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Search Results: 1 - 10 of 1018 matches for " Yoshiko Masuda "
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Synthesis of CaO-SiO2 Compounds Using Materials Extracted from Industrial Wastes  [PDF]
Nobuaki Yamaguchi, Yoshiko Masuda, Yoshishige Yamada, Hideaki Narusawa, Cho Han-Cheol, Yukimichi Tamaki, Takashi Miyazaki
Open Journal of Inorganic Non-metallic Materials (OJINM) , 2015, DOI: 10.4236/ojinm.2015.51001
Abstract: Mineral trioxide aggregate (MTA) cement is an attractive material in endodontic dentistry. The purpose of this study was to produce calcium silicate, which is a major component of MTA, from waste materials. A dental alginate impression gel and used chalks were selected and mixed in a suitable ratio (Code: EXP). As a control, CaCO3 and a commercial diatomite were used (Code: CON). Each powder was heated to 850C and 1000C, and then kneaded with water. TG-DTA, compressive tests, SEM observations, elemental mapping analyses, and XRD analyses were performed. TG-DTA indicated that weight reduction of CaCO3 started at 600C, and it completely decomposed on heating at 850C. The strength was affected by the temperature. After heating, CaCO3 was transformed into CaO and/or Ca2SiO4, and Ca(OH)2 was formed by mixing with water. There were no differences between EXP and CON. These data suggested that recycled wastes might be promising MTA sources.
Padr?es clínicos de acne em mulheres de diferentes faixas etárias
Schmitt, Juliano Vilaverde;Masuda, Paula Yoshiko;Miot, Hélio Amante;
Anais Brasileiros de Dermatologia , 2009, DOI: 10.1590/S0365-05962009000400005
Abstract: background: acne is a frequent skin disease that occurs in both sexes and all age-groups. women present several clinical disease patterns; moreover, persistence after adolescence is common. objective: to analyze clinical and epidemiological characteristics associated with different age-groups affected by acne in women. methods: cross-sectional study involving female patients diagnosed with acne, at a general dermatology outpatient clinic. variables related to disease and patients were assessed through a standardized questionnaire. results: one hundred and three women were assessed. the average age of patients at the time of the consultation was 21.7 ± 7.3 years. two groups were defined (cut-off age of 21 years), with means of 15.8 ± 2.3 and 28.0 ± 5.1 years. there was correlation between disease duration and current age (r=0.7). there were group differences among frequencies of covariables: combined oral contraceptive (or=48.1), lesions located on upper chest (or=11.6), lesions on upper dorsum (or=0.2), predominance on upper half of face (or=0.1) and age at disease onset (or=1.8). among adult women, 80% reported acne onset before 20 years of age. conclusion: chronologic and topographic patterns of female acne in different age-groups were defined, reinforcing the importance of an individualized diagnostic and therapeutic approach.
Constitutively Active Soluble Form of Erythropoietin Receptor Suppresses Growth and Angiogenesis of Xenografts of Transfected Cancer Cell Lines  [PDF]
Yoshiko Yasuda, Yasuhiro Maeda, Satoshi Hara, Motoyoshi Tanaka, Eiji Koike, Yoh Watanabe, Seiji Masuda, Harufumi Yamasaki, Katsumi Okumoto, Hiroyoshi Konishi, Yoshitaka Horiuchi, Hiroshi Hoshiai
Journal of Cancer Therapy (JCT) , 2011, DOI: 10.4236/jct.2011.21005
Abstract: We examined the effect of blocking the erythropoietin (Epo) signaling using an anti-Epo antibody, soluble form of Epo receptor (sEpoR) capable of binding to Epo or EpoR antagonist, and proved to be effective against xenografts of female reproductive organ malignancies and of cancer cell lines in nude mice. We transfected seven cancer cell lines of various origins to express constitutively active sEpoR, and examined their tumorigenesis in nude mice. Suppression of the tumor growth, decrease in viable and proliferating cells and reduction of vascular density were seen individually in all xenografts of transfected cell lines compared with the controls. Quantitative RT-PCR analyses showed that expression levels of Epo, EpoR, ?1A-adrenaline receptor (?1A-ADR) and muscalinic acetylcholine receptor subunit 3 mRNAs (m3-AchR) were higher in the majority of the wild-type xenografts than in the corresponding cell lines except for A549. In some of the transfected xenografts, EpoR, ?1A-ADR and m3-AchR mRNAs were down-regulated. Western blot analyses revealed that the constitutively activated ERK1/2MAPK was discernible in the majority of non-transfected cell lines and was reduced in the transfected cell lines. However, it was regained after exposure to acetylcholine and/or noradrenaline. These findings suggest that constitutively active sEpoR can effectively destroy the xenografts but signals from the autonomic neurotransmitters of the host produced under stress may interfere with this antitumor activity.
