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Search Results: 1 - 10 of 93637 matches for " Yu-Yin Yi "
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Supply Chain Coordination for Strong Retailer with Extended Warranty under Network Externality  [PDF]
Yan-Fei Tan, Yu-Yin Yi, Jun-Jiang Yao
Journal of Service Science and Management (JSSM) , 2015, DOI: 10.4236/jssm.2015.83041
Abstract: This paper constructed a retailer-leading supply chain system considering the extended warranty (EW) with single manufacturer and single retailer to study the influence of network externality on retailer-leading supply chain coordination. First of all, we analyzed and compared the retail price, EW price, EW quality, and the total system profit in centralized and decentralized model respectively. Then we analyzed the influence of network externality on decision variables and system profits. We found that the network externality increased the loss of decision efficiency. After that, we considered the coordination of the supply chain system with extended warranty. Finally, some numerical examples were presented for further analysis.
Closed-loop supply chain game models with product remanufacturing

YI Yu-yin,

系统工程理论与实践 , 2009,
Abstract: 在制造商领导的Stackelberg博弈、零售商领导的Stackelberg博弈、制造商和零售商Nash均衡博弈等三种博弈结构下建立了再制造闭环供应链博弈模型,研究和对比了不同市场力量结构对均衡回收率、批发价、零售价、渠道成员利润、渠道总利润的影响. 研究结果表明:零售商的回收率在市场无领导者时最高, 在零售商领导的市场中最低.批发价格在制造商领导时最高, 最小的是零售商领导情形.零售价在零售商领导时最高, 最小是市场无领导者情形.消费者和整个行业均受益于无领导者的市场结构. 然而,制造商和零售商均有动机成为领导者.
Study of RNA Interference Targeting NET-1 Combination with Sorafenib for Hepatocellular Carcinoma Therapy In Vitro and In Vivo
Song He,Ying-ze Wei,Gui-lan Wang,Yu-yin Xu,Jia-ming Zhou,Yi-xin Zhang,Li Chen
Gastroenterology Research and Practice , 2013, DOI: 10.1155/2013/685150
Abstract: The aim of this study is to explore the inhibitory effects of RNA interference (RNAi) targeting NET-1 or combined with sorafenib on HCC in vitro and in vivo and the possible underlying mechanisms. The expressions of NET-1 mRNA and protein were detected by RT-QPCR and western blot. The ability of proliferation was determined by CCK-8 assay. Apoptosis was examined by flow cytometry (FCM). Abilities of migration and invasion were measured by scratch-wound assay and transwell assay. MHCC97H cells with stable transfection of NET-1shRNA were injected subcutaneously to prepare nude mice model of HCC and Caspase-3, Caspase-8, and Caspase-9 mRNAs of tumor tissues in different groups were examined. NET-1 mRNA and protein were reduced sharply in MHCC97H cells transfected with NET-1shRNA. The abilities of proliferation and migration were inhibited and apoptosis was promoted in either NET-1shRNA or sorafenib as compared with untreated cells in vitro and in vivo ( ). The mRNA levels of caspase-3, caspase-8, and caspase-9 of tumor tissues were reduced in different treatment groups compared with untreated group, particularly in combination group. ( ). The combination NET-1shRNA with sorafenib dramatically enhanced the effects of sorafenib antitumor ,which may involve in blocking ras signaling pathway and stimulating apoptotic pathways simultaneously. 1. Introduction Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide [1], with some certain geographic regions in developing countries where the incidence of HCC is 16–32 times higher than in developed countries. Gene therapy, a new and promising therapeutic strategy, has been used for many cancers including HCC. SiRNA-targeted silencing of the genes associated with tumor cell proliferation or metastasis, as one method of gene therapy, shows great potency on HCC treatment. New EST tetraspanin-1, also called NET-1(C4.8, Tspan-1, P503S), a member of the tetraspan superfamily (TM4SF) [2–4], seems to be rather expressed in most HCC than in normal adult liver tissues [5]. This attractive characteristic of tumor-specific expression could made NET-1 as potential therapeutic target for HCC. Sorafenib, an oral multikinase inhibitor approved by the US Food and Drug Administration for the treatment of patients with advanced renal cell carcinoma (RCC) and those with refractory HCC. Recent years, in vivo and in vitro studies have shown that sorafenib could inhibit tumor growth and disrupts tumor microvasculature through antiproliferative, antiangiogenic, and/or proapoptotic effects. Sorafenib represents
