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Search Results: 1 - 10 of 1356 matches for " Yuji Nishiuchi "
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Short Hydration in Chemotherapy with Cisplatin plus S-1 for Advanced or Recurrent Gastric Cancer: A Retrospective Study  [PDF]
Akihito Tsuji, Yuji Negoro, Yoshihiro Okita, Masahito Kotaka, Takamasa Nishiuchi, Takeshi Kotake, Hironaga Satake, Yukimasa Hatachi
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.615137
Abstract: Background: Despite there are a few reports that assessed the S-1 + CDDP regimen with short hydration regimen for unresectable or metastatic gastric cancer, there is no consensus on the best regimen for short hydration. The aim of study was to evaluate the safety and the efficacy of S-1 plus cisplatin doublet chemotherapy with short hydration. Methods: S-1 was administered orally (p.o.) twice daily for the first 3 weeks of a 5-week cycle. Dose of S-1 administered was calculated according to the body surface area. CDDP was given as an intravenous (i.v.) infusion of 60 mg/m2 on day 8 of each cycle. Patients received the total of 1900 ml infusion containing 1000 ml of acetate Ringer’s solution as pre- and post-hydraion. 300 ml of 20% mannitol was administered as a diuretic. Results: 35 patients with unresectable or recurrent gastric cancer were enrolled. The reasons for termination of S-1 + CDDP were as follows: 21 (63.6%) by progressive disease; 12 (31.4%) by toxicity. Even though 12 of 35 patients (34.2%) were discontinued S-1 + CDDP chemotherapy, only one patient was discontinued by Grade 2 of increased creatinine. TTF (time to progression) was 174 days (3 - 586 days), and the median of the total number of treatment cycles of S-1 + CDDP was 3.31. Median overall survival, as secondary endpoint, was 518 days. Conclusions: Our study suggested that the short hydration regimen is as safe and efficient as the continuous hydration regimen.
Generation of novel cationic antimicrobial peptides from natural non-antimicrobial sequences by acid-amide substitution
Satoshi Ueno, Masaomi Minaba, Yuji Nishiuchi, Misako Taichi, Yasushi Tamada, Toshimasa Yamazaki, Yusuke Kato
Annals of Clinical Microbiology and Antimicrobials , 2011, DOI: 10.1186/1476-0711-10-11
Abstract: The pro-regions of nematode cecropin P1-P3 (P1P-P3P) were selected as parent sequences. P1P-P3P and their acid-amide-substituted mutants (NP1P-NP3P) were chemically synthesized. Bactericidal and membrane-disruptive activities of these peptides were evaluated. Conformational changes were estimated from far-ultraviolet circular dichroism (CD) spectra.NP1P-NP3P acquired potent bactericidal activities via membrane-disruption although P1P-P3P were not antimicrobial. Far-ultraviolet CD spectra of NP1P-NP3P were similar to those of their parent peptides P1P-P3P, suggesting that NP1P-NP3P acquire microbicidal activity without remarkable conformational changes. NP1P-NP3P killed bacteria in almost parallel fashion with their membrane-disruptive activities, suggesting that the mode of action of those peptides was membrane-disruption. Interestingly, membrane-disruptive activity of NP1P-NP3P were highly diversified against acidic liposomes, indicating that the acid-amide-substituted nematode cecropin pro-region was expected to be a unique and promising skeleton for novel synthetic CAMPs with diversified membrane-discriminative properties.The acid-amide substitution successfully generated some novel CAMPs in our trial study. These novel CAMPs were derived from natural non-antimicrobial sequences, and their sequences were completely distinct from any categories of known CAMPs, suggesting that such mutated natural sequences could be a promising source of novel skeletons of CAMPs.Cationic antimicrobial peptides (CAMPs) are well recognized to be promising as novel antimicrobial and antitumor agents. Natural CAMPs are structurally much diverse (e.g., linear cationic α-helical CAMPs, those enriched for specific amino acids, and those containing disulphide bonds and stable β-sheets) [1]. Because each category exhibits characteristic antimicrobial properties, numerous researchers have tried to identify novel skeletons of natural CAMPs from various organisms over the last two decades. Man
On the Generalization of Hilbert’s 17th Problem and Pythagorean Fields  [PDF]
Yuji Shimizuike
Advances in Pure Mathematics (APM) , 2013, DOI: 10.4236/apm.2013.37A001

The notion of preordering, which is a generalization of the notion of ordering, has been introduced by Serre. On the other hand, the notion of round quadratic forms has been introduced by Witt. Based on these ideas, it is here shown that 1) a field F is formally real n-pythagorean iff the nth radical, RnF is a preordering (Theorem 2), and 2) a field F is n-pythagorean iff for any n-fold Pfister form ρ. There exists an odd integer l(>1) such that l×ρ is a round quadratic form (Theorem 8). By considering upper bounds for the number of squares on Pfister’s interpretation, these results finally lead to the main result (Theorem 10) such that the generalization of pythagorean fields coincides with the generalization of Hilbert’s 17th Problem.

