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Search Results: 1 - 10 of 9374 matches for " Young Joo Cha "
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Association of Uncoupling Protein-1 Haplotypes with Body Fat Area
Young Joo Kim,My-Young Cheong,Min Ho Cha,Jong Yeol Kim
Interdisciplinary Bio Central , 2009,
Abstract: Obesity is a major cause of morbidity and mortality and is associated with risks for type 2 diabetes mellitus, heart disease, metabolic syndrome, hypertension, stroke, and certain forms of cancer. The glutamate decarboxylase 2 (GAD2), insulin-induced gene 2 (INSIG2), ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), melanocortin 4 receptor (MC4R), fresh touring origination (FTO), and uncoupling protein-1 (UCP-1) genes have been investigated for their association with obesity.Since the A-3826G SNP in the UCP-1 gene was first shown to be the key genetic determinant of obesity and body fat accumulation, many studies have been performed in various populations to measure the association of the G allele of this SNP with obesity phenotypes. The association of the A-3826G SNP with obesity has been controversial, however, suggesting that one SNP does not sufficiently explain the effects of genomic variation on body fat accumulation.In this study, 9 SNPs were newly identified in the 5’-flanking region of the UCP-1 gene by direct sequencing of genomic DNA from 21 Korean subjects, and 6 haplotypes were obtained by SNP genotyping and haplotype reconstruction. According to our haplotype analysis, ht2 of the G allele of A-3826G, was significantly associated with overall fat measures after age and body weight were adjusted. Ht6 of the A allele of A-3826G, was significantly linked to reduced fat accumulation. These results provide an explanation for the controversies that have been reported in many obesity association studies and suggest that haplotype associations between polymorphic loci and neighbor loci that harbor functional sequence variants can be exploited to identify disease-predisposing alleles.
Enzymatic analysis of the effect of naturally occurring Leu138Pro mutation identified in SHV β-lactamase on hydrolysis of penicillin and ampicillin
Nabin Rayamajhi, Jeong Joo, Seung Cha, Subarna Pokherl, Min Shin, Young Yoo, Han Yoo
BMC Microbiology , 2011, DOI: 10.1186/1471-2180-11-29
Abstract: Kinetic analysis of the mutant proteins showed that Km value of the purified L138P mutant was comparatively higher than SHV-1, SHV-33 and SHV-33(L138P) enzyme for penicillin and ampicillin. Docking simulation of the SHV-1 and SHV-(L138P) enzymes also confirmed that β-lactamases preferred penicillin to ampicillin and the SHV-1 had a higher binding affinity for antibiotics compared to the SHV-(L138P) and other mutants.Our result demonstrated that L138P has a reduced role in penicillin and ampicillin hydrolyzing properties of SHV β-lactamases. These naturally occurring mutations rendering reduced function of the existing protein could trigger the emergence or acquisition of more effective alternative mechanisms for β-lactam hydrolysis.Antimicrobial resistance based on hydrolysis of the antibiotic by β-lactamases is currently a worldwide problem. It is one of the single most prevalent mechanisms responsible for resistance to β-lactams in clinical isolates of the Enterobacteriaceae [1-3]. Among the four classes (A to D) of β-lactamases, plasmid mediated class A and C β-lactamases have been of high clinical concern in hospital as well as community acquired infections [1,4]. Promiscuous plasmids carrying β-lactamase encoding genes are described to spread drug resistance among different groups of microbes under local selection pressure imposed by the commonly used antibiotics [1,5,3]. One of the most common plasmid mediated β-lactamase enzymes is closely related to TEM and SHV penicillinase [6,3]. Recently CTX-M and AmpC type β-lactamase are being widely reported from Enterobacteriaceae that are associated with nosocomial and community acquired infections [1,7].Use of extended-spectrum β-lactam antibiotics has led to the occurrence of variants of these β-lactamases carrying amino acid substitutions that alter the enzyme's substrate specificity [1,6,8,9]. SHV-1 is an important plasmid mediated β-lactamase found in the chromosome of most strains of Klebsiella pneumonia. Its h
Joo Hwan Cha,Young Hee Kim,Jae Kyun Lee,Yong Seo Cho
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536811054730
Abstract: In the title compound, C21H21NO6, each of the cyclohexenone rings adopts a half-chair conformation. Each of the pairs of hydroxy and carbonyl O atoms are oriented to allow for the formation of intramolecular O—H...O hydrogen bonds, which are typical of xanthene derivatives.
