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Search Results: 1 - 10 of 110940 matches for " Yue Zhang "
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A Mapping Method of Using the Compound Use Cases to Generate User Interface  [PDF]
Bingbing Xia, Yue Zhang
Open Journal of Applied Sciences (OJAppS) , 2012, DOI: 10.4236/ojapps.2012.23026
Abstract: To support the requirement analysis of the user interfaces and the auto generation of the final user interfaces, we should improve the traditional modeling method which centered on the system and the implementation, and turn to use the modeling method which centered on the usage and the user. The compound use cases describe the system function from the user point of view. Based on the compound use cases, we can generate the final user interfaces.
ETS-FUSions Networking, Triggering and Beyond
Yue Zhang
Genetics & Epigenetics , 2012, DOI: 10.4137/GEG.S4166
Abstract: Gene fusion is a hallmark of cancer development with the mechanisms underlying their genesis emerging. The Staege and Max paper together with another recent paper have provided a comprehensive first view on current TET-ETS translocation studies. This significance, the trigering of gene fusion and beyond will be discussed in this article.
Biology of the Mi-2/NuRD Complex in SLAC (Stemness, Longevity/Ageing, and Cancer)
Yue Zhang
Gene Regulation and Systems Biology , 2012, DOI: 10.4137/GRSB.S6510
Abstract: The dynamic chromatin activities of Mi-2/Nucleosome Remodeling and Histone deacetylation (Mi-2/NuRD) complexes in mammals are at the basis of current research on stemness, longevity/ageing, and cancer (4-2-1/SLAC), and have been widely studied over the past decade in mammals and the elegant model organism, Caenorhabditis elegans. Interestingly, a common emergent theme from these studies is that of distinct coregulator-recruited Mi-2/NuRD complexes largely orchestrating the 4-2-1/SLAC within a unique paradigm by maintaining genome stability via DNA repair and controlling three types of transcriptional programs in concert in a number of cellular, tissue, and organism contexts. Thus, the core Mi-2/NuRD complex plays a central role in 4-2-1/SLAC. The plasticity and robustness of 4-2-1/SLAC can be interpreted as modulation of specific coregulator(s) within cell-specific, tissue-specific, stage-specific, or organism-specific niches during stress induction, ie, a functional module and its networking, thereby conferring differential responses to different environmental cues. According to “Occam’s razor”, a simple theory is preferable to a complex one, so this simplified notion might be useful for exploring 4-2-1/SLAC with a holistic view. This thought could also be valuable in forming strategies for future research, and could open up avenues for cancer prevention and antiageing strategies.
Biology of the Mi-2/NuRD Complex in SLAC (Stemness, Longevity/Ageing, and Cancer)
Yue Zhang
Gene Regulation and Systems Biology , 2011,
Abstract:
ETS-FUSions Networking, Triggering and Beyond
Yue Zhang
Genetics & Epigenetics , 2010,
Abstract:
Effect of Kangxianling Decoction on expression of hepatocyte growth factor mRNA and phosphorylations of extracellular signal-regulated protein kinase 1/2 and p38 in renal tissue of rats with unilateral ureteral obstruction
Yue ZHANG
Zhong Xi Yi Jie He Xue Bao , 2007,
Abstract: Objective: To study the effect of Kangxianling Decoction (KXLD), a compound traditional Chinese herbal medicine, on expression of hepatocyte growth factor (HGF) mRNA and phosphorylations of extracellular signal-regulated protein kinase 1/2 (ERK 1/2) and p38 in renal tissue of rats with unilateral ureteral obstruction (UUO).Methods: Eighteen male SD rats were randomly divided into 3 groups: sham-operated group, untreated group and KXLD-treated group. A rat model of renal interstitial fibrosis was established by UUO. Rats with UUO were sacrificed after intragastric administration of KXLD for 14 days, and the parameters such as serum creatinine (SCr), blood urea nitrogen (BUN) and hydroxyproline in the kidney of rats in 3 groups were analyzed. The expression of HGF mRNA in kidney tissue was determined by reverse transcription polymerase chain reaction. The expressions of c-Met protein, ERK1/2 protein, p38 protein and the phosphorylations of ERK1/2 and p38 were determined by Western blotting method.Results: The levels of SCr, BUN and hydroxyproline in the untreated group were significantly increased as compared with those in the sham-operated group (P<0.05). The expression of HGF mRNA in the untreated group was significantly down-regulated. The expression of c-Met protein and the phosphorylations of ERK1/2 and p38 in the kidney tissue of rats with UUO in the untreated group were significantly up-regulated. After intervention with KXLD, the phosphorylations of ERK1/2 and p38 were all significantly inhibited except for c-Met expression. The HGF mRNA was increased in KXLD-treated group.Conclusion: KXLD can decrease the level of collagen in the obstructed kidney of rats with UUO and alleviate the renal interstitial fibrosis in rats with UUO through enhancing the HGF mRNA expression and inhibiting the phosphorylations of ERK1/2 and p38.
