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Search Results: 1 - 10 of 51116 matches for " Yuan-Peng Xia "
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The Efficacy and Adverse Reaction of Bleeding of Clopidogrel plus Aspirin as Compared to Aspirin Alone after Stroke or TIA: A Systematic Review
Yan Huang, Man Li, Jian-Yong Li, Min Li, Yuan-Peng Xia, Ling Mao, Bo Hu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065754
Abstract: Background and Purpose Given the high risk of stroke after TIA (transient ischemia attack) or stroke and the adverse reaction of bleeding of antiplatelets, we undertook a meta-analysis, reviewed randomized controlled trials (RCTs) comparing aspirin plus clopidogrel with aspirin alone to determine the efficacy and adverse reaction of bleeding of the two protocols in the prevention of stroke. Methods We analyzed the incidences of stroke, bleeding and severe bleeding by using fixed-effect model or random-effect model on the basis of the result of heterogeneity test. Results Five qualified RCTs satisfied the inclusion criteria. We found that treatment with aspirin plus clopidogrel was associated with lower incidence of stroke (Risk Ratio (RR), 0.66, 95% confidence interval (CI), 0.47 to 0.93), higher incidence of bleeding (RR, 1.75, 95% CI, 1.48 to 2.05) as compared with aspirin-alone treatment. In terms of severe bleeding, no statistical difference existed between them (RR, 2.21, 95% CI, 0.25 to 19.52). Conclusion The combined use of aspirin and clopidogrel is more effective than aspirin alone for patients with previous TIA or stroke for the prevention of stroke, with risk of bleeding being higher. No statistical difference was found in severe bleeding between the two treatment protocols.
Recombinant Human Sonic Hedgehog Protein Regulates the Expression of ZO-1 and Occludin by Activating Angiopoietin-1 in Stroke Damage
Yuan-peng Xia, Quan-wei He, Ya-nan Li, Sheng-cai Chen, Ming Huang, Yong Wang, Yuan Gao, Yan Huang, Meng-die Wang, Ling Mao, Bo Hu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0068891
Abstract: This study examines the regulating effect of Sonic Hedgehog (Shh) on the permeability of the blood-brain barrier (BBB) in cerebral ischemia. By employing permanent middle cerebral artery occlusion (pMCAO) model, we find that Shh significantly decreases brain edema and preserves BBB permeability. Moreover, Shh increases zonula occludens-1 (ZO-1), occludin and angiopiotetin-1 (Ang-1) expression in the ischemic penumbra. Blockage of Shh with cyclopamine abolishes the effects of Shh on brain edema, BBB permeability and ZO-1, occludin, Ang-1 expression. Primary brain microvessel endothelial cells (BMECs) and astrocytes were pre-treated with Shh, cyclopamine, Ang-1-neutralizing antibody, and subjected to oxygen-glucose deprivation (OGD). Results show that the Ang-1 protein level in the culture medium of Shh-treated astrocytes is significantly higher. Shh also increased ZO-1, occludin and Ang-1 expression in BMECs, while cyclopamine and Ang-1-neutralizing antibody inhibited the effects of Shh on the ZO-1 and occludin expression, respectively. This study suggests that, under ischemic insults, Shh triggers Ang-1 production predominantly in astrocytes, and the secreted Ang-1 acts on BMECs, thereby upregulating ZO-1 and occludin to repair the tight junction and ameliorate the brain edema and BBB leakage.
Physiological and biochemical responses of different scion/rootstock combinations grapevine to partial rootzone drought.

