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Search Results: 1 - 10 of 31408 matches for " Young-Cheol Lee "
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Synergistic Effect of Various Regulatory Factors in Th1/Th2 Balance; Immunotherapeutic Approaches in Asthma
Young-Cheol Lee
International Journal of Biomedical Science , 2008,
Abstract: The immune balance controlled by T helper 1 (Th1) and T helper 2 (Th2) is crucial for immunoregulation and its imbalance causes various immune diseases including allergic asthma. Therefore, diagnosis of Th1/Th2 balance in autoimmune diseases including asthma is essential for the application of immune balance regulating drugs. Th1/Th2 balance is not only controlled by Th1 cells and Th2 cells, but also by various regulatory factors including regulatory T cells, sexual factor, chemokines, transcription factors, signal transduction pathway (STAT6) etc. From that point of view, conception of ‘‘Th1/Th2 balance’’ resembles the balance of yin and yang which is main concept of Korean traditional medicine for treatment diseases. This article discusses various regulatory factors that influence Th1/Th2. Current research strategies seek to exploit these observations to improve the generation of novel targets for regulating Th1/Th2 balance. The Th1/Th2 balance could be influenced by imunomodulatory drugs (including herbs, prescription and its main components) but this way of therapy needs further evaluation focused on this various factors and synergistic effect.
Optimal Design of a Centrifugal Compressor Impeller Using Evolutionary Algorithms
Soo-Yong Cho,Kook-Young Ahn,Young-Duk Lee,Young-Cheol Kim
Mathematical Problems in Engineering , 2012, DOI: 10.1155/2012/752931
Abstract: An optimization study was conducted on a centrifugal compressor. Eight design variables were chosen from the control points for the Bezier curves which widely influenced the geometric variation; four design variables were selected to optimize the flow passage between the hub and the shroud, and other four design variables were used to improve the performance of the impeller blade. As an optimization algorithm, an artificial neural network (ANN) was adopted. Initially, the design of experiments was applied to set up the initial data space of the ANN, which was improved during the optimization process using a genetic algorithm. If a result of the ANN reached a higher level, that result was re-calculated by computational fluid dynamics (CFD) and was applied to develop a new ANN. The prediction difference between the ANN and CFD was consequently less than 1% after the 6th generation. Using this optimization technique, the computational time for the optimization was greatly reduced and the accuracy of the optimization algorithm was increased. The efficiency was improved by 1.4% without losing the pressure ratio, and Pareto-optimal solutions of the efficiency versus the pressure ratio were obtained through the 21st generation.
Effects of Radix Adenophorae and Cyclosporine A on an OVA-Induced Murine Model of Asthma by Suppressing to T Cells Activity, Eosinophilia, and Bronchial Hyperresponsiveness
Seong-Soo Roh,Seung-Hyung Kim,Young-Cheol Lee,Young-Bae Seo
Mediators of Inflammation , 2008, DOI: 10.1155/2008/781425
Abstract:
Antiasthmatic Effects of Hesperidin, a Potential Th2 Cytokine Antagonist, in a Mouse Model of Allergic Asthma
Seung-Hyung Kim,Bok-Kyu Kim,Young-Cheol Lee
Mediators of Inflammation , 2011, DOI: 10.1155/2011/485402
Abstract: Background and Objective. The features of asthma are airway inflammation, reversible airflow obstruction, and an increased sensitivity to bronchoconstricting agents, termed airway hyperresponsiveness (AHR), excess production of Th2 cytokines, and eosinophil accumulation in the lungs. To investigate the antiasthmatic potential of hesperidin as well as the underlying mechanism involved, we studied the inhibitory effect and anti-inflammatory effect of hesperidin (HPN) on the production of Th2 cytokines, eotaxin, IL-17, -OVA-specific IgE in vivo asthma model mice. Methods. In this paper, BALB/c mice were systemically sensitized to ovalbumin (OVA) followed intratracheally, intraperitoneally, and by aerosol allergen challenges. We investigated the effect of HPN on airway hyperresponsiveness, pulmonary eosinophilic infiltration, various immune cell phenotypes, Th2 cytokine production and OVA-specific IgE production in a mouse model of asthma. Results. In BALB/c mice, we found that HPN-treated groups had suppressed eosinophil infiltration, allergic airway inflammation, and AHR, and these occurred by suppressing the production of IL-5, IL-17, and OVA-specific IgE. Conclusions. Our data suggest that the therapeutic mechanism by which HPN effectively treats asthma is based on reductions of Th2 cytokines (IL-5), eotaxin, OVA-specific IgE production, and eosinophil infiltration via inhibition of GATA-3 transcription factor. 