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Search Results: 1 - 10 of 2371 matches for " Yoshitsugu Yamada "
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Hyperbolic Transformation and Average Elasticity in the Framework of the Fixed Effects Logit Model  [PDF]
Yoshitsugu Kitazawa
Theoretical Economics Letters (TEL) , 2012, DOI: 10.4236/tel.2012.22034
Abstract: In this paper, a simple transformation is proposed for the fixed effects logit model, which constructs some valid moment conditions including the first-order condition for one of the conditional MLE proposed by Chamberlain (1980) [1]. Some Monte Carlo experiments are carried out for the GMM estimator based on the transformation. In addition, the average elasticity of the logit probability with respect to the exponential function of explanatory variable is proposed in the framework of the fixed effects logit model, which is computable without the fixed effects.
Some Additional Moment Conditions for a Dynamic Count Panel Data Model with Predetermined Explanatory Variables  [PDF]
Yoshitsugu Kitazawa
Open Journal of Statistics (OJS) , 2013, DOI: 10.4236/ojs.2013.35038

This paper proposes some additional moment conditions for the linear feedback model with explanatory variables being predetermined, which is proposed by [1] for the purpose of dealing with count panel data. The newly proposed moment conditions include those associated with the equidispersion, the Negbin I-type model and the stationarity. The GMM estimators are constructed incorporating the additional moment conditions. Some Monte Carlo experiments indicate that the GMM estimators incorporating the additional moment conditions perform well, compared to that using only the conventional moment conditions proposed by [2,3].

Complex Regional Pain Syndrome Revived by Epileptic Seizure Then Disappeared Soon during Treatment with Regional Intravenous Nerve Blockade: A Case Report
Masahiko Sumitani,Arito Yozu,Toshiya Tomioka,Satoru Miyauchi,Yoshitsugu Yamada
Anesthesiology Research and Practice , 2011, DOI: 10.1155/2011/494975
Abstract: We present a case of complex regional pain syndrome (CRPS), in which symptoms, including burning pain and severe allodynia, were alleviated by using a regional intravenous nerve blockade (Bier block) combined with physiotherapy, but reappeared following an epileptic seizure. Symptoms disappeared again following control of epileptic discharges, as revealed by single-photon emission computed tomography (SPECT) and electroencephalography (EEG) results. Although systemic toxicity of a local anesthetic applied by Bier block was suspected as a cause of the first seizure, the patient did not present any other toxic symptoms, and seizures repeatedly occurred after Bier block cessation; the patient was then diagnosed as having temporal symptomatic epilepsy. This case suggests that symptoms of CRPS may be sustained by abnormal brain conditions, and our findings contribute to the understanding of how the central nervous system participates in maintaining pain and allodynia associated with CRPS. 1. Introduction Complex regional pain syndrome (CRPS) causes extreme pain. Dysfunctions of the peripheral nervous system, including the sensory and sympathetic nervous systems, are typically considered to sustain CRPS. The central nervous system (CNS) has also been reported to play an important role in CRPS emergence and maintenance [1]. Although many clinical studies on CRPS and studies using animal models have been conducted, the pathophysiological mechanism of CRPS is not yet clear [2–5]. Here, we report a case of a CRPS patient whose pain was improved by a regional intravenous nerve blockade combined with physiotherapy; however, CRPS relapsed into intolerable pain and severe allodynia following an epileptic seizure. Recurrent CRPS then rapidly improved through the control of epileptic discharges. During epileptic episodes, we investigated the CRPS patient using single-photon emission computed tomography (SPECT) and electroencephalography (EEG). Our findings may contribute to the understanding of how the CNS participates in maintaining CRPS-related pain and allodynia. 2. Case Report A 65-year-old woman with aortic regurgitation following infectious endocarditis had undergone twice aortic valve replacement procedures within 2 months. After the second operation, more than 3 weeks were required before she could be weaned from intensive treatment, including artificial ventilation and sedative drug administration. Following recovery from heart failure, sedative drug administration was discontinued. The patient’s clouded consciousness persisted for several days, but she did
Diagnosis and Treatment of Attention-Deficit Hyperactivity Disorder in Patients with Chronic Pain  [PDF]
Satoshi Kasahara, Yumiko Okamura, Ko Matsudaira, Hiroyuki Oka, Yoshie Suzuki, Yasuko Murakami, Toshiharu Tazawa, Hayato Shimazaki, Shin-ichi Niwa, Yoshitsugu Yamada
Open Journal of Psychiatry (OJPsych) , 2017, DOI: 10.4236/ojpsych.2017.74023
Abstract: Aims: To investigate rates of attention-deficit hyperactivity disorder (ADHD) in patients with chronic pain attending a pain clinic, the effects of a screening measure for ADHD in patients with chronic pain, and the effects of ADHD drugs on both pain and ADHD symptoms. Methods: We retrospectively surveyed 110 patients with chronic pain visiting the Anesthesiology and Pain Relief Center at the University of Tokyo in Japan, who had also consulted a psychiatrist, between April 2012 and July 2015. Results: Of the total of 110 patients with chronic pain, 35 (31.8%) were also diagnosed with ADHD, and the average Wender Utah Rating Scale (WURS) score among the ADHD patients was 39.0 ± 22.1 (n = 25). Only 36.0% of these patients exceeded the cutoff value, suggesting that 64.0% of the patients with ADHD were not identified by screening with the WURS. Twenty-six patients initiated treatment with ADHD medication, with dosage adjustment completed in 21. Of these 21 patients 20 (95.0%) had improved ADHD symptoms. Improved pain symptoms were observed in 14 patients (66.6%), with a reduction in the pain numerical rating scale of 64.7% ± 30.1%. Conclusions: This is the first study investigating the comorbidity of ADHD and chronic pain at pain clinics showing a high level of comorbidity and amelioration of pain and ADHD symptoms with treatment. Careful interpretation is required when the WURS is used to screen patients with chronic pain.
