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Search Results: 1 - 10 of 24957 matches for " Young-Su Seo "
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Stability in Generalized Functions
Young-Su Lee
Abstract and Applied Analysis , 2011, DOI: 10.1155/2011/502903
Abstract: We consider the following additive functional equation with -independent variables: ∑(=1∑)==1(∑)
Stability of a Quadratic Functional Equation in the Spaces of Generalized Functions
Lee Young-Su
Journal of Inequalities and Applications , 2008,
Abstract: Making use of the pullbacks, we reformulate the following quadratic functional equation: in the spaces of generalized functions. Also, using the fundamental solution of the heat equation, we obtain the general solution and prove the Hyers-Ulam stability of this equation in the spaces of generalized functions such as tempered distributions and Fourier hyperfunctions.
Stability of a Quadratic Functional Equation in the Spaces of Generalized Functions
Young-Su Lee
Journal of Inequalities and Applications , 2008, DOI: 10.1155/2008/210615
Abstract: Making use of the pullbacks, we reformulate the following quadratic functional equation: f(x+y+z)+f(x)+f(y)+f(z)=f(x+y)+f(y+z)+f(z+x) in the spaces of generalized functions. Also, using the fundamental solution of the heat equation, we obtain the general solution and prove the Hyers-Ulam stability of this equation in the spaces of generalized functions such as tempered distributions and Fourier hyperfunctions.
A two-genome microarray for the rice pathogens Xanthomonas oryzae pv. oryzae and X. oryzae pv. oryzicola and its use in the discovery of a difference in their regulation of hrp genes
Young-Su Seo, Malinee Sriariyanun, Li Wang, Janice Pfeiff, Jirapa Phetsom, Ye Lin, Ki-Hong Jung, Hui Hsien Chou, Adam Bogdanove, Pamela Ronald
BMC Microbiology , 2008, DOI: 10.1186/1471-2180-8-99
Abstract: Three biological replicates of the microarray experiment to compare global gene expression in representative strains of Xoo and Xoc grown in PSB vs. XOM2 were carried out. The non-specific error rate and the correlation coefficients across biological replicates and among duplicate spots revealed that the microarray data were robust. 247 genes of Xoo and 39 genes of Xoc were differentially expressed in the two media with a false discovery rate of 5% and with a minimum fold-change of 1.75. Semi-quantitative-RT-PCR assays confirmed differential expression of each of 16 genes each for Xoo and Xoc selected for validation. The differentially expressed genes represent 17 functional categories.We describe here the construction and validation of a two-genome microarray for the two pathovars of X. oryzae. Microarray analysis revealed that using representative strains, a greater number of Xoo genes than Xoc genes are differentially expressed in XOM2 relative to PSB, and that these include hrp genes and other genes important in interactions with rice. An exception was the rax genes, which are required for production of the host resistance elicitor AvrXa21, and which were expressed constitutively in both pathovars.The rice pathogens Xanthomonas oryzae pathovar oryzae (Xoo) and Xanthomonas oryzae pathovar oryzicola (Xoc) cause economically significant disease in many rice-growing regions of the world [1]. Xoo invades rice vascular tissue to cause bacterial leaf blight, whereas Xoc colonizes the mesophyll parenchyma tissue to cause bacterial leaf streak. Xoo gains access to the xylem through wounds or natural openings such as hydathodes, while Xoc, in contrast, enters the leaf mainly through stomata [2]. Xoo and Xoc are closely related, infect the same host, and are often both established in the same rice fields. The complete genome sequences of Japanese Xoo strain T7174 (also called MAFF311018) and Korean Xoo strain KACC10331 have been published [3,4]. The genome sequences of a t
IRAK1/4-Targeted Anti-Inflammatory Action of Caffeic Acid
Woo Seok Yang,Deok Jeong,Young-Su Yi,Jae Gwang Park,Hyohyun Seo,Sang Hyun Moh,Sungyoul Hong,Jae Youl Cho
