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Search Results: 1 - 10 of 3183 matches for " Youngjo Lim "
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Associations of Single Nucleotide Polymorphisms in the Bovine FADS6 Gene with Fatty Acid Composition in Hanwoo (Korean Cattle)  [PDF]
Krishnamoorthy Srikanth, Anam Kwan, Eunjin Lee, Seonkwan Kim, Youngjo Lim, Hoyoung Chung
Open Journal of Genetics (OJGen) , 2015, DOI: 10.4236/ojgen.2015.54010
Abstract: The bovine fatty acid desaturase (FADS) gene cluster consists of FADS1, FADS2, FADS3, and FADS6, which acts as key enzymes in fatty acid metabolism. Of these, the genetics effects of variants in FADS1, FADS2 and FADS3 have been previously studied. However, the genetic effects of variants of FADS6 gene have not been studied. The aim of this study was to identify genetic variants in the bovine fatty acid desaturase 6 (FADS6) gene and study their association with fatty acid composition in Hanwoo cattle. Six genetic variants were observed, three each in intron 2 and exon 6 by DNA sequencing analyses. The association of genetic variants with fatty acid composition was evaluated in 90 Hanwoo steers. The variants were confirmed and the animals were genotyped by RFLP (Restriction Fragment Length Polymorphism) and AS-PCR (Allele Specific PCR) analyses. The analysis revealed that palmitoleic acid (C16:1n7) was associated with g.3391G > A, g.3660A > C and g.15657C > T, and stearic acid (C18:0) showed highly significant association with g.3660A > C segments. Both g.3391G > A, g.3660A > C also had strong additive and dominance effect for Palmitoleic acid, while g.3660A > C also had a strong dominance effect for stearic acid. These results could be useful for modulating fatty acid composition in beef and produce meat with higher monounsaturated fatty acid to saturated fatty acid ratio (MUFA/SFA), which had been shown to have positive health effect in humans.
4-(1H-Tetrazol-5-yl)benzene-1,3-diol
Youngjo Kim
Acta Crystallographica Section E , 2013, DOI: 10.1107/s160053681300411x
Abstract: In the title compound, C7H6N4O2, rings are almost coplanar, the dihedral angle between them being 8.45 (13)°. An intramolecular N—H...O hydrogen bond occurs. In the crystal, the molecules are linked by O—H...N and N—H...O hydrogen bonds into a three-dimensional network.
2,8,9-Tris(2-methylpropyl)-2,5,8,9-tetraaza-1λ5-phosphatricyclo[3.3.3.01,5]undecan-5-ium chloride dihydrate
Junseong Lee,Youngjo Kim
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812045618
Abstract: The asymmetric unit of the title hydrated salt, C18H40N4P+·Cl ·2H2O, consists of two ionic molecules and four water molecules. The molecular geometry around the pentacoordinate P atom is trigonal–bipyramidal, with a H atom and an apical N atom in axial positions and three N atoms with isobutyl substituents in equatorial positions. The Cl ions and water molecules are connected via O—H...Cl hydrogen bonds, forming chains along [100]. The ethylene bridging groups are disordered with refined site-occupancy ratios of 0.578 (9):0.422 (9).
Bis{2,2′-[methylazanediylbis(methylene)]bis(4,6-dimethylphenolato)-κ3O,N,O′}titanium(IV) toluene sesquisolvate
Yongseog Chung,Youngjo Kim
Acta Crystallographica Section E , 2013, DOI: 10.1107/s1600536813007022
Abstract: The title compound, [Ti(C19H23NO2)2]·1.5C7H8, crystallizes with one titanium complex molecule per asymmetric unit together with one and a half toluene molecules. The TiIV atom is coordinated by two fully deprotonated O,N,O′-tridentate phenoxyamine ligands in a distorted octahedral environment. Within this arrangement the O atoms occupy the equatorial sites and the N atoms the axial sites. One of the toluene molecules is disordered over two sets of sites in a 0.628 (18):0.372 (18) ratio.
μ-Oxido-bis{bis[(pentafluorophenyl)methanolato](η5-pentamethylcyclopentadienyl)titanium(IV)}
Junseong Lee,Youngjo Kim
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811027814
Abstract: The dinuclear title complex, [Ti2(C10H15)2(C7H2F5O)4O], features two TiIV atoms bridged by an O atom. Each Ti atom is bonded to a η5-pentamethylcyclopentadienyl ring, two (pentafluorophenyl)methanolate anions and to the bridging O atom. The environment around each Ti atom can be considered as a distorted tetrahedron.
