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Search Results: 1 - 10 of 30813 matches for " Yong Eun Chung "
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Ascorbic Acid Attenuates Acute Ethanol-Induced Liver Injury in SMP30 Knockout Mice  [PDF]
Eun-Mi Cho, H. M. Arif Ullah, Ahmed K. Elfadl, Myung-Jin Chung, Soong-Koo Kim, Yong Deuk Kim, Eun-Joo Lee, Kyu-Shik Jeong
Food and Nutrition Sciences (FNS) , 2017, DOI: 10.4236/fns.2017.812083
Abstract:
Ascorbic acid (AA) is recognized as a free radical scavenger that protects cells from oxidative stress-induced damage. However, no studies have investigated the role of AA in acute alcoholic liver disease using senescence marker protein-30 (SMP30) knockout (KO) mice. SMP30 is a novel 34-kDa protein involved in AA biosynthesis. The present study aimed to elucidate the physiological functions of AA in acute ethanol-induced liver injury using SMP30 KO mice, which cannot synthesize AA in vivo. After a 4-week experimental period, mice were divided into six groups. The following three groups comprised the ethanol treatment groups: WT-E group (wild-type), KV-E group (AA-supplemented), and KT-E group (AA-deficient). Mice were exposed to an acute dose of ethanol (6 g ethanol/kg) administered by gavage once a day for three days. The other three control groups, namely, WT-C, KV-C, and KT-C control groups, received an equal volume of water via oral administration. Analysis of changes in body weight showed that mice in the KT-E group had significant loss of body weight compared to the control, KV-E, and WT-E groups. Behavioral analysis revealed that alcohol exposure significantly increased alcohol sensitivity in the KT-E group, whereas the WT-E, KV-E, and control groups developed ethanol tolerance. Aspartate transaminase (AST) levels in the KT-E group were significantly higher than those in the control, KV-E, and WT-E groups. The number of large and binucleated hepatocytes was significantly higher in the KT-E group than in the KV-E and WT-E groups. In addition, cytochrome P450 2E1 (CYP2E1) was over expressed in the central vein in the KT-E group when compared to the KV-E and WT-E groups. Our current findings indicate that AA supplementation in SMP30 KO mice can alleviate alcohol-induced liver damage by down regulating CYP2E1 expression. These results suggest that reduced CYP2E1 expression is a novel mechanism responsible for AA-induced reduction of ethanol-mediated oxidative stress.
Nest Box Preference by Secondary Cavity-Nesting Birds in Forested Environments
Choi, Chang-Yong,Hyun-Young Nam,Eun-Jae Lee,,Ok-Sik Chung
Journal of Ecology and Field Biology , 2007,
Abstract: We placed and monitored 2,137 nest boxes to determine how the size of the entrance hole andthe box placement influenced nest box selection by secondary cavity-nesting birds and to derive recommendationsfor the use of nest boxes for management of cavity-nesting birds in forested environments. A total of566 pairs of seven bird species used the nest boxes from 1997 to 2006, 562 of which were secondarycavity-nesters. Sympatric tits such as varied tits (Parus varius), great tits (P. major), and marsh tits (P. palustris)were common breeding birds in nest boxes, and showed clear preferences for 4.0 cm, 3.5 cm and 3.0 cm nestholes, respectively. Tree sparrows (Passer montanus) and Eurasian nuthatches (Sitta europaea) preferred 4 cmand 3.5 cm holes, respectively. We did not detect selection for the directional orientation for the entrance hole,but the birds appeared to avoid nest boxes that faced steep or gentle upward slopes and those less than 1.8m from the ground. These results are probably related to avoidance of disturbance and predation. We suggestthat diverse species can be supported by the placement of nest boxes with entrance holes of various sizes andthat specific species can be targeted by selecting the hole sizes preferred by those species. To attract secondarycavity-nesters, managers should avoid placing nest boxes close to the ground and facing hills. This study alsosuggests that careful selection and placement of nest boxes is needed to avoid biases in research using nestboxes.
