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Search Results: 1 - 10 of 23001 matches for " Yuan Weiguang "
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Association of CD40 Gene Polymorphisms with Sporadic Breast Cancer in Chinese Han Women of Northeast China
Chen Shuang, Li Dalin, Yuan Weiguang, Fu Zhenkun, Xu Fengyan, Pang Da, Dianjun Li
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0023762
Abstract: Background Breast cancer is a polygenetic disorder with a complex inheritance pattern. Single nucleotide polymorphisms (SNPs), the most common genetic variations, influence not only phenotypic traits, but also interindividual predisposition to disease, treatment outcomes with drugs and disease prognosis. The co-stimulatory molecule CD40 plays a prominent role in immune regulation and homeostasis. Accumulating evidence suggests that CD40 contributes to the pathogenesis of cancer. Here, we set out to test the association between polymorphisms in the CD40 gene and breast carcinogenesis and tumor pathology. Methodology and Principal Findings Four SNPs (rs1800686, rs1883832, rs4810485 and rs3765459) were genotyped by the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method in a case-control study including 591 breast cancer patients and 600 age-matched healthy controls. Differences in the genotypic distribution between breast cancer patients and healthy controls were analyzed by the Chi-square test for trends. Our preliminary data showed a statistically significant association between the four CD40 gene SNPs and sporadic breast cancer risk (additive P = 0.0223, 0.0012, 0.0013 and 0.0279, respectively). A strong association was also found using the dominant, recessive and homozygote comparison genetic models. In the clinical features analysis, significant associations were observed between CD40 SNPs and lymph node metastasis, human epidermal growth factor receptor 2 (C-erbB2), estrogen receptor (ER), progesterone receptor (PR) and tumor protein 53 (P53) statuses. In addition, our haplotype analysis indicated that the haplotype Crs1883832Grs4810485, which was located within the only linkage disequilibrium (LD) block identified, was a protective haplotype for breast cancer, whereas Trs1883832Trs4810485 increased the risk in the studied population, even after correcting the P value for multiple testing (P = 0.0337 and 0.0430, respectively). Conclusions and Significance Our findings primarily show that CD40 gene polymorphisms contribute to sporadic breast cancer risk and have a significant association with clinicopathological features among Chinese Han women from the Heilongjiang Province.
HVEM Gene Polymorphisms Are Associated with Sporadic Breast Cancer in Chinese Women
Dalin Li, Zhenkun Fu, Shuang Chen, Weiguang Yuan, Yanhong Liu, Liqun Li, Da Pang, Dianjun Li
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0071040
Abstract: As a costimulatory molecule, Herpesvirus entry mediator (HVEM) can bind with several costimulatory members, thus HVEM plays different roles in T cell immunity. HVEM and its ligands have been involved in the pathogenesis of various autoimmune, inflammatory diseases and tumors. In the current study, we conducted a case-control study comparing polymorphisms of HVEM and breast cancer. Subjects included 575 females with breast cancer and 604 age-matched healthy controls. Six HVEM SNPs (rs2281852, rs1886730, rs2234163, rs11573979, rs2234165, and rs2234167) were genotyped by PCR-RFLP. The results showed significant differences in genotypes and alleles between rs1886730 and rs2234167 (P<0.05). One haplotype (CTGCGG) that was associated with breast cancer was found via haplotype analysis. Our research also indicated an association between polymorphisms of HVEM and clinicopathologic features, including lymph node metastasis, estrogen receptor, progesterone receptor and P53. Our results primarily indicate that polymorphisms of the HVEM gene were associated with the risk of sporadic breast cancer in northeast Chinese females.