1. Introduction The features of asthma are airway inflammation, reversible airflow obstruction, and an increased sensitivity to bronchoconstricting agents, termed airway hyperresponsiveness (AHR), excess production of Th2 cytokines, and eosinophil accumulation in the lungs [1]. The immune cells involved in regulating allergic airway inflammatory responses include monocytes/macrophages, dendritic cells, neutrophils, basophils, mast cells, eosinophils, T and B lymphocytes [2]. Moreover, it is well established that there is a strong interaction between eosinophils and Th2 cells in the asthmatic airways and that Th2 cell-derived cytokines, namely IL-4, IL-5, and IL-13, play critical roles in orchestrating and amplifying allergic inflammation in asthma [3]. CD4+ T cells play a crucial role in immune protection, and they do so through their capacity to help B cells make antibodies, to recruit neutrophils, eosinophils, and basophils to sites of inflammation, and, through their production of cytokines and chemokines, to orchestrate the immune responses [4]. Suppression of cytokine production in activated CD4+ T cells may be useful for the treatment of
ATLAS: A Traffic Load Aware Sensor MAC Design for Collaborative Body Area Sensor Networks
Md. Obaidur Rahman,Choong Seon Hong,Sungwon Lee,Young-Cheol Bang
Sensors , 2011, DOI: 10.3390/s111211560
Abstract: In collaborative body sensor networks, namely wireless body area networks(WBANs), each of the physical sensor applications is used to collaboratively monitor thehealth status of the human body. The applications of WBANs comprise diverse and dynamictraffic loads such as very low-rate periodic monitoring (i.e., observation) data and high-ratetraffic including event-triggered bursts. Therefore, in designing a medium access control(MAC) protocol for WBANs, energy conservation should be the primary concern duringlow-traffic periods, whereas a balance between satisfying high-throughput demand andefficient energy usage is necessary during high-traffic times. In this paper, we design atraffic load-aware innovative MAC solution for WBANs, called ATLAS. The design exploitsthe superframe structure of the IEEE 802.15.4 standard, and it adaptively uses the contentionaccess period (CAP), contention free period (CFP) and inactive period (IP) of the superframebased on estimated traffic load, by applying a dynamic “wh” (whenever which is required)approach. Unlike earlier work, the proposed MAC design includes load estimation fornetwork load-status awareness and a multi-hop communication pattern in order to preventenergy loss associated with long range transmission. Finally, ATLAS is evaluated throughextensive simulations in ns-2 and the results demonstrate the effectiveness of the protocol.
Effects of Corni fructus on ovalbumin-induced airway inflammation and airway hyper-responsiveness in a mouse model of allergic asthma
Seung-Hyung Kim, Bok-Kyu Kim, Young-Cheol Lee
Journal of Inflammation , 2012, DOI: 10.1186/1476-9255-9-9
Abstract: In this study, BALB/c mice were systemically sensitized to ovalbumin (OVA) by intraperitoneal (i.p.), intratracheal (i.t.) injections and intranasal (i.n.) inhalation of OVA. We investigated the effect of CF on airway hyperresponsiveness, pulmonary eosinophilic infiltration, various immune cell phenotypes, Th2 cytokine production, and OVA-specific immunoglobulin E (IgE) production.The CF-treated groups showed suppressed eosinophil infiltration, allergic airway inflammation, and AHR via reduced production of interleuin (IL) -5, IL-13, and OVA-specific IgE.Our data suggest that the therapeutic effects of CF in asthma are mediated by reduced production of Th2 cytokines (IL-5), eotaxin, and OVA-specific IgE and reduced eosinophil infiltration.Allergic asthma generally presents with symptoms of wheezing, coughing, breathlessness, and airway inflammation. It is a chronic inflammatory disease of the airways, characterized by airway eosinophilia and goblet cell hyperplasia with mucus hypersecretion to inhaled allergens and nonspecific stimuli [1,2]. In particular, eosinophilic inflammation is considered the hallmark of airway inflammation in asthma [3]. The inflammatory process in allergic asthma is dominated by Th2 cells that produce IL-4, IL-5, and IL-13 [4], which activate eosinophils and induce the production of IgE by B cells [5,6].CF is a Korean traditional medicinal herb with tonic, analgesic, and diuretic activity and has been commonly used to facilitate liver and kidney function, reduce urination, and decrease perspiration. We previously reported that CF has anti-allergic activity in mouse splenic B cells and IC-2 mast cells [7]. Sung et al. [8] reported that aqueous extracts of CF have anti-inflammatory and analgesic activities in murine RAW 264.7 macrophage cells. Moreover, Du et al. [9] reported that the polysaccharides in crude and processed CF enhance nonspecific immunity, specific humoral immunity, and specific cellular immunity in immunosuppressed mice, and
The one-dimensional holographic display
Kim Young-Cheol
Physics , 2006,
Abstract: This paper introduces a new concept of one-dimensional hologram which represents one line image, and a new kind of display structure using it. This one-dimensional hologram is similar to a superpositioned diffraction lattice. And the interference patterns can be efficiently computed with a simple optical computing structure. This is a Proposal for a new kind of display method.
