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Search Results: 1 - 10 of 14575 matches for " Young Sook Park "
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Cornual patency and integrity following laparoscopic cornuotomy for interstitial pregnancy  [PDF]
Young-Sam Choi, Dae-Sook Eun, Yun-Sang Oh, Ji-No Park
Open Journal of Obstetrics and Gynecology (OJOG) , 2012, DOI: 10.4236/ojog.2012.22024
Abstract: Objective: To evaluate cornual patency and integrity following laparoscopic cornuotomy. Study Design: This is a prospective cohort study on seven women who underwent laparoscopic cornuotomy for interstitial pregnancy. The cornual patency and integrity were evaluated using hysterosalpingography (HSG) and magnetic resonance imaging (MRI). On MRI, the entire cornual wall thickness were measured bilaterally at 5-mm intervals. The thickness of the affected and unaffected cornua matched at the corresponding contralateral point in each of the women. Statistically, all possible pairwise 28 comparisons were compared using paired t-tests. Results: Among six eligible women, four women had excellent cornual patency on the affected side. Among seven women (i.e., 28 pairs), no significant difference was observed in cornual thickness compared to the unaffected cornu and no remarkable defects were seen in the endometrial and cornual contour. But there is no statistical significance. Conclusion: Laparoscopic cornuotomy seems to have advantage to preserve the cornu in interstitial pregnancy.
The Cerebral Hemodynamic Correlates of Quantitative EEG to The Right Cranial Cervical Ganglion Block in Beagle Dogs
Woo-Dae Park,Young-Sook Lee
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2011.2414.2420
Abstract: The sympathetic nerves act on changes in cerebral blood flow. These changes have been related to changes in brain waves. Therefore, we investigated the hypothesis that changes in brain waves could be affected by changes in cerebral blood flow following a block of the Cranial Cervical Ganglion (CCG) in dogs. A total of 25 healthy beagle dogs were divided into 3 groups. Group 1 (no. = 10) underwent a block of the right CCG (rCCGB) using 1% lidocaine. Group 2 (no. = 10) served as a control for group 1. This group was injected with 1% lidocaine into the right or left side digastric muscle. Group 3 (no. = 5) served as a control for groups 1 and 2. This group underwent rCCGB using saline. After injecting drugs into the digastric muscles or CCGB, the quantitative EEG (95% spectral edge frequency (95% SEF), the Median Frequency (MF) and the relative band power ( , , , ), : ratio) was measured at 5, 10, 15, 20, 25 and 30 min for each 1 min. There was a 95% SEF increase in group 1 at 20 min and the MF was significantly decreased at 5 min and significantly increased at 15 min compared to those of the other groups (p<0.05). In the relative band power, the low frequencies ( , ) were significantly increased while the high frequencies ( , ) were decreased at 5 min (p<0.05). Thereafter, the low frequencies ( , ) were significantly decreased and the high frequency ( , ) was significantly increased between 10 and 20 min (p<0.05). The : ratio showed that the value decreased in the right frontal lobe. The results suggest that the rCCGB is expected to be useful in the treatment of neural and cerebral disorders in dogs because the block has a significant effect on the change of the Cerebral Blood Flow Rate (CBFr).