Local anesthesia with ropivacaine for patients undergoing laparoscopic cholecystectomy
Yu-Yin Liu, Chun-Nan Yeh, Hsiang-Lin Lee, Shang-Yu Wang, Chun-Yi Tsai, Chih-Chung Lin, Tzu-Chieh Chao, Ta-Sen Yeh, Yi-Yin Jan
World Journal of Gastroenterology , 2009,
Abstract: AIM: To investigate the effect of pain relief after infusion of ropivacaine at port sites at the end of surgery.METHODS: From October 2006 to September 2007, 72 patients undergoing laparoscopic cholecystectomy (LC) were randomized into two groups of 36 patients. One group received ropivacaine infusion at the port sites at the end of LC and the other received normal saline. A visual analog scale was used to assess postoperative pain when the patient awakened in the operating room, 6 and 24 h after surgery, and before discharge. The amount of analgesics use was also recorded. The demographics, laboratory data, hospital stay, and perioperative complications were compared between the two groups.RESULTS: There was no difference between the two groups preoperatively in terms of demographic and laboratory data. After surgery, similar operation time, blood loss, and no postoperative morbidity and mortality were observed in the two groups. However, a significantly lower pain score was observed in the patients undergoing LC with local anesthesia infusion at 1 h after LC and at discharge. Regarding analgesic use, the amount of meperidine used 1 h after LC and the total used during admission were lower in patients undergoing LC with local anesthesia infusion. This group also had a shorter hospital stay.CONCLUSION: Local anesthesia with ropivacaine at the port site in LC patients significantly decreased postoperative pain immediately. This explains the lower meperidine use and earlier discharge for these patients.
Aryl Hydrocarbon Receptor Downregulates MYCN Expression and Promotes Cell Differentiation of Neuroblastoma
Pei-Yi Wu, Yung-Feng Liao, Hsueh-Fen Juan, Hsuan-Cheng Huang, Bo-Jeng Wang, Yen-Lin Lu, I-Shing Yu, Yu-Yin Shih, Yung-Ming Jeng, Wen-Ming Hsu, Hsinyu Lee
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088795
Abstract: Neuroblastoma (NB) is the most common malignant disease of infancy. MYCN amplification is a prognostic factor for NB and is a sign of highly malignant disease and poor patient prognosis. In this study, we aimed to investigate novel MYCN-related genes and assess how they affect NB cell behavior. The different gene expression found in 10 MYCN amplification NB tumors and 10 tumors with normal MYCN copy number were analyzed using tissue oligonucleotide microarrays. Ingenuity Pathway Analysis was subsequently performed to identify the potential genes involved in MYCN regulation pathways. Aryl hydrocarbon receptor (AHR), a receptor for dioxin-like compounds, was found to be inversely correlated with MYCN expression in NB tissues. This correlation was confirmed in a further 14 human NB samples. Moreover, AHR expression in NB tumors was found to correlate highly with histological grade of differentiation. In vitro studies revealed that AHR overexpression in NB cells induced spontaneous cell differentiation. In addition, it was found that ectopic expression of AHR suppressed MYCN promoter activity resulting in downregulation of MYCN expression. The suppression effect of AHR on the transcription of MYCN was compensated for by E2F1 overexpression, indicating that E2F1 is involved in the AHR-regulating MYCN pathway. Furthermore, AHR shRNA promotes the expression of E2F1 and MYCN in NB cells. These findings suggest that AHR is one of the upstream regulators of MYCN. Through the modulation of E2F1, AHR regulates MYCN gene expression, which may in turn affect NB differentiation.
