A, which is an endocrine disrupting chemical, was investigated using immobilized marine microalga and plant cells from the viewpoint of bioremediation of bisphenol A. Immobilized marine microalga of Amphidinium crassum glucosylated bisphenol A to the corresponding glucoside. On the other hand, bisphenol A was glycosylated to its glucoside, diglycoside, gentiobioside, and gentiobiosylglucoside, which was a new compound, by immobilized plant cells of Catharanthus roseus.
Synthesis of Capsaicin Oligosaccharides and Their Anti-Allergic Activity
——Synthesis of Capsaicin Oligosaccharides as Anti-Allergic Food-Additives
 [PDF]

Kei Shimoda, Naoji Kubota, Masaaki Akagi
Advances in Chemical Engineering and Science (ACES) , 2012, DOI: 10.4236/aces.2012.21006
Abstract: The production of β-maltooligosaccharides of capsaicin was investigated using Lactobacillus delbrueckii and cyclodextrin glucanotransferase (CGTase) as biocatalysts. The cells of L. delbrueckii glucosylated capsaicin to give its β-glucoside. The β-glucoside of capsaicin was converted into the corresponding β-maltoside and β-maltotrioside by CGTase. On the other hand, β-melibioside and β-isomaltoside of capsaicin, which were two new compounds, were synthesized by chemical glycosylation. The β-glucoside, β-maltoside, β-melibioside, and β-isomaltoside of capsaicin showed inhibitory effects on IgE antibody production.
Development of air conditioning technologies to reduce CO2 emissions in the commercial sector
Yukiko Yoshida
Carbon Balance and Management , 2006, DOI: 10.1186/1750-0680-1-12
Abstract: The Climate Change Research Hall (CCRH) of the National Institute for Environmental Studies (NIES) is used as a case study. CCRH was built in line with the "Green Government Buildings" program of the Government Buildings Department at the Ministry of Land, Infrastructure and Transport in Japan. We have assessed the technology used in this building, and found that there is a possibility to reduce energy consumption in the HVAC system by 30%.Saving energy reduces CO2 emissions in the commercial sector, although emission factors depend on the country or region. Consequently, energy savings potential may serve as a criterion in selecting HVAC technologies with respect to emission reduction targets.Heating, ventilating, air conditioning (HVAC) and lighting systems in buildings are a major source of carbon dioxide (CO2) emissions in the commercial sector. Reduction of this source is a common issue for Asian countries that share similar constraints in developing solutions [1,2].In Japan, a cooperative academic, industrial, and governmental project has been established to develop a new system called the Comprehensive Assessment System for Building Environmental Efficiency (CASBEE). It evaluates all forms of energy usage within buildings [3].The Climate Change Research Hall (CCRH: completed in 2001, ferroconcrete, three floors, 4900 m2 total floor space) at the National Institute for Environmental Studies in Japan was constructed according to the latest sustainable environment designs, including global warming abatement technology for buildings [4].Consumption of electricity for lighting, which is related to the interior heat generation load, changes little from season to season. This building is equipped with 32 W high-frequency fluorescent lights whose intensity is controlled to keep a constant brightness independent of the outdoor brightness. The automatic control of lighting was found to realize approximately 30% in annual energy savings compared to lighting with no auto
Assessment of the health of Americans: the average health-related quality of life and its inequality across individuals and groups
Yukiko Asada
Population Health Metrics , 2005, DOI: 10.1186/1478-7954-3-7
Abstract: This study uses the 1990 and 1995 National Health Interview Survey from the United States. The measure of HRQL is the Health and Activity Limitation Index (HALex). The measure of health inequality across individuals is the Gini coefficient. This study provides confidence intervals (CI) for the Gini coefficient by a bootstrap method. To describe health inequality by group, this study decomposes the overall Gini coefficient into the between-group, within-group, and overlap Gini coefficient using race (White, Black, and other) as an example. This study looks at how much contribution the overlap Gini coefficient makes to the overall Gini coefficient, in addition to the absolute mean differences between groups.The average HALex was the same in 1990 (0.87, 95% CI: 0.87, 0.88) and 1995 (0.87, 95% CI: 0.86, 0.87). The Gini coefficient for the HALex distribution across individuals was greater in 1995 (0.097, 95% CI: 0.096, 0.099) than 1990 (0.092, 95% CI: 0.091, 0.094). Differences in the average HALex between all racial groups were the same in 1995 as 1990. The contribution of the overlap to the overall Gini coefficient was greater in 1995 than in 1990 by 2.4%. In both years, inequality between racial groups accounted only for 4–5% of overall inequality.The average HRQL of Americans was the same in 1990 and 1995, but inequality in HRQL across individuals was greater in 1995 than 1990. Inequality in HRQL by race was smaller in 1995 than 1990 because race had smaller effect on the way health was distributed in 1995 than 1990. Analysis of the average HRQL and its inequality provides information on the health of a population invisible in the traditional analysis of population health.To assess the health of a population, we have traditionally relied on the average or overall level of health in a population. For example, 77.2 years of life expectancy for Americans in 2001 [1] or an infant mortality rate of 6.8 per 1,000 in the United States in 2001 [2] provide some information ab
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