Plasma Brain-derived Neurotrophic Factor in Hemodialysis Patients
Seok Joon Shin, Hye Eun Yoon, Sungjin Chung, Yong Gu Kim, Dai-Jin Kim
International Journal of Medical Sciences , 2012,
Abstract: Objective: Brain-derived neurotrophic factor (BDNF) is a neurotrophin which modulates neuronal survival and proliferation. Recently, plasma BDNF is associated with inflammatory conditions. The present study was to investigate the changes of the plasma BDNF level in hemodialysis patients and to evaluate the relationship between the plasma BDNF and uremic inflammation. Method: We measured the plasma BDNF, serum IL-2, IL-4, IFN-γ and TNF-α in hemodialysis patients and control subjects. In addition, we investigated the associations of the plasma BDNF with clinical or biochemical parameters. Results: The plasma BDNF level was significantly higher in hemodialysis patients than in the control subjects (median, 312.3 vs. 630.3 pg/ml, p < 0.05). In subgroup analysis, hemodialysis patients with diabetes showed higher values of the plasma BDNF than the patients without diabetes. However, there were no significant differences in age and gender subgroups of the hemodialysis patients. The logBDNF was positively correlated with hs-CRP and IFN-γ, and negatively correlated with serum albumin. In multivariate regression analysis, the logBDNF was independently associated with the presence of diabetes (β-coefficient = 0.399, p = 0.041) and IFN-γ (β-coefficient = 0.538, p = 0.003). Conclusion: The plasma BDNF may increase in hemodialysis patients, and more prominently in the patients with diabetes. Furthermore, the plasma BDNF might reflect inflammatory condition in hemodialysis patients.
Characterization of Incidental Liver Lesions: Comparison of Multidetector CT versus Gd-EOB-DTPA-Enhanced MR Imaging
Yong Eun Chung, Myeong-Jin Kim, Yeo-Eun Kim, Mi-Suk Park, Jin Young Choi, Ki Whang Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066141
Abstract: As a result of recent developments in imaging modalities and wide spread routine medical checkups and screening, more incidental liver lesions are found frequently on US these days. When incidental liver lesions are found on US, physicians have to make a decision whether to just follow up or to undergo additional imaging studies for lesion characterization. In order to choose the next appropriate imaging modality, the diagnostic accuracy of each imaging study needs to be considered. Therefore, we tried to compare the accuracy of contrast-enhanced multidetector CT (MDCT) and Gd-EOB-DTPA-enhanced MRI for characterization of incidental liver masses. We included 127 incidentally found focal liver lesions (94 benign and 33 malignant) from 80 patients (M:F = 45:35) without primary extrahepatic malignancy or chronic liver disease. Two radiologists independently reviewed Gd-EOB-DTPA-enhanced MRI and MDCT. The proportion of confident interpretations for differentiation of benign and malignant lesions and for the specific diagnosis of diseases were compared. The proportion of confident interpretations for the differentiation of benign and malignant lesions was significantly higher with EOB-MRI(94.5%–97.6%) than with MDCT (74.0%–92.9%). In terms of specific diagnosis, sensitivity and accuracy were significantly higher with EOB-MRI than with MDCT for the diagnosis of focal nodular hyperplasia (FNH) and focal eosinophilic infiltration. The diagnoses of the remaining diseases were comparable between EOB-MRI and MDCT. Hence, our results suggested that Gd-EOB-MRI may provide a higher proportion of confident interpretations than MDCT, especially for the diagnosis of incidentally found FNH and focal eosinophilic infiltration.
Derivation of Regression Coefficients for Sea Surface Temperature Retrieval over East Asia
Myoung-Hwan AHN,Eun-Ha SOHN,Byong-Jun HWANG,Chu-Yong CHUNG,Xiangqian WU,
Myoung-Hwan AHN
,Eun-Ha SOHN,Byong-Jun HWANG,Chu-Yong CHUNG,Xiangqian WU

大气科学进展 , 2006,
Abstract: Among the regression-based algorithms for deriving SST from satellite measurements, regionally optimized algorithms normally perform better than the corresponding global algorithm. In this paper, three algorithms are considered for SST retrieval over the East Asia region (15°–55°N, 105°–170°E), including the multi-channel algorithm (MCSST), the quadratic algorithm (QSST), and the Pathfinder algorithm (PFSST). All algorithms are derived and validated using collocated buoy and Geostationary Meteorological Satellite (GMS-5) observations from 1997 to 2001. An important part of the derivation and validation of the algorithms is the quality control procedure for the buoy SST data and an improved cloud screening method for the satellite brightness temperature measurements. The regionally optimized MCSST algorithm shows an overall improvement over the global algorithm, removing the bias of about 0.13°C and reducing the root-mean-square difference (rmsd) from 1.36°C to 1.26°C. The QSST is only slightly better than the MCSST. For both algorithms, a seasonal dependence of the remaining error statistics is still evident. The Pathfinder approach for deriving a season-specific set of coefficients, one for August to October and one for the rest of the year, provides the smallest rmsd overall that is also stable over time.
