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Search Results: 1 - 10 of 140359 matches for " Yukiko K Hayashi "
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Microwave assisted resonant domain wall nucleation in permalloy nanowires
Masamitsu Hayashi,Yukiko K. Takahashi,Seiji Mitani
Physics , 2012, DOI: 10.1063/1.4764053
Abstract: We have designed a system to study microwave assisted domain wall nucleation in permalloy nanowires. We find a substantial decrease in the nucleation field when microwave fields are applied, in comparison to pulse fields. A clear resonance peak is observed in the frequency dependence of the nucleation field, which coincides with the uniform mode ferromagnetic resonance frequency. Owing to the well-defined nucleation process, the switching field distribution is small in contrast to previous reports. Our results show that localized microwave field provides an efficient tool for injecting domain walls into magnetic nanowires.
Chromosome 4q;10q translocations; Comparison with different ethnic populations and FSHD patients
Tsuyoshi Matsumura, Kanako Goto, Gaku Yamanaka, Je Lee, Cheng Zhang, Yukiko K Hayashi, Kiichi Arahata
BMC Neurology , 2002, DOI: 10.1186/1471-2377-2-7
Abstract: To clarify the influence on the deletion of the repeats, we surveyed three different ethnic populations and FSHD patients using the BglII/BlnI dosage test.The frequency of translocation in 153 Japanese, 124 Korean, 114 Chinese healthy individuals and 56 Japanese 4q35-FSHD patients were 27.5%, 29.8%, 19.3%, and 32.1%, respectively. The ratio of '4 on 10' (trisomy and quatrosomy of chromosome 4) was higher than that of '10 on 4' (nullsomy and monosomy of chromosome 4) in all populations.The inter-chromosomal exchange was frequently observed in all four populations we examined, and no significant difference was observed between healthy and diseased groups.Facioscapulohumeral muscular dystrophy (FSHD) is a common form of muscular disorder with an autosomal dominant trait. FSHD is characterized by weakness and atrophy of facial, shoulder-girdle and humeral muscles, with occasional subsequent pelvic-girdle and lower limb involvement. More than 95% of patients with FSHD have a smaller (< 35 kb) EcoRI fragment on chromosome 4q35 detected by probe p13E-11 and are called 4q35-FSHD [1-3]. This EcoRI fragment in normal individuals contains tandem repeated 3.3-kb KpnI units (D4Z4) varying from 11 to 150 in number, while 4q35-FSHD patients showed less than ten units [2,3]. No responsible gene has been isolated within the FSHD gene region.Probe p13E-11 cross-hybridizes with chromosome 10q26, which contains highly homologous 3.3-kb KpnI repeated units. Since the BlnI restriction enzyme site exists exclusively within each unit derived from 10q26, but not in D4Z4 (an unit from 4q35), double enzyme digestion using EcoRI and BlnI can discriminate as 4q35 (BlnI-resistant) and 10q26 (BlnI-sensitive) units [4]. In a Dutch control population, subtelomeric translocations between chromosomes 4 and 10 were seen in about 20% of individuals [5-7]. Furthermore, somatic mosaicism was found in 40% of de novo FSHD families and 46% of these individuals had BlnI-resistant units on chromosome 10 [8].
Large amplitude microwave emission and reduced nonlinear phase noise in Co2Fe(Ge0.5Ga0.5) Heusler alloy based pseudo spin valve nanopillars
Jaivardhan Sinha,Masamitsu Hayashi,Yukiko K. Takahashi,Tomohiro Taniguchi,Maksim Drapeko,Seiji Mitani,Kazuhiro Hono
Physics , 2011, DOI: 10.1063/1.3647771
Abstract: We have studied microwave emission from a current-perpendicular-to-plane pseudo spin valve nanopillars with Heusler alloy Co2Fe(Ga0.5Ge0.5) electrodes. Large emission amplitude exceeding 150 nV/Hz^0.5, partly owing to the large magnetoresistance, and narrow generation linewidth below 10 MHz are observed. We also find that the linewidth shows significant dependence on the applied field magnitude and its angle within the film plane. A minimum in the linewidth is observed when the slope of the frequency versus current becomes near zero. This agrees with theoretical prediction that takes into account non-linear phase noise as a source for linewidth broadening.
