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Search Results: 1 - 10 of 32459 matches for " Yong-Moon Park "
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Gender Difference in the Association of Metabolic Syndrome and Its Components with Age-Related Cataract: The Korea National Health and Nutrition Examination Survey 2008-2010
Young-Hoon Park, Jeong Ah Shin, Kyungdo Han, Hyeon Woo Yim, Won-Chul Lee, Yong-Moon Park
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0085068
Abstract: Purpose To explore the relationship of the metabolic syndrome (MetS) and its components with age-related cataract in a representative Korean population. Methods We analyzed the data from the Korea National Health and Nutrition Examination Surveys (2008–2010). A total of 11,076 adults (4,811 men and 6,265 women) aged 40 and over who completed ophthalmologic examination were evaluated. Cataract was defined as the presence of cortical, nuclear, anterior (sub)capsular or posterior subcapsular cataract, from slit-lamp examination or previous cataract surgery. MetS was defined according to the Joint Interim Statement proposed in 2009 from the International Diabetes Federation and the American Heart Association/National Heart, Lung, and Blood Institute. Results The prevalence of cataract and MetS in this population was 39.4% (37.1% for men and 41.6% for women) and 38.5% (37.6% for men and 39.4% for women), respectively. Cataract prevalence tended to increase with the number of MetS components in both genders (both P< 0.001). After being controlled for confounders, however, MetS was significantly associated with cataract only in women (adjusted odds ratio (aOR), 1.24; 95% confidence interval (CI), 1.02–1.50]. Reduced HDL cholesterol, elevated fasting glucose, and elevated triglycerides were also significantly associated with cataract in women (aOR, 95% CI; 1.27 (1.07–1.50), 1.23 (1.01–1.50), and 1.26 (1.04–1.52), respectively). In the subgroup analysis for cataract subtype, MetS and reduced HDL cholesterol were significantly associated with nuclear cataract in women (aOR, 95% CI; 1.25 (1.07–1.55) and 1.25 (1.03–1.52), respectively). However, such associations were not found in men. Conclusions Our results suggest that MetS and its components appear to be associated with age-related cataract only among Korean women, especially in nuclear cataract.
Sarcopenia as a Determinant of Blood Pressure in Older Koreans: Findings from the Korea National Health and Nutrition Examination Surveys (KNHANES) 2008–2010
Kyungdo Han, Yu-Mi Park, Hyuk-Sang Kwon, Seung-Hyun Ko, Seung-Hwan Lee, Hyeon Woo Yim, Won-Chul Lee, Yong Gyu Park, Mee Kyoung Kim, Yong-Moon Park
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0086902
Abstract: Background Blood pressure (BP) is directly and causally associated with body size in the general population. Whether muscle mass is an important factor that determines BP remains unclear. Objective To investigate whether sarcopenia is associated with hypertension in older Koreans. Participants We surveyed 2,099 males and 2,747 females aged 60 years or older. Measurements Sarcopenia was defined as an appendicular skeletal muscle mass divided by body weight (ASM/Wt) that was <1 SD below the gender-specific mean for young adults. Obesity was defined as a body mass index (BMI) ≥25 kg/m2. Subjects were divided into four groups based on presence or absence of obesity or sarcopenia. Hypertension was defined as a systolic BP (SBP) ≥140 mmHg, a diastolic BP (DBP) ≥90 mmHg, or a self-reported current use of antihypertensive medications. Results The overall prevalence of hypertension in the four groups was as follows 49.7% for non-obese non-sarcopenia, 60.9% for non-obese sarcopenia, 66.2% for obese non-sarcopenia and 74.7% for obese sarcopenia. After adjustment for age, gender, regular activity, current smoking and alcohol use, the odds ratio (OR) for having hypertension was 1.5 (95% confidence interval (CI) = 1.23–1.84) in subjects in the non-obese sarcopenia group, 2.08 (95% CI = 1.68–2.57) in the obese non-sarcopenia group and 3.0 (95% CI = 2.48–3.63) in the obese sarcopenia group, compared with the non-obese non-sarcopenia group (p for trend <0.001). Controlling further for body weight and waist circumference did not change the association between hypertension and sarcopenia. The association between sarcopenia and hypertension was more robust in the subjects with diabetes mellitus. Conclusion Body composition beyond BMI has a considerable impact on hypertension in elderly Koreans. Subjects with sarcopenic obesity appear to have a greater risk of hypertension than simply obese or sarcopenia subjects.