Diagnostic Radiation Exposure of Injury Patients in the Emergency Department: A Cross-Sectional Large Scaled Study
Je Sung You, Hye-Jeong Lee, Yong Eun Chung, Hye Sun Lee, Myo Jeong Kim, Sung Phil Chung, Myeong-Jin Kim, Incheol Park, Ki Whang Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0084870
Abstract: In contrast to patients with underlying cancer or chronic disease, injury patients are relatively young, and can be expected to live their natural lifespan if injuries are appropriately treated. Multiple and repeated diagnostic scans might be performed in these patients during admission. Nevertheless, radiation exposure in injury patients has been overlooked and underestimated because of the emergent nature of such situations. Therefore, we tried to assess the cumulative effective dose (cED) of injury patients in the emergency department. We included patients who visited the emergency department (ED) of a single tertiary hospital due to injury between February 2010 and February 2011. The cED for each patient was calculated and compared across age, sex and injury mechanism. A total of 11,676 visits (mean age: 28.0 years, M:F = 6,677:4,999) were identified. Although CT consisted of only 7.8% of total radiologic examinations (n=78,025), it accounted for 87.1% of the total cED. The mean cED per visit was 2.6 mSv. A significant difference in the cED among injury mechanisms was seen (p<0.001) and patients with traffic accidents and fall down injuries showed relatively high cED values. Hence, to reduce the cED of injury patients, an age-, sex- and injury mechanism-specific dose reduction strategy should be considered.
Synaptonemal Complex Protein 3 Is a Prognostic Marker in Cervical Cancer
Hanbyoul Cho, Kyung Hee Noh, Joon-Yong Chung, Mikiko Takikita, Eun Joo Chung, Bo Wook Kim, Stephen M. Hewitt, Tae Woo Kim, Jae-Hoon Kim
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0098712
Abstract: Synaptonemal complex protein 3 (SCP3), a member of Cor1 family, is up-regulated in various cancer cells; however, its oncogenic potential and clinical significance has not yet been characterized. In the present study, we investigated the oncogenic role of SCP3 and its relationship with phosphorylated AKT (pAKT) in cervical neoplasias. The functional role of SCP3 expression was investigated by overexpression or knockdown of SCP3 in murine cell line NIH3T3 and human cervical cancer cell lines CUMC6, SiHa, CaSki, and HeLa both in vitro and in vivo. Furthermore, we examined SCP3 expression in tumor specimens from 181 cervical cancer and 400 cervical intraepithelial neoplasia (CIN) patients by immunohistochemistry and analyzed the correlation between SCP3 expression and clinicopathologic factors or survival. Overexpression of SCP3 promoted AKT-mediated tumorigenesis both in vitro and in vivo. Functional studies using NIH3T3 cells demonstrated that the C-terminal region of human SCP3 is important for AKT activation and its oncogenic potential. High expression of SCP3 was significantly associated with tumor stage (P = 0.002) and tumor grade (P<0.001), while SCP3 expression was positively associated with pAKT protein level in cervical neoplasias. Survival times for patients with cervical cancer overexpressing both SCP3 and pAKT (median, 134.0 months, n = 68) were significantly shorter than for patients with low expression of either SCP3 or pAKT (161.5 months, n = 108) as determined by multivariate analysis (P = 0.020). Our findings suggest that SCP3 plays an important role in the progression of cervical cancer through the AKT signaling pathway, supporting the possibility that SCP3 may be a promising novel cancer target for cervical cancer therapy.
Development of a Bead-Based Multiplex Genotyping Method for Diagnostic Characterization of HPV Infection
Mee Young Chung, Yong-Wan Kim, Su Mi Bae, Eun Hye Kwon, Pankaj Kumar Chaturvedi, Gantumur Battogtokh, Woong Shick Ahn
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0032259
Abstract: The accurate genotyping of human papillomavirus (HPV) is clinically important because the oncogenic potential of HPV is dependent on specific genotypes. Here, we described the development of a bead-based multiplex HPV genotyping (MPG) method which is able to detect 20 types of HPV (15 high-risk HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68 and 5 low-risk HPV types 6, 11, 40, 55, 70) and evaluated its accuracy with sequencing. A total of 890 clinical samples were studied. Among these samples, 484 were HPV positive and 406 were HPV negative by consensus primer (PGMY09/11) directed PCR. The genotyping of 484 HPV positive samples was carried out by the bead-based MPG method. The accuracy was 93.5% (95% CI, 91.0–96.0), 80.1% (95% CI, 72.3–87.9) for single and multiple infections, respectively, while a complete type mismatch was observed only in one sample. The MPG method indiscriminately detected dysplasia of several cytological grades including 71.8% (95% CI, 61.5–82.3) of ASCUS (atypical squamous cells of undetermined significance) and more specific for high grade lesions. For women with HSIL (high grade squamous intraepithelial lesion) and SCC diagnosis, 32 women showed a PPV (positive predictive value) of 77.3% (95% CI, 64.8–89.8). Among women >40 years of age, 22 women with histological cervical cancer lesions showed a PPV of 88% (95% CI, 75.3–100). Of the highest risk HPV types including HPV-16, 18 and 31 positive women of the same age groups, 34 women with histological cervical cancer lesions showed a PPV of 77.3% (95% CI, 65.0–89.6). Taken together, the bead-based MPG method could successfully detect high-grade lesions and high-risk HPV types with a high degree of accuracy in clinical samples.
