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Search Results: 1 - 10 of 2794 matches for " Yoshihiro Inoue "
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Effect of Silver-Loaded Zeolite on the Susceptibility of Escherichia Coli Against Antibiotics  [PDF]
Yoshihiro Inoue, Hajime Hamashima
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2012, DOI: 10.4236/jbnb.2012.31015
Abstract: We investigated the effect of silver-loaded zeolite (Ag-Z) on antibacterial activity of some antibiotics against Es-cherichia coli against antibiotics. We treated the bacterial suspension of E. coli by Ag-Z to be the level which the decrease of viable cell count was not observed. Susceptibility test of E. coli treated with Ag-Z was carried out against four antibiotics with different mode of action. Apparent increase in susceptibility was found in the case of rifampicin, not in others. The result suggests that application of Ag-Z to ward environment might give a good outcome at the treatment with rifampicin and at the treatment for pathogenic microbe spread through the air, such as tubercle bacilli.
Electrochemical Analysis of the Redox State of Silver Contained in Antibacterial Material  [PDF]
Yoshihiro Inoue, Hajime Hamashima
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2012, DOI: 10.4236/jbnb.2012.32019
Abstract: Introduction of silver into some inorganic material causes the resulting mixture to have antibacterial activity. Here, we investigated the role of silver in the bactericidal activity of silver-loaded zeolite, by measuring the effects of silver-loaded zeolite on Escherichia coli cell viability under conditions in which the oxidation state of the silver was controlled electrochemically. Bactericidal activity was observed when the sweeping voltage between 0 and 0.7 V was applied to the silver electrode. When nitrogen gas bubbling or reactive oxygen scavengers were added to the experimental system, bactericidal activity decreased. These results indicated that the redox cycle, Ag0 <—> Ag+, caused the dissolved oxygen to form reactive oxygen species.
The Significance of Angiotensin Converting Enzyme Inhibitor or Angiotensin II Receptor Blocker Use in Sudden Cardiac Death  [PDF]
Makoto Onodera, Satoshi Kikuchi, Yasuhisa Fujino, Yoshihiro Inoue, Yuji Fujita
International Journal of Clinical Medicine (IJCM) , 2017, DOI: 10.4236/ijcm.2017.88046
Abstract: Objectives: To investigate the relationship between the use of angiotensin converting enzyme (ACE) inhibitor or angiotensin II receptor blocker (ARB) and hyperkalemia in patients diagnosed with sudden cardiac death. Methods: We examined oral ACE inhibitor or ARB use among cardiopulmonary arrest patients brought by ambulance to our emergency room during a 5-year period from January 2012 to December 2016. The cause of death was determined to be sudden cardiac death, despite temporary return of spontaneous circulation after starting cardiopulmonary resuscitation. Subjects were dichotomized into 2 groups, those taking and those not taking an ACE inhibitor or ARB. Variables determined retrospectively included serum potassium, estimated glomerular filtration rate as an index of kidney function and time from cardiopulmonary arrest to return of spontaneous circulation. The Mann-Whitney U-test was used to compare continuous data, and the chi-square test to compare categorical data between groups. The results are expressed as the median plus range. Statistical significance was assumed at p < 0.05. Results: Thirty-five patients met the inclusion criteria. The mean age was 77.1 years (range, 35 - 93 years), and there were 26 males and 9 females. Eleven subjects were ACE inhibitor or ARB users, and 24 were non-users. The serum potassium level was significantly higher in users than non-users (median, 6.2 mEq/L (range, 4.5 - 10.0) vs. 5.2 mEq/L (range, 3.6 - 8.3); p = 0.001). The estimated glomerular filtration rate was significantly lower in users than non-users (median, 25.1 mL/min/1.73 m2 (range, 4.6 - 60.3) vs. 46.9 mL/min/1.73 m2 (range, 19.8 - 97.1); p = 0.009). There was no significant difference in time from cardiopulmonary arrest to return of spontaneous circulation between the 2 groups (median, 24 minutes (range, 3 - 111) vs. 29 minutes (range, 10 - 54); p = 0.355). Conclusion: It is possible that hyperkalemia induced by ACE inhibitor or ARB use is a cause of sudden cardiac death, especially in patients with chronic kidney disease.