QI Wei,LI En-mao,ZHAI Heng,WANG Xiao-fang,DU Yuan-peng,

应用生态学报 , 2008,
Abstract: By using self-made wooden boxes with two separated zones,the grapevine Vitis vinifera cv.Malvasia(M) grafted on rootstocks 3309C,420A and 110R,respectively,was planted,and the physiological and biochemical responses of these scion/rootstock combinations to bilateral alternative irrigation(AI) and unilateral irrigation(UI) were studied.The results showed that in treatments AI and UI,the average leaf ABA content of test scion/rootstock combinations increased by 267.5% and 394.7%,respectively,while stomatal conduction and transpiration decreased markedly.In treatment UI,the leaf SOD and CAT activities and Pro content were notably enhanced,with the greatest increment in M/110R and followed by in M/420A and M/3309C;while in treatment AI,the leaf SOD and CAT activities of test scion/rootstock combinations enhanced slightly and Pro content increased markedly.UI induced a remarkable increase of leaf relative electronic conductivity and MDA and H2O2 contents,with the highest increment in M/3309C and the lowest in M/110R.In summary,the drought resistance of different scion/rootstock combinations grapevine mainly depended on the variety of rootstock.110R had a higher drought-resistance than 420A and 3309C.Comparing with unilateral irrigation,bilateral alternative irrigation had lesser damage to grapevine,being a profitable water-saving irrigation technique.
Progress in Materials Used for Solidly Mounted Film Bulk Acoustic Resonators
LIU Gang, ZHU Jia-Qi, WANG Sai, LU Xiao-Xin, LIU Yuan-Peng, HUO Shi-Yu, YUAN Xin-Wei
无机材料学报 , 2010, DOI: 10.3724/sp.j.1077.2010.01233
Abstract: Solidly mounted film bulk acoustic resonator (SMR-FBAR) is a breakthrough technology being developed recently in the field of electronics industry and has many excellent features, such as operation frequency of above 2 GHz, ultra-high Q factor and durable mechanical property, etc. The unique features of the SMR-FBAR make it not only be a hot spot in labs, but also attractive in particular applications. For instance, SMR-FBAR can be used to create the essential frequency shaping elements found in the third generation of wireless communication systems, including filters, duplexers, and oscillators. Materials are the key element in devices and their quality plays a critical role in determining the resonance characteristics of these acoustic resonators. In this paper, with the clue of the structure of device, the recent developments of materials used for solidly mounted film bulk acoustic resonators are reviewed, including piezoelectric films (AlN, ZnO, etc), high/low acoustic impedance materials and electrode films. The relationship between material properties and device performance is also discussed. Finally, the potential development direction on the investigation of materials used for solidly mounted film bulk acoustic resonators is prospected.
Polymorphism in 5' Regulatory Region of the Porcine Fat Mass and Obesity Associated (FTO) Gene is Associated with Intramuscular Fat Content in a Jinhua x Pietrain F2 Reference Population
Zhang Li-Fan,Miao Xiu-Ting,Hua Xu-Chuan,Jiang Xiao-Ling,Lu Yuan-Peng,Xu Ning-Ying
Journal of Animal and Veterinary Advances , 2012,
Abstract: As a newly described candidate gene in obesity, FTO gene showed a strong and highly significant association with the obesity-related traits in various human populations. It has been suggested that FTO gene play a key role in the regulation of energy balance and feed intake. Here we sequenced the -2.0 kb of the 5' flanking region of the porcine FTO gene, 7 SNPs were detected in this region and genotyped on the Jinhua x Pietrain F2 reference population. Using a gene-wide haplotype-tagging approach, three tag SNPs were examined. The SNPs of g -1191 A>G had significant associations with Intramuscular Fat (IMF) content (p<0.05), but not with the Average Backfat Thickness (ABF), Leaf Fat weight (LF) or Average Daily Gain (ADG). Additionally, allele frequencies of the g -1191A>G mutation were studied in 6 pig breeds and the G allele was mainly occurred in Chinese native pig breeds. These results provided the solid evidence that FTO gene was associated with the intramuscular fat deposition in pigs.
Study on phytoremediation with H2O2 pretreatment in heavy metal contaminated soils

YANG Qiang,LIN Qi,WANG Zhao-wei,WANG Yuan-peng,

浙江大学学报(农业与生命科学版) , 2005,
Abstract: Effect of hydrogen peroxide on the solubilization and rhizospheric dynamics of heavy metals in contaminated soils was studied. The results showed that water soluble Cu and Zn increased significantly after being treated with H_2O_2, which indicatd that H_2O_2 is a safe and efficient reagent to be used in enhancing the availability of heavy metals in soil. Addition of Fe~2+ decreased the water soluble Cu and Zn. The more was Fe~~2+ added, the less was the water soluble Cu and Zn. Planting ryegrass in the contaminated soil pretreated with hydrogen peroxide led to further increase of water soluble Cu and Zn present. And it was more effective of hydrogen peroxide in releasing Cu into soil solution than Zn. The fractionation of heavy metals was similarly distributed among soils. But hydrogen peroxide pretreatment distinctively increased the copper in the soluble plus exchangeable fraction (SE-Cu) in the planted soil, which indicated that binding strength of heavy metals in soil was weakened after the soil was treated with hydrogen peroxide, and was liable to be mobilized by the influence of the rhizosphere of ryegrass. Besides, the increase of copper and zinc levels in the weekly and specifically adsorbed fraction (WSA-Cu, WSA-Zn) and decrease of residual Cu and Zn levels were also observed in planted soil after hydrogen peroxide treatment. In conclusion, hydrogen peroxide pretreatment might be an efficient way for enhancing the bioavailability of heavy metals in soil and promoting the absorption of heavy metals by plants.
Preliminary Application of PCR-DGGE to Analyzing Microbial Diversity in Biofilters Treating Air Loaded with Ammonia