Joo Hwan Cha,Young Hee Kim,Sun-Joon Min,Yong Seo Cho
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811043686
Abstract: In the title compound, C25H29NO6, each of the cyclohexenone rings adopts a half-chair conformation. Each of the pairs of hydroxy and carbonyl O atoms are oriented to allow for the formation of intramolecular O—H...O hydrogen bonds, which are typical of xanthene derivatives. The nitro group is rotationally disordered over two orientations in a 0.544 (6):0.456 (6) ratio. In the crystal, weak intermolecualr C—H...O hydrogen bonds link molecules into layers parallel to the ab plane.
Comparison of the bright band characteristics measured by Micro Rain Radar (MRR) at a mountain and a coastal site in South Korea
Comparison of the Bright Band Characteristics Measured by Micro Rain Radar (MRR) at a Mountain and a Coastal Site in South Korea

Joo-Wan Cha,Ki-Ho Chang,Seong Soo Yum,Young-Jean Choi,
Joo-Wan CHA
,Ki-Ho CHANG,Seong Soo YUM,Young-Jean CHOI

大气科学进展 , 2009,
Abstract: Data from a long term measurement of Micro Rain Radar (MRR) at a mountain site (Daegwallyeong, DG, one year period of 2005) and a coastal site (Haenam, HN, three years 2004--2006) in South Korea were analyzed to compare the MRR measured bright band characteristics of stratiform precipitation at the two sites. On average, the bright band was somewhat thicker and the sharpness (average gradient of reflectivity above and below the reflectivity peak) was slightly weaker at DG, compared to those values at HN. The peak reflectivity itself was twice as strong and the relative location of the peak reflectivity within the bright band was higher at HN than at DG. Importantly, the variability of these values was much larger at HN than at DG. The key parameter to cause these differences is suggested to be the difference of the snow particle densities at the two sites, which is related to the degree of riming. Therefore, it is speculated that the cloud microphysical processes at HN may have varied significantly from un-rimed snow growth, producing low density snow particles, to the riming of higher density particles, while snow particle growth at DG was more consistently affected by the riming process, and therefore high density snow particles. Forced uplifting of cloudy air over the mountain area around DG might have resulted in an orographic supercooling effect that led to the enhanced riming of supercooled cloud drops.