Rough Set Soft Computing Cancer Classification and Network: One Stone, Two Birds
Yue Zhang
Cancer Informatics , 2010,
Abstract: Gene expression profiling provides tremendous information to help unravel the complexity of cancer. The selection of the most informative genes from huge noise for cancer classification has taken centre stage, along with predicting the function of such identified genes and the construction of direct gene regulatory networks at different system levels with a tuneable parameter. A new study by Wang and Gotoh described a novel Variable Precision Rough Sets-rooted robust soft computing method to successfully address these problems and has yielded some new insights. The significance of this progress and its perspectives will be discussed in this article.
Top Quark Mediated Dark Matter
Yue Zhang
Physics , 2012, DOI: 10.1016/j.physletb.2013.01.063
Abstract: We study the top quark portal dominated dark matter interactions, and its implications for the gamma ray line searches. In this picture, the dark matter interactions with photons and gluons are loop induced by the axial anomaly of the top quark current. We show there can be a natural suppression of the tree-level annihilation of dark matter, and the photon channel in turn has a substantial rate when the main annihilation proceeds into gluons. We observe a competition between the indirect detection of gamma ray line and the search with monojet plus missing energy events at LHC, and the 7 TeV data already set an upper bound of ~ 10^{-28} cm^3/s on the photonic annihilation cross section. This upper limit is compatible with a thermal WIMP scenario.
Supernova Cooling in a Dark Matter Smog
Yue Zhang
Physics , 2014, DOI: 10.1088/1475-7516/2014/11/042
Abstract: A light hidden gauge boson with kinetic mixing with the usual photon is a popular setup in theories of dark matter. The supernova cooling via radiating the hidden boson is known to put an important constraint on the mixing. I consider the possible role dark matter, which under reasonable assumptions naturally exists inside supernova, can play in the cooling picture. Because the interaction between the hidden gauge boson and DM is likely unsuppressed, even a small number of dark matter compared to protons inside the supernova could dramatically shorten the free streaming length of the hidden boson. A picture of a dark matter "smog" inside the supernova, which substantially relaxes the cooling constraint, is discussed in detail.
Simulation Experiments and Kinetics for the Formation of Organic Sulfide in Marine Carbonate Reservoirs  [PDF]
Changtao Yue, Shuyuan Li, Yonghan Zhang
Open Journal of Geology (OJG) , 2012, DOI: 10.4236/ojg.2012.22007
Abstract: Thermal simulation experiments on the system of gasoline and magnesium sulfate were carried out using an autoclave operating at high temperature and high pressure in the presence of water. Properties of the gas-oil-solid 3-phase products were analyzed by some advanced analytical methods including gas chromatography, microcoulometry, capillary gas chromatography in combination with a pulsed flame photometric detector, FT-IR and X-ray diffraction. The results showed that the reaction could proceed at 450℃ - 550℃ to produce MgO, S, C, H2S, CO2 and a series of organic sulfides such as mercaptans, sulfoethers and thiophenes as the main products. According to the reaction kinetics, the calculated activation energy of the reaction is 68.9 kJ·mol-1.
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