YIN Jun,CHEN Ying-xu,LIU He,WANG Yuan-peng,

环境科学 , 2004,
Abstract: As a new DNA fingerprinting technique, denaturing gradient gel electrophoresis (DGGE) can be used to analyze the microbial diversity in different environmental samples. Three biofilters treating air loaded with ammonia will be studied with respect to microbial diversity by applying cultivation-independent molecular methods DGGE. The principal objectives of this paper include the development and application of a suitable set of molecular tools to deliver information about the possible microbial community changes within carriers during treatment of ammonia-contaminated gas. Carriers were sampled at different time during operation of biofilters. After extraction and purification of the genomic DNA, the 16S rRNA genes (V3 region) were amplified by using the specific primers. These amplified DNA fragments were then separated by paralleled DGGE. The profile of DGGE showed that the same carrier at different time had the different bands' patterns. The structural diversity of the microbial community was examined by the Shannon index of general diversity H. Shannon indexes of three kinds of carriers all showed a decrease with time, which had a similar trend to NH 3 removal efficiency.
Design and Implementation of a Exception Propagation Analysis Tool

JIANG Shu-juan XU Bao-wen JIANG Yuan-peng,

计算机科学 , 2008,
Abstract: Exception handling is a technology that tests and handles exception.Exception propagation induces a control flow other than the main control flow,so it changes the data flows,control flows of programs and the dependence relationshi Pbetween the structure elements of programs.For the analysis of C++ programs to be correct and precise,the flows induced by exception propagation must be properly analyzed.The paper describes the design and implementation of the CETool,an exception propagation analysis tool we ha...
Chlorophyll a and other environmental parameters in the Xiaoqing River Estuary, Laizhou Bay: spatial distributions and statistical analysis

GAO Yuan-peng,YAO Peng,MI Tie-zhu,CHEN Hong-tao,ZHANG Xin-quan,YU Zhi-gang,
,姚 鹏,米铁柱,陈洪涛,张欣泉,于志刚

海洋科学 , 2011,
Abstract: Based on the observations from Jun.6 to 7,2002 in the Xiaoqing River Estuary,Laizhou Bay,Bohai,the spatial distributions and statistical correlations of chlorophyll a(Chl-a) and other environmental parameters,such as nutrient,dissolved oxygen(DO),chemical oxygen demand(COD),were analyzed.Regression analysis of Chl-a with DO and nutrients was performed to better understand their relationships.The research area is quite shallow,the water body is mixed equably,and there is no obvious stratification.So all para...
Climate Division of Seasonal Precipitation and Their Changing Trend in Xinjiang

XIN Yu,MAO Wei-yi,LI Yuan-peng,ZHANG Xin,LU Ge,BO Li-jian,

中国沙漠 , 2009,
Abstract: 利用新疆88个测站1961—2006年逐日降水量资料,采用EOF(主成分分析)、REOF(旋转主成分分析)、线性趋势、kendall-τ检验以及累积距平、t检验、信噪比相结合等方法,对新疆四季降水量的空间特征、变化趋势以及突变时间等进行了对比诊断分析\.结果表明,新疆四季降水量EOF的前3个载荷向量场均表现为全疆一致的降水偏多或偏少型、南北疆反变化的南多(少)北少(多)型以及东西反向的东多(少)西少(多)型等3大整体异常结构;在同一约束条件下,不同季节REOF分析所揭示的降水气候分区不同,冬季大致可划分为3个区,春季6个区,夏季7个区,秋季5个区;除南疆偏西地区冬季降水量未出现显著突变增加趋势外,新疆大部地区于1986年前后冬夏降水量同时显著突变增多,与其上空大气可降水量(APW)的增加有关;北疆春季降水量既没有显著的增加趋势,也未发生过突变;南疆大部地区春季降水量曾出现过显著突变增加,但突变时间早晚不一;从长期变化趋势看,北疆北部、中天山两侧及其以东地区秋季降水量虽增加不显著,但在1978年前后出现过突变增加,是季降水量突变最早区域;北疆西部冬、夏、秋降水量均显著增加,是新疆降水量增加最敏感区域,但秋季降水量的突变增加是从1997年开始的,比冬夏突变晚11 a左右,比其东部地区偏晚30 a左右。
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