Mediators of Inflammation , 2013, DOI: 10.1155/2013/518183
Abstract: Caffeic acid (CA) is a phenolic compound that is frequently present in fruits, grains, and dietary supplements. Although CA has been reported to display various biological activities such as anti-inflammatory, anti-cancer, anti-viral, and anti-oxidative effects, the action mechanism of CA is not yet fully elucidated. In this study, the anti-inflammatory action mechanism of CA was examined in lipopolysaccharide (LPS) treated macrophages (RAW264.7 cells) and HCl/EtOH-induced gastritis. CA was found to diminish nitric oxide (NO) and prostaglandin E2 (PGE2) production in LPS-stimulated RAW264.7 cells. Additionally, mRNA levels of tumor necrosis factor (TNF)-α, cyclooxygenase (COX)-2, and inducible NO synthase (iNOS) were downregulated by CA. CA also strongly suppressed the nuclear translocation of AP-1 family proteins and the related upstream signaling cascade composed of interleukin-1 receptor-associated kinase 1 (IRAK1), IRAK4, TGF-β-activated kinase 1 (TAK1), mitogen-activated protein kinase kinase 4/7 (MKK4/7), and c-Jun N-terminal kinase (JNK). In a direct kinase assay, CA was revealed to directly inhibit IRAK1 and IRAK4. CA also ameliorated HCl/EtOH-induced gastric symptoms via the suppression of JNK, IRAK1, and IRAK4. Therefore, our data strongly suggest that CA acts as an anti-inflammatory drug by directly suppressing IRAK1 and IRAK4. 1. Introduction Upon infection by foreign pathogens, innate immune cells, which include macrophages, keratinocytes, and Langerhans cells, are activated via pattern recognition receptors such as the toll-like receptors (TLRs). Once activated, these cells can phagocytose materials from pathogens and infected cells and subsequently produce various inflammatory mediators such as interleukin (IL)-1, IL-6, tumor necrosis factor (TNF)-α, and the mediators nitric oxide (NO) and prostaglandin E2 (PGE2) that can stimulate other immune cells [1, 2]. Numerous intracellular signaling cascades, including non-receptor protein tyrosine kinases, phosphoinositide 3-kinase (PI3K), phosphoinositide-dependent kinase 1 (PDK1), and mitogen-activated protein kinases (MAPK) that are required for the translocation of transcription factors such as nuclear factor (NF)-κB and activator protein (AP)-1, are involved in these processes [3, 4]. Consequently, inflammatory cells can express numerous inflammatory genes that encode proinflammatory cytokines, inducible NO synthase (iNOS) for NO release, and cyclooxygenase (COX)-2 for prostaglandin E2 (PGE2) production [5–8]. The excessive activation of inflammatory cells is known to generate an
shin-jae,rhim, wee-haeng,hur, young-su,park,seo-youn,choi, chang-bae,lee, 朴仁珠, woo-shin,lee
兽类学报 , 2003,
Abstract: ?为更好地保护和管理部分哺乳类动物及其栖息地,自2001年6月至2002年3月在韩国白头大干山脉8个被道路切割的林区内调查了道路两边一定距离内所见哺乳动物随距离增加而变化的丰富度。我们共调查了10种哺乳类(野猪、狍、獐、黄鼬、貉、豹猫、华南兔、松鼠、花鼠、鼹)的各种痕迹(粪便、足迹、食痕、卧迹及休息处),发现距道路近处两边的丰富度确有较大下降。这说明道路建设的确影响哺乳类的生境选择及其利用方式。所以今后在道路设计、管理及扩充等方面均需充分考虑和满足所有野生动物整个生命过程所需的空间要求。
Cycloaddition Functionalizations to Preserve or Control the Conductance of Carbon Nanotubes
Young-Su Lee,Nicola Marzari
Physics , 2006, DOI: 10.1103/PhysRevLett.97.116801
Abstract: We identify a class of covalent functionalizations that preserves or controls the conductance of single-walled metallic carbon nanotubes. [2+1] cycloadditions can induce bond cleaving between adjacent sidewall carbons, recovering in the process the $sp^2$ hybridization and the ideal conductance of the pristine tubes. This is radically at variance with the damage permanently induced by other common ligands, where a single covalent bond is formed with a sidewall carbon. Chirality, curvature, and chemistry determine bond cleaving, and in turn the electrical transport properties of a functionalized tube. A well-defined range of diameters can be found for which certain addends exhibit a bistable state, where the opening or closing of the sidewall bond, accompanied by a switch in the conductance, could be directed with chemical, optical or thermal means.
