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Search Results: 1 - 10 of 167434 matches for " Yolande E Appelman "
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Gender gap in acute coronary heart disease: Myth or reality?
Mette Claassen,Kirsten C Sybrandy,Yolande E Appelman,Folkert W Asselbergs
World Journal of Cardiology , 2012, DOI: 10.4330/wjc.v4.i2.36
Abstract: AIM: To investigate potential gender differences in the prevalence of cardiovascular risk factors, cardiovascular disease (CVD) management, and prognosis in acute coronary syndrome (ACS). METHODS: A systematic literature search was performed through Medline using pre-specified keywords. An additional search was performed, focusing specifically on randomized controlled clinical trials in relation to therapeutic intervention and prognosis. In total, 92 relevant articles were found. RESULTS: Women with CVD tended to have more hypertension and diabetes at the time of presentation, whereas men were more likely to smoke. Revascularization by percutaneous coronary intervention and coronary artery bypass surgery were performed more often in men. Women were at a greater risk of short-term mortality and complications after revascularization. Interestingly, women under 40 years presenting with ACS were at highest risk of cardiovascular death compared with men of the same age, irrespective of risk factors. This disadvantage disappeared in older age. The long-term mortality risk of ACS was similar in men and women, and even in favor of women. CONCLUSION: Mortality rates are higher among young women with ACS, but this difference tends to disappear with age, and long-term prognosis is even better among older women.
Automated peritoneal lavage: an extremely rapid and safe way to induce hypothermia in post-resuscitation patients
Monique C de Waard, Hagen Biermann, Stijn L Brinckman, Yolande E Appelman, Ronald H Driessen, Kees H Polderman, Armand RJ Girbes, Albertus Beishuizen
Critical Care , 2013, DOI: 10.1186/cc12518
Abstract: Aiming at a rapid induction and stable maintenance phase, MTH induced via continuous peritoneal lavage (PL) using Velomedix(R) Inc. automated PL system was evaluated and compared to historical controls in which hypothermia was achieved using cooled saline intravenous infusions and cooled blankets.In sixteen PL patients time to reach core target temperature of 32.5oC was 30 minutes (interquartile range [IQR]: 19-60), which was significantly faster compare to 150 minutes (IQR: 112-240) in controls. The median rate of cooling during the induction phase in the PL group of 4.1oC/hr (IQR: 2.2-8.2) was significantly faster compared to 0.9oC/hr (IQR: 0.5-1.3) in controls. During the 24 hours maintenance phase mean core temperature in the PL patients was 32.38+/-0.18oC (range: 32.03-32.69oC) and in control patients 32.46+/-0.48oC (range: 31.20-33.63oC), indicating more steady temperature control in the PL group compared to controls. Furthermore, the coefficient of variation (VC) for temperature during the maintenance phase was lower in the PL group (VC: 0.5%) compared to the control group (VC: 1.5%). In contrast to 23% of the control patients, none of the PL patients showed overshoot of hypothermia below 31oC during the maintenance phase. Survival and neurological outcome was not different between the two groups. Neither shivering nor complications related to insertion or use of the PL method were observed.Using PL in post CA patients results in rapidly reached target temperature and a very precise maintenance, unprecedented in clinical studies evaluating MTH techniques. This opens the way to investigate the effects on neurological outcome and survival of ultra-rapid cooling compared to standard cooling in controlled trials in various patient groups. Trial registration: ClinicalTrials.Gov NCT01016236
Interventions to improve physical activity in the elderly (a field project in four municipalities)
Anniek Appelman
International Journal of Integrated Care , 2012,
Fatal dialysis disequilibrium syndrome: A tale of two patients
Shaikh Nissar,Louon Andr′e,Hanssens Yolande
Journal of Emergencies, Trauma and Shock , 2010,
Abstract: Dialysis disequilibrium syndrome (DDS) is a central nervous system disorder, which occurs during hemodialysis (HD) or within 24 h following the first HD. DDS commonly occurs in patients suffering from end-stage renal failure undergoing HD for the first time. In a critically ill patient suffering from severe sepsis or septic shock, the combined effects of post-HD brain edema and changes in the brain due to septic encephalopathy, may become amplified leading to DDS. Here we report 2 cases with acute renal failure (ARF), undergoing HD for more than a week and being ventilated and who developed DDS. DDS might have contributed to the sudden deterioration and death in these septic patients. The first case was a 31-year-old male, involved in a motor vehicle accident and had a severe abdominal injury. Underwent laparotomy and hemostasis was achieved. On day 4, the patient developed hemorrhagic shock associated with ARF, which prompted daily HD. On day 8, he went into septic shock. On day 16, 1 h after his daily HD, he became unresponsive and his pupils became dilated and fixed and he expired 2 days later. The second case was a young male who suffered severe abdominal and chest injury after a fall from a height. He developed ARF on day 3 and required HD. On day 9, he had septic shock. Three days later, during his daily HD, he became unconscious and his pupils were not reacting to light and the patient died on day 12. Conclusion: In patients with severe sepsis/septic shock, DDS may occur even after repeated sessions of HD. The acute care physicians, intensivists, and nephrologists should be aware of the risks of DDS.