Rimmed Vacuoles in Becker Muscular Dystrophy Have Similar Features with Inclusion Myopathies
Kazunari Momma, Satoru Noguchi, May Christine V. Malicdan, Yukiko K. Hayashi, Narihiro Minami, Keiko Kamakura, Ikuya Nonaka, Ichizo Nishino
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052002
Abstract: Rimmed vacuoles in myofibers are thought to be due to the accumulation of autophagic vacuoles, and can be characteristic in certain myopathies with protein inclusions in myofibers. In this study, we performed a detailed clinical, molecular, and pathological characterization of Becker muscular dystrophy patients who have rimmed vacuoles in muscles. Among 65 Becker muscular dystrophy patients, we identified 12 patients who have rimmed vacuoles and 11 patients who have deletions in exons 45–48 in DMD gene. All patients having rimmed vacuoles showed milder clinical features compared to those without rimmed vacuoles. Interestingly, the rimmed vacuoles in Becker muscular dystrophy muscles seem to represent autophagic vacuoles and are also associated with polyubiquitinated protein aggregates. These findings support the notion that rimmed vacuoles can appear in Becker muscular dystrophy, and may be related to the chronic changes in muscle pathology induced by certain mutations in the DMD gene.
Heme oxygenase-1 induction in the brain during lipopolysaccharide-induced acute inflammation
Shigeru Maeda,Ichiro Nakatsuka,Yukiko Hayashi,Hitoshi Higuchi
Neuropsychiatric Disease and Treatment , 2008,
Abstract: Shigeru Maeda1, Ichiro Nakatsuka1, Yukiko Hayashi1, Hitoshi Higuchi1, Masahiko Shimada2, Takuya Miyawaki11Department of Dental Anesthesiology, Okayama University Hospital, Okayama, Japan; 2Orofacial Pain Management, Department of Oral Restitution, Graduate School, Tokyo Medical and Dental University, Tokyo, JapanAbstract: Delirium occurs in 23% of sepsis patients, in which pro-inflammatory cytokines and nitric oxide are suggested to be involved. However, in animal experiments, even a subseptic dose of lipopolysaccharide (LPS) injection induces both pro-inflammatory cytokines and inducible nitric oxide synthase in the brain, suggesting that the brain oxidative reaction can be induced in the subseptic condition. Then, we evaluated the changes of heme oxygenase-1 (HO-1), a sensitive oxidative marker, as well as interleukin (IL)-1β, IL-6, and inductible nitric oxide synthase (iNOS) mRNA in the hypothalamus and hippocampus of rats using real-time PCR after peripheral injection of LPS (2.0 mg/kg). As a result, these four kinds of mRNAs were induced significantly in both areas after LPS injection. These results suggest that peripheral inflammation induces an oxidative reaction in the brain, even if the inflammation is not lethal. It is also considered that several pathways are involved in brain HO-1 induction.Keywords: heme oxygenase-1, interleukin-1β, interleukin-6, lipopolysaccharide, hypothalamus, hippocampus
Comparison between Hydroponically and Conventionally and Organically Grown Lettuces for Taste, Odor, Visual Quality and Texture: A Pilot Study  [PDF]
Matthew T. Murphy, Fannie Zhang, Yukiko K. Nakamura, Stanley T. Omaye
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.22017
Abstract: Hydroponic production of vegetables is becoming more common. In this study hydroponic lettuce, grown by a local distributor, and conventionally and organically field-grown lettuce, purchased at local retail stores were compared by descriptive analysis for taste, odor, visual quality and texture. Five lettuce varieties were compared; Romaine, Green Leaf, Red Leaf, Butter, and Common lettuce. A twenty-three member sensory panel randomly rated the lettuce using a 5 point scale or a 3 point scale for taste, odor, visual quality and texture. Analysis of variance (ANOVA) was performed for each lettuce variety with comparison between those hydroponically, organically or conventionally grown. Overall, panel members equally like the different lettuce samples. The results showed that for each of the five varieties of let-tuces, all lettuces were perceived to be equal in their sensory evaluation for locally grown hydroponic lettuce or pur-chased from local grocery outlets as organically or conventionally grown.