High-Density Expression of Ca2+-Permeable ASIC1a Channels in NG2 Glia of Rat Hippocampus
Yen-Chu Lin,Yu-Chao Liu,Yu-Yin Huang,Cheng-Chang Lien
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0012665
Abstract: NG2 cells, a fourth type of glial cell in the mammalian CNS, undergo reactive changes in response to a wide variety of brain insults. Recent studies have demonstrated that neuronally expressed acid-sensing ion channels (ASICs) are implicated in various neurological disorders including brain ischemia and seizures. Acidosis is a common feature of acute neurological conditions. It is postulated that a drop in pH may be the link between the pathological process and activation of NG2 cells. Such postulate immediately prompts the following questions: Do NG2 cells express ASICs? If so, what are their functional properties and subunit composition? Here, using a combination of electrophysiology, Ca2+ imaging and immunocytochemistry, we present evidence to demonstrate that NG2 cells of the rat hippocampus express high density of Ca2+-permeable ASIC1a channels compared with several types of hippocampal neurons. First, nucleated patch recordings from NG2 cells revealed high density of proton-activated currents. The magnitude of proton-activated current was pH dependent, with a pH for half-maximal activation of 6.3. Second, the current-voltage relationship showed a reversal close to the equilibrium potential for Na+. Third, psalmotoxin 1, a blocker specific for the ASIC1a channel, largely inhibited proton-activated currents. Fourth, Ca2+ imaging showed that activation of proton-activated channels led to an increase of [Ca2+]i. Finally, immunocytochemistry showed co-localization of ASIC1a and NG2 proteins in the hippocampus. Thus the acid chemosensor, the ASIC1a channel, may serve for inducing membrane depolarization and Ca2+ influx, thereby playing a crucial role in the NG2 cell response to injury following ischemia.
LASSA: Emotion Detection via Information Fusion
Ning Yu, Sandra Kübler, Joshua Herring, Yu-Yin Hsu, Ross Israel and Charese Smiley
Biomedical Informatics Insights , 2012, DOI: 10.4137/BII.S8949
Abstract: Due to the complexity of emotions in suicide notes and the subtle nature of sentiments, this study proposes a fusion approach to tackle the challenge of sentiment classification in suicide notes: leveraging WordNet-based lexicons, manually created rules, character-based n-grams, and other linguistic features. Although our results are not satisfying, some valuable lessons are learned and promising future directions are identified.
LASSA: Emotion Detection via Information Fusion
Ning Yu,Sandra Kübler,Joshua Herring,Yu-Yin Hsu
Biomedical Informatics Insights , 2012,
Atrioventricular Septal Defect with Cor Triatriatum Sinister
Yu-Yin Liu,Yao-Kuang Huang,Chi-Nan Tseng,Yu-Sheng Chang
Chang Gung Medical Journal , 2007,
Abstract: Cor triatriatum (CT) is a rare cardiac anomaly, characterized by a membrane in the leftatrium which separates the atrium into the proximal and distal chambers. Association of CTwith atrioventricular septal defects (AVSD) is extremely rare; only three cases with completeAVSD and 10 with partial AVSD have been reported. In this study, we present an 11-month-old female infant with complete AVSD and cor triatriatum. The patient recovereduneventfully after surgery and normal cardiac performance was achieved 2 years later.
Multi-Instance Learning by Treating Instances As Non-I.I.D. Samples
Zhi-Hua Zhou,Yu-Yin Sun,Yu-Feng Li
Computer Science , 2008,
Abstract: Multi-instance learning attempts to learn from a training set consisting of labeled bags each containing many unlabeled instances. Previous studies typically treat the instances in the bags as independently and identically distributed. However, the instances in a bag are rarely independent, and therefore a better performance can be expected if the instances are treated in an non-i.i.d. way that exploits the relations among instances. In this paper, we propose a simple yet effective multi-instance learning method, which regards each bag as a graph and uses a specific kernel to distinguish the graphs by considering the features of the nodes as well as the features of the edges that convey some relations among instances. The effectiveness of the proposed method is validated by experiments.
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