Anti-Cancer Effect of Thiacremonone through Down Regulation of Peroxiredoxin 6
Miran Jo, Hyung-Mun Yun, Kyung-Ran Park, Mi Hee Park, Dong Hun Lee, Seung Hee Cho, Hwan-Soo Yoo, Yong-Moon Lee, Heon Sang Jeong, Youngsoo Kim, Jae Kyung Jung, Bang Yeon Hwang, Mi Kyeong Lee, Nam Doo Kim, Sang Bae Han, Jin Tae Hong
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0091508
Abstract: Thiacremonone (2, 4-dihydroxy-2, 5-dimethyl-thiophene-3-one) is an antioxidant substance as a novel sulfur compound generated from High-Temperature-High-Pressure-treated garlic. Peroxiredoxin 6 (PRDX6) is a member of peroxidases, and has glutathione peroxidase and calcium-independent phospholipase A2 (iPLA2) activities. Several studies have demonstrated that PRDX6 stimulates lung cancer cell growth via an increase of glutathione peroxidase activity. A docking model study and pull down assay showed that thiacremonone completely fits on the active site (cys-47) of glutathione peroxidase of PRDX6 and interacts with PRDX6. Thus, we investigated whether thiacremonone inhibits cell growth by blocking glutathione peroxidase of PRDX6 in the human lung cancer cells, A549 and NCI-H460. Thiacremonone (0–50 μg/ml) inhibited lung cancer cell growth in a concentration dependent manner through induction of apoptotic cell death accompanied by induction of cleaved caspase-3, -8, -9, Bax, p21 and p53, but decrease of xIAP, cIAP and Bcl2 expression. Thiacremonone further inhibited glutathione peroxidase activity in lung cancer cells. However, the cell growth inhibitory effect of thiacremonone was not observed in the lung cancer cells transfected with mutant PRDX6 (C47S) and in the presence of dithiothreitol and glutathione. In an allograft in vivo model, thiacremonone (30 mg/kg) also inhibited tumor growth accompanied with the reduction of PRDX6 expression and glutathione peroxidase activity, but increased expression of cleaved caspase-3, -8, -9, Bax, p21 and p53. These data indicate that thiacremonone inhibits tumor growth via inhibition of glutathione peroxidase activity of PRDX6 through interaction. These data suggest that thiacremonone may have potentially beneficial effects in lung cancer.
Predicting the Development of Diabetes Using the Product of Triglycerides and Glucose: The Chungju Metabolic Disease Cohort (CMC) Study
Seung-Hwan Lee, Hyuk-Sang Kwon, Yong-Moon Park, Hee-Sung Ha, Seung Hee Jeong, Hae Kyung Yang, Jin-Hee Lee, Hyeon-Woo Yim, Moo-Il Kang, Won-Chul Lee, Ho-Young Son, Kun-Ho Yoon
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0090430
Abstract: Background To determine whether the TyG index, a product of the levels of triglycerides and fasting plasma glucose (FPG) might be a valuable marker for predicting future diabetes. Methods A total of 5,354 nondiabetic subjects who had completed their follow-up visit for evaluating diabetes status were selected from a large cohort of middle-aged Koreans in the Chungju Metabolic Disease Cohort study. The risk of diabetes was assessed according to the baseline TyG index, calculated as ln[fasting triglycerides (mg/dL) × FPG (mg/dL)/2]. The median follow-up period was 4.6 years. Results During the follow-up period, 420 subjects (7.8%) developed diabetes. The baseline values of the TyG index were significantly higher in these subjects compared with nondiabetic subjects (8.9±0.6 vs. 8.6±0.6; P<0.0001) and the incidence of diabetes increased in proportion to TyG index quartiles. After adjusting for age, gender, body mass index, waist circumference, systolic blood pressure, high-density lipoprotein (HDL)-cholesterol level, a family history of diabetes, smoking, alcohol drinking, education level and serum insulin level, the risk of diabetes onset was more than fourfold higher in the highest vs. the lowest quartile of the TyG index (relative risk, 4.095; 95% CI, 2.701–6.207). The predictive power of the TyG index was better than the triglyceride/HDL-cholesterol ratio or the homeostasis model assessment of insulin resistance. Conclusions The TyG index, a simple measure reflecting insulin resistance, might be useful in identifying individuals at high risk of developing diabetes.
Quantitative Analysis of Sphingomyelin by High-Performance Liquid Chromatography after Enzymatic Hydrolysis
Seunghyun Lee,Youn-Sun Lee,Kyeong-Mi Choi,Kwang-Sik Yoo,Dong-Mi Sin,Wonkyun Kim,Yong-Moon Lee,Jin-Tae Hong,Yeo-Pyo Yun,Hwan-Soo Yoo
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/396218
Abstract: Sphingomyelin is the most abundant sphingolipid in mammalian cells and is mostly present in the plasma membrane. A new analytical method using high-performance liquid chromatography (HPLC) was developed to quantify sphingomyelin in mouse plasma and tissues, 3T3-L1 cells, rat aortic smooth muscle cells, and HT-29 cells. Sphingomyelin and dihydrosphingomyelin, an internal standard, were separated by high-performance thin-layer chromatography and simultaneously hydrolyzed with sphingolipid ceramide N-deacylase and sphingomyelinase to release sphingosine and dihydrosphingosine, respectively. Sphingomyelin content was measured by HPLC following o-phthalaldehyde derivatization. Sphingomyelin concentrations in 3T3-L1 cells, rat aortic smooth muscle cells, and HT-29 cells were 60.10±0.24, 62.69±0.08, and 58.38±0.37 pmol/μg protein, respectively, whereas those in brain, kidney, and liver of ICR mice were 55.60±0.43, 43.75±0.21, and 22.26±0.14 pmol/μg protein. The sphingomyelin concentration in mouse plasma was 407.40±0.31 μM. The limits of detection and quantification for sphingomyelin were 5 and 20 pmol, respectively, in the HPLC analysis with fluorescence detection. This sensitivity was sufficient for analyzing sphingomyelin in biological samples. In conclusion, this analytical method is a sensitive and specific technique for quantifying sphingomyelin and was successfully applied to diverse biological samples with excellent reproducibility.