A detailed study of the high-mass clump interacting with the bubble N10
Yingxiu Ma,Jianjun Zhou,Jarken. Esimbek,Weiguang Ji,Gang Wu,Ye Yuan
Physics , 2013, DOI: 10.1007/s10509-013-1405-6
Abstract: We performed a detailed study of the high-mass clump interacting with bubble N10 based on the spectral lines $^{12}CO(3-2)$, $HCO^+(4-3)$, $N_2H^+(4-3)$ and $CH_3OH(7(0,7)-6(0,6))$ and continuum emission data at 450 $\mu$m and 850 $\mu$m released on CADC and Spitzer data. Blue-shifted optically thick line $^{12}CO (3-2)$ seems to indicate that the outer envelope of the high-mass clump is still falling toward the center. Detection of $CH_3OH(7(0,7)-6(0,6))$ suggests that a hot core has formed around YSO N10-7. And position-velocity diagram of $N_2H^+ (4-3)$ indicates the cold dense core of the clump has not been destroyed by the star formation activities. The mass of N10-7 is about 27.44 $M_\odot$. The ratio $HCO^+(4-3)/N_2H^+ (4-3)$ in the outer part of the clump is larger than that in the inner part of it. The reason may be that the CO abundance relative to $N_2H^+ (4-3)$ increased in the outer part of the high-mass clump, more $N_2H^+ (4-3)$ were converted into $HCO^+(4-3)$.
Introduction to the Symbolic Integration System
Weiguang Mao
Computer Science , 2013,
Abstract: Symbolic integration is an important module of a typical Computer Algebra System. As for now, Mathematica, Matlab, Maple and Sage are all mainstream CAS. They share the same framework for symbolic integration at some points. In this book first we review the state of the art in the field of CAS. Then we focus on typical frameworks of the current symbolic integration systems and summarize the main mathematical theories behind these frameworks. Based on the open-source computer algebra system maTHmU developed by our team in our university, we propose a potential framework to improve the performance of the current symbolic integration system.
Investigation of CD28 Gene Polymorphisms in Patients with Sporadic Breast Cancer in a Chinese Han Population in Northeast China
Shuang Chen, Qing Zhang, Liming Shen, Yanhong Liu, Fengyan Xu, Dalin Li, Zhenkun Fu, Weiguang Yuan, Da Pang, Dianjun Li
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0048031
Abstract: Background CD28 is one of a number of costimulatory molecules that play crucial roles in immune regulation and homeostasis. Accumulating evidence indicates that immune factors influence breast carcinogenesis. To clarify the relationships between polymorphisms in the CD28 gene and breast carcinogenesis, a case-control study was conducted in women from Heilongjiang Province in northeast of China. Methodology/Principal Findings Our research subjects consisted of 565 female patients with sporadic breast cancer and 605 age- and sex-matched healthy controls. In total, 12 single nucleotide polymorphisms (SNPs) in the CD28 gene were successfully determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The relationship between the CD28 variants and clinical features, including histological grade, tumor size, lymph node metastasis, human epidermal growth factor receptor 2 (C-erbB2), estrogen receptor (ER), progesterone receptor (PR), and tumor protein 53 (P53) status were analyzed. A statistically significant association was observed between rs3116496 and breast cancer risk under different genetic models (additive P = 0.0164, dominant P = 0.0042). Different distributions of the rs3116496 ‘T’ allele were found in patients and controls, which remained significant after correcting the P value for multiple testing using Haploview with 10,000 permutations (corrected P = 0.0384). In addition, significant associations were observed between rs3116487/rs3116494 (D’ = 1, r2 = 0.99) and clinicopathological features such as C-erbB2 and ER status, in breast cancer patients. Conclusions/Significance Our findings indicate that CD28 gene polymorphisms contribute to sporadic breast cancer risk and have a significant association with clinicopathological features in a northeast Chinese Han population.