Bojungikgitang and banhabaekchulchonmatang in adult patients with tinnitus, a randomized, double-blind, three-arm, placebo-controlled trial - study protocol
Nam-Kwen Kim, Dong-Hyo Lee, Jung-Hun Lee, Yong-Leol Oh, In-Hwan Yoon, Eun-Sung Seo, Chung-Ho Lee
Trials , 2010, DOI: 10.1186/1745-6215-11-34
Abstract: We aim to establish basic clinical efficacy and safety data for bojungikgitang and banhabaekchulchonmatang, which are approved as herbal medications by the Korea Food and Drug Administration in adult patients with tinnitus.This study was a randomised, double-blind, placebo-controlled trial with three parallel arms (bojungikgitang, banhabaekchulchonmatang, and a placebo). Participants included in the study met the following criteria: typical conditions of intermittent or continuous tinnitus, for more than three months, with involuntary perceptions of the concept of a sound in the absence of an external source. Participants received bojungikgitang, banhabaekchulchonmatang, or a placebo-drug for eight weeks. The total duration of each arm was eleven weeks. Each participant was examined for signs and symptoms of tinnitus before and after taking medication. Post-treatment follow-up was performed two weeks after the final administration of medication.This trial provided evidence for the efficacy and safety of bojungikgitang and banhabaekchulchonmatang in adult patients with tinnitus. The primary outcome measure was the Tinnitus Handicap Inventory, an assessment used to identify difficulties that may be experienced due to tinnitus. The secondary measures were included an Acoustic Examination and the Visual Analogue Scale. We employed the Euro-Qol 5-Dimension and the Health Utilities Index Mark 3, a health-related quality of life questionnaire. Safety was assessed by complete blood cell count, erythrocyte sedimentation rate, blood chemistry, urine analysis, PA chest film, brain computed tomography, otologic examination, and vital signs.Current Controlled Trials ISRCTN23691284Tinnitus is a common disorder,[1] with approximately 5-15% of the general population experiencing an unremitting sensation of tinnitus [2]. Of patients who suffer with the condition, 1 to 2% are seriously impaired. Hearing loss, regardless of the cause, is the most important risk factor for the developm
Comparison of CT and MRI for presurgical characterization of paraaortic lymph nodes in patients with pancreatico-biliary carcinoma
Young Chul Kim, Mi-Suk Park, Seung-Whan Cha, Yong Eun Chung, Joon Suk Lim, Kyung Sik Kim, Myeong-Jin Kim, Ki Whang Kim
World Journal of Gastroenterology , 2008,
Abstract: AIM: To determine the accuracy of computed tomography (CT) and magnetic resonance (MR) for presurgical characterization of paraaortic lymph nodes in patients with pancreatico-biliary carcinoma.METHODS: Two radiologists independently evaluated CT and MR imaging of 31 patients who had undergone lymphadenectomy (9 metastatic and 22 non-metastatic paraaortic nodes). Receiver operating characteristic (ROC) curve analysis was performed using a five point scale to compare CT with MRI. To re-define the morphologic features of metastatic nodes, we evaluated CT scans from 70 patients with 23 metastatic paraaortic nodes and 47 non-metastatic ones. The short axis diameter, ratio of the short to long axis, shape, and presence of necrosis were compared between metastatic and non-metastatic nodes by independent samples t-test and Fisher’s exact test. P < 0.05 was considered statistically significant.RESULTS: The mean area under the ROC curve for CT (0.732 and 0.646, respectively) was slightly higher than that for MRI (0.725 and 0.598, respectively) without statistical significance (P = 0.940 and 0.716, respectively). The short axis diameter of the metastatic lymph nodes (mean = 9.2 mm) was significantly larger than that of non-metastatic ones (mean = 5.17 mm, P < 0.05). Metastatic nodes had more irregular margins (44.4%) and central necrosis (22.2%) than non-metastatic ones (9% and 0%, respectively), with statistical significance (P < 0.05).CONCLUSION: The accuracy of CT scan for the characterization of paraaortic nodes is not different from that of MRI. A short axis-diameter (> 5.3 mm), irregular margin, and presence of central necrosis are the suggestive morphologic features of metastatic paraaortic nodes.
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