Oral Local Anesthesia Successfully Ameliorated Neuropathic Pain in an Upper Limb Suggesting Pain Alleviation through Neural Plasticity within the Central Nervous System: A Case Report
Jun Hozumi,Masahiko Sumitani,Arito Yozu,Toshiya Tomioka,Hiroshi Sekiyama,Satoru Miyauchi,Yoshitsugu Yamada
Anesthesiology Research and Practice , 2011, DOI: 10.1155/2011/984281
Abstract: Neural blockades are considered an alternative to pharmacotherapy for neuropathic pain although these blockades elicit limited effects. We encountered a patient with postbrachial plexus avulsion injury pain, which was refractory to conventional treatments but disappeared temporarily with the administration of the local anesthetic lidocaine around the left mandibular molar tooth during dental treatments. This analgesic effect on neuropathic pain by oral local anesthesia was reproducible. Under conditions of neuropathic pain, cerebral somatotopic reorganization in the sensorimotor cortices of the brain has been observed. Either expansion or shrinkage of the somatotopic representation of a deafferentated body part correlates with the degree of neuropathic pain. In our case, administration of an oral local anesthetic shrank the somatotopic representation of the mouth, which is next to the upper limb representation and thereby expanded the upper limb representation in a normal manner. Consequently, oral local anesthesia improved the pain in the upper limb. This case suggests that pain alleviation through neural plasticity within the brain is related to neural blockade. 1. Introduction Neuropathic pain typically appears following peripheral nerve injury due to neuropathies, plexopathies, and trauma to selected sites within the central nervous system (CNS). Recently, evidence-based recommendations of pharmacological treatments for neuropathic pain have been proposed based on both positive and negative results from multiple randomized controlled trials. However, approximately 10–15% of all neuropathic pain patients are refractory to pharmacotherapy. For these cases, more invasive pain-management interventions, such as intrathecal drug delivery, neurostimulation, or neural blockade, may be used. Ideally, blocking neural transmission, either temporarily by using local anesthetics or permanently by surgical nerve ablation, can reduce neuropathic pain; however, no neural blockades have been found to be consistently successful [1]. Here, we report on a case of a patient with postbrachial plexus avulsion injury pain whose neuropathic pain had been refractory to several evidence-based pharmacotherapies and interventions, such as spinal cord stimulation, cervical epidural blockade, and brachial plexus blockade. His pain could be well controlled by oral local anesthesia, suggesting pain alleviation through neural plasticity within the CNS. 2. Case Report A 49-year-old man, who had a left brachial plexus avulsion injury 10 years before, experienced severe neuropathic
Soluble Isoform of the Receptor for Advanced Glycation End Products as a Biomarker for Postoperative Respiratory Failure after Cardiac Surgery
Tokujiro Uchida, Nagara Ohno, Miho Asahara, Yoshitsugu Yamada, Osamu Yamaguchi, Makoto Tomita, Koshi Makita
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070200
Abstract: Purpose Postoperative respiratory failure is a major problem which can prolong the stay in the intensive care unit in patients undergoing cardiac surgery. We measured the serum levels of the soluble isoform of the receptor for advanced glycation end products (sRAGE), and we studied its association with postoperative respiratory failure. Methods Eighty-seven patients undergoing elective cardiac surgery were enrolled in this multicenter observational study in three university hospitals. Serum biomarker levels were measured perioperatively, and clinical data were collected for 7 days postoperatively. The duration of mechanical ventilation was studied for 28 days. Results Serum levels of sRAGE elevated immediately after surgery (median, 1751 pg/mL; interquartile range (IQR) 1080–3034 pg/mL) compared with the level after anesthetic induction (median, 884 pg/mL; IQR, 568–1462 pg/mL). Postoperative sRAGE levels in patients undergoing off-pump coronary artery bypass grafting (median, 1193 pg/mL; IQR 737–1869 pg/mL) were significantly