Association of OX40L Polymorphisms with Sporadic Breast Cancer in Northeast Chinese Han Population
Yuan Weiguang, Li Dalin, Xu Lidan, Cai Yonggang, Chen Shuang, Liu Yanhong, Xu Fengyan, Fu Zhenkun, Pang Da, Li Dianjun
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0041277
Abstract: OX40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of OX40-OX40L is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. The genetic variants of OX40L can increase the risk of SLE, atherosclerosis, systemic sclerosis and show gender-specific effects in some studies. Accordingly, we performed a case-control study including 557 breast cancer patients and 580 age- and sex-matched healthy controls to investigate whether single nucleotide polymorphisms (SNPs) in the OX40L gene are associated with sporadic breast cancer susceptibility and progression in Chinese Han women. Seven SNPs of OX40L (rs6661173, rs1234313, rs3850641, rs1234315, rs12039904, rs844648 and rs10912580) were genotyped with the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The results indicated that rs3850641G allele could increase the susceptibility to breast cancer (P = 0.009662), even in the validation study (P = 0.0001515). A significant association between rs3850641 and breast cancer risk was observed under the additive model and dominant model (P = 0.01042 and 0.01942, respectively). The haplotype analysis showed that haplotype Ars844648Ars10912580 was significantly associated with breast cancer, even after 10,000 permutations for haplotypes in block only (P = 0.0003). In clinicopathologic features analysis, the association between rs1234315 and C-erbB2 status was significant (P = 0.02541). Our data primarily indicates that rs3850641 of OX40L gene contributes to sporadic breast carcinogenesis in a northeast Chinese Han population.
ICOS gene polymorphisms are associated with sporadic breast cancer: a case-control study
Fengyan Xu, Dalin Li, Qiujin Zhang, Zhenkun Fu, Jie Zhang, Weiguang Yuan, Shuang Chen, Da Pang, Dianjun Li
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-392
Abstract: In the study cohort, we genotyped five SNPs (rs11889031, rs10932029, rs4675374, rs10183087 and rs10932037) in ICOS gene among 609 breast cancer patients and 665 age-matched healthy controls. Furthermore, the positive results were replicated in an independent validation cohort of 619 patients and 682 age-matched healthy controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine the genotypes.In rs10932029, compared with TT genotype and T allele, the CT genotype and C allele showed a significantly increased risk of breast cancer (P = 0.030, OR = 1.467, 95% CI 1.037-2.077; P = 0.017, OR = 1.481, 95% CI 1.070-2.049, respectively), and the associations were also significant in the validation cohort (P = 0.002, OR = 1.693, 95% CI 1.211-2.357; P = 0.003, OR = 1.607, 95% CI 1.171-2.204, respectively). Haplotype analysis showed that CTCAC haplotype containing rs10932029 T allele had a lower frequency in cases than in controls (P = 0.015), whereas haplotype CCCAC containing rs10932029 C allele was more common in cases than in controls (P = 0.013). In the analysis of clinicopathologic features, rs11889031 CT genotype and T allele were associated with progesterone receptor (PR) status and lymph node metastasis, which were further supported by our validation cohort. Moreover, some haplotypes were associated with estrogen receptor (ER) and PR statuses.These results indicate that ICOS gene polymorphisms may affect the risk of breast cancer and show that some SNPs are associated with breast cancer characteristics in a northern Chinese population.Breast cancer is one of the most common malignant tumors contributing to the high mortality of females worldwide. The etiology of breast cancer is a complex combination of both environmental and genetic factors, so the determination of genetic polymorphism provided a new way to investigate the etiology of such complex genetic disease. Accordingly, significant associations have been demonstr
Association of TNF-α, TNFRSF1A and TNFRSF1B Gene Polymorphisms with the Risk of Sporadic Breast Cancer in Northeast Chinese Han Women
Fengyan Xu, Guiqin Zhou, Shaoli Han, Weiguang Yuan, Shuang Chen, Zhenkun Fu, Dalin Li, Hua Zhang, Dianjun Li, Da Pang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0101138