Observation of Environmental Stress Cracking in Polymethylmethacrylate by Using the Chemiluminescence Method  [PDF]
Yuji Higuchi
Materials Sciences and Applications (MSA) , 2015, DOI: 10.4236/msa.2015.611107
Abstract: Polymethylmethacrylate (PMMA) is highly regarded for its transparency, and is used in such products as cameras and Video Tape Recorders as plastic lenses to take advantage of its excellent optical properties. Also, it is used in numerous other industrial fields like automobile lamp lenses, billboards, and lighting equipment. The phenomenon of environmental stress cracking is known to occur in PMMA due to ethanol, and there are cases when this may become a factor which causes damage of molded products. In the present paper, upon close observation by using the method of chemiluminescence in order to elucidate the mechanism by which this environmental stress cracking occurs, we report that we are able to capture the formation of a radical at the moment of cracking.
The Change in Self-Esteem among Middle School Students in Japan, 1989-2002  [PDF]
Yuji Ogihara
Psychology (PSYCH) , 2016, DOI: 10.4236/psych.2016.711136
Abstract: This paper examined temporal changes in self-esteem among middle school students in Japan from 1989 to 2002. Previous research showed that self-esteem decreased among middle school students between 1999 and 2006. However, it was unclear whether such a decrease was also present in other periods of time. To obtain a better understanding of how people adapt to socio-economic environments, it is important to gain a more comprehensive view of such long-term cultural/social changes. Therefore, to supplement the findings of the existing research on changes in self-esteem, we analyzed large-sample time-series data collected in Japan in 1989 and 2002. We found that middle schoolers’ self-esteem decreased from 1989 to 2002, consistent with previous research. Thus, our study extends the previous research by presenting additional data showing the decrease in self-esteem in Japan.
Rheological Behavior of Nanosilica Suspensions in Poly(Ethylene Oxide) Solutions with Sodium Chloride  [PDF]
Yuji Hirose
Materials Sciences and Applications (MSA) , 2017, DOI: 10.4236/msa.2017.85022
Abstract: Suspensions of silica nanoparticles showed shear-thickening profiles under steady shear conditions up on addition of a small amount of poly(ethylene oxide) (PEO). The suspensions turned into gels upon shaking and their fluidity was recovered several minutes after resting. We studied the rheological properties of these shake gels with small amounts of sodium chloride (NaCl). Gelation occurred at lower shear rates upon addition of small amounts of NaCl. In addition, the time taken by the gelated samples to recover their original viscosity increased with the increasing NaCl content. The weakened repulsive interactions between the silica particles upon NaCl addition lead to particles in closer proximity, and three-dimensional networks of PEO chains are easily formed as the electric double layer of the particles becomes thinner.
Orbital Phase Theory and the Diastereoselectivity of Some Organic Reactions  [PDF]
Yuji Naruse
Journal of Materials Science and Chemical Engineering (MSCE) , 2018, DOI: 10.4236/msce.2018.67005
The orbital phase refers to the relationship between orbitals that originates from their wave character. We show here that the orbital phase essentially determines the diastereoselectivity of the following three organic reactions. 1) Torquoselectivity of the electrocyclicring-opening reaction of 3-substituted cyclobutenes; 2) Contradictory torquoselectivity of the retro-Nazarov reaction; 3) Diastereoselectivity in electrophilic addition to substituted ethylenes.
