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Search Results: 1 - 10 of 49139 matches for " Yoon-Sun Kim "
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Long Chain Polyunsaturated Fatty Acids Alter Oxytocin Signaling and Receptor Density in Cultured Pregnant Human Myometrial Smooth Muscle Cells
Paul Y. Kim, Miao Zhong, Yoon-Sun Kim, Barbara M. Sanborn, Kenneth G. D. Allen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0041708
Abstract: Epidemiological studies and interventional clinical trials indicate that consumption of long chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) such as docosahexaenoic acid (DHA) lengthen gestational duration. Although the mechanisms are not well understood, prostaglandins (PG) of the 2-series are known to play a role in the initiation and progress of labor. In animal studies, modest DHA provision has been shown to reduce placental and uterine PGE2 and PGF2α, matrix metalloproteinase (MMP)-2 and MMP-9 expression, and placental collagenase activity. However, modulation of PG biosynthesis may not account for all the effects of LC n-3 PUFAs in labor. We investigated one potential PG-independent mechanism of LC PUFA action using cultured pregnant human myometrial smooth muscle cells. Our goal was to characterize the effect of LC PUFA treatment on oxytocin signaling, a potent uterotonic hormone involved in labor. The addition of 10 μM–100 μM DHA or arachidonic acid (AA) to the culture media for 48 h resulted in dose dependent enrichment of these fatty acids in membrane lipid. DHA and AA significantly inhibited phosphatidylinositol turnover and [Ca2+]i mobilization with oxytocin stimulation compared to bovine serum albumin control and equimolar oleic acid. DHA and AA significantly reduced oxytocin receptor membrane concentration without altering binding affinity or rate of receptor internalization. These findings demonstrate a role for LC n-3 PUFAs in regulation of oxytocin signaling and provide new insight into additional mechanisms pertaining to reports of dietary fish and fish oil consumption prolonging gestation.
Bacterial Inactivation of Wound Infection in a Human Skin Model by Liquid-Phase Discharge Plasma
Paul Y. Kim, Yoon-Sun Kim, Il Gyo Koo, Jae Chul Jung, Gon Jun Kim, Myeong Yeol Choi, Zengqi Yu, George J. Collins
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0024104
Abstract: Background We investigate disinfection of a reconstructed human skin model contaminated with biofilm-formative Staphylococcus aureus employing plasma discharge in liquid. Principal Findings We observed statistically significant 3.83-log10 (p<0.001) and 1.59-log10 (p<0.05) decreases in colony forming units of adherent S. aureus bacteria and 24 h S. aureus biofilm culture with plasma treatment. Plasma treatment was associated with minimal changes in histological morphology and tissue viability determined by means of MTT assay. Spectral analysis of the plasma discharge indicated the presence of highly reactive atomic oxygen radicals (777 nm and 844 nm) and OH bands in the UV region. The contribution of these and other plasma-generated agents and physical conditions to the reduction in bacterial load are discussed. Conclusions These findings demonstrate the potential of liquid plasma treatment as a potential adjunct therapy for chronic wounds.
Mitochondrial DNA Haplogroup Analysis Reveals no Association between the Common Genetic Lineages and Prostate Cancer in the Korean Population
Wook Kim, Tag-Keun Yoo, Dong-Jik Shin, Hyun-Wook Rho, Han-Jun Jin, Eun-Tak Kim, Yoon-Sun Bae
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0002211
Abstract: Mitochondrial DNA (mtDNA) variation has recently been suggested to have an association with various cancers, including prostate cancer risk, in human populations. Since mtDNA is haploid and lacks recombination, specific mutations in the mtDNA genome associated with human diseases arise and remain in particular genetic backgrounds referred to as haplogroups. To assess the possible contribution of mtDNA haplogroup-specific mutations to the occurrence of prostate cancer, we have therefore performed a population-based study of a prostate cancer cases and corresponding controls from the Korean population. No statistically significant difference in the distribution of mtDNA haplogroup frequencies was observed between the case and control groups of Koreans. Thus, our data imply that specific mtDNA mutations/lineages did not appear to have a significant effect on a predisposition to prostate cancer in the Korean population, although larger sample sizes are necessary to validate our results.
Lack of Association between Y-Chromosomal Haplogroups and Prostate Cancer in the Korean Population
Wook Kim, Tag-Keun Yoo, Sung-Joo Kim, Dong-Jik Shin, Chris Tyler-Smith, Han-Jun Jin, Kyoung-Don Kwak, Eun-Tak Kim, Yoon-Sun Bae
PLOS ONE , 2007, DOI: 10.1371/journal.pone.0000172
Abstract: The Y chromosome has recently been suggested to have an association with prostate cancer risk in human populations. Since this chromosome is haploid and lacks recombination over most of its length, haplotypes constructed from binary markers throughout the chromosome can be used for association studies. To assess the possible Y-chromosomal contribution to prostate cancer risk, we have therefore analyzed 14 Y-chromosomal binary markers in 106 prostate cancer cases and 110 controls from the Korean population. In contrast to previous findings in the Japanese population, no statistically significant difference in the distribution of Y-chromosomal haplogroup frequencies was observed between the case and control groups of Koreans. Thus, our data imply that the previously reported associations between Y-chromosomal lineages and a predisposition to, or protection against, prostate cancer might be explained by statistical fluctuations, or by genetic effects that are seen only in some environments.
