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Search Results: 1 - 10 of 9442 matches for " Young Pyo Jang "
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Herbal Formula, PM014, Attenuates Lung Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease
Hyojung Lee,Youngeun Kim,Hye Jin Kim,Soojin Park,Young Pyo Jang,Sungki Jung,Heejae Jung,Hyunsu Bae
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/769830
Abstract: Chronic obstructive pulmonary disease (COPD), which is characterized by airway obstruction, leads to, as the two major forms of COPD, chronic bronchitis and emphysema. This study was conducted to evaluate the effects of herbal formula, PM014, in a murine model of COPD. Balb/c mice were treated once with each herb extract in PM014 or PM014 mixture via an oral injection. Lipopolysaccharide (LPS) or elastase/LPS were administrated to the mice to induce a disease that resembles COPD. PM014 treatment significantly attenuated the increased accumulation of immune cells in bronchoalveolar lavage fluid (BALF) compared to control mice. In addition, the TNF-α and IL-6 levels in BALF were decreased in the PM014 mice. Furthermore, histological analysis demonstrated that PM014 attenuated the hazardous effects of lung inflammation. These data suggest that PM014 exerts beneficial effects against forms of COPD such as lung inflammation.
Ulmus davidiana var. japonica Nakai Upregulates Eosinophils and Suppresses Th1 and Th17 Cells in the Small Intestine
Han-Sung Lee, Min Seong Jang, Jung-Hwan Kim, Chun-Pyo Hong, Eun-Jung Lee, Eun Ji Jeun, Chan Kim, Eun-Kyung Kim, Kwang-Seong Ahn, Bo-Gie Yang, Kwang Seok Ahn, Young Pyo Jang, Kyoo-Seok Ahn, You-Me Kim, Myoung Ho Jang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076716
Abstract: The bark of Ulmus davidiana var. japonica Nakai (Ulmaceae) has been used in traditional Korean medicine for chronic inflammation in the gastrointestinal tract. Here we investigated the frequency and cytokine profile of the major immune cells in the small intestinal lamina propria (SI LP), spleen, and mesenteric lymph nodes (MLNs) of mice treated orally with Ulmus davidiana var. japonica Nakai bark water extract (UDE) to address the immunomodulatory role of this herb in intestinal homeostasis. B6 mice were given 5g/kg UDE once daily for 14 days. They were then sacrificed, and cells were isolated from the spleen, MLNs, and SI LP. The proportion of B versus T lymphocytes, CD4+ versus CD8+ T lymphocytes, Th1 and Th17 cells, and Foxp3+ regulatory T cells in the spleen, MLNs, and SI LP were analyzed. The frequency of antigen-presenting cells (APCs), including dendritic cells, macrophages, and eosinophils in the SI LP and the expression of costimulatory molecules on APCs were also evaluated. The numbers and frequencies of Th1 and Th17 cells in the SI LP were significantly reduced in the UDE-treated mice compared with PBS controls. In addition, the proportion of IL-4-producing eosinophils in the SI LP was significantly elevated in the UDE-treated mice compared with controls. Taken together, these data indicate that UDE up-regulates the number and frequency of SI LP eosinophils, which can down-regulate the Th1 and Th17 responses via IL-4 secretion and contribute to intestinal homeostasis.