Cordyceps sinensis Acts As an Adenosine A3 Receptor Agonist on Mouse Melanoma and Lung Carcinoma Cells, and Human Fibrosarcoma and Colon Carcinoma Cells  [PDF]
Noriko Yoshikawa, Arisa Nishiuchi, Erika Kubo, Yu Yamaguchi, Masaru Kunitomo, Satomi Kagota, Kazumasa Shinozuka, Kazuki Nakamura
Pharmacology & Pharmacy (PP) , 2011, DOI: 10.4236/pp.2011.24034
Abstract: Cordyceps sinensis, a parasitic fungus on the larva of Lapidoptera, has been used as a traditional Chinese medicine. We previously reported that the growth of B16-BL6 mouse melanoma (B16-BL6) cells and mouse Lewis lung carcinoma (LLC) cells was inhibited by cordycepin (3’-deoxyadenosine), an ingredient of Cordyceps sinensis, and its effect was antagonized by MRS1191, a selective adenosine A3 receptor (A3-R) antagonist although adenosine (up to 100 μM) had no effect on the growth of B16-BL6 and LLC cells. In this study, we investigated whether water extracts of Cordyceps sinensis (WECS) inhibit the growth of B16-BL6 cells, LLC cells, HT1080 human fibrosarcoma (HT1080) cells and CW-2 human colon carcinoma (CW-2) cells via their A3-R. As a result, the growth of all cell lines were potently inhibited by WECS (10 μg/mL) and the inhibitory effect of WECS was significantly antagonized by MRS1191 (1 μM). Furthermore, WECS included 2.34% w/w cordycepin and 0.12% w/w adenosine as components according to the HPLC- ECD system. In conclusion, WECS inhibited the proliferation of four cancer cell lines by stimulation of A3-R and the main component in WECS with anticancer action might be cordycepin instead of adenosine.
The defense response in Arabidopsis thaliana against Fusarium sporotrichioides
Asano Tomoya,Kimura Makoto,Nishiuchi Takumi
Proteome Science , 2012, DOI: 10.1186/1477-5956-10-61
Abstract: Background Certain graminaceous plants such as Zea mays and Triticum aestivum serve as hosts for Fusarium sporotrichioides; however, molecular interactions between the host plants and F. sporotrichioides remain unknown. It is also not known whether any interaction between Arabidopsis thaliana and F. sporotrichioides can occur. To understand these interactions, we performed proteomic analysis. Results Arabidopsis leaves and flowers were inoculated with F. sporotrichioides. Accumulation of PLANT DEFENSIN1.2 (PDF1.2) and PATHOGENESIS RELATED1 (PR1) mRNA in Arabidopsis were increased by inoculation of F. sporotrichioides. Furthermore, mitogen-activated protein kinase 3 (MPK3) and mitogen-activated protein kinase 6 (MPK6), which represent MAP kinases in Arabidopsis, were activated by inoculation of F. sporotrichioides. Proteomic analysis revealed that some defense-related proteins were upregulated, while the expression of photosynthesis- and metabolism-related proteins was down regulated, by inoculation with F. sporotrichioides. We carried out the proteomic analysis about upregulated proteins by inoculation with Fusarium graminearum. The glutathione S-transferases (GSTs), such as GSTF4 and GSTF7 were upregulated, by inoculation with F. graminearum-infected Arabidopsis leaves. On the other hand, GSTF3 and GSTF9 were uniquely upregulated, by inoculation with F. sporotrichioides. Conclusions These results indicate that Arabidopsis is a host plant for F. sporotrichioides. We revealed that defense response of Arabidopsis is initiated by infection with F. sporotrichioides.
Vortex generation in the RSP game on the triangular lattice
Hiroyuki Nishiuchi,Naomichi Hatano,Kenn Kubo
Physics , 2008, DOI: 10.1016/j.physa.2007.10.032
Abstract: A new model of population dynamics on lattices is proposed. The model consists of players on lattice points, each of which plays the RSP game with neighboring players. Each player copies the next hand from the hand of the neighbouring player with the maximum point. The model exhibits a steady pattern with pairs of vortices and sinks on the triangular lattice. It is shown that the stationary vortex is due to the frustrations on the triangular lattice. A frustration is the three-sided situation where each of the three players around a triangle chooses the rock, the scissors and the paper, respectively.
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