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Search Results: 1 - 10 of 4407 matches for " Yoshiki Tanaka "
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On nonlocally coupled complex Ginzburg-Landau equation
Dan Tanaka,Yoshiki Kuramoto
Physics , 2003,
Abstract: A Ginzburg-Landau type equation with nonlocal coupling is derived systematically as a reduced form of a universal class of reaction-diffusion systems near the Hopf bifurcation point and in the presence of another small parameter. The reaction-diffusion systems to be reduced are such that the chemical components constituting local oscillators are non-diffusive or hardly diffusive, so that the oscillators are almost uncoupled, while there is an extra diffusive component which introduces effective nonlocal coupling over the oscillators. Linear stability analysis of the reduced equation about the uniform oscillation is also carried out. This revealed that new types of instability which can never arise in the ordinary complex Ginzburg-Landau equation are possible, and their physical implication is briefly discussed.
Application of Nanofiber Fabricated by Cotton Candy Method to Electric Double-Layer Capacitor  [PDF]
Akihiro Tada, Tomohiko Adachi, Yoshiki Tanaka, Yoshifumi Aoi, Atsushi Yokoyama, Hiroyuki Hamada
Open Journal of Composite Materials (OJCM) , 2018, DOI: 10.4236/ojcm.2018.83011
Abstract: In recent years, application of carbon-based nano material to electrode material has been paid attention, however, due to its higher cost, it would be difficult to put it into practical use. Then, we have proposed to make nano carbon fiber with lower production cost. The purpose of our research was, to apply our nano carbon fiber to electrical double-layer capacitor electrode. We used cotton candy method to make nano fiber, and applied microwave heating for carbonization. By applying nano carbon fiber to electrical double-layer capacitor electrode, we got results that thicker electrode containing nano carbon fiber leads to lower resistance value, compared with electrode without containing nano carbon fiber. From this result, it was indicated that by containing nano carbon fiber, the electric bypass was formed in the electrode.
Knee hemarthrosis after arthroscopic surgery in an athlete with low factor XIII activity
Tsujii Akira,Tanaka Yoshinari,Yonetani Yasukazu,Shiozaki Yoshiki
Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology , 2012, DOI: 10.1186/1758-2555-4-35
Abstract: We report a thirteen-year-old tennis player with knee hemarthrosis caused by low factor XIII activity. She visited our hospital because of medial peripatellar pain for two years. Although there was no abnormal sign in X-ray or MRI, diagnostic arthroscopy was performed. It revealed some cartilage debris, medial plica and complete septum of suprapatellar plica. Removing the debris by washing out and resecting the medial plica, she could return to play tennis without perioperative symptom. Two months after the first operation, her knee got swelling without any apparent cause. Since 20 ml blood was aspirated twice and MRI revealed suprapatellar mass, we performed arthroscopy again. Suprapatellar mass was old blood clot covered with complete suprapatellar plica. Resection of suprapatellar plica and washing out blood clot were performed, and severe postoperative hemarthrosis was progressively occurred. As factor XIII level was 54% preoperatively, we diagnosed that this condition was caused by low activity level of the factor and administered factor XIII concentrates. The level got improved to 129% and then hemarthrosis gradually relieved. She had no signs of recurrence. We should keep in mind of low factor XIII activity case in case of unexplained postoperative hemarthrosis after arthroscopy because consumption of the factor might promote this condition.
Localization of Liv2 as an Immature Hepatocyte Marker in EB Outgrowth
Ikkei Takashimizu,Yoshiki Tanaka,Susumu Yoshie,Yoshiya Kano
The Scientific World Journal , 2009, DOI: 10.1100/tsw.2009.18
Bacterial Neuraminidase Rescues Influenza Virus Replication from Inhibition by a Neuraminidase Inhibitor
Tomoko Nishikawa, Kazufumi Shimizu, Torahiko Tanaka, Kazumichi Kuroda, Tadatoshi Takayama, Tatsuo Yamamoto, Nobuhiro Hanada, Yoshiki Hamada
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0045371
Abstract: Influenza virus neuraminidase (NA) cleaves terminal sialic acid residues on oligosaccharide chains that are receptors for virus binding, thus playing an important role in the release of virions from infected cells to promote the spread of cell-to-cell infection. In addition, NA plays a role at the initial stage of viral infection in the respiratory tract by degrading hemagglutination inhibitors in body fluid which competitively inhibit receptor binding of the virus. Current first line anti-influenza drugs are viral NA-specific inhibitors, which do not inhibit bacterial neuraminidases. Since neuraminidase producing bacteria have been isolated from oral and upper respiratory commensal bacterial flora, we posited that bacterial neuraminidases could decrease the antiviral effectiveness of NA inhibitor drugs in respiratory organs when viral NA is inhibited. Using in vitro models of infection, we aimed to clarify the effects of bacterial neuraminidases on influenza virus infection in the presence of the NA inhibitor drug zanamivir. We found that zanamivir reduced progeny virus yield to less than 2% of that in its absence, however the yield was restored almost entirely by the exogenous addition of bacterial neuraminidase from Streptococcus pneumoniae. Furthermore, cell-to-cell infection was severely inhibited by zanamivir but restored by the addition of bacterial neuraminidase. Next we examined the effects of bacterial neuraminidase on hemagglutination inhibition and infectivity neutralization activities of human saliva in the presence of zanamivir. We found that the drug enhanced both inhibitory activities of saliva, while the addition of bacterial neuraminidase diminished this enhancement. Altogether, our results showed that bacterial neuraminidases functioned as the predominant NA when viral NA was inhibited to promote the spread of infection and to inactivate the neutralization activity of saliva. We propose that neuraminidase from bacterial flora in patients may reduce the efficacy of NA inhibitor drugs during influenza virus infection. (295 words).