A Novel Tumor-Promoting Function Residing in the 5′ Non-coding Region of vascular endothelial growth factor mRNA
Kiyoshi Masuda,Shigetada Teshima-Kondo ,Mina Mukaijo,Naoko Yamagishi,Yoshiko Nishikawa,Kensei Nishida,Tomoko Kawai,Kazuhito Rokutan
PLOS Medicine , 2008, DOI: 10.1371/journal.pmed.0050094
Abstract: Background Vascular endothelial growth factor-A (VEGF) is one of the key regulators of tumor development, hence it is considered to be an important therapeutic target for cancer treatment. However, clinical trials have suggested that anti-VEGF monotherapy was less effective than standard chemotherapy. On the basis of the evidence, we hypothesized that vegf mRNA may have unrecognized function(s) in cancer cells. Methods and Findings Knockdown of VEGF with vegf-targeting small-interfering (si) RNAs increased susceptibility of human colon cancer cell line (HCT116) to apoptosis caused with 5-fluorouracil, etoposide, or doxorubicin. Recombinant human VEGF165 did not completely inhibit this apoptosis. Conversely, overexpression of VEGF165 increased resistance to anti-cancer drug-induced apoptosis, while an anti-VEGF165-neutralizing antibody did not completely block the resistance. We prepared plasmids encoding full-length vegf mRNA with mutation of signal sequence, vegf mRNAs lacking untranslated regions (UTRs), or mutated 5′UTRs. Using these plasmids, we revealed that the 5′UTR of vegf mRNA possessed anti-apoptotic activity. The 5′UTR-mediated activity was not affected by a protein synthesis inhibitor, cycloheximide. We established HCT116 clones stably expressing either the vegf 5′UTR or the mutated 5′UTR. The clones expressing the 5′UTR, but not the mutated one, showed increased anchorage-independent growth in vitro and formed progressive tumors when implanted in athymic nude mice. Microarray and quantitative real-time PCR analyses indicated that the vegf 5′UTR-expressing tumors had up-regulated anti-apoptotic genes, multidrug-resistant genes, and growth-promoting genes, while pro-apoptotic genes were down-regulated. Notably, expression of signal transducers and activators of transcription 1 (STAT1) was markedly repressed in the 5′UTR-expressing tumors, resulting in down-regulation of a STAT1-responsive cluster of genes (43 genes). As a result, the tumors did not respond to interferon (IFN)α therapy at all. We showed that stable silencing of endogenous vegf mRNA in HCT116 cells enhanced both STAT1 expression and IFNα responses. Conclusions These findings suggest that cancer cells have a survival system that is regulated by vegf mRNA and imply that both vegf mRNA and its protein may synergistically promote the malignancy of tumor cells. Therefore, combination of anti-vegf transcript strategies, such as siRNA-based gene silencing, with anti-VEGF antibody treatment may improve anti-cancer therapies that target VEGF.