Pinellia ternata, Citrus reticulata, and Their Combinational Prescription Inhibit Eosinophil Infiltration and Airway Hyperresponsiveness by Suppressing CCR3+ and Th2 Cytokines Production in the Ovalbumin-Induced Asthma Model
In-Soo Ok,Seung-Hyung Kim,Bok-Kyu Kim,Jang-Cheon Lee,Young-Cheol Lee
Mediators of Inflammation , 2009, DOI: 10.1155/2009/413270
Abstract: Background and Objective. This study was aimed to analyse the curative effects of Pinellia ternata, Citrus reticulata, and their combination on airway hyperresponsiveness (AHR) to inhaled methacholine, pulmonary eosinophilic infiltration, Th2 cytokine production, and IgE and histamine production in a murine model of asthma. Methods. For this purpose, BALB/c mice were systemically sensitized to ovalbumin (OVA) followed intratracheally, intraperitoneally, and by aerosol allergen challenges for 12 weeks. We examined the development of pulmonary eosinophilic accumulation, control of Th2 cytokine, immunoglobulin E (IgE), and histamine productions in a murine model of asthma. Results. Our data suggest that the therapeutic mechanism by which Pinellia ternata, Citrus reticulata, and their combinational prescription effectively treats asthma is based on reductions of eosinophil infiltration, eotaxin receptor (CCR3), histamine, OVA-specific IgE productions in serum, and Th2 cytokines (IL-5, IL-13) by marked reductions of IL-5 and IL-13 mRNA expression in lung tissue. Conclusions. These findings provide evidence that Pinellia ternata, Citrus reticulata, and their combination play a regulatory role in allergic inflammation and offer therapeutic approaches as novel CCR3 antagonists for treatment asthma. However, it is not clear whether pharmacological activities of prescription composed of two herbs are potentiated due to synergistic effect or additive effect.
Short-Term Effect of Standard Automated Perimetry Testing on Intraocular Pressure in Patients with Open-Angle Glaucoma
Chang Mok Lee,Young Cheol Yoo
ISRN Ophthalmology , 2013, DOI: 10.1155/2013/956504
Abstract:
Short-Term Effect of Standard Automated Perimetry Testing on Intraocular Pressure in Patients with Open-Angle Glaucoma
Chang Mok Lee,Young Cheol Yoo
ISRN Ophthalmology , 2013, DOI: 10.1155/2013/956504
Abstract: Purpose. To evaluate the short-term effect of standard automated perimetry (SAP) testing on intraocular pressure (IOP) in patients with open-angle glaucoma (OAG). Methods. We tested 45 patients (71 eyes) with OAG that had stable IOP under medical treatment. IOP was measured four times using an iCare rebound tonometer (RBT) immediately before, immediately after, 10 minutes after, and 20 minutes after SAP testing. Logistic regression analyses were performed to determine the relationships among SAP test duration, mean deviation of the SAP result, type of glaucoma medications, patient age, and significant IOP change (exceeding 2?mmHg) from baseline IOP. Results. The mean baseline IOP was 13.29 ± 3.06?mmHg. Although IOP changes immediately and 20 minutes after SAP testing were not statistically significant, the IOP change 10 minutes after SAP testing (?0.57 ± 1.84?mmHg) was statistically significant. However, the changes were within the margin of error of the RBT. Test duration, mean deviation, patient age, and type of glaucoma medications did not have a significant influence on IOP change (all ). Conclusions. IOP measured by RBT did not vary significantly after SAP testing in patients with OAG. It may be not necessary to reject IOP measured after SAP testing in patients with OAG. 1. Introduction Intraocular pressure (IOP) remains the only treatable risk factor for the management of glaucoma. Repeated IOP measurement and standard automated perimetry (SAP) testing are simple but fundamental procedures used to assess the stage of progression and to determine adequate treatment for patients with glaucoma [1, 2]. On a daily basis in our practice, IOP is measured after SAP testing. Afterward, both the SAP results and IOP are discussed with the patients, and their treatment strategies for glaucoma may be adjusted. There is a possibility that visual field examination performed before IOP measurement using both topical anesthetics and fluorescein dye affects the IOP values, misleading the clinician to strengthen the patients’ glaucoma treatment plan. Currently, there is no consensus in the literature about the effects of SAP testing on IOP. One prospective study reported that IOP varied significantly and tended to increase immediately after SAP testing in patients with primary open-angle glaucoma (POAG), but other studies have reported no significant difference [3–5]. But, there was no trial that evaluates serial changes of IOP values through timeline after SAP testing. The aim of the present study was to evaluate the short-term effects of SAP testing on IOP
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