Hepatic microRNA expression is associated with the response to interferon treatment of chronic hepatitis C
Yoshiki Murakami, Masami Tanaka, Hidenori Toyoda, Katsuyuki Hayashi, Masahiko Kuroda, Atsushi Tajima, Kunitada Shimotohno
BMC Medical Genomics , 2010, DOI: 10.1186/1755-8794-3-48
Abstract: 99 CHC patients with no anti-viral therapy history were enrolled. The expression level of 470 mature miRNAs found their biopsy specimen, obtained prior to the combination therapy, were quantified using microarray analysis. The miRNA expression pattern was classified based on the final virological response to the combination therapy. Monte Carlo Cross Validation (MCCV) was used to validate the outcome of the prediction based on the miRNA expression profile.We found that the expression level of 9 miRNAs were significantly different in the sustained virological response (SVR) and non-responder (NR) groups. MCCV revealed an accuracy, sensitivity, and specificity of 70.5%, 76.5% and 63.3% in SVR and non-SVR and 70.0%, 67.5%, and 73.7% in relapse (R) and NR, respectively.The hepatic miRNA expression pattern that exists in CHC patients before combination therapy is associated with their therapeutic outcome. This information can be utilized as a novel biomarker to predict drug response and can also be applied to developing novel anti-viral therapy for CHC patients.Hepatitis C virus (HCV) infection affects more than 3% of the world population. HCV infection frequently induces chronic liver diseases ranging from chronic hepatitis (CH) C, to liver cirrhosis (LC) and hepatocellular carcinoma (HCC) [1]. The current standard treatment for CHC combines pegylated interferon (Peg-IFN) and ribavirin, and has been found to be effective in only 50% of HCV genotype 1b infection. Furthermore this form of therapy is often accompanied by adverse effects; therefore, there is a pressing need to develop alternative strategies to treat CHC and to identify patients that will not be responsive to treatment [2].MicroRNAs (miRNAs) are endogenous small non-coding RNAs that control gene expression by degrading or suppressing the translation of target mRNAs [3,4]. There are currently 940 identifiable human miRNAs (The miRBase Sequence Database -- Release 15.0). These miRNAs can recognize hundreds of
Retear of anterior cruciate ligament grafts in female basketball players: a case series
Yoshinari Tanaka, Yasukazu Yonetani, Yoshiki Shiozaki, Takuya Kitaguchi, Nozomi Sato, Shinya Takeshita, Shuji Horibe
Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology , 2010, DOI: 10.1186/1758-2555-2-7
Abstract: Sixty-four female basketball players (aged 12 to 29 years) who underwent primary anatomic double-bundle ACL reconstruction using hamstring grafts participated in the study. We investigated incidence, mechanism, and patient characteristics of ACL graft retears. Mann-Whitney U test was used for statistical analysis, and the level of significance was determined at P < 0.05.Six patients suffered from ACL graft retear (9.4%). Mean duration between primary ACL reconstruction and incidence of retears was 11.7 months. However, there were no other postoperative graft ruptures after 24 months. Primary injury and retear mechanisms varied by patient. At six months after the primary ACL reconstruction surgery, mean quadriceps and hamstring strengths were 81% and 87%, respectively, indicating favorable recovery of muscle strength. However, preoperative quadriceps and hamstring strength in the retear group were 65% and 71%, respectively. In particular, preoperative quadriceps strength in the retear group demonstrated a lower value than that in the uninjured group (P < 0.05).We observed a high incidence of ACL graft retears in competitive female basketball players, as previously reported. Considering the timing of graft retear occurrences, an early return to playing basketball should be avoided following ACL reconstruction. Closer attention should be paid to player preoperative condition, as well as muscle strength and postoperative status.Anterior cruciate ligament (ACL) rupture is a disabling knee injury which frequently occurs in young athletes. Previous studies have critically assessed risk factors for primary ACL injury, including variables such as gender, levels of sports activity, and anatomical characteristics [1,2]. Female to male ratio of ACL injuries in basketball players was 3.6 and 4.5 in high school and in college, respectively [3].ACL reconstruction is currently the gold standard to restore knee function after ACL rupture [4], but long-term efficacy has not been full
Clinical significance in the number of involved lymph nodes in patients that underwent surgery for pathological stage III-N2 non-small cell lung cancer
Takeshi Hanagiri, Masaru Takenaka, Soich Oka, Yoshiki Shigematsu, Yoshika Nagata, Hidehiko Shimokawa, Hidetaka Uramoto, Fumihiro Tanaka
Journal of Cardiothoracic Surgery , 2011, DOI: 10.1186/1749-8090-6-144