Celastrol, an NF-κB Inhibitor, Improves Insulin Resistance and Attenuates Renal Injury in db/db Mice
Jung Eun Kim, Mi Hwa Lee, Deok Hwa Nam, Hye Kyoung Song, Young Sun Kang, Ji Eun Lee, Hyun Wook Kim, Jin Joo Cha, Young Youl Hyun, Sang Youb Han, Kum Hyun Han, Jee Young Han, Dae Ryong Cha
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0062068
Abstract: The NF-κB pathway plays an important role in chronic inflammatory and autoimmune diseases. Recently, NF-κB has also been suggested as an important mechanism linking obesity, inflammation, and metabolic disorders. However, there is no current evidence regarding the mechanism of action of NF-κB inhibition in insulin resistance and diabetic nephropathy in type 2 diabetic animal models. We investigated the effects of the NF-κB inhibitor celastrol in db/db mice. The treatment with celastrol for 2 months significantly lowered fasting plasma glucose (FPG), HbA1C and homeostasis model assessment index (HOMA-IR) levels. Celastrol also exhibited significant decreases in body weight, kidney/body weight and adiposity. Celastrol reduced insulin resistance and lipid abnormalities and led to higher plasma adiponectin levels. Celastrol treatment also significantly mitigated lipid accumulation and oxidative stress in organs including the kidney, liver and adipose tissue. The treated group also exhibited significantly lower creatinine levels and urinary albumin excretion was markedly reduced. Celastrol treatment significantly lowered mesangial expansion and suppressed type IV collagen, PAI-1 and TGFβ1 expressions in renal tissues. Celastrol also improved abnormal lipid metabolism, oxidative stress and proinflammatory cytokine activity in the kidney. In cultured podocytes, celastrol treatment abolished saturated fatty acid-induced proinflammatory cytokine synthesis. Taken together, celastrol treatment not only improved insulin resistance, glycemic control and oxidative stress, but also improved renal functional and structural changes through both metabolic and anti-inflammatory effects in the kidney. These results suggest that targeted therapy for NF-κB may be a useful new therapeutic approach for the management of type II diabetes and diabetic nephropathy.
Genetic Variants in MicroRNA Machinery Genes Are Associate with Idiopathic Recurrent Pregnancy Loss Risk
Yong Wook Jung, Young Joo Jeon, HyungChul Rah, Ji Hyang Kim, Ji Eun Shin, Dong Hee Choi, Sun Hee Cha, Nam Keun Kim
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095803
Abstract: Objective Key molecules involved in microRNA (miRNA) biogenesis, such as DROSHA, XPO5, and DICER, have been identified in trophoblast cells, confirming that the miRNA biogenesis pathway is active in human placenta. In addition, miRNAs regulate uterine gene expression associated with inflammatory responses during the peri-implantation period and participate in maternal-fetal immune tolerance. The purpose of this study was to demonstrate whether genetic polymorphisms in miRNA machinery genes show an association with idiopathic recurrent pregnancy loss (RPL) in Korean women. Study design We performed a case-control study with 238 controls and 338 women who had experienced at least two consecutive pregnancy losses between 1999 and 2010. Genotypes of miRNA machinery genes, including DICER rs3742330, DROSHA rs10719, RAN GTPase (RAN) rs14035, and exportin-5 (XPO5) rs11077 were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The logistic odds ratios (ORs) of RPL were estimated with a 95% confidence interval (CI) in multivariate analysis after maternal age adjustment. Gene-gene interactions among the loci of the four gene polymorphisms were evaluated using the multifactor dimensionality reduction (MDR) method. Results The RAN rs14035 CC genotype and DICER rs3742330/DROSHA rs10719 GG/TC+CC, rs3742330/RAN rs14035 GG/CC, and DICER rs3742330/XPO5 rs11077 GG/AC+CC combinations were significantly associated with increased RPL risk, whereas the RAN rs14035 CT, DICER rs3742330/RAN rs14035 AA+AG/CT+TT, DROSHA rs10719/RAN rs14035 TC+CC/CT+TT, and RAN rs14035/XPO5 rs11077 CT+TT/AA combinations reduced RPL risk. The A-T-T-C and G-C-T-A allele combinations (DICER/DROSHA/RAN/XPO5) were 20 times more frequent in the RPL group than in the control group. Conclusion Our study demonstrates the relationship between RPL development and the polymorphism of the miRNA machinery gene RAN and combined genotype of DROSHA/DICER.
