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Search Results: 1 - 10 of 130220 matches for " Yu-Hsiang Chen "
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Nonlinear Dynamic Trans/Cis Regulatory Circuit for Gene Transcription via Microarray Data
Yu-Hsiang Chang,Yu-Chao Wang,Bor-Sen Chen
Gene Regulation and Systems Biology , 2007,
Abstract: The trans-regulatory circuit is considered as the regulatory interactions between upstream regulatory genes and transcription factor binding site motifs or cis elements. And the cis-regulatory circuit is viewed as a dynamic interactive circuit among binding site motifs with their effective action on the expression scheme of target gene. In brief, gene transcription depends on the trans/cis regulatory circuits. In this study, nonlinear trans/cis regulatory circuits for gene transcription in yeast are constructed using microarray data, translation time delay, and information of transcription factors (TFs) binding sites. We provide a useful nonlinear dynamic modeling and develop a parameter estimating method for the construction of trans/cis regulatory circuits, which is powerful for understanding gene transcription. We apply our method to construct trans/cis regulatory circuits of yeast cell cycle-related genes and successfully quantify their regulatory abilities and find possible cis-element interactions. Not only could the data of yeast be applied by our method, but those of other species also could. The proposed method can provide a quantitative basis for system analysis of gene circuits, which is potential for gene regulatory circuit design with a desired gene expression.
Slow-Roll Inflation Preceded by a Topological Defect Phase à la Chaplygin Gas
Mariam Bouhmadi-Lopez,Pisin Chen,Yu-Chien Huang,Yu-Hsiang Lin
Physics , 2012, DOI: 10.1103/PhysRevD.87.103513
Abstract: We present a simple toy model corresponding to a network of frustrated topological defects of domain walls or cosmic strings that exist previous to the standard slow-roll inflationary era of the universe. Such a network (i) can produce a slower inflationary era than that of the standard scenario if it corresponds to a network of frustrated domain walls or (ii) can induce a vanishing universal acceleration; i.e., the universe would expand at a constant speed, if it corresponds to a network of frustrated cosmic strings red. Those features are phenomenologically modeled by a Chaplygin gas that can interpolate between a network of frustrated topological defects and a de Sitter-like or a power-law inflationary era. We show that this scenario can alleviate the quadruple anomaly of the cosmic microwave background spectrum. Using the method of the Bogoliubov coefficients, we obtain the spectrum of the gravitational waves as would be measured today for the whole range of frequencies. We comment on the possible detection of this spectrum by the planned detectors like BBO and DECIGO.
Does Adequate Bladder Cuff Excision Impact Outcomes in Patients Undergoing Nephroureterectomy for Upper Tract Urothelial Carcinoma
Chen-Pang Hou,Phei-Lang Chang,Chien-Lun Chen,Yu-Hsiang Lin
Chang Gung Medical Journal , 2011,
Abstract: Background: Nephroureterectomy with bladder cuff excision has been the gold standardsurgical treatment for upper tract urothelial carcinoma. In this study, wedetermined the independent prognostic factors for upper tract urothelial carcinoma.Methods: The records of 285 consecutive patients undergoing nephroureterectomywith bladder cuff excision at our institution between 2003 and 2007 werereviewed. Kaplan-Meier survival curves were used to determine the 5-yearcancer-specific survival rates for all patient groups. Cox proportional hazardregression was performed to determine the factors that had an independentimpact on the survival of patients with upper tract urothelial carcinoma.Results: A total of 192 patients matching the inclusion criteria were enrolled in ourstudy. The mean follow-up time was 43.81 months. We found that the femalegender, a lower ureter free of invasion, and an adequate bladder cuff excisionwere independent factors for a better tumor recurrence-free survival rate. Thepathology stage and recurrence (none, intravesical or extravesical) wereindependent factors for the overall survival rate. A non-adequate ureterectomy including the bladder cuff was associated with a high body mass index(BMI) and the infiltrating tumor pattern of urothelial carcinoma.Conclusion: Nnephroureterectomy together with adequate bladder cuff excision plays anextremely important role in the surgical treatment of upper urinary tracturothelial carcinoma. Patients with incomplete resections of the bladder cuffare at increased risk of tumor recurrence.