Improvement of Uncertainty Relations for Mixed States
Yong Moon Park
Physics , 2004, DOI: 10.1063/1.1876874
Abstract: We study a possible improvement of uncertainty relations. The Heisenberg uncertainty relation employs commutator of a pair of conjugate observables to set the limit of quantum measurement of the observables. The Schroedinger uncertainty relation improves the Heisenberg uncertainty relation by adding the correlation in terms of anti-commutator. However both relations are insensitive whether the state used is pure or mixed. We improve the uncertainty relations by introducing additional terms which measure the mixtureness of the state. For the momentum and position operators as conjugate observables and for the thermal state of quantum harmonic oscillator, it turns out that the equalities in the improved uncertainty relations hold.
Ergodic property of Markovian semigroups on standard forms of von Neumann algebras
Yong Moon Park
Mathematics , 2005, DOI: 10.1063/1.2113067
Abstract: We give sufficient conditions for ergodicity of the Markovian semigroups associated to Dirichlet forms on standard forms of von Neumann algebras constructed by the method proposed in Refs. [Par1,Par2]. We apply our result to show that the diffusion type Markovian semigroups for quantum spin systems are ergodic in the region of high temperatures where the uniqueness of the KMS-state holds.
Erratum: Dirichlet Forms and Dirichlet Operators for Infinite Particle Systems: Essential Self-adjointness
Veni Choi,Yong Moon Park,Hyun Jae Yoo
Physics , 2010, DOI: 10.1063/1.532662
Abstract: We reprove the essential self-adjointness of the Dirichlet operators of Dirchlet forms for infinite particle systems with superstable and sub-exponentially decreasing interactions.
Equity of access to long-term care among the Korean elderly  [PDF]
Ju Moon Park
Health (Health) , 2013, DOI: 10.4236/health.2013.510221

The aim of the current study is to examine the extent to which equity in the utilization of longterm care services has been achieved in the Republic of Korea (hereafter Korea), based on the Aday—Andersen Access Framework that takes into consideration a series of variables hypothesized as predictive of utilization. The current study used cross-sectional survey data collected and conducted by the Korea Labor Institute (KLI) between August 1 to December 22, 2006. The sample for this study was 5544 persons who are older than 60 years. The study was extracted from a larger nationally representative cross-sectional survey of 10,255 individuals. The stratified cluster sampling technique was used to draw the survey respondents. A self-administered questionnaire was used to collect the data from the sample. Descriptive and logistic regression analysis was performed examining the relationship between the dependent variable and the independent variables and the relative importance of factors. The results indicate that a universal health insurance system has not yielded a fully equitable distribution of services. The limitation of benefit coverage as well as disparities in consumer cost-sharing and associated patterns of utilization across plans high out-of-pocket payment can be a barrier to health care utilization, which results in inequity and differential long-term care utilization between sub-groups of older adults. Health policy reforms in Korea must continue to concentrate on expanding insurance coverage, reducing the inequities reflected in disparities in consumer cost-sharing and associated patterns of utilization across plans, and establishing a financially separate insurance system for poor older adults. The behavioral responses of physicians to the method of reimbursement, and the subsequent impact on overall rates of utilization and expenditures need to be more fully understood. In addition, further research is needed to identify the nonfinancial barriers that persist for certain demographic subgroups, i.e., those 70 and older, men, lacking social network members, those who have four or more family members, and those who have no schooling.

Disability and health service utilization among old Koreans  [PDF]
Ju Moon Park
Health (Health) , 2014, DOI: 10.4236/health.2014.65058

This study compared persons with disabilities with those without disabilities in terms of health services utilization and examined the factors associated with the use of inpatient hospital services. Data on a sample of 4040 older adults (65+ years of age) from the Korean Longitudinal Study of Ageing were used. Descriptive and logistic regression analysis was performed examining sample characteristics of participants with and without disabilities and factors significantly associated with health services utilization. This study showed that the elderly with disabilities used significantly more inpatient hospital services than the elderly without disabilities. As expected, poor health was clearly the most influential factor explaining the use of inpatient hospital services. The second most influential factor in determining use of medical services is disability. Persons with disabilities had a twofold or more increase in the odds of using inpatient hospital services. Likewise, the person with chronic condition had also an additional twofold increase in risk for medical services due to the chronic condition. Chronic conditions were clearly the third influential factor explaining the use of inpatient hospital services. Finally, females were a small margin more likely to use inpatient hospital services than males.

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