Lipophilic Compound-Mediated Gene Expression and Implication for Intervention in Reactive Oxygen Species (ROS)-Related Diseases: Mini-review
Yukiko K. Nakamura,Stanley T. Omaye
Nutrients , 2010, DOI: 10.3390/nu2070725
Abstract: In addition to exhibiting antioxidant properties, conjugated linoleic acid (CLA) and vitamin E may modulate gene expression of endogenous antioxidant enzymes. Depending on cellular microenvironments, such modulation reflects either antioxidant or prooxidant outcomes. Although epidemiological/experimental studies have indicated that CLA and vitamin E have health promoting properties, recent findings from clinical trials have been inconclusive. Discrepancies between the results found from prospective studies and recent clinical trials might be attributed to concentration-dependent cellular microenvironment alterations. We give a perspective of possible molecular mechanisms of actions of these lipophilic compounds and their implications for interventions of reactive oxygen species (ROS)-related diseases.
Metabolic diseases and pro- and prebiotics: Mechanistic insights
Yukiko K Nakamura, Stanley T Omaye
Nutrition & Metabolism , 2012, DOI: 10.1186/1743-7075-9-60
Abstract:
Association between a C8orf13–BLK Polymorphism and Polymyositis/Dermatomyositis in the Japanese Population: An Additive Effect with STAT4 on Disease Susceptibility
Tomoko Sugiura, Yasushi Kawaguchi, Kanako Goto, Yukiko Hayashi, Takahisa Gono, Takefumi Furuya, Ichizo Nishino, Hisashi Yamanaka
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0090019
Abstract: Background Accumulating evidence has shown that several non-HLA genes are involved in the susceptibility to polymyositis/dermatomyositis. This study aimed to investigate the involvement of C8orf13–BLK, one of the strongest candidate genes for autoimmune diseases, in susceptibility to polymyositis/dermatomyositis in the Japanese population. A possible gene–gene interaction between C8orf13–BLK and STAT4, which we recently showed to be associated with Japanese polymyositis/dermatomyositis, was also analyzed. Methods A single-nucleotide polymorphism in C8orf13–BLK (dbSNP ID: rs13277113) was investigated in the Japanese population using a TaqMan assay in 283 polymyositis patients, 194 dermatomyositis patients, and 656 control subjects. Results The C8orf13–BLK rs13277113A allele was associated with overall polymyositis/dermatomyositis (P<0.001, odds ratio [OR] 1.44, 95% confidence interval [CI] 1.19–1.73), as well as polymyositis (P = 0.011, OR 1.32, 95% CI 1.06–1.64) and dermatomyositis (P<0.001, OR 1.64, 95% CI 1.26–2.12). No association was observed between the C8orf13–BLK rs13277113A allele and either interstitial lung disease or anti-Jo-1 antibody positivity. The C8orf13–BLK rs13277113 A and STAT4 rs7574865 T alleles had an additive effect on polymyositis/dermatomyositis susceptibility. The strongest association was observed in dermatomyositis, with an OR of 3.07 (95% CI; 1.57–6.02) for the carriers of four risk alleles at the two SNP sites, namely, rs1327713 and rs7574865. Conclusions This study established C8orf13–BLK as a new genetic susceptibility factor for polymyositis/dermatomyositis. Both C8orf13–BLK and STAT4 exert additive effects on disease susceptibility. These observations suggested that C8orf13–BLK, in combination with STAT4, plays a pivotal role in creating genetic susceptibility to polymyositis/dermatomyositis in Japanese individuals.
Life Cycle Replacement by Gene Introduction under an Allee Effect in Periodical Cicadas
Yukiko Nariai,Saki Hayashi,Satoru Morita,Yoshitaka Umemura,Kei-ichi Tainaka,Teiji Sota,John R. Cooley,Jin Yoshimura
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018347
Abstract: Periodical cicadas (Magicicada spp.) in the USA are divided into three species groups (-decim, -cassini, -decula) of similar but distinct morphology and behavior. Each group contains at least one species with a 17-year life cycle and one with a 13-year cycle; each species is most closely related to one with the other cycle. One explanation for the apparent polyphyly of 13- and 17-year life cycles is that populations switch between the two cycles. Using a numerical model, we test the general feasibility of life cycle switching by the introduction of alleles for one cycle into populations of the other cycle. Our results suggest that fitness reductions at low population densities of mating individuals (the Allee effect) could play a role in life cycle switching. In our model, if the 13-year cycle is genetically dominant, a 17-year cycle population will switch to a 13-year cycle given the introduction of a few 13-year cycle alleles under a moderate Allee effect. We also show that under a weak Allee effect, different year-classes (“broods”) with 17-year life cycles can be generated. Remarkably, the outcomes of our models depend only on the dominance relationships of the cycle alleles, irrespective of any fitness advantages.
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