Study design and rationale of 'Influence of Cilostazol-based triple anti-platelet therapy on ischemic complication after drug-eluting stent implantation (CILON-T)' study: A multicenter randomized trial evaluating the efficacy of Cilostazol on ischemic vascular complications after drug-eluting stent implantation for coronary heart disease
Seung-Pyo Lee, Jung-Won Suh, Kyung Woo Park, Hae-Young Lee, Hyun-Jae Kang, Bon-Kwon Koo, In-Ho Chae, Dong-Ju Choi, Seung-Woon Rha, Jang-Whan Bae, Myeong-Chan Cho, Taek-Geun Kwon, Jang-Ho Bae, Hyo-Soo Kim, CILON-T investigators
Trials , 2010, DOI: 10.1186/1745-6215-11-87
Abstract: CILON-T trial was a prospective, randomized, open-label, multi-center, near-all-comer trial to demonstrate the superiority of triple anti-platelet therapy to dual anti-platelet therapy in reducing 6 months' major adverse cardiovascular/cerebrovascular events, composite of cardiac death, nonfatal myocardial infarction, target lesion revascularization and ischemic stroke. It also tested whether triple anti-platelet therapy is superior to dual anti-platelet therapy in inhibiting platelet reactivity in patients receiving percutaneous coronary intervention with drug-eluting stent. Total 960 patients were randomized to receive either dual anti-platelet therapy or triple anti-platelet therapy for 6 months and also, randomly stratified to either lipophilic statin (atorvastatin) or non-lipophilic statin (rosuvastatin) indefinitely. Secondary endpoints included all components of major adverse cardiovascular/cerebrovascular events, platelet reactivity as assessed by VerifyNow P2Y12 assay, effect of statin on major adverse cardiovascular/cerebrovascular events, bleeding complications, and albumin-to-creatinine ratio to test the nephroprotective effect of cilostazol. Major adverse cardiovascular/cerebrovascular events will also be checked at 1, 2, and 3 years to test the 'legacy' effect of triple anti-platelet therapy that was prescribed for only 6 months after percutaneous coronary intervention.CILON-T trial will give powerful insight into whether triple anti-platelet therapy is superior to dual anti-platelet therapy in reducing ischemic events and platelet reactivity in the real-world unselected patients treated with drug-eluting stent for coronary heart disease. Also, it will verify the laboratory and clinical significance of drug interaction between lipophilic statin and clopidogrel.National Institutes of Health Clinical Trials Registry (ClinicalTrials.gov identifier# NCT00776828).Current guidelines recommend at least 6 months of dual anti-platelet agents, consisting of aspi
Simulation of Multifilament Semicrystalline Polymer Fiber Melt-Spinning
Young-Pyo Jeon,Christopher L. Cox
Journal of Engineered Fibers and Fabrics , 2009,
Abstract: The goal of this effort is to provide an accurate simulation of multifilament fiber melt spinning, applicable for a wide range of material and process conditions. For ease of use, the model should run on a standard laptop or desktop computer in reasonable time (one hour or less). Most melt spinning models simulate the formation of a single filament, with little or no attention given to multifilament effects. Available multifilament simulations are primarily limited to Newtonian constitutive models for the polymer flow. We present a multifilament simulation based on the flow-enhanced crystallization approach of Shrikhande et al. [J. Appl. Polym. Sci., 100, 2006, 3240-3254] combined with a variant on the multifilament quench model of Zhang, et al. [J. Macromol. Sci. Phys., 47, 2007, 793-806]. We demonstrate the versatility of this model by applying it to isotactic polypropylene and polyethylene terephthalate, under a variety of process conditions.
Alstonia scholaris R. Br. Significantly Inhibits Retinoid-Induced Skin Irritation In Vitro and In Vivo
Soo-Jin Lee,Sun-A Cho,Su-Sun An,Yong-Joo Na,Nok-Hyun Park,Han-Sung Kim,Chan-Woo Lee,Han-Kon Kim,Eun-Kyung Kim,Young-Pyo Jang,Jin-Woong Kim
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/190370
Abstract: Topical retinoids inhibit matrix metalloproteinases and accelerate collagen synthesis, thereby triggering antiaging effects in the skin. However, topical retinoids can cause severe skin reactions, including scaling, erythema, papules, and inflammation. The present study demonstrates that the ethanolic bark extract of Alstonia scholaris R. Br. can significantly inhibit all-trans retinoic acid-induced inflammation in human HaCat keratinocyte cells. Furthermore, two representative retinoid-induced proinflammatory cytokines, monocyte chemoattractant protein-1 and interleukin-8, were significantly suppressed by A. scholaris extract (by 82.1% and 26.3% at 100 ppm, and dose-dependently across the tested concentrations) in vitro. In a cumulative irritation patch test, A. scholaris extract decreased retinol-induced skin irritation, while strengthening the ability of retinoids to inhibit matrix metalloproteinase-1 expression, which is strongly associated with aging effects. These results suggest that A. scholaris is a promising compound that may increase the antiaging function of retinoids while reducing their ability to cause skin irritation.