Abstract: Background The interaction of tumor necrosis factor-α (TNF-α) with its receptors: TNFRSF1A and TNFRSF1B is critical for the promotion of tumor growth, invasion and metastasis. To better understand the roles of single nucleotide polymorphisms (SNPs) in the TNF-α, TNFRSF1A and TNFRSF1B genes in the development of breast cancer, we explored the associations between SNPs in these three genes and breast cancer susceptibility in northeast Chinese Han women. Methodology/Principal Findings This case-control study was conducted among 1016 breast cancer patients and 806 age-matched healthy controls. Seven SNPs in the TNF-α (rs1800629, rs361525), TNFRSF1A (rs767455, rs4149577 and rs1800693) and TNFRSF1B (rs1061622 and rs1061624) genes were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. In TNFRSF1B, the rs1061622 GT genotype and the G allele conferred a reduced susceptibility to breast cancer (P = 0.000662, OR = 0.706, 95% CI: 0.578–0.863; P = 0.002, OR = 0.769, 95% CI; 0.654–0.905, respectively). Moreover, the AG genotype, the AA genotype and the A allele in rs1061624 conferred an increased risk of breast cancer (P = 0.007, OR = 1.470, 95% CI:1.112–1.943; P = 0.00109, OR = 1.405 95% CI:1.145–1.724; P = 0.001, OR = 1.248 95% CI:1.092–1.426, respectively). These two SNPs also had associations with breast cancer risk under the dominant model. In haplotype analysis, the CTA (rs767455 C-rs4149577 T-rs1800693 A) haplotype in TNFRSF1A and the TA (rs1061622 T-rs1061624 A) haplotype in TNFRSF1B had higher frequencies in breast cancer patients (P = 0.00324; P = 0.000370, respectively), but the frequency of GG (rs1061622 G-rs1061624 G) haplotype in TNFRSF1B was lower in breast cancer patients (P = 0.000251). The associations of the three haplotypes remained significant after correcting for multiple testing. In addition, significant associations were also observed between TNFRSF1A polymorphisms and lymph node metastasis, P53, estrogen receptor (ER) and progesterone receptor (PR) statuses. Conclusions Our results suggest that rs1061622 and rs1061624 in TNFRSF1B may affect breast cancer risk, and SNPs in TNFRSF1A are associated with the clinical features of breast cancer.
High-Quality BN-Graphene-BN Nanoribbon Capacitors Modulated by Graphene Side-gate Electrodes
Yang Wang,Xiaolong Chen,Weiguang Ye,Zefei Wu,Yu Han,Tianyi Han,Yuheng He,Yuan Cai,Ning Wang
Physics , 2014, DOI: 10.1063/1.4904715
Abstract: High-quality BN-Graphene-BN nanoribbon capacitors with double side-gates of graphene are experimentally realized. Graphene electronic properties can be significantly modulated by the double side-gates. The modulation effects are very obvious and followed the metallic electrode behavior of numerical simulations, while the theoretically predicted negative quantum capacitance was not observed, possibility due to the over-estimated or weakened interactions between the graphene nanoribbon and side-gate electrodes.
Empirical Study on Trust Repair of Government in Public Crisis Event  [PDF]
Xiaobao Peng, Weiguang Gong, Mengling Peng
Open Journal of Business and Management (OJBM) , 2016, DOI: 10.4236/ojbm.2016.42040
Abstract: The trust of the public for government is greatly damaged because of the frequent occurrence of public crisis event, which has resulted in serious trust crisis of the government. To date trust repair has been a key issue to study by local governments. This paper researches that the initial trust of the public for government and the severity and attribution of public crisis event are exerted influence upon the trust damage of government under the political and cultural environment of current China in the methods of situational simulated and questionnaire survey. Moreover, the repair effects of two different trust repair strategies (denial and apology) are verified in this paper as well. The research findings show that the strength level of initial trust of the public for government and the severity of the public crisis event are positively correlated with the trust damage of government; different attribution of different public crisis event is made no difference with different damage degree of trust of government; different trust repair strategy is made significant difference upon repair effect, and the repair effect of apology is better than that of denial; the strength level of initial trust of the public for government is positively correlated with the repair effect of trust of government, that is to say, if the initial trust of the public upon government is stringer, the damaged trust of government will be easier to repair. Theoretical perspective of trust repair of government is expanded in this paper, which has provided repair strategy and solution for trust crisis caused by government in the current situation of China.
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