A case of hypereosinophilic syndrome presenting with intractable gastric ulcers
Tae Young Park, Chang Hwan Choi, Suh Yoon Yang, In Soo Oh, In-Do Song, Hyun Woong Lee, Hyung Joon Kim, Jae Hyuk Do, Sae Kyung Chang, Ah Ra Cho, Young Joo Cha
World Journal of Gastroenterology , 2009,
Abstract: We report a rare case of hypereosinophilic syndrome (HES) presenting with intractable gastric ulcers. A 71-year-old man was admitted with epigastric pain. Initial endoscopic findings revealed multiple, active gastric ulcers in the gastric antrum. He underwent Helicobacter pylori (H pylori) eradication therapy followed by proton pump inhibitor (PPI) therapy. However, follow-up endoscopy at 4, 6, 10 and 14 mo revealed persistent multiple gastric ulcers without significant improvement. The proportion of his eosinophil count increased to 43% (total count: 7903/mm3). Abdominal-pelvic and chest computed tomography scans showed multiple small nodules in the liver and both lungs. The endoscopic biopsy specimen taken from the gastric antrum revealed prominent eosinophilic infiltration, and the liver biopsy specimen also showed eosinophilic infiltration in the portal tract and sinusoid. A bone marrow biopsy disclosed eosinophilic hyperplasia as well as increased cellularity of 70%. The patient was finally diagnosed with HES involving the stomach, liver, lung, and bone marrow. When gastric ulcers do not improve despite H pylori eradication and prolonged PPI therapy, infiltrative gastric disorders such as HES should be considered.
Direct Look from a Predator Shortens the Risk-Assessment Time by Prey
Sang-im Lee, Soyun Hwang, Young-eun Joe, Hyun-kyung Cha, Gun-ho Joo, Hyeon-jeong Lee, Ji-won Kim, Piotr G. Jablonski
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0064977
Abstract: Decision making process is an important component of information use by animals and has already been studied in natural situations. Decision making takes time, which is expressed as a cost in evolutionary explanations of decision making abilities of animals. However, the duration of information assessment and decision making process has not been measured in a natural situation. Here, we use responses of wild magpies (Pica pica) to predictably approaching humans to demonstrate that, regardless of whether the bird perceived high (decided to fly away) or low (resumed foraging) threat level, the bird assessed the situation faster when approaching humans looked directly at it than when the humans were not directly looking at it. This indicates that prey is able to extract more information about the predator’s intentions and to respond sooner when the predator is continuously (“intently”) looking at the prey. The results generally illustrate how an increase of information available to an individual leads to a shorter assessment and decision making process, confirming one of central tenets of psychology of information use in a wild bird species in its natural habitat.
Preliminary Results of the Ground-Based Orographic Snow Enhancement Experiment for the Easterly Cold Fog (Cloud) at Daegwallyeong during the 2006 Winter
Preliminary Results of the Ground-Based Orographic Snow Enhancement Experiment for the Easterly Cold Fog (Cloud) at Daegwallyeong during the 2006 Winter

Myoung-Joo LEE,Ki-Ho CHANG,Gyun-Myoung PARK,Jin-Yim JEONG,Ha-Young YANG,Ki-Deok JEONG,Joo-Wan CHA,Sung-Soo YUM,Jae-Cheol NAM,Kyungsik KIM,Byung-Chul CHOI,
Myoung-Joo LEE
,Ki-Ho CHANG,Gyun-Myoung PARK,Jin-Yim JEONG,Ha-Young YANG,Ki-Deok JEONG,Joo-Wan CHA,Sung-Soo YUM,Jae-Cheol NAM,Kyungsik KIM,Byung-Chul CHOI

大气科学进展 , 2009,
Abstract: The snow enhancement experiments, carried out by injecting AgI and water vapor into orographically enhanced clouds (fog), have been conducted to confirm Li and Pitter's forced condensation process in a natural situation. Nine ground-based experiments have been conducted at Daegwallyeong in the Taebaek Mountains for the easterly foggy days from January--February 2006. We then obtained the optimized conditions for the Daegwallyeong region as follows: the small seeding rate (1.04 g min-1) of AgI for the easterly cold fog with the high humidity of Gangneung. Additional experiments are needed to statistically estimate the snowfall increment caused by the small AgI seeding into the orographical fog (cloud) over the Taebaek Mountains.
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