Effects of Emotional Valence (Positive or Negative Visual Images) and Arousal Levels (High or Low Arousal Levels) on the Useful Field of View  [PDF]
Naoko Masuda
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.64045
Abstract: One of two emotional valence (positive or negative) images and two arousal (high or low) images was presented for 500 ms to participants. After the image vanished from the screen, a letter was presented in the central visual field, while a number was also presented in one of the peripheral visual fields (upper right, upper left, bottom right, and bottom left). There were four conditions of degree of eccentricity of the presented number. The participants identified both the letter and number simultaneously. By calculating the correct performance rate of the peripheral identification task, the range of the useful field of view (UFOV) was speculated. Results showed that performance rates of the central and peripheral tasks were worse for the high arousal, negative emotion stimuli compared with the other three conditions. Moreover, performance rates of the peripheral task were better for the positive emotion conditions than those for the negative emotion conditions when the stimulus eccentricities were 3 or 12 degrees. We concluded that the range of the UFOV could be affected by the interaction between the emotional valence and arousal level of visual stimuli. This study was the first report that emotional valence and arousal level interacted each other and did affect our human visual cognition.
Relationship between Taste Sensitivity and Eating Style in Japanese Female University Students  [PDF]
Yoshiko Kato, Roswith Roth
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.33044
Abstract: This study investigated the relationship between taste sensitivity, the frequency and the preference for eating foods rich in zinc, dietary habits, and restrained eating among Japanese female undergraduate students. Forty-three subjects be-tween the ages of 20 and 22 participated in this study. After a taste-sensitivity test for sweetness and saltiness the stu-dents completed a food list indicating the intake frequency and preference of foods rich in zinc and their eating habits. The students were divided into four groups: high salt-taste sensitivity (SA-HG), low salt-taste sensitivity (SA-LG), high sweet-taste sensitivity (SW-HG), and low sweet-taste sensitivity (SW-LG). Individuals in the SA-HG group ate more foods rich in zinc and were more concerned with their health than those in the SA-LG group. Further, the SW-LG group ate more convenience foods than the SW-HG group. High salt-taste sensitivity could be predicted by eating more but less preference of foods rich in zinc, less snacking, and greater regularity of meals. On the other hand there is a signifi-cant positive relationship between the frequencies of eating and preference for foods rich in zinc. This means the results were inconsistent, further research is needed to clarify this point.
Reasons for the Creation of New Social Networks by the Elderly after Relocation  [PDF]
Yoshiko Kudo, Kazuko Saeki
Health (Health) , 2013, DOI: 10.4236/health.2013.512A005

It is important for the relocated elderly to create social networks within their new environment for their lives and their health. This research examined the reasons why the relocated elderly create social networks in the neighborhood. The research subject area is one snowfall town in Hokkaido, Japan. The subjects are 20 elderly people, who have been relocated to the town. The public health nurses individually conducted an interview and broke down the verbatim records into qualitative descriptions. The subjects ranged from 68 to 94 years old. Reasons why the elderly create social networks in their neighborhoods are to make their lives easier, to prepare for emergencies, to get rid of their loneliness, and to enjoy their lives. Community health providers should understand the need for neighboring social networks based on the elderly people’s condition, and support and create new networks in their community depending on their situations.

The Correlation between Sexuality and Family Functioning among Patients with Inflammatory Bowel Disease in Japan  [PDF]
Yoshiko Miki, Naohiro Hohashi
Open Journal of Nursing (OJN) , 2018, DOI: 10.4236/ojn.2018.810054
Abstract: Purpose: The objective of this study was to examine the correlation between the sexuality of patients with Inflammatory Bowel Disease and family functioning. Methods: The study took the form of a self-administered questionnaire survey, utilizing the Sexuality Satisfaction Index for IBD (SEXSI-IBD) for measuring sexuality and the Survey of Family Environment Survey of Family Environment (SFE) for measuring family functioning. SEXSI-IBD consists of 28 items and five domains, and SFE consists of 30 items and five domains. The participants were recruited at 15 self-help groups and 14 hospitals. Results: Of 146 participants, 48.6% were male and 52.4% female, with an average age of 41.1 years. A significant correlation was observed between the item average score of SEXSI-IBD and Overall Satisfaction Score (OSS) of SFE. Significant correlations were observed in two domains of the SEXSI-IBD, “Daily interaction” and “Sexual communication,” and in all five domains of the SFE. In particular, for “Daily interaction,” the strongest correlation was observed in the SFE’s “Macro system” and “Family internal environment system.” A correlation was observed between the “Physical contact importance” in SEXSI-IBD and the “Macro system” in the OSS of the SFE. Conclusions: Sexuality correlates with family functioning not only in the family internal environment system but also in the family external environment system. Through an approach aimed at elevating the degree of satisfaction for sexuality, it becomes possible to improve family functioning and realize a sense of family well-being.