Active Vibration Control of a Microactuator for the Hard Disk Drive Using Self-Sensing Actuation
Minoru Sasaki,Yoshihiro Inoue,Hiroyuki Yamada
Smart Materials Research , 2012, DOI: 10.1155/2012/920747
Abstract: This paper presents the self-sensing control of a microactuator for hard disk drives. The microactuator uses a PZT actuator pair installed on the suspension assembly. The self-sensing microactuator forms a combined sensing and actuation mechanism. Direct velocity feedback and positive position feedback are used in this paper. Our experimental results show that both strategies are effective in suppressing vibrational modes and successfully demonstrate the feasibility of using a self-sensing actuator on an HDD suspension assembly. 1. Introduction A suspension assembly in a hard disk drive (HDD) is subject to excitation by many disturbances, including the airflow due to the rapidly spinning disks, and noncircular track motion of the head and slider due to resonance in the components. A servo system that can cope with these problems requires a very high servo bandwidth and position error signal sampling frequency. In conventional servo systems, the sampling frequency is limited by data storage efficiency. The desire to more effectively suppress the effect of disturbances has led many researchers to propose the addition of more sensors and actuators. One example which has been proposed is to use a piezoelectric actuator on the suspension in a dual-stage system with one of the two strips as the sensor and the other as the actuator [1, 2]. This, however, reduces the effectiveness of the actuator by half and is not efficient. An alternate approach is to use it as a self-sensing microactuator [3–9], which is the subject of this paper. For dual-stage servo system, the performance of self-sensing actuator systems exceeds that of other vibration compensation systems. We implemented two active strategies in order to experimentally demonstrate the effectiveness of a self-sensing system in structural vibration control. The strategies are direct velocity feedback (DVF) and positive position feedback (PPF). DVF, also known as strain rate feedback (SRF) has been used in the active damping of a flexible space structure [10]. In DVF, the structural velocity coordinate is fed back to the compensator and the compensator velocity coordinate multiplied by a negative gain is applied to the structure. DVF has a wide active damping region and can stabilize more than one mode given sufficient bandwidth. In PPF, the structural position coordinate is fed directly to the compensator where a scalar gain is applied and the result sent to the structure [11, 12]. PPF offers quick damping for a particular mode provided the modal characteristics are known. PPF is also easy to implement.
NSAIDs, Mitochondria and Calcium Signaling: Special Focus on Aspirin/Salicylates
Yoshihiro Suzuki,Toshio Inoue,Chisei Ra
Pharmaceuticals , 2010, DOI: 10.3390/ph3051594
Abstract: Aspirin (acetylsalicylic acid) is a well-known nonsteroidal anti-inflammatory drug (NSAID) that has long been used as an anti-pyretic and analgesic drug. Recently, much attention has been paid to the chemopreventive and apoptosis-inducing effects of NSAIDs in cancer cells. These effects have been thought to be primarily attributed to the inhibition of cyclooxygenase activity and prostaglandin synthesis. However, recent studies have demonstrated unequivocally that certain NSAIDs, including aspirin and its metabolite salicylic acid, exert their anti-inflammatory and chemopreventive effects independently of cyclooxygenase activity and prostaglandin synthesis inhibition. It is becoming increasingly evident that two potential common targets of NSAIDs are mitochondria and the Ca 2+ signaling pathway. In this review, we provide an overview of the current knowledge regarding the roles of mitochondria and Ca 2+ in the apoptosis-inducing effects as well as some side effects of aspirin, salicylates and other NSAIDs, and introducing the emerging role of L-type Ca 2+ channels, a new Ca 2+ entry pathway in non-excitable cells that is up-regulated in human cancer cells.
Endoscopic Hemostasis of Nonvariceal Gastrointestinal Bleeding  [PDF]
Yoshihiro Inoue, Yasuhisa Fujino, Makoto Onodera, Satoshi Kikuchi, Masayuki Sato, Hisaho Sato, Masahiro Kojika, Shigeatsu Endo
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.519147
Abstract: We investigated 2668 patients with non-variceal upper gastrointestinal bleeding and 660 patients with lower gastrointestinal bleeding treated between 1987 and 2011 in our hospital. Upper gastrointestinal bleeding was associated with gastric ulcer, duodenal ulcer, Mallory-Weiss syndrome, esophageal disease, and others. Endoscopic hemostasis was performed in approximately 67% of all cases with upper gastrointestinal bleeding and approximately 90% of cases with ulcer. The hemostasis success rate was over 90% for ulcer bleeding, and was also generally high for other diseases. The total number of patients with lower gastrointestinal bleeding was lower, with it being approximately 20% of those with upper gastrointestinal bleeding. Endoscopic hemostasis was performed in approximately 30% of the patients with lower gastrointestinal bleeding. The hemostasis success rate was generally high, but treatment switch to surgery or interventional radiology (IVR) was observed in some cases with colorectal diverticular bleeding.