The Arabidopsis thaliana Homeobox Gene ATHB12 Is Involved in Symptom Development Caused by Geminivirus Infection
Jungan Park,Hyun-Ju Lee,Choong-Ill Cheon,Sung-Han Kim,Yoon-Sun Hur,Chung-Kyun Auh,Kyung-Hwan Im,Dae-Jin Yun,Sukchan Lee,Keith R. Davis
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0020054
Abstract: Geminiviruses are single-stranded DNA viruses that infect a number of monocotyledonous and dicotyledonous plants. Arabidopsis is susceptible to infection with the Curtovirus, Beet severe curly top virus (BSCTV). Infection of Arabidopsis with BSCTV causes severe symptoms characterized by stunting, leaf curling, and the development of abnormal inflorescence and root structures. BSCTV-induced symptom development requires the virus-encoded C4 protein which is thought to interact with specific plant-host proteins and disrupt signaling pathways important for controlling cell division and development. Very little is known about the specific plant regulatory factors that participate in BSCTV-induced symptom development. This study was conducted to identify specific transcription factors that are induced by BSCTV infection.
Safety and feasibility of countering neurological impairment by intravenous administration of autologous cord blood in cerebral palsy
Young-Ho Lee, Kyung Choi, Jin Moon, Hyun-Joo Jun, Hye-Ryeong Kang, Se-In Oh, Hyung Kim, Jang Um, Mi Kim, Yun Choi, Young-Jun Lee, Hee-Jin Kim, Jong-Hwa Lee, Su Son, Soo-Jin Choi, Wonil Oh, Yoon-Sun Yang
Journal of Translational Medicine , 2012, DOI: 10.1186/1479-5876-10-58
Abstract: Patients diagnosed with CP were enrolled in this study if their parents had elected to bank their CB at birth. Cryopreserved CB units were thawed and infused intravenously over 10~20 minutes. We assessed potential efficacy over 6 months by brain magnetic resonance imaging (MRI)-diffusion tensor imaging (DTI), brain perfusion single-photon emission computed tomography (SPECT), and various evaluation tools for motor and cognitive functions.Twenty patients received autologous CB infusion and were evaluated. The types of CP were as follows: 11 quadriplegics, 6 hemiplegics, and 3 diplegics. Infusion was generally well-tolerated, although 5 patients experienced temporary nausea, hemoglobinuria, or urticaria during intravenous infusion. Diverse neurological domains improved in 5 patients (25%) as assessed with developmental evaluation tools as well as by fractional anisotropy values in brain MRI-DTI. The neurologic improvement occurred significantly in patients with diplegia or hemiplegia rather than quadriplegia.Autologous CB infusion is safe and feasible, and has yielded potential benefits in children with CP.Cord blood (CB) was introduced for the first time in humans to reconstitute the hematopoietic system in patient with Fanconi anemia [1]. Since the first cord blood transplantation (CBT), more than 20,000 CBTs have been reported worldwide and more than 400,000 CB units have been stored in more than 100 CB banks [2]. The clinical use of CB has expanded into various areas such as inherited metabolic disorders. CBT for Hurler syndrome resulted in either stabilization or improvement of neurocognitive function, and maintenance of new skills [3]. CBT for infantile Krabbe disease was highly effective if patients received transplants early in the course of the disease [4]. In such patients, CBT can prevent demyelination in the central and, often, the peripheral nervous system, extending life and improving overall quality of life. Kurtzberg, et al found that donor cells could
Clinical characteristics that distinguish eosinophilic organ infiltration from metastatic nodule development in cancer patients with eosinophilia
Lee Taehoon,Lee Yoon,Yoon Sun,Kim Su-Jeong
World Journal of Surgical Oncology , 2012, DOI: 10.1186/1477-7819-10-175
Abstract: Background When new space-occupying lesions are observed together with peripheral blood eosinophilia in patients diagnosed with cancer, the possibility of eosinophilic organ involvement should be differentiated from metastasis of primary cancer, since a misdiagnosis could lead to unnecessary chemotherapy. The aim of this study is to identify the clinical characteristics of eosinophilic organ involvement that distinguish it from distant metastasis in patients with primary cancer. Methods The medical records of 43 cancer patients who developed hepatic or pulmonary nodules with peripheral blood eosinophilia between January 2005 and February 2010 in the Asan Medical Center (Seoul) were reviewed. Eosinophilic infiltration and distant metastasis were identified on the basis of pathological findings and radiological features. Fisher’s exact test, χ2 test or Mann-Whitney test were used for statistical analysis. Results In total, 33 patients (76%) were diagnosed with eosinophilic infiltration, 5 (12%) with cancer metastasis and 5 (12%) had undetermined diagnoses. Compared to the patients with metastases, the patients with eosinophilic infiltration were significantly more likely to have serology indicating a parasitic infection, a history of eating raw food, high serum levels of total IgE, normal liver function, normal C-reactive protein levels, a normal erythrocyte sedimentation rate, and fewer and smaller nodules. The most common underlying malignancy in the eosinophilic organ infiltration group was stomach cancer. Physicians tended to neglect the eosinophilia in patients with a history of cancer. Conclusions Several clinical characteristics of eosinophilic organ infiltration distinguish it from cancer metastasis. Physicians should make greater efforts to determine the causes of organ involvement with peripheral blood eosinophilia, especially in cancer patients.