Abstract: This study evaluated 121 patients with p-stage III/N2 NSCLC.The histological types included 65 adenocarcinomas, 39 squamous cell carcinomas and 17 others. The average number of dissected lymph nodes was 23.8 (range: 6-55). The average number of involved lymph nodes was 5.9 (range: 1-23). The 5-year survival rate of the patients was 51.0% for single lymph node positive, 58.9% for 2 lymph nodes positive, 34.2% for 3 lymph nodes positive, and 30.0% for 4 lymph nodes positive, and 20.4% for more than 5 lymph nodes positive. The patients with either single or 2 lymph nodes positive had a significantly more favorable prognosis than the patients with more than 5 lymph nodes positive. A multivariate analysis revealed that the number of involved lymph nodes was a significant independent prognostic factor.Surgery appears to be preferable as a one arm of multimodality therapy in p-stage III/N2 patients with single or 2 involved lymph nodes. The optimal incorporation of surgery into the multimodality approach therefore requires further clinical investigation.More than 1.6 million new cases of lung cancer are diagnosed worldwide each year, causing approximately 1.3 million deaths annually and representing the highest mortality rate in comparison to any other major malignancies [1,2]. A surgical resection remains the mainstay for patients with early stage non-small cell carcinoma (NSCLC) [3]. However, lung cancer patients are often diagnosed with advanced disease due to the aggressiveness of this type of cancer [4,5]. A careful staging workup is very important to determine the optimal treatment strategy. Chemotherapy and radiotherapy is the current standard of care for patients with locally advanced (stage IIIA and stage IIIB) NSCLC. However, regardless of the total dose of radiation and the optimal chemotherapy, the outcome of stage III patients remains poor, with a median survival of 10-15 months, and 5-year survival rates of only 5-15% [6,7].It is necessary to establish a trea
A Macrocyclic Peptide that Serves as a Cocrystallization Ligand and Inhibits the Function of a MATE Family Transporter
Christopher J. Hipolito,Yoshiki Tanaka,Takayuki Katoh,Osamu Nureki,Hiroaki Suga
Molecules , 2013, DOI: 10.3390/molecules180910514
Abstract: The random non-standard peptide integrated discovery (RaPID) system has proven to be a powerful approach to discover de novo natural product-like macrocyclic peptides that inhibit protein functions. We have recently reported three macrocyclic peptides that bind to Pyrococcus furiosus multidrug and toxic compound extrusion (PfMATE) transporter and inhibit the transport function. Moreover, these macrocyclic peptides were successfully employed as cocrystallization ligands of selenomethionine-labeled PfMATE. In this report, we disclose the details of the RaPID selection strategy that led to the identification of these three macrocyclic peptides as well as a fourth macrocyclic peptide, MaD8, which is exclusively discussed in this article. MaD8 was found to bind within the cleft of PfMATE’s extracellular side and blocked the path of organic small molecules being extruded. The results of an ethidium bromide efflux assay confirmed the efflux inhibitory activity of MaD8, whose behavior was similar to that of previously reported MaD5.
From bench to bedside, work in cell-based myocardial regeneration therapy  [PDF]
Shigeru Miyagawa, Yoshiki Sawa
Journal of Biomedical Science and Engineering (JBiSE) , 2014, DOI: 10.4236/jbise.2014.72012

In clinical cellular cardiomyoplasty, bone marrow cells and myoblasts are introduced mainly to ischemic cardiomyopathy tissue via several cell delivery systems, such as needle injection or catheter. These clinical studies have demonstrated the safety and feasibility of this technique, but its effectiveness for treating heart failure, especially in the long term, is still under discussion. Neither of these cell types can differentiate into cardiomyocytes; rather, they improve the failing heart mainly by the paracrine effects of some cytokines, such as Hepatocyte growth factor (HGF) and Vascular endothelial growth factor (VEGF). Thus, many researchers have a great interest in stem cells, which exist in bone marrow, circulating blood, atrium, and adipose tissue, and can differentiate into cardiomyocytes. Although several stem cells with the potential to differentiate into various cell types have been reported, few can differentiate into cardiomyocytes. Moreover, beating cells that can demonstrate synchronized contraction with native cardiomyocytes are critical for the complete repair of severe heart failure. Therefore, stem cells with a high differentiation capacity should be explored for the goal of completely repairing severely damaged myocardium. In this review, we summarize the clinical protocols and basic experiments for cellular cardiomyoplasty using bone marrow cells, myoblasts, and other stem cells.

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