μ-Oxido-bis[bis(pentafluorophenolato)(η5-pentamethylcyclopentadienyl)titanium(IV)]
Junseong Lee,Youngjo Kim
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811029357
Abstract: The dinuclear title complex, [Ti2(C10H15)2(C6F5O)4O], features two TiIV atoms bridged by an O atom, which lies on an inversion centre. The TiIV atom is bonded to a η5-pentamethylcyclopentadienyl ring, two pentafluorophenolate anions and to the bridging O atom. The environment around the TiIV atom can be considered as a distorted tetrahedron. The cyclopentadienyl ring is disordered over two sets of sites [site occupancy = 0.824 (8) for the major component].
Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways
Youngjo Kim, Edward T Kipreos
Cell Division , 2007, DOI: 10.1186/1747-1028-2-18
Abstract: To maintain genome integrity, DNA replication must be strictly regulated to occur only once per cell cycle. Replication is, therefore, tightly regulated to prevent the re-initiation of DNA replication within the same S phase. A failure to restrict DNA replication results in 're-replication', in which the genome is over-replicated within the same cell cycle via origin re-firing. In eukaryotes, the extent of DNA replication is controlled by temporally restricting the assembly of the pre-replicative complex (pre-RC) through a process termed 'replication licensing' (reviewed in [1,2]). Pre-RCs form on replication origins through the sequential binding of DNA replication proteins during late mitosis or G1 phase. The six-member origin recognition complex (ORC) binds replication origins on newly-synthesized chromatin. During late mitosis or G1 phase, the replication licensing factors Cdt1 and Cdc6 are recruited to the origin. Cdt1 and Cdc6 together load the presumptive replicative helicase, the Mcm2-7 complex, onto the origin to complete pre-RC formation. During S phase, pre-RCs are activated by phosphorylation via CDK and DDK (Dbf4-dependent kinase) activity. This phosphorylation allows the recruitment of essential replication factors, including Cdc45, Mcm10, RPA, proliferating cell nuclear antigen (PCNA), and DNA polymerases α and δ.Cdt1 and Cdc6 are essential loading factors for the Mcm2-7 complex, and they are negatively regulated during S phase to ensure that the Mcm2-7 complex cannot re-bind to origins that have already fired. In budding yeast, Cdt1 is exported from the nucleus during S phase [3]. In contrast, fission yeast and metazoan Cdt1 homologs are degraded during S phase [1,2,4]. The other replication licensing factor, Cdc6, is regulated by degradation during S phase in budding and fission yeast, while in metazoa, Cdc6 is exported from the nucleus [1,2,4,5]. In most eukaryotic species examined, redundant regulation prevents reassembly of pre-RCs in S phase. Th
Rejoinder: Likelihood Inference for Models with Unobservables Another View
Youngjo Lee,John A. Nelder
Statistics , 2010, DOI: 10.1214/09-STS277REJ
Abstract: Rejoinder to "Likelihood Inference for Models with Unobservables: Another View" by Youngjo Lee and John A. Nelder [arXiv:1010.0303]
Likelihood Inference for Models with Unobservables: Another View
Youngjo Lee,John A. Nelder
Statistics , 2010, DOI: 10.1214/09-STS277
Abstract: There have been controversies among statisticians on (i) what to model and (ii) how to make inferences from models with unobservables. One such controversy concerns the difference between estimation methods for the marginal means not necessarily having a probabilistic basis and statistical models having unobservables with a probabilistic basis. Another concerns likelihood-based inference for statistical models with unobservables. This needs an extended-likelihood framework, and we show how one such extension, hierarchical likelihood, allows this to be done. Modeling of unobservables leads to rich classes of new probabilistic models from which likelihood-type inferences can be made naturally with hierarchical likelihood.
2-Benzhydryl-6-tert-butyl-4-methylphenol
Sungwoo Yoon,Junseong Lee,Youngjo Kim
Acta Crystallographica Section E , 2013, DOI: 10.1107/s1600536813002006
Abstract: The title compound, C24H26O, was prepared by the reaction between 2-tert-butyl-4-methylphenol and diphenylmethanol in the presence of sulfuric acid. Three benzene rings are attached directly to the central C—H group in a twisted propeller conformation with the local pseudo-C3 rotational axis coinciding with the C—H bond. There are three short C—H...O contacts in the molecule.
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