Emergency Physicians’ Adherence to Center for Disease Control and Prevention Guidance During the 2009 Influenza A H1N1 Pandemic
Yu-Hsiang Hsieh,Gabor D. Kelen,Andrea F. Dugas,Kuan-Fu Chen
Western Journal of Emergency Medicine : Integrating Emergency Care with Population Health , 2013,
Abstract: Introduction: Little is known regarding compliance with management guidelines for epidemicinfluenza in adult emergency department (ED) settings during the 2009 novel influenza A(H1N1) epidemic, especially in relation to the Centers for Disease Control and Prevention (CDC)guidance.Methods: We investigated all patients with a clinical diagnosis of influenza at an inner-citytertiary academic adult ED with an annual census of approximately 60,000 visits from May 2008to December 2009. We aimed to determine patterns of presentation and management for adultpatients with an ED diagnosis of influenza during the H1N1 pandemic, using seasonal influenza(pre-H1N1) as reference and to determine the ED provider’s adherence to American College ofEmergency Physicians and CDC guidance during the 2009 H1N1 influenza pandemic. Adherenceto key elements of CDC 2009 H1N1 guidance was defined as (1) the proportion of admittedpatients who were recommended to receive testing or treatment who actually received testingfor influenza or treatment with antivirals; and (2) the proportion of high-risk patients who weresupposed to be treated who actually were treated with antivirals.Results: Among 339 patients with clinically diagnosed influenza, 88% occurred during the H1N1pandemic. Patients were similarly managed during both phases. Median length of visit (pre-H1N1:385 min, H1N1: 355 min, P > 0.05) and admission rates (pre-H1N1: 8%, H1N1: 11%, P > 0.05)were similar between the 2 groups. 28% of patients in the pre-H1N1 group and 16% of patientsin the H1N1 group were prescribed antibiotics during their ED visits (P > 0.05). There were 34admitted patients during the pandemic;, 30 (88%) of them received influenza testing in the ED,and 22 (65%) were prescribed antivirals in the ED. Noticeably, 19 (56%) of the 34 admittedpatients, including 6 with a positive influenza test, received antibiotic treatment during their ED stay.Conclusion: During the recent H1N1 pandemic, most admitted patients received ED diagnostictesting corresponding to the current recommended guidance. Antibiotic treatment for ED patientsadmitted with suspected influenza is not uncommon. However, less than 70% of admitted patientsand less than 50% of high-risk patients were treated with antivirals during their ED visit, indicatinga specific call for closer adherence to guidelines in future influenza pandemics.
What is the optimal fluid status in critically ill patients?
Yu-Hsiang Chou
Critical Care , 2012, DOI: 10.1186/cc11446
Abstract: In order to clarify the correlation between fluid therapy and mortality, it is necessary to use high or low fluid volumes as a covariate in a Cox's proportional hazards model of mortality. As we know, fluid resuscitation is a critical step to achieve early goal-directed therapy. Whether patients achieved the goal or not should also be included in analysis. Other parameters related to fluid status, such as central venous pressure level, body composition detected by bioimpedance device, and brain natriuretic peptide level, can be added to the analysis in future studies.The author declares that they have no competing interests.
Prediagnosis of Obstructive Sleep Apnea via Multiclass MTS
Chao-Ton Su,Kun-Huang Chen,Li-Fei Chen,Pa-Chun Wang,Yu-Hsiang Hsiao
Computational and Mathematical Methods in Medicine , 2012, DOI: 10.1155/2012/212498
Abstract: Obstructive sleep apnea (OSA) has become an important public health concern. Polysomnography (PSG) is traditionally considered an established and effective diagnostic tool providing information on the severity of OSA and the degree of sleep fragmentation. However, the numerous steps in the PSG test to diagnose OSA are costly and time consuming. This study aimed to apply the multiclass Mahalanobis-Taguchi system (MMTS) based on anthropometric information and questionnaire data to predict OSA. Implementation results showed that MMTS had an accuracy of 84.38% on the OSA prediction and achieved better performance compared to other approaches such as logistic regression, neural networks, support vector machine, C4.5 decision tree, and rough set. Therefore, MMTS can assist doctors in prediagnosis of OSA before running the PSG test, thereby enabling the more effective use of medical resources.