Identification and analysis of in planta expressed genes of Magnaporthe oryzae
Soonok Kim, Jongsun Park, Sook-Young Park, Thomas K Mitchell, Yong-Hwan Lee
BMC Genomics , 2010, DOI: 10.1186/1471-2164-11-104
Abstract: A cDNA library was constructed with RNA from rice leaves (Oryza sativa cv. Hwacheong) infected with M. oryzae strain KJ201. To enrich for fungal genes, subtraction library using PCR-based suppression subtractive hybridization was constructed with RNA from infected rice leaves as a tester and that from uninfected rice leaves as the driver. A total of 4,148 clones from two libraries were sequenced to generate 2,302 non-redundant ESTs. Of these, 712 and 1,562 ESTs could be identified to encode fungal and rice genes, respectively. To predict gene function, Gene Ontology (GO) analysis was applied, with 31% and 32% of rice and fungal ESTs being assigned to GO terms, respectively. One hundred uniESTs were found to be specific to fungal infection EST. More than 80 full-length fungal cDNA sequences were used to validate ab initio annotated gene model of M. oryzae genome sequence.This study shows the power of ESTs to refine genome annotation and functional characterization. Results of this work have advanced our understanding of the molecular mechanisms underpinning fungal-plant interactions and formed the basis for new hypothesis.Rice blast, caused by Magnaporthe oryzae, is one of the most devastating diseases in rice growing regions worldwide, causing 11-15% yield loss annually [1]. Genetic tractability as well as economic importance makes this disease a model pathosystem to understand plant-microbe interactions. The genome sequences of both organisms are available [2-4], and both forward and reverse genomic studies to understand molecular mechanisms for pathogenesis on a genome scale have been undertaken [5]. Understanding the precise molecular mechanisms of infection will facilitate design of novel control strategies.The process of M. oryzae infection starts when a conidium lands on the rice leaf surface. After germination by hydration, an appressorium develops at the tip of the germ tube, from which a penetration peg emerges to penetrate the cuticle layer into the rice c
Seroprevalence of Helicobacter pylori in female Vietnamese immigrants to Korea
Su Jung Baik,Sun Young Yi,Hye Sook Park,Bo Hyun Park
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i6.517
Abstract: AIM: To investigate the seroprevalence of Helicobacter pylori (H. pylori) and its relationship to nutritional factors in female Vietnamese immigrants to Korea. METHODS: A total of 390 female immigrants from Vietnam and 206 Korean male spouses participated in the study. Blood samples from 321 female immigrants and 201 Korean male spouses were analyzed for H. pylori antibodies. Data on age, sex, alcohol consumption, smoking status, dietary nutritional factors and gastrointestinal symptoms were collected using questionnaires. The daily intakes of the following nutrients were estimated: energy, protein, niacin, lipid, fiber, calcium, iron, sodium, potassium, zinc, folate, cholesterol, and vitamins A, B1, B2, B6, C and E. RESULTS: The prevalence of H. pylori positivity was lower in the immigrants than in age-matched Korean females (55.7% vs 71.4%, respectively; P < 0.0001) and the domestic population of Vietnam. The prevalence of H. pylori positivity among married couples was 31.7% for both spouses. There were no statistically significant differences in the incidence of smoking, amount of alcohol consumed, or nutritional factors between the H. pylori-positive and negative groups. CONCLUSION: The prevalence of H. pylori positivity was lower among female Vietnamese immigrants than among Korean females. Nutritional factors did not differ between the H. pylori-positive and negative groups.
Trends in the Aggressiveness of End-of-Life Care for Korean Pediatric Cancer Patients Who Died in 2007–2010
June Dong Park, Hyoung Jin Kang, Young Ae Kim, MinKyoung Jo, Eun Sook Lee, Hee Young Shin, Young Ho Yun
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0099888
Abstract: Background In light of the Korean Supreme Court's 2009 ruling favoring a patient's right to die with dignity, we evaluated trends in aggressive care in a cohort of pediatric cancer patients. Methods We conducted a population-based retrospective study that used administrative data for patients who died in 2007–2010 among the 5,203 pediatric cancer patients registered at the Korean Cancer Central Registry (KCCR) during 2007–2009. Results In the time period covered, 696 patients died. The proportion who had received chemotherapy in the last 30 days of life decreased from 58.1% to 28.9% (P<0.001), those who received new chemotherapy in the same time period decreased from 55.2% to 15.1% (P<0.001), and those who received treatment in the last 2 weeks of life decreased from 51.4% to 21.7% (P<0.001). In the last 30 days of life, the proportion of patients whose hospital admission period was over 14 days increased from 70.5% to 82.5% (P = 0.03), the proportion who received cardiopulmonary resuscitation decreased from 28.6% to 9.6% (P<0.001), and we found no statistically significant trends in the proportion of emergency department visits, intensive care unit admissions, or mechanical ventilation. Conclusions In this study, in contrast with earlier ones, the aggressiveness of end-of-life care of Korean pediatric cancer patients decreased dramatically.