Early Nephrology Referral Reduces the Economic Costs among Patients Who Start Renal Replacement Therapy: A Prospective Cohort Study in Korea
Jeonghwan Lee, Jung Pyo Lee, Ji In Park, Jin Ho Hwang, Hye Min Jang, Ji-Young Choi, Yong-Lim Kim, Chul Woo Yang, Shin-Wook Kang, Nam-Ho Kim, Yon Su Kim, Chun Soo Lim, CRC for ESRD investigators
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0099460
Abstract: Background The nature of cost-saving effects of early referral to a nephrologist in patients with chronic kidney disease (CKD) is not fully evaluated. We evaluated the health care costs before and after dialysis according to the referral time. Methods A total of 879 patients who were newly diagnosed as having end-stage renal disease from August 2008 to June 2011 were prospectively enrolled. The early referral (ER) group was defined as patients who were referred to a nephrologist more than a year before dialysis and had visited a nephrology clinic 2 or more times. Patients whose referral time was less than a year were considered the late referral (LR) group. Information about medical costs was acquired from the claim data of the Korea Health Insurance Review and Assessment Service. Results The total medical costs during the first 12 months after the initiation of dialysis were not different between the 526 ER patients and the 353 LR patients. However, the costs of the ER patients during the first month were significantly lower than those of the LR patients (ER vs. LR: 3029±2219 vs. 3438±2821 US dollars [USD], P = 0.025). The total 12-month health care costs before the initiation of dialysis were significantly lower in the ER group (ER vs. LR: 6206±5873 vs. 8610±7820 USD, P<0.001). In the multivariate analysis, ER significantly lowered the health care costs during the 12 months before (2534.0±436.2 USD, P<0.001) and the first month (428.5±172.3 USD, P = 0.013) after the initiation of dialysis. Conclusions The ER of patients with CKD to a nephrologist is associated with decreased medical costs during the pretreatment period of renal replacement therapy and the early period of dialysis initiation.
Hyers-Ulam stability of a generalized additive set-valued functional equation
Sun Young Jang, Choonkil Park and Young Cho
Journal of Inequalities and Applications , 2013, DOI: 10.1186/1029-242X-2013-101
Abstract: n this paper, we define a generalized additive set-valued functional equation, which is related to the following generalized additive functional equation $$ f(x_1 + \cdots + x_l) = (l-1)f\left( \frac{x_1 + \cdots + x_{l-1}} {l-1}\right) + f(x_l)$$ for a fixed integer $l$ with $l>1$, and prove the Hyers-Ulam stability of the generalized additive set-valued functional equation.
Genome-wide comparative analysis of the Brassica rapa gene space reveals genome shrinkage and differential loss of duplicated genes after whole genome triplication
Jeong-Hwan Mun, Soo-Jin Kwon, Tae-Jin Yang, Young-Joo Seol, Mina Jin, Jin-A Kim, Myung-Ho Lim, Jung Sun Kim, Seunghoon Baek, Beom-Soon Choi, Hee-Ju Yu, Dae-Soo Kim, Namshin Kim, Ki-Byung Lim, Soo-In Lee, Jang-Ho Hahn, Yong Pyo Lim, Ian Bancroft, Beom-Seok Park
Genome Biology , 2009, DOI: 10.1186/gb-2009-10-10-r111
Abstract: We assembled 65.8 megabase-pairs of non-redundant euchromatic sequence of B. rapa and compared this sequence to the Arabidopsis genome to investigate chromosomal relationships, macrosynteny blocks, and microsynteny within blocks. The triplicated B. rapa genome contains only approximately twice the number of genes as in Arabidopsis because of genome shrinkage. Genome comparisons suggest that B. rapa has a distinct organization of ancestral genome blocks as a result of recent whole genome triplication followed by a unique diploidization process. A lack of the most recent whole genome duplication (3R) event in the B. rapa genome, atypical of other Brassica genomes, may account for the emergence of B. rapa from the Brassica progenitor around 8 million years ago.This work demonstrates the potential of using comparative tiling sequencing for genome analysis of crop species. Based on a comparative analysis of the B. rapa sequences and the Arabidopsis genome, it appears that polyploidy and chromosomal diploidization are ongoing processes that collectively stabilize the B. rapa genome and facilitate its evolution.Flowering plants (angiosperms) have evolved in genome size since their sudden appearance in the fossil records of the late Jurassic/early Cretaceous period [1-4]. The genome expansion seen in angiosperms is mainly attributable to occasional polyploidy. Estimation of polyploidy levels in angiosperms indicates that the genomes of most (>90%) extant angiosperms, including many crops and all the plant model species sequenced thus far, have experienced one or more episodes of genome doubling at some point in their evolutionary history [5,6]. The accumulation of transposable elements (TEs) has been another prevalent factor in plant genome expansion. Recent studies on maize, rice, legumes, and cotton have demonstrated that the genome sizes of these crop species have increased significantly due to the accumulation and/or retention of TEs (mainly long terminal repeat retrotr