lower than in patients undergoing aortic surgery (median, 1883 pg/mL; IQR, 1406–4456 pg/mL; p = 0.0024) and valve surgery (median, 2302 pg/mL; IQR, 1447–3585 pg/mL; p = 0.0005), and postoperative sRAGE correlated moderately with duration of cardiopulmonary bypass (rs = 0.44, p<0.0001). Receiver operating characteristic curve analysis demonstrated that postoperative sRAGE had a predictive performance with area under the curve of 0.81 (95% confidence interval 0.71–0.88) for postoperative respiratory failure, defined as prolonged mechanical ventilation >3 days. The optimum cutoff value for prediction of respiratory failure was 3656 pg/mL, with sensitivity and specificity of 62% and 91%, respectively. Conclusions Serum sRAGE levels elevated immediately after cardiac surgery, and the range of elevation was associated with the morbidity of postoperative respiratory failure. Early postoperative sRAGE levels appear to be linked to cardiopulmonary bypass, and may have predictive performance for postoperative respiratory failure; however, large-scale validation studies are needed.
Magnetism and infrared divergence in a Hubbard-phonon interacting system
Yoshitsugu Sekine
Physics , 2010,
Abstract: We show that a finite Hubbard-phonon interacting system has ferromagnetic or unique spin-singlet ground state under the infrared singular condition. The key tool is a unitary transformation introduced by Arai and Hirokawa. We construct a concrete infrared singular representation using the operator algebraic method. The method is essentially same as one for the van Hove model using the Wightman functional method.
Phonon Bose-Einstein condensation in a Hubbard-phonon interacting system with infrared divergence
Yoshitsugu Sekine
Physics , 2013,
Abstract: We show that a finite Hubbard-phonon interacting system exhibits phonon BEC at sufficiently low temperature. We also have the gauge symmetry breaking for phonons. The key tools are a unitary transformation introduced by Arai and Hirokawa \protect{\cite{AH1}} and the Araki-Woods representation. This system is essentially the same as a free system or the van Hove model.
Pinning Down Viral Proteins: A New Prototype for Virus–Host Cell Interaction
Yoshitsugu Kojima,Akihide Ryo
Frontiers in Microbiology , 2010, DOI: 10.3389/fmicb.2010.00107
Abstract: Pin1 is an enzyme that specifically catalyzes the cis–trans isomerization of phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif in its substrate proteins. Recent studies demonstrate that stability of several viral proteins is regulated by phosphorylation-dependent prolyl-isomerization by a host factor Pin1. Pin1 is now positioned as an important modulator of the molecular crosstalk between virus and host cells and could be a unique target for anti-virus therapy. This new type of post-translational modification by Pin1 might be involved in the regulation of other viral proteins.
Vaccination with Human Induced Pluripotent Stem Cells Creates an Antigen-Specific Immune Response Against HIV-1 gp160
Yoshitsugu Kojima,Akihide Ryo
Frontiers in Microbiology , 2011, DOI: 10.3389/fmicb.2011.00027
Abstract: Induced pluripotent stem cells (iPSCs) are artificially derived from somatic cells that have been transduced with defined reprogramming factors. A previous report has indicated the possibility of using iPSCs as an immune stimulator to generate antigen-specific immunity. In our current study, we have investigated whether human iPSCs (hiPSCs) have the ability to enhance specific immune response against a human immunodeficiency virus type 1 (HIV-1) antigen in a xenogenic mouse model. Our results show that BALB/c mice immunized with hiPSCs transduced with an adenoviral vector encoding HIV-1 gp160 exhibited prominent antigen-specific cellular immune responses. We further found that pre-treatment of hiPSCs with ionizing radiation promotes the secretion of pro-inflammatory cytokines such as interleukin-1 alpha (IL-1α), IL-12, and IL-18. These cytokines might promote the activation of antigen-presenting cells and the effective induction of cellular immunity. Our present findings thus demonstrate that a hiPSCs-based vaccine has the potential to generate cellular immunity against viral antigens such as HIV-1 gp160 in a xenogenic condition.
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