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Search Results: 1 - 10 of 1810 matches for " Yuen KH "
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Cytoprotective and enhanced anti-inflammatory activities of liposomal piroxicam formulation in lipopolysaccharide-stimulated RAW 264.7 macrophages
Chiong HS, Yong YK, Ahmad Z, Sulaiman MR, Zakaria ZA, Yuen KH, Hakim MN
International Journal of Nanomedicine , 2013, DOI: http://dx.doi.org/10.2147/IJN.S42801
Abstract: oprotective and enhanced anti-inflammatory activities of liposomal piroxicam formulation in lipopolysaccharide-stimulated RAW 264.7 macrophages Original Research (256) Total Article Views Authors: Chiong HS, Yong YK, Ahmad Z, Sulaiman MR, Zakaria ZA, Yuen KH, Hakim MN Published Date March 2013 Volume 2013:8 Pages 1245 - 1255 DOI: http://dx.doi.org/10.2147/IJN.S42801 Received: 15 January 2013 Accepted: 07 February 2013 Published: 25 March 2013 Hoe Siong Chiong,1 Yoke Keong Yong,1 Zuraini Ahmad,1 Mohd Roslan Sulaiman,1 Zainul Amiruddin Zakaria,1 Kah Hay Yuen,2 Muhammad Nazrul Hakim1,3 1Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia; 2School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor, Malaysia; 3Sports Academy, Universiti Putra Malaysia, Serdang, Malaysia Background: Liposomal drug delivery systems, a promising lipid-based nanoparticle technology, have been known to play significant roles in improving the safety and efficacy of an encapsulated drug. Methods: Liposomes, prepared using an optimized proliposome method, were used in the present work to encapsulate piroxicam, a widely prescribed nonsteroidal anti-inflammatory drug. The cytotoxic effects as well as the in vitro efficacy in regulation of inflammatory responses by free-form piroxicam and liposome-encapsulated piroxicam were evaluated using a lipopolysaccharide-sensitive macrophage cell line, RAW 264.7. Results: Cells treated with liposome-encapsulated piroxicam demonstrated higher cell viabilities than those treated with free-form piroxicam. In addition, the liposomal piroxicam formulation resulted in statistically stronger inhibition of pro-inflammatory mediators (ie, nitric oxide, tumor necrosis factor-α, interleukin-1β, and prostaglandin E2) than piroxicam at an equivalent dose. The liposome-encapsulated piroxicam also caused statistically significant production of interleukin-10, an anti-inflammatory cytokine. Conclusion: This study affirms the potential of a liposomal piroxicam formulation in reducing cytotoxicity and enhancing anti-inflammatory responses in vitro.
Simulation of Dose Assessment for Special Environmental Radioactivity Distribution Using Monte Carlo Technique  [PDF]
Kh. Allam
Open Journal of Modelling and Simulation (OJMSi) , 2014, DOI: 10.4236/ojmsi.2014.23011
Abstract: Many researchers use the estimation method of exposure doses due to natural radioactivity adopted by UNSCEAR equation, which is based on an infinite plan source modeling. The results in most cases are acceptable within acceptable accuracy and error. However, in many cases, this approach cannot be applied e.g., for more complicated source geometry, composition, radioactivity distribution and so on. In previous situations, simulation and modeling are needed for exposure dose calculation to get more acceptable and accurate results. In the present work, modeling and recalculation of exposure dose rate are performed for an important previous published study about Hammam Pharaon. The study is selected because of its special physical characterization parameters and possible effects on Egyptian tourism. The effects of radionuclides distribution with soils and source composition, density, and geometry as recommended by NCRP 129 have been taken into consideration. The results for depth profile calculation show the conformation with the NCRP 129, which indicates a reduction in the free air exposure dose due to the fact that the above soil covered the active slab by 20% - 25% for 1 cm cover-up to 95% - 100% for 30 cm cover. In addition, the effect of density variation in dose rate is studied. A comparison with previous results has been performed.
A Qualitative Study of the Internal Audit Functions of Two Leading Gaming Corporations: Macau Evidence  [PDF]
Philip Law, Desmond Yuen
Open Journal of Accounting (OJAcct) , 2013, DOI: 10.4236/ojacct.2013.24016
Abstract: As the authors’ request, the paper \"A Qualitative Study of the Internal Audit Functions of Two Leading Gaming Corporations: Macau Evidence\" published in Vol.2, No.4, 110-114, 2013 has been withdrawn from the website.
Auditors’ Perceptions of Corporate Governance in Hong Kong  [PDF]
Philip Law, Desmond Yuen
Open Journal of Accounting (OJAcct) , 2018, DOI: 10.4236/ojacct.2018.71006
Corporate governance system plays an important role in the contemporary accounting and management literature. The purpose of this study is to examine the auditors’ perceptions on corporate governance in the Hong Kong market. 92 experienced professionals of Big 4 audit firm auditors are interviewed to summarize the ideas of how to maintain an efficient corporate governance system. Results of the study show that effective corporate governance should avoid family directors to dominate the board. Second, effective audit committee plays a crucial role in order to maintain sound corporate governance. The study would be advantageous for listed companies in HK to adopt a better corporate governance structure in the firm.