Chronic Academic Stress Increases a Group of microRNAs in Peripheral Blood
Manami Honda, Yuki Kuwano, Sakurako Katsuura-Kamano, Yoshiko Kamezaki, Kinuyo Fujita, Yoko Akaike, Shizuka Kano, Kensei Nishida, Kiyoshi Masuda, Kazuhito Rokutan
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0075960
Abstract: MicroRNAs (miRNAs) play key roles in regulation of cellular processes in response to changes in environment. In this study, we examined alterations in miRNA profiles in peripheral blood from 25 male medical students two months and two days before the National Examination for Medical Practitioners. Blood obtained one month after the examination were used as baseline controls. Levels of seven miRNAs (miR-16, -20b, -26b, -29a, -126, -144 and -144*) were significantly elevated during the pre-examination period in association with significant down-regulation of their target mRNAs (WNT4, CCM2, MAK, and FGFR1 mRNAs) two days before the examination. State anxiety assessed two months before the examination was positively and negatively correlated with miR-16 and its target WNT4 mRNA levels, respectively. Fold changes in miR-16 levels from two days before to one month after the examination were inversely correlated with those in WNT4 mRNA levels over the same time points. We also confirmed the interaction between miR-16 and WNT4 3′UTR in HEK293T cells overexpressing FLAG-tagged WNT4 3′UTR and miR-16. Thus, a distinct group of miRNAs in periheral blood may participate in the integrated response to chronic academic stress in healthy young men.
Reconstruction of the Lacustrine Delta and Lake Level Change Analyzing Subsurface Geology and Geomorphology: Changes That Occurred during the Holocene in the Oguraike Reclaimed Land Area, Southern Kyoto, Japan  [PDF]
Yuka Ito, Fujio Masuda
Open Journal of Geology (OJG) , 2012, DOI: 10.4236/ojg.2012.23021
Abstract: A paleo-lacustrine delta in Kyoto, Japan was reconstructed on the basis of subsurface geological and geomorphological analysis, and paleo-lake level changes were estimated from the structure of the delta. These analyses of the study region, i.e., the Oguraike reclaimed land area provided evidence that Lake Ogura existed until about 60 years ago in southern Kyoto, Japan. The Uji river delta was provided influents to this lake until ca. 400 years ago, as is indicated by an upward-coarsening delta succession of about 2 - 4 m thickness. The lake level could also have changed in the past as a result of a change in altitude of the delta-front (foreset) and delta-plain boundary, which probably reflects the lake surface elevation. About 400 years ago, the Paleo-Uji River was separated from Ogura Lake because a levee was constructed along the river for building a castle and for constructing a waterway for transportation. As a result of this construction, the lake level that was more than 13.0 m in elevation was reduced by 1.5 m. In a more ancient times, the lake level experienced two stages—one in which the elevation was more than 13.5 m, and one in which the elevation was reduced to less than 10 m. These changes in the lake level are represented by a flat surface with four steps and small cliff of height ca. 0.5 - 2 m (relative elevation) separating them, recognized at the southern lakeshore. The observation of strata along with the archaeological survey in the north of Ogura Lake reveals that the lake level was decreased ca. 800 - 680 years ago. The lake level was at its highest during two periods, the first from before the 8th century to the end of the 8th century and the second from the 14th century to 400 years ago.
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