Progranulin as a Prognostic Biomarker for Breast Cancer Recurrence in Patients Who Had Hormone Receptor-Positive Tumors: A Cohort Study
Dong Hoe Koo, Cheol-Young Park, Eun Sook Lee, Jungsil Ro, Sang Woo Oh
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0039880
Abstract: Background Progranulin (PGRN) is considered to play an important role in breast cancer tumorigenesis and in inhibiting tamoxifen-induced apoptosis. We aimed to determine whether PGRN levels are associated with breast cancer recurrence after curative surgery. Methodology/Principal Findings We evaluated the associations between preoperative serum PGRN levels and breast cancer recurrence in a cohort of 697 newly diagnosed breast cancer patients who underwent curative surgery between April 2001 and December 2004. The mean age ± standard deviation (SD) was 46±9.8 years, and all patients with hormone receptor (HR)-positive tumors received adjuvant tamoxifen therapy. At a median follow-up of 62.2 months (range, 2.9–98.2), 89 patients (12.8%) had experienced a recurrence and 51 patients (7.3%) had died. In the HR-positive group, serum PGRN levels were associated with recurrence according to the log-rank test for trend (p for trend = 0.049). There was no association between PGRN levels and recurrence in the HR-negative group (p for trend = 0.658). Adjusted hazard ratios, including possible confounders, revealed a linear relationship between serum PGRN levels and recurrence in the HR-positive group (p for trend = 0.049), and this association was further strengthened after excluding patients who had no lymph node metastasis (p for trend = 0.038). Conclusions/Significance Serum PGRN levels were clinically significant for predicting recurrence in patients with HR-positive breast cancer during adjuvant tamoxifen therapy.
A Novel Pathogenicity Gene Is Required in the Rice Blast Fungus to Suppress the Basal Defenses of the Host
Myoung-Hwan Chi,Sook-Young Park,Soonok Kim,Yong-Hwan Lee
PLOS Pathogens , 2009, DOI: 10.1371/journal.ppat.1000401
Abstract: For successful colonization and further reproduction in host plants, pathogens need to overcome the innate defenses of the plant. We demonstrate that a novel pathogenicity gene, DES1, in Magnaporthe oryzae regulates counter-defenses against host basal resistance. The DES1 gene was identified by screening for pathogenicity-defective mutants in a T-DNA insertional mutant library. Bioinformatic analysis revealed that this gene encodes a serine-rich protein that has unknown biochemical properties, and its homologs are strictly conserved in filamentous Ascomycetes. Targeted gene deletion of DES1 had no apparent effect on developmental morphogenesis, including vegetative growth, conidial germination, appressorium formation, and appressorium-mediated penetration. Conidial size of the mutant became smaller than that of the wild type, but the mutant displayed no defects on cell wall integrity. The Δdes1 mutant was hypersensitive to exogenous oxidative stress and the activity and transcription level of extracellular enzymes including peroxidases and laccases were severely decreased in the mutant. In addition, ferrous ion leakage was observed in the Δdes1 mutant. In the interaction with a susceptible rice cultivar, rice cells inoculated with the Δdes1 mutant exhibited strong defense responses accompanied by brown granules in primary infected cells, the accumulation of reactive oxygen species (ROS), the generation of autofluorescent materials, and PR gene induction in neighboring tissues. The Δdes1 mutant displayed a significant reduction in infectious hyphal extension, which caused a decrease in pathogenicity. Notably, the suppression of ROS generation by treatment with diphenyleneiodonium (DPI), an inhibitor of NADPH oxidases, resulted in a significant reduction in the defense responses in plant tissues challenged with the Δdes1 mutant. Furthermore, the Δdes1 mutant recovered its normal infectious growth in DPI-treated plant tissues. These results suggest that DES1 functions as a novel pathogenicity gene that regulates the activity of fungal proteins, compromising ROS-mediated plant defense.