To the Question of Validity Grüneisen Solid State Equation  [PDF]
Vladimir Kh. Kozlovskiy
World Journal of Condensed Matter Physics (WJCMP) , 2012, DOI: 10.4236/wjcmp.2012.24038
Abstract: The first justified theory of solid state was proposed by Grüneisen in the year 1912 and was based on the virial theorem. The forces of interaction between two atoms were assumed as changing with distance between them according to inverse power laws. But only virial theorem is insufficient to deduce the equation of state, so this author has introduced some relations, which are correct, when the forces linearly depend on displacement of atoms. But with such law of interaction the phase transitions cannot take place. Debye received Grüneisen equation in another way. He deduced the expression for thermocapacity, using Plank formula for energy of harmonic vibrator. Taking into account the dependence of atomic vibration frequency from distance between atoms, when the forces of interaction are anharmonic, he received the equation of state, which in classical limit turns to Grüneisen equation. The question, formulated by Debye is—How can we come to phase transitions, when Plank formula for harmonic vibrator was used? Debye solved this question not perfectly, because he was born to small anharmonicity. In the presented work a chain of atoms is considered, and their movement is analysed by means of relations, equivalent to virial theorem and theorem of Lucas (disappearing of mean force). Both are the results of variation principle of Hamilton. The Grüneisen equation for low temperature (not very low, where quantum expression for energy is essential) was obtained, and a family of isotherms and isobars are drown, which show the existence of spinodals, where phase transitions occur. So, Grüneisen equation is an equation of state for low temperatures.
To Problem of the Rewinding of the Tape with Automatically Adjustable Influences  [PDF]
Muhsin Kh. Teshaev
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.515217
Abstract: In this work the problem of rewinding of a tape with constant speed is considered. Considering that drums represent bodies of variable weight, the equations of motion of system are formulated. Taking into account parametrical clearing of system of servo-constraints, the structure of force of reaction of servo-constraints which provides steady realization of servo-constraints (a constancy of linear speed of a tape) is defined. For realization of servo-constraints, it is offered to build digital watching system (DWS) and the full system of equations of DWS is formed. Laws of change of the operating influences, systems providing stability under the relation of the variety defined of servo-constraints are defined.
The Boguslawski Melting Model  [PDF]
Vladimir Kh. Kozlovskiy
World Journal of Condensed Matter Physics (WJCMP) , 2016, DOI: 10.4236/wjcmp.2016.61007
Abstract: The anharmonic vibrator, whose expression of potential energy contains second and third powers of coordinates, is treated on the basis of dynamical procedure, which presents the state of motion by means of mean position and mean amplitude of vibration. The divergent statistical integral comes here not into consideration. The free energy is represented through mean atomic displacement and developed in power series, retaining fourth degree. The graphs show that at certain temperature, the minimum in free energy disappears, and the atom escapes from the potential pit. A simple atomic model that represents this phenomenon is proposed and the influence of model dimension and pressure on melting temperature will be presented.
Oscillation Criteria of second Order Non-Linear Differential Equations  [PDF]
Hishyar Kh. Abdullah
Open Journal of Applied Sciences (OJAppS) , 2012, DOI: 10.4236/ojapps.2012.24B029
Abstract: In this paper we are concerned with the oscillation criteria of second order non-linear homogeneous differential equation. Example have been given to illustrate the results.
Dynamical Examinations of Vibrator Models, Describing Some Non Elastic Properties of Crystals  [PDF]
Vladimir Kh. Kozlovskiy
World Journal of Condensed Matter Physics (WJCMP) , 2017, DOI: 10.4236/wjcmp.2017.73007
Abstract: On the base of a vibrator atomic model the mechanical and thermal properties of the object are analyzed. The potential energy of the vibrator is represented by means of positive term with coordinate deflection in second power and negative term with deflection in fourth power. With the use of dynamical procedure of calculation, which permits to calculate mean deflection and root mean square amplitude of vibrations, the dependence of applied force from mean amplitude and temperature is calculated. This dependence shows a maximum (or minimum, when the direction of force is reversed), the height of which diminishes with rising temperature. When the force reaches the value of the maximum, the object does not elastic counteract to the force, and gliding begins. It is also considered a vibrator with positive term, containing the deflection in second power and a term, where the deflection treats in third power (Boguslawski vibrator). Exact calculations of the dependence of the force from the temperature in adiabatic process, where the entropy is maintained constant, shows that it is represented by means of a curve with a maximum, so that stretching leads to cooling till the point of maximum is reached.
Model of Cubic Cell for Description of Some Phase Transitions in Crystals  [PDF]
Vladimir Kh. Kozlovskiy
World Journal of Condensed Matter Physics (WJCMP) , 2018, DOI: 10.4236/wjcmp.2018.84011
Abstract: The purpose of the research is to develop a dynamical theory of phase transitions in crystalline structures, when except for temperature, the pressure is acting. So, the phase diagram temperature-pressure (dimensions) must be constructed. In general case, it is a complicated question, which can be solved for simple models of crystal, as three atomic models, introduced in the work of Frenkel [1]. In this model, three identical atoms are placed on the straight line and interact with the forces, which can be described by the expression, given in the article of Lennard-Jones [2]. Such simple model may have success, when the crystalline structure is simple, which consists of one type of atoms, for example: carbon. The model was generalized to cubic cell model with a moving atom in the inner part of the cell. The rigorous calculation of phase diagram for transition graphite-diamond shows some similarity with results of numerous experimental investigations (which are not discussed here). So, the way of phase diagram calculation may attract attention.
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