Trace Element Analysis of Potassium by Resonance Ionization Mass Spectrometry
Yoshihiro Iwata,Yoshizumi Inoue,Makoto Minowa
Physics , 2008, DOI: 10.1143/JJAP.48.076505
Abstract: A simple resonance ionization mass spectrometer is built with a Quadrupole Mass Spectrometer (QMS) and two laser diodes aiming at trace analysis of potassium. The overall detection efficiency is estimated comparing the yields of resonance ionization and electron-impact ionization in the same QMS. A clear discrimination of $^{39}\rm K$, $^{40}\rm K$ and $^{41}\rm K$ is demonstrated with a help of isotope shifts of the atomic levels.
Development of a Compact Resonance Ionization Mass Spectrometer for Trace Element Analysis of Potassium
Yoshihiro Iwata,Yoshizumi Inoue,Makoto Minowa
Physics , 2010,
Abstract: A compact resonance ionization mass spectrometer is developed using two laser diodes and a quadrupole mass spectrometer to perform trace element analysis of potassium. With the help of a narrow linewidth of the laser diode, the isotope shifts of $^{40}{\rm K}$ and $^{41}{\rm K}$ of the 405 nm line with respect to $^{39}{\rm K}$, corresponding to the transition of $4\,^2$S$_{1/2}\rightarrow$ $5\,^2$P$^\circ_{1/2}$, are measured to be $207\pm13$ MHz and $451\pm10$ MHz, respectively, by comparing them to the known hyperfine splitting widths of the $4\,^2{\rm S}_{1/2}$ ground state of each potassium isotope. The overall detection efficiency of an order of $\sim10^{-6}$ in our setup indicates the availability of RIMS to the analysis of the trace metal impurities on or in a certain material such as the contamination assessment of semiconductor wafers.
A Study of Mallory-Weiss Syndrome Secondary to Upper Gastrointestinal Bleeding  [PDF]
Yoshihiro Inoue, Yasuhisa Fujino, Makoto Onodera, Satoshi Kikuchi, Masayuki Sato, Hisaho Sato, Hironobu Noda, Masahiro Kojika, Yasushi Suzuki, Shigeatsu Endo
Open Journal of Clinical Diagnostics (OJCD) , 2014, DOI: 10.4236/ojcd.2014.43021
Abstract:

Background: In Mallory-Weiss Syndrome (MWS), vomiting causes the mucous membrane and submucosa near the esophagogastric mucosal junction to tear and bleed. Thus, MWS can arise after heavy drinking and as a complication of endoscopic upper gastrointestinal examinations or procedures. However, there has been no report of MWS secondary to upper gastrointestinal bleeding thus far. Case Subjects: Of 79 MWS cases over a 10-year period from 2002 to 2011, we identified and studied 6 cases, in which MWS was probably caused by another lesion causing upper gastrointestinal bleeding. Results: There were 2 cases, each of gastric ulcers, duodenal ulcers, and varicose veins. In 3 cases, MWS was discovered during treatment of the primary lesion and was simultaneously treated. In the other 3 cases, patients were treated for MWS according to endoscopic diagnosis, and the primary lesion was overlooked; in these cases, the primary lesion was identified and treated after the bleeding recurred. One patient with cirrhosis died of hepatic failure. Conclusion: Care should be taken when dealing with MWS because it can occur as a result of vomiting caused by hematemesis or as a complication of endoscopic examination and treatment. When assessing MWS, other hemorrhagic lesions may be overlooked.

The East Japan Great Earthquake and Three Cases of Near-Drowning with Tsunami Due to the Earthquake  [PDF]
Yoshihiro Inoue, Yasuhisa Fujino, Makoto Onodera, Satoshi Kikuchi, Masayuki Sato, Hisaho Sato, Hironobu Noda, Masahiro Kojika, Yasushi Suzuki, Shigeatu Endo
Open Journal of Clinical Diagnostics (OJCD) , 2014, DOI: 10.4236/ojcd.2014.43023
Abstract:

We encountered the Great East Japan Earthquake on March 11, 2011. The magnitude of the earthquake is 9.0 and it is one of the greatest from A.D. 1900 to now. The earthquake developed large tsunami and many people living on the pacific coast of east Japan died from lung disorder caused by near drowning with tsunami. We also encountered three cases of lung disorders caused by near drowning. All three were females, and two of them were old elderly. All segments of both lungs were involved in all the three patients, necessitating ICU admission and endotracheal intubation and mechanical ventilation. All three died within three weeks. In at least two cases, misswallowing of oil was suspected from the features noted at the time of the detection. Many bacteria were detected from the phlegm of two cases.

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