Identification and Functional Analysis of Light-Responsive Unique Genes and Gene Family Members in Rice
Ki-Hong Jung,Jinwon Lee,Chris Dardick,Young-Su Seo,Peijian Cao,Patrick Canlas,Jirapa Phetsom,Xia Xu,Shu Ouyang,Kyungsook An,Yun-Ja Cho,Geun-Cheol Lee,Yoosook Lee,Gynheung An,Pamela C. Ronald
PLOS Genetics , 2008, DOI: 10.1371/journal.pgen.1000164
Abstract: Functional redundancy limits detailed analysis of genes in many organisms. Here, we report a method to efficiently overcome this obstacle by combining gene expression data with analysis of gene-indexed mutants. Using a rice NSF45K oligo-microarray to compare 2-week-old light- and dark-grown rice leaf tissue, we identified 365 genes that showed significant 8-fold or greater induction in the light relative to dark conditions. We then screened collections of rice T-DNA insertional mutants to identify rice lines with mutations in the strongly light-induced genes. From this analysis, we identified 74 different lines comprising two independent mutant lines for each of 37 light-induced genes. This list was further refined by mining gene expression data to exclude genes that had potential functional redundancy due to co-expressed family members (12 genes) and genes that had inconsistent light responses across other publicly available microarray datasets (five genes). We next characterized the phenotypes of rice lines carrying mutations in ten of the remaining candidate genes and then carried out co-expression analysis associated with these genes. This analysis effectively provided candidate functions for two genes of previously unknown function and for one gene not directly linked to the tested biochemical pathways. These data demonstrate the efficiency of combining gene family-based expression profiles with analyses of insertional mutants to identify novel genes and their functions, even among members of multi-gene families.
AbaA Regulates Conidiogenesis in the Ascomycete Fungus Fusarium graminearum
Hokyoung Son, Myung-Gu Kim, Kyunghun Min, Young-Su Seo, Jae Yun Lim, Gyung Ja Choi, Jin-Cheol Kim, Suhn-Kee Chae, Yin-Won Lee
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0072915
Abstract: Fusarium graminearum (teleomorph Gibberella zeae) is a prominent pathogen that infects major cereal crops such as wheat, barley, and maize. Both sexual (ascospores) and asexual (conidia) spores are produced in F. graminearum. Since conidia are responsible for secondary infection in disease development, our objective of the present study was to reveal the molecular mechanisms underlying conidiogenesis in F. graminearum based on the framework previously described in Aspergillus nidulans. In this study, we firstly identified and functionally characterized the ortholog of AbaA, which is involved in differentiation from vegetative hyphae to conidia and known to be absent in F. graminearum. Deletion of abaA did not affect vegetative growth, sexual development, or virulence, but conidium production was completely abolished and thin hyphae grew from abnormally shaped phialides in abaA deletion mutants. Overexpression of abaA resulted in pleiotropic defects such as impaired sexual and asexual development, retarded conidium germination, and reduced trichothecene production. AbaA localized to the nuclei of phialides and terminal cells of mature conidia. Successful interspecies complementation using A. nidulans AbaA and the conserved AbaA-WetA pathway demonstrated that the molecular mechanisms responsible for AbaA activity are conserved in F. graminearum as they are in A. nidulans. Results from RNA-sequencing analysis suggest that AbaA plays a pivotal role in conidiation by regulating cell cycle pathways and other conidiation-related genes. Thus, the conserved roles of the AbaA ortholog in both A. nidulans and F. graminearum give new insight into the genetics of conidiation in filamentous fungi.
Cross-Family Translational Genomics of Abiotic Stress-Responsive Genes between Arabidopsis and Medicago truncatula
Daejin Hyung, Chaeyoung Lee, Jin-Hyun Kim, Dongwoon Yoo, Young-Su Seo, Soon-Chun Jeong, Jai-Heon Lee, Youngsoo Chung, Ki-Hong Jung, Douglas R. Cook, Hong-kyu Choi
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0091721
Abstract: Cross-species translation of genomic information may play a pivotal role in applying biological knowledge gained from relatively simple model system to other less studied, but related, genomes. The information of abiotic stress (ABS)-responsive genes in Arabidopsis was identified and translated into the legume model system, Medicago truncatula. Various data resources, such as TAIR/AtGI DB, expression profiles and literatures, were used to build a genome-wide list of ABS genes. tBlastX/BlastP similarity search tools and manual inspection of alignments were used to identify orthologous genes between the two genomes. A total of 1,377 genes were finally collected and classified into 18 functional criteria of gene ontology (GO). The data analysis according to the expression cues showed that there was substantial level of interaction among three major types (i.e., drought, salinity and cold stress) of abiotic stresses. In an attempt to translate the ABS genes between these two species, genomic locations for each gene were mapped using an in-house-developed comparative analysis platform. The comparative analysis revealed that fragmental colinearity, represented by only 37 synteny blocks, existed between Arabidopsis and M. truncatula. Based on the combination of E-value and alignment remarks, estimated translation rate was 60.2% for this cross-family translation. As a prelude of the functional comparative genomic approaches, in-silico gene network/interactome analyses were conducted to predict key components in the ABS responses, and one of the sub-networks was integrated with corresponding comparative map. The results demonstrated that core members of the sub-network were well aligned with previously reported ABS regulatory networks. Taken together, the results indicate that network-based integrative approaches of comparative and functional genomics are important to interpret and translate genomic information for complex traits such as abiotic stresses.
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