Fagopyrum tataricum (Buckwheat) Improved High-Glucose-Induced Insulin Resistance in Mouse Hepatocytes and Diabetes in Fructose-Rich Diet-Induced Mice
Chia-Chen Lee,Wei-Hsuan Hsu,Siou-Ru Shen,Yu-Hsiang Cheng,She-Ching Wu
Experimental Diabetes Research , 2012, DOI: 10.1155/2012/375673
Abstract: Fagopyrum tataricum (buckwheat) is used for the treatment of type 2 diabetes mellitus in Taiwan. This study was to evaluate the antihyperglycemic and anti-insulin resistance effects of 75% ethanol extracts of buckwheat (EEB) in FL83B hepatocytes by high-glucose (33 mM) induction and in C57BL/6 mice by fructose-rich diet (FRD; 60%) induction. The active compounds of EEB (100 μg/mL; 50 mg/kg bw), quercetin (6 μg/mL; 3 mg/kg bw), and rutin (23 μg/mL; 11.5 mg/kg bw) were also employed to treat FL83B hepatocytes and animal. Results indicated that EEB, rutin, and quercetin
Antiviral Prescriptions to U.S. Ambulatory Care Visits with a Diagnosis of Influenza before and after High Level of Adamantane Resistance 2005–06 Season
Yu-Hsiang Hsieh,Kuan-Fu Chen,Charlotte A. Gaydos,Richard E. Rothman,Gabor D. Kelen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0008945
Abstract: Rapid emergence of influenza A viruses resistance to anti-influenza drugs has been observed in the past five years. Our objective was to compare antiviral prescription patterns of ambulatory care providers to patients with a diagnosis of influenza before and after the 2005–2006 influenza season, which was temporally concordant with the emergence of adamantane resistance. We also determined providers' adherence to Centers for Disease Control and Prevention (CDC) 2006 interim treatment guidelines for influenza after the dissemination of guidelines.
The Effects of Davallic Acid from Davallia divaricata Blume on Apoptosis Induction in A549 Lung Cancer Cells
An-Sheng Cheng,We-Chang Chang,Yu-Hsiang Cheng,Kai-Yu Chen,Kai-Hsien Chen,Tsu-Liang Chang
Molecules , 2012, DOI: 10.3390/molecules171112938
Abstract: Traditional or folk medicinal herbs continue to be prescribed in the treatment of various diseases and conditions in many cultures. Recent scientific efforts have focused on the potential roles of extracts of traditional herbs as alternative and complementary medications for cancer treatment. In Taiwan, Davallia divaricata Blume has been traditionally employed in folk medicine for therapy of lung cancer, davallic acid being the major active compound of D. divaricata Blume. In this study, we investigated the inhibitory activity of davallic acid on the proliferation of A549 lung cancer cells. Davallic acid was extracted from D. divaricata Blume, and its effects on cell viability, cell cycle distribution, ROS level, and apoptotic protein expression in A549 cells were determined. Davallic acid significantly induced reactive oxygen species (ROS) generation as well as caspase-3, -8, and -9 activation, thereby repressing A549 cell growth and elevating apoptotic activity. Since lung cancer has a high incidence of recurrence, these results indicate that davallic acid may have the potential to be a natural anti-lung cancer compound, and may provide a basis for further study of its use in combating cancer.
Interleukin-19 Mediates Tissue Damage in Murine Ischemic Acute Kidney Injury
Yu-Hsiang Hsu, Hsing-Hui Li, Junne-Ming Sung, Wei-Ting Chen, Ya-Chin Hou, Ming-Shi Chang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056028
Abstract: Inflammation and renal tubular injury are major features of acute kidney injury (AKI). Many cytokines and chemokines are released from injured tubular cells and acts as proinflammatory mediators. However, the role of IL-19 in the pathogenesis of AKI is not defined yet. In bilateral renal ischemia/reperfusion injury (IRI)-induced and HgCl2-induced AKI animal models, real-time quantitative (RTQ)-PCR showed that the kidneys, livers, and lungs of AKI mice expressed significantly higher IL-19 and its receptors than did sham control mice. Immunohistochemical staining showed that IL-19 and its receptors were strongly stained in the kidney, liver, and lung tissue of AKI mice. In vitro, IL-19 upregulated MCP-1, TGF-β1, and IL-19, and induced mitochondria-dependent apoptosis in murine renal tubular epithelial M-1 cells. IL-19 upregulated TNF-α and IL-10 in cultured HepG2 cells, and it increased IL-1β and TNF-α expression in cultured A549 cells. In vivo, after renal IRI or a nephrotoxic dose of HgCl2 treatment, IL-20R1-deficient mice (the deficiency blocks IL-19 signaling) showed lower levels of blood urea nitrogen (BUN) in serum and less tubular damage than did wild-type mice. Therefore, we conclude that IL-19 mediates kidney, liver, and lung tissue damage in murine AKI and that blocking IL-19 signaling may provide a potent therapeutic strategy for treating AKI.
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