Antitumor enhancement of celecoxib, a selective Cyclooxygenase-2 inhibitor, in a Lewis lung carcinoma expressing Cyclooxygenase-2
Won Park, Young Oh, Jae Han, Hongryull Pyo
Journal of Experimental & Clinical Cancer Research , 2008, DOI: 10.1186/1756-9966-27-66
Abstract: For immunoblot analysis of COX-2 and PGE2, cells were treated with irradiation in the presence or absence of celecoxib. The right thighs of male, 6-week old C57/BL mice were subcutaneously injected with 1 × 106 LLC cells. The animals were randomized into one of six groups: (1) no treatment, (2) 25 mg/kg celecoxib daily, (3) 75 mg/kg celecoxib daily, (4) 10 Gy irradiation, (5) 10 Gy irradiation plus 25 mg/kg celecoxib daily, and (6) 10 Gy irradiation plus 75 mg/kg celecoxib daily. Mice were irradiated only once, and celecoxib was administered orally. Mice were irradiated with 4-MV photons once the tumor volume of the control group reached 500 mm3. All mice were sacrificed when the mean tumor volume of control animals grew to 4000 mm3. The left lobes of the lungs were extracted for the measurement of metastatic nodules.Irradiation resulted in a dose-dependent increase in PGE2 production. PGE2 synthesis decreased markedly after treatment with celecoxib alone or in combination with irradiation. Compared to mice treated with low dose celecoxib, mean tumor volume decreased significantly in mice treated with a high dose of celecoxib with or without irradiation. Mice treated with a high dose celecoxib alone, with irradiation alone, or with irradiation plus celecoxib had markedly fewer metastatic lung nodules than controls. The mean metastatic area was the smallest for mice treated with irradiation plus a high dose celecoxib.Oral administration of high dose celecoxib significantly inhibited tumor growth, as compared to a low dose treatment. Radiotherapy in combination with high dose celecoxib delayed tumor growth and reduced the number of pulmonary metastases to a greater extent than celecoxib or radiotherapy alone.Radiotherapy is a common treatment for localized cancers. The radiation dose is important for tumor control. However, the therapeutic efficacy of radiotherapy is often limited by normal tissue damage within or nearby the field of radiation. In clinical practice, t
Gefitinib radiosensitizes non-small cell lung cancer cells through inhibition of ataxia telangiectasia mutated
Soo-Yeon Park, Young Kim, Hongryull Pyo
Molecular Cancer , 2010, DOI: 10.1186/1476-4598-9-222
Abstract: In clonogenic survival assays performed in three NSCLC cell lines, gefitinib radiosensitized NCI-H460 and VMRC-LCD but not A549 cells. Gefitinib pretreatment induced multinucleated cells after IR exposure in NCI-H460 and VMRC-LCD, but not in A549 cells. Gefitinib also inhibited activation of ataxia telangiectasia mutated (ATM) after IR-exposure in NCI-H460 and VMRC-LCD, but not in A549 cells. An ATM specific inhibitor increased IR-induced multinucleated cells in both NCI-H460 and A549 cells. Gefitinib pretreatment inhibited the gradual decrease of γH2AX foci relative to time after IR exposure in NCI-H460 but not in A549 cells. Suppression of COX-2 in A549 cells induced multinucleated cells and caused radiosensitization after gefitinib+IR treatment. In contrast, COX-2 overexpression in NCI-H460 cells attenuated the induction of multinucleation and radiosensitization after the same treatment.Our results suggest that gefitinib radiosensitizes NSCLC cells by inhibiting ATM activity and therefore inducing mitotic cell death, and that COX-2 overexpression in NSCLC cells inhibits this action of gefitinib.Lung cancer is the leading cause of cancer-related deaths in men and women worldwide [1], and about 80% of lung cancers are non-small cell lung carcinoma (NSCLC). The 5-year survival rate of patients with NSCLC remains among the lowest of all major human cancers at less than 15% [2]. Obviously, novel therapeutic strategies to improve survival of patients with NSCLC are needed. Epidermal growth factor receptor (EGFR) has been regarded as an attractive target molecule for the treatment of various cancers including NSCLC. Recently developed inhibitors of this molecule have shown dramatic results in a subset of patients with NSCLC and have become a routinely applied anticancer agent for this subset of patients [3-5].EGFR belongs to the ErbB family of plasma membrane receptor tyrosine kinases and controls many important cellular functions. Increased EGFR expression has been obs
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