Yong-Hoon YOUN,Young-Hyang PARK,Ae-Sook SUH
Gayana (Concepción) , 2004,
The PEX7-Mediated Peroxisomal Import System Is Required for Fungal Development and Pathogenicity in Magnaporthe oryzae
Jaeduk Goh, Junhyun Jeon, Kyoung Su Kim, Jongsun Park, Sook-Young Park, Yong-Hwan Lee
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0028220
Abstract: In eukaryotes, microbodies called peroxisomes play important roles in cellular activities during the life cycle. Previous studies indicate that peroxisomal functions are important for plant infection in many phytopathogenic fungi, but detailed relationships between fungal pathogenicity and peroxisomal function still remain unclear. Here we report the importance of peroxisomal protein import through PTS2 (Peroxisomal Targeting Signal 2) in fungal development and pathogenicity of Magnaporthe oryzae. Using an Agrobacterium tumefaciens-mediated transformation library, a pathogenicity-defective mutant was isolated from M. oryzae and identified as a T-DNA insert in the PTS2 receptor gene, MoPEX7. Gene disruption of MoPEX7 abolished peroxisomal localization of a thiolase (MoTHL1) containing PTS2, supporting its role in the peroxisomal protein import machinery. ΔMopex7 showed significantly reduced mycelial growth on media containing short-chain fatty acids as a sole carbon source. ΔMopex7 produced fewer conidiophores and conidia, but conidial germination was normal. Conidia of ΔMopex7 were able to develop appressoria, but failed to cause disease in plant cells, except after wound inoculation. Appressoria formed by ΔMopex7 showed a defect in turgor generation due to a delay in lipid degradation and increased cell wall porosity during maturation. Taken together, our results suggest that the MoPEX7-mediated peroxisomal matrix protein import system is required for fungal development and pathogenicity M. oryzae.
Polyphenol-Rich Fraction of Brown Alga Ecklonia cava Collected from Gijang, Korea, Reduces Obesity and Glucose Levels in High-Fat Diet-Induced Obese Mice
Eun Young Park,Eung Hwi Kim,Mi Hwi Kim,Young Wan Seo,Jung Im Lee,Hee Sook Jun
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/418912
Abstract: Ecklonia cava (E. cava) is a brown alga that has beneficial effects in models of type 1 and type 2 diabetes. However, the effects of E. cava extracts on diet-induced obesity and type 2 diabetes have not been specifically examined. We investigated the effects of E. cava on body weight, fat content, and hyperglycemia in high-fat diet- (HFD) induced obese mice and sought the mechanisms involved. C57BL/6 male mice were fed a HFD (60% fat) diet or normal chow. After 3 weeks, the HFD diet group was given extracts (200 mg/kg) of E. cava harvested from Jeju (CA) or Gijang (G-CA), Korea or PBS by oral intubation for 8 weeks. Body weights were measured weekly. Blood glucose and glucose tolerance were measured at 7 weeks, and fat pad content and mRNA expression of adipogenic genes and inflammatory cytokines were measured after 8 weeks of treatment. G-CA was effective in reducing body weight gain, body fat, and hyperglycemia and improving glucose tolerance as compared with PBS-HFD mice. The mRNA expression of adipogenic genes was increased, and mRNA expression of inflammatory cytokines and macrophage marker gene was decreased in G-CA-treated obese mice. We suggest that G-CA reduces obesity and glucose levels by anti-inflammatory actions and improvement of lipid metabolism.
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