Preparation of Silver Nanoparticles Doped PVDF: Formation of Piezoelectric Polymorph
Dipankar Mandal,Sun Yoon,Kap Jin Kim
Physics , 2011,
Abstract: The preparation of polymorphism control of Poly(vinylidene fluoride) (PVDF) by silver nanoparticles (Ag NPs) is investigated. The Ag NPs were prepared by simple one step process from AgNO3, where N,N-dimethylformamide(DMF) act as reducing agent as well the solvent of the host polymer, PVDF. It was observed that PVDF is one of the best stabilizers of Ag NPs. The thick films (10-20 {\mu}m) were prepared by simple solution casting followed by solvent drying and crystallizing PVDF polymorph. Here we observed that PVDF polymorph can be control by the content of the Ag NPs regardless of other processing conditions. The formation piezoelectric polymorph ({\beta} phase) by adequate amount of Ag NPs doping in PVDF was explained by the specific interaction between the surface charge of the Ag NPs and electric dipoles (CF2 dipoles) comprising in PVDF. In this work we also address the suitable technique for correct crystallographic phase identification in PVDF, as a large number of works in this field have already been misled. The significant higher temperature shift of melting temperature of {\beta}-phase was observed by Ag NPs doping, which has prime importance in diverse fields of electronic applications, i.e. IR-sensors, piezoelectric and pyroelectric sensor,transducers as well as actuators.
Nanopatterning graphite by ion-beam-sputtering: Effects of polycrystallinity
Sun Mi Yoon,J. -S. Kim,D. Yoon,H. Cheong,Y. Kim,H. H. Lee
Physics , 2014,
Abstract: Employing graphites having distinctly different mean grain sizes, we study the effects of polycrystallinity on the pattern formation by ion-beam-sputtering. The grains influence the growth of the ripples in highly anisotropic fashion; Both the mean uninterrupted ripple length along its ridge and the surface width depend on the mean size of the grains, which is attributed to the large sputter yield at the grain boundary compared with that on terrace. In contrast, the ripple wavelength does not depend on the mean size of the grains. Coarsening of the ripples-accompanying the mass transport across the grain boundaries-should not be driven by thermal diffusion, rather by ion-induced processes.
Flux fluctuations in a multi-random-walker model and surface growth dynamics
S. Y. Yoon,Byoung-sun Ahn,Yup Kim
Physics , 2005,
Abstract: We study the dynamics of visitation flux in a multi-random-walker model by comparison to surface growth dynamics in which one random walker drops a particle to a node at each time the walker visits the node. In each independent experiment (trial or day) for the multi-random-walker model, the number of walkers are randomly chosen from the uniform distribution $[< N_{RW} > -\triangle N_{RW}, < N_{RW} > +\triangle N_{RW} ]$. The averaged fluctuation $\bar {\sigma} ({T_{RW}})$ of the visitations over all nodes $i$ and independent experiments is shown to satisfy the power-law dependence on the walk step $T_{RW}$ as $\bar {\sigma} ({T_{RW}})\simeq {T_{RW}}^\beta$. Furthermore two distinct values of the exponent $\beta$ are found on a scale-free network, a random network and regular lattices. One is $\beta_i$, which is equal to the growth exponent $\beta$ for the surface fluctuation $W$ in one-random-walker model, and the other is $\beta=1$. $\beta_i$ is found for small $\triangle N_{RW}$ or for the system governed by the internal intrinsic dynamics. In contrast $\beta=1$ is found for large $\triangle N_{RW}$ or for the system governed by the external flux variations. The implications of our results to the recent studies on fluctuation dynamics of the nodes on networks are discussed.
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