Effect of additional treatment with EXenatide in patients with an Acute Myocardial Infarction (EXAMI): study protocol for a randomized controlled trial
Martijn Scholte, Leo Timmers, Flip JP Bernink, Robert N Denham, Aernout M Beek, Otto Kamp, Michaela Diamant, Anton JG Horrevoets, Hans WM Niessen, Weena JY Chen, Albert C van Rossum, Niels van Royen, Pieter A Doevendans, Yolande Appelman
Trials , 2011, DOI: 10.1186/1745-6215-12-240
Abstract: The EXAMI trial is a multi-center, prospective, randomized, placebo controlled trial, designed to evaluate clinical outcome of exenatide infusion on top of standard treatment, in patients with an acute myocardial infarction, successfully treated with primary percutaneous coronary intervention. A total of 108 patients will be randomized to exenatide (5 μg bolus in 30 minutes followed by continuous infusion of 20 μg/24 h for 72 h) or placebo treatment. The primary end point of the study is myocardial infarct size (measured using magnetic resonance imaging with delayed enhancement at 4 months) as a percentage of the area at risk (measured using T2 weighted images at 3-7 days).If the current study demonstrates cardioprotective effects, exenatide may constitute a novel therapeutic option to reduce infarct size and preserve cardiac function in adjunction to reperfusion therapy in patients with acute myocardial infarction.ClinicalTrials.gov: NCT01254123Myocardial infarction (MI) causes loss of cardiomyocytes and may lead to loss of ventricular function, morbidity and mortality. The impairment of left ventricular function may lead to heart failure and death and has a major impact on the quality of life of the patient. Infarct size is a major prognostic factor after MI[1,2]. Reduction of infarct size has therefore been an important objective of strategies to improve clinical outcomes in patients that suffer acute MI.It was previously demonstrated that early reperfusion of the infarct related coronary artery, usually by primary percutaneous intervention (PCI) limits myocardial necrosis and improves clinical outcome in patients with acute MI[3]. Despite adequate reperfusion, however, most patients still suffer irreversible cardiomyocyte loss. Ironically, part of this loss is induced by the reperfusion itself. Reperfusion induces several biochemical and metabolic changes, which lead to accelerated apoptosis of cardiomyocytes[4]. This phenomenon is referred to as reperfusion inj
Collective excitation spectrum of a disordered Hubbard model
Yolande H. Szczech,Michael A. Tusch,David E. Logan
Physics , 1998, DOI: 10.1088/0953-8984/9/44/017
Abstract: We study the collective excitation spectrum of a d=3 site-disordered Anderson-Hubbard model at half-filling, via a random-phase approximation (RPA) about broken-symmetry, inhomogeneous unrestricted Hartree-Fock (UHF) ground states. We focus in particular on the density and character of low-frequency collective excitations in the transverse spin channel. In the absence of disorder, these are found to be spin-wave-like for all but very weak interaction strengths, extending down to zero frequency and separated from a Stoner-like band, to which there is a gap. With disorder present, a prominent spin-wave-like band is found to persist over a wide region of the disorder-interaction phase plane in which the mean-field ground state is a disordered antiferromagnet, despite the closure of the UHF single-particle gap. Site resolution of the RPA excitations leads to a microscopic rationalization of the evolution of the spectrum with disorder and interaction strength, and enables the observed localization properties to be interpreted in terms of the fraction of strong local moments and their site-differential distribution.
Genetic Polymorphisms of CYP2C9: Comparison of Prevalence in the Lebanese Population with Other Populations  [PDF]
Yolande B. Saab, Taimour Langaee
Pharmacology & Pharmacy (PP) , 2011, DOI: 10.4236/pp.2011.22011
Abstract: Background: There is little knowledge about genotyping of cytochrome P450s in the Middle East, and there has not been any report on the genotype of CYP 2C9 allelic variants in Lebanese population. Aims and objectives: The purpose of the study was to determine and compare the frequencies of the cytochrome P450 CYP2C9 variants in the Lebanese population with the frequencies in other ethnic populations. Methods: CYP2C9 genotypes were determined in a total of 146 samples of unrelated, healthy Lebanese individuals residing in different areas in Lebanon. Following DNA extraction from buccal cells and polymerase chain reaction, genotyping was performed by Pyrosequencing method. CYP2C9 genotypes results were compared to other populations; i.e., Middle Easterns, Europeans, Asians, and African Americans. Results and discussion: The frequencies of the CYP2C29*2, CYP2C9*3, and CYP2C9*4 alleles were 11.305%, 11.645%, and 1.025% respectively. No CYP2C9*5 allele variants were found among the Lebanese study sample. Vol- unteers could be divided into three CYP2C9 genotype groups: subjects (76.71%) with no mutated alleles (CYP 2C9*1*1; homozygous extensive metabolizers, EM), 21.23% with one mutated allele (CYP 2C9*1*2, *1*3, *1*4, and *1*5; heterozygous intermediate metabolizers IM), and 2.06% with two mutated alleles, homozygous variants as poor metabolizers, PM). The comparative analysis using genotype groups of different populations showed differences among Leba- nese and other Caucasians. Conclusion: This is the first report from Lebanon on CYP2C9 variants; it highlights a higher frequency of CYP2C9 extensive metabolizers compared to other populations including Caucasians. The results serve as a database on CYP 2C9 polymorphisms and baseline clinical data for dosing and avoiding adverse drug reac- tions of drugs metabolised by CYP2C9 in Lebanese patients.
Le genre d’une migration post-coloniale : de Meknès (Maroc) à Montréal (Québec)
Yolande Cohen
Genre & Histoire , 2010,
Abstract: La subjectivité des actrices et leur perception des événements qui ont marqué leur époque ont été largement réhabilitées par l’histoire sociale et par l’histoire des femmes et du genre. Les historiennes sont alors conviées à expliciter à leur tour leurs motivations à traiter de tel ou tel sujet et à dévoiler leur propre point de vue, le lieu d’où elles parlent et écrivent. La réflexivité est ainsi devenu un passage obligé en sciences sociales ces dernières années et cet exercice appara t d’au...
Women and leadership from a pastoral perspective of friendship
Yolande Dreyer
HTS Theological Studies/Teologiese Studies , 2009, DOI: 10.4102/hts.v58i1.552
Abstract: The aim of the article is to describe leadership from the perspective of friendship. This perspective highlights a pastoral rather than a power oriented approach to leadership. Such an approach would be compatible with an attitude of service as an essential characteristic of the church. It could also contribute to the healing of church structures that have become entangled in power games. It could lead to the healing of women and other disempowered groups who have for centuries been the victims of the power struggles of church institutions.
Du nursing au care : le genre d'une profession
Aporia : The Nursing Journal , 2012,
Abstract: Cet article présente une analyse détaillée de la professionnalisation du nursing au Québec (Canada). L'emphase porte sur deux variables principales qui permet de mieux comprendre les aspects genrés de la profession et sa féminisation persistante. Le cas québécois, présenté dans le cadre de cet article, et étudié dans son contexte canadien, permet d'identifier plusieurs éléments qui ont conduit à faire du care le fondement du nursing. L'auteure retient deux facteurs principaux, qui se trouvent à l'intersection de rapports de classe, de genre et d'ethnicité dès les débuts de la réforme du nursing : le r le précurseur des réformatrices et les origines confessionnelles du nursing. La combinaison de ces facteurs explique la persistance d'une ségrégation sexuelle